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Zhang et al. characterize the mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner mitochondrial membrane stress by inducing membrane subdomains promoting homeostatic fission and mtDNA degradation.

The authors developed a highly sensitive skin-conformal NIR organic photodetector with fast photoresponse speed that achieves MHz-speed, angle-free, and long-range (100 m) wireless optical communication with stable performance under mechanical deformation.

Compiling data on floral introductions and European colonial history of regions worldwide, the authors find that compositional similarity of floras is higher than expected among regions once occupied by the same empire and similarity increases with the length of time the region was occupied by that empire.

Ionic thermoelectric materials are promising for harvesting energy, but n-type materials are not as efficient as p-type materials. Here the authors report a homologous n-/p-type thermoelectric material using a liquid crystal elastomer network for energy harvesting.

In-sensor computing offers a promising solution for image processing with reduced data transfer. Here, the authors report programmable and multifunctional van der Waals optoelectronic sensors, showing their application for snapshot compression and recognition of dynamic videos and 3D spectral data.

The recent increase in Antarctic Ice Sheet mass is driven by enhanced precipitation from frequent atmospheric rivers, stronger westerlies, and reduced sea ice, which together offset ice loss from outlet glacier discharge, according to reanalysis and regional climate modelling.

Tuning of metal atom coordination in dual atom catalysts remains challenging. Here, axial dual Fe-Co atoms are incorporated into a COF and N-doped graphene, as bifunctional oxygen catalyst. The axial Fe-Co orbital coupling optimizes orbital energy levels enhancing its electrocatalytic performance.

The authors report by homogeneously integrating a ring quantum cascade laser with a passive waveguide geometry, it is possible to reach a stable and tunable quantum walk comb state while improving the light outcoupling by 2 orders of magnitude.

Gap junction channels formed by Cx32 enable intercellular communication, and their disruption causes CMT1X disease. Here, authors use cryo-EM and molecular dynamics simulations to show how specific lipids and sterols may directly control Cx32 channel gating

Memristors with on/off ratios up to 10⁸ and analogue resistive switching can be created using the intercalation/de-intercalation of silver ions in a two-dimensional metallic electrode to modulate ion migration.

Fire hydrants can create stagnant zones in drinking water systems that degrade water quality. This study shows that stagnant water has much higher metal and microbial levels than flowing water, revealing distinct chemical and microbial shifts that may pose health risks.

DNA damage can arise from natural cellular processes, but how cells prevent resulting mutations is unclear. Here, the authors show that the enzyme Polκ protects mouse tissues from mutations caused by endogenous guanine lesions, revealing how DNA repair and damage tolerance pathways cooperate to maintain genome integrity.

CrI3 is a van der Waals material which exhibits magnetic ordering down to the monolayer limit. Here, using ultrafast optical spectroscopy, Padmanabhan and Buessen et al. investigate the coupling between the magnetically ordered spins and lattice distortions, finding a coherent spin-coupled phonon mode.

Laser-induced conversion electron Mössbauer spectroscopy, which detects electrons emitted by ²²⁹Th nuclei in a thin ThO₂ sample excited by vacuum ultraviolet light, is demonstrated, opening the possibility of a conversion-electron-based nuclear clock.

Strong bulk van der Waals materials are fabricated by the compressive moulding of two-dimensional nanosheets near room temperature through water-mediated densification, providing an energy-efficient way for synthesizing various van der Waals materials and a potential for tailoring compositions.

Inspired by the induced fit theory in molecular biology, this work successfully prepared Ga-based semiconductor films with weak substrate dependence, holding great promise for next-generation electronics and optoelectronics.

This study presents LoopID, which profiles proteins at targeted interacting enhancer–promoter (E-P) pairs, identifying the histone demethylase JMJD2 as a regulator of E-P interactions through biomolecular condensate formation independent of its catalytic activity.

Sebaceous tumours are a rare skin tumour which have highly variable outcomes. Here, the authors analyse tumours from 222 patients to identify genomic mutations to assess the molecular portrait of the spectrum of tumours.

Liu et al. report the design of organic cation to selectively enhance in-plane distortion for localizing excitons and suppress out-of-plane and intra-octahedral distortions for minimizing the formation of self-trapped excitons, enabling 2D perovskites with fast X-ray scintillation response (0.62 ns) and high light yield (19,700 photons MeV⁻¹).

The impact of tumour heterogeneity on metastatic potential in prostate cancer remains poorly understood. Here, the analysis of single nuclei RNA sequencing and whole-genome sequencing from samples from five patients suggests an interplay between clonal evolution and cellular plasticity driving metastatic seeding.

Hepatitis C virus (HCV) variability and its phenotypic consequences aren’t well studied in relation to viral replication fitness and disease severity. Here, the authors identify a replication-enhancing domain in non-structural protein 5A, linking high replication fitness to severe disease outcomes, with implications for understanding HCV pathogenesis in immunocompromised patients.

We present comprehensive thermodynamic and spectroscopic evidence for an antiferromagnetically ordered heavy-fermion ground state in the van der Waals metal CeSiI.

Kappa-opioid receptors (KORs) influence pain and itch. Here, using cryoEM, spectroscopy, and cell tests, the authors show how specific amino acids shape KOR responses. These findings may guide development of pain treatments with fewer side effects.

The variability in clinical outcomes of SARS-CoV-2 infection is partly due to deficiencies in production or response to type I interferons (IFN). Here, the authors describe a FIP200-dependent lysosomal degradation pathway, independent of canonical autophagy and type I IFN, that restricts SARS-CoV-2 replication, offering insights into critical COVID-19 pneumonia mechanisms.

The spontaneous topological Hall effect, combining non-coplanar antiferromagnetic order with finite scalar spin chirality in the absence of a magnetic field, is now experimentally demonstrated for the triangular lattice compounds CoTa₃S₆ and CoNb₃S₆.

New two-dimensional semiconductors may exhibit properties beyond inherent semiconducting attributes. Here the authors report protonated semiconducting III–V-derived van der Waals crystals with memristive properties.

A simple transport model infers a material’s electronic dimensionality from standard transport measurements, revealing temperature-, doping- and alloying-driven shifts between low-dimensional and 3D transport in SrTiO₃, Bi₂O₂Se and Pb_1-xSn_xTe.

The 2D material hBN hosts various optically addressable spin defects, promising for quantum technology applications. Here the authors report the co-existence of spin-1 and spin-1/2 defects in hBN, show their room temperature coherent control and optical readout, as well as cross-relaxation.

The authors report the synthesis of (La_0.9Y_0.1)H₁₀ superhydrides and their characterization using synchrotron-based, spatially resolved x-ray diffraction and electrical transport imaging. They reveal μm-scale structural inhomogeneity with coexisting cubic and hexagonal clathrate phases exhibiting distinct superconducting transition temperatures.

The microbiota influences the cytotoxicity of chemotherapy in patients with colorectal cancer but the impact on metastatic relapse is less clear. Here, the authors report that chemotherapy-induced intestinal mucositis induces systemic immune changes via production the microbial metabolite, indole-3-propionic acid (IPA), preventing metastases.

Fe3GaTe2 is a van der Waals material with a Curie temperature well above room temperature, making it an attractive material for integration into spintronic devices. Here, Kajale et al demonstrate spin-orbit torque induced switching of the magnetization of Fe3GaTe2, above room temperature, using a Pt spin Hall layer.

NiPS₃, a van der Waals antiferromagnet exhibits exciton emission with a very sharp linewidth. The exact origin of this is has been a subject of active debate. Here, Wang et al study the behavior of this sharp exciton peak under applied magnetic fields, and find a Zeeman-like splitting, indicating the exciton has triplet-singlet character.

By combining large-scale first-principles GW-BSE calculations and micro-reflection spectroscopy, the nature of the exciton resonances in WSe₂/WS₂ moiré superlattices is identified, highlighting non-trivial exciton states and suggesting new ways of tuning many-body physics.

Data obtained from the MicroBooNE liquid-argon time projection chamber are used to exclude the single light sterile neutrino interpretation of the LSND and MiniBooNE anomalies at the 95% confidence level.

Accumulation of senescent cells is associated with age-related diseases. Here, the authors present a prodrug nanoplatform to trigger ferroptosis specifically and exclusively in senescent cells.

Researchers demonstrate a persistent spin helix in an organic–inorganic hybrid ferroelectric halide perovskite whose layered nature makes it intrinsically like a quantum well. They demonstrate a switchable spin-polarized band structure via an intrinsic ferroelectric field.

The authors embed a multiple quantum-well WS₂ heterostructure in a planar microcavity and show the systematic control of the normal mode coupling-strength. They find a strong enhancement of the characteristic time scale, which they attribute to long-lived dark excitations emerging in the structure.

Anisotropic hybridization between conduction and unpaired f electrons is rarely observed. Now, a lanthanide-based two-dimensional compound exhibits nodal hybridization, giving rise to heavy-fermion behaviour.

Fe₃GeTe₂, known as FGT, is a van der Waals magnetic material that was recently shown to host magnetic skyrmions. Here, Birch et al using both X-ray and electron microscopy to study the stability of skyrmions in FGT, revealing how the sample history can influence skyrmion formation

Altermagnets recently emerged as a new class of magnetic materials, arising from specific spin crystal symmetries. This paper studies a layered triangular lattice altermagnet, cobalt-intercalated NbSe2, using scanning tunneling microscopy and spectroscopy.

Moiré structures often exhibit long-range order. Here, the authors use scanning tunneling microscopy to identify an incommensurate moiré structure with a short-range-ordered charge density modulation.

Multiple complementary optical signatures confirm the persistence of ferroelectricity and inversion-symmetry-breaking magnetic order down to monolayer NiI₂, introducing the physics of type-II multiferroics into the area of van der Waals materials.

Drug-resistant bacterial infections hinder tissue repair and regeneration. Here, authors present a lysozyme nanofibril-based hydrogel that mimics neutrophil extracellular traps, enabling pathogen elimination and promoting tissue regeneration.

The controlled manipulation of the topological phases of electronic materials is a central goal of modern condensed matter research. Here, the authors demonstrate controllable switching between two distinct topological phases in a layered ferromagnet via thermal cycling.

Efficient lead optimization in drug discovery requires improving potency, synthetic accessibility, and physicochemical properties. Here, the authors utilize machine learning to screen large chemical spaces, demonstrating automated selection of optimized molecules to improve cycle times.

Recent studies have reported the exceptional plasticity of InSe van der Waals crystals, but their deformation-correlated lattice dynamics remains unexplored. Here, the authors investigate the correlations of plastic interlayer slip, lattice anharmonicity and thermal transport in β-InSe crystals via neutron scattering techniques.

Myocardial infarction triggers inflammation driven by immune cell reprogramming, but the epigenetic regulators involved remain unclear. Here, the authors show that histone acetyltransferase 1 enhances postinfarction inflammation by promoting histone succinylation in monocytes.

This study finds that prime editing of Adrb1^A187V in the mouse brain boosts excitability of β1- adrenergic neurons, wake behaviors, and memory, while lowering sleep pressure. In an Alzheimer’s model, Adrb1^A187V also restored physiological REM sleep amounts.

The authors report the discovery of charge order with onset temperature of 800 K in the kagome superconductor YRu₃Si₂. In addition, they observe time-reversal symmetry breaking below 25 K, field-induced magnetism below 90 K and bulk multi-gap superconductivity below 3.4 K.

A Josephson diode is made by fabricating an inversion symmetry breaking van der Waals heterostructure of NbSe₂/Nb₃Br₈/NbSe₂, demonstrating that even without a magnetic field, the junction can be superconducting with a positive current but resistive with a negative current.