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Scalable fabrication of quantum emitters with precise spatial positioning remains challenging. Here the authors present a scalable method for the deterministic fabrication of high-quality single-photon emitter arrays in hexagonal boron nitride, using nano-indentation to enable site-specific impurity insertion.

SARS-CoV-2 variants resistant to current antivirals pose a significant threat, especially to high-risk patients. The authors identify a deletion mutation in M^pro that confers resistance to ensitrelvir but increases susceptibility to nirmatrelvir, suggesting potential for sequential or alternative therapeutic strategies in prolonged antiviral treatments.

TRPC5 ion channels play a critical role in the brain. Here, the authors report cryo-EM structures of the TRPC1/C5 heteromer and TRPC5 bound to two agonists, providing structural insights into channel assembly and modulation.

Determining graphene domain size and distribution is important for realizing functional electronic devices. Here, the authors use liquid crystals to study graphene surfaces, via the liquid crystal molecules aligning with the domains, and use nematic to smectic transitions to study defects.

Adipose CoA handling is critical for lipid metabolism and homeostasis. Here, the authors identify TMEM120A as an ER-resident CoA binding protein enriched in adipocytes that promotes fatty acid recycling to support energy metabolism and limit lipotoxic stress, while its loss leads to adipose inflammation and metabolic dysfunction under high-fat diet conditions.

By controlling the coalescence of multiple unidirectional grains on vicinal sapphire substrates, wafer-scale channels of single-crystalline molybdenum disulfide can be grown, which exhibit coherent quantum transport across large length scales.

Semiconductors are promising for high performance spintronics but the low functioning temperature hampers their applications. Here the authors achieve a strong room temperature modulation of spin-dependent resistance in GaN nanowires, which marks an important step towards practical spintronic devices.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

A prime editing-based screen of BCR–ABL1 single-nucleotide variants finds resistance against clinically used tyrosine kinase inhibitors.

A photoreactive crosslinker can be used to directly pattern thin films of exfoliated two-dimensional flakes, and the technique can be performed sequentially to create patterned van der Waals heterostructures at wafer scales.

An analysis of memory T cells induced by messenger RNA vaccination reveals that they maintain polyfunctionality in response to the Omicron spike protein.

Cut-seq1, Cut-seq2, DeepCut and CLOVE-seq methods find optimized single-guide RNAs to detect a large number of rare variants in cells.

The absence of a band gap in graphene hinders its use in electronics. Here, the authors open a band gap as large as 3.9 electronvolts in graphene grown by chemical vapour deposition by treating it in hydrogen plasma, and then use this material to create a room temperature field- effect transistor.

Water plays an essential role in enzyme catalysis, but direct observations linking enzyme catalysis and active-site water pose a significant challenge due to experimental difficulties. Here, the authors employ an ultraviolet photolysis technique with temperature-controlled X-ray crystallography to track the catalytic pathway of carbonic anhydrase II at 1.2 Å resolution.

The first conference on ‘Infection and Immunity’ was organized by the Institute for Basic Science and Korean Association of Immunologists and held in Daejeon, South Korea, from 12 to 14 July 2023. The conference focused on the biology of CD8⁺ T cells in the context of viral disease and cancer.

Interlayer electronic states in twisted bilayer graphene are characterized by flat-band regions hosting many-body electronic effects. Here, the authors observe two-photon photoluminescence excitation and excited-state absorption spectra on graphene containing a variety of twist angles to access the dark exciton transitions and estimate the exciton binding energy.

Nanoscale filaments with a Magnéli structure are shown to be responsible for resistance switching in thin films of TiO₂, and the properties of the filaments are directly observed during the switching process.

Here, the authors compared measurements between 34 laboratories from 19 countries, to quantify by mass spectrometry four ceramides of clinical relevance in human blood plasma Standard Reference Materials. The main goals were to evaluate concordance obtained in a large inter-laboratory trial and to report absolute concentrations of four circulating lipids in a publicly available standard.

High-throughput sequencing is used to identify somatic variants in cancer patients. Here, the authors perform panel-based profiling of 5095 clinical samples and demonstrate that many clinically-actionable variants have low variant allele fractions, requiring assays with high detection sensitivity.

In ambient conditions, the detection of topological surface states in topological insulators is impaired by the presence of bulk and quantum well states. Here, Park et al. demonstrate how such topological states in epitaxial ultrathin Bi₂Se₃may be isolated using terahertz time-domain spectroscopy.

We find that rhinoceros beetles passively deploy and retract their hindwings without muscular activity, demonstrating this with insect-like microrobots.

Light-matter interactions in quantum materials have primarily been studied from the perspective of light-induced phases. Here the authors report quantum interference between light-induced excitation paths in the van der Waals material FePS₃ resulting in quantum-mechanical birefringence and linear dichroism.

TNF inhibitor (TNFi) has been used to manage active inflammation in ankylosing spondylitis (AS), but not all patients respond. Here, through longitudinal and multi-omics profiling, the authors show that elevated type-I IFN signature and allograft inflammatory factor-1 expression at baseline inversely correlate with TNFi responsiveness in AS patients.

Design of electrocatalyst in lithium sulfur batteries is important to improve electrochemical performance. Here, authors use protective carbon layer to modulate the metal p-band center and prevent undesirable phase change of electrocatalyst for realizing 1 A h level lithium sulfur pouch cell.

Laser-induced ultrafast demagnetization has been thought to depend mainly on total absorbed laser power, with little regard for photon energy. Here, the authors use spintronic terahertz emission spectroscopy to demonstrate that photon energy significantly influences magnetization dynamics, revealing that shorter-wavelength high-energy photons extend demagnetization and recovery time scales, thus providing interesting insights and opportunities for optical control in spintronics.

The Pohang Accelerator Laboratory X-ray Free Electron Laser (PAL-XFEL) in South Korea has now entered operation with a timing jitter of just 20 fs.