Search

Group II intron splicing in plant chloroplasts likely requires Maturase K, a relative of bacterial maturases. Here, the authors demonstrate that, unlike its bacterial ancestors, Maturase K acts within a heteromultimeric splicing complex.

The study introduces polyethyleneimine as an additive in a thermocell, enhancing thermopower from 1.4 to 7.76 mV/K. It achieves long-term stability and scalability by enabling thermosensitive adsorption-desorption, selective reactions, and Manning condensation, converting low-grade heat to electricity efficiently.

A soft three-dimensional core–shell cable can form reliable free-standing interconnects between soft, rigid and hybrid electronic components, and can be stretched by up to around 800%.

Pancreatic ductal carcinoma is often diagnosed at a late stage due to challenges in detection. Here, the authors develop a serum metabolomics-based algorithm, which outperforms existing detection methods.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

The underlying regulatory mechanisms of of human cortical diversity remains poorly understood. Here, authors profiled human brain cells to study how they use different gene programs across cortical regions, revealing molecular rules and specific transcription factors that drive functional specialization of neurons in the brain

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Chen et al. identify a brain-to-bone communication axis whereby extracellular vesicles from aged brain neurons transport WDFY1 protein to distal bone, driving bone-fat imbalance and promoting osteoporosis.

van Lengerich et al. developed a human TREM2 antibody with a transport vehicle (ATV) that improves brain exposure and biodistribution in mouse models. ATV:TREM2 promotes microglial energetic capacity and metabolism via mitochondrial pathways.

Here, the authors show that common fragile sites are unstable under loose activation of the DNA-replication checkpoint. Tight checkpoint activation or CDK1 inhibition stabilizes them by advancing completion of their replication via extra replication-initiation events that are dependent on S-phase availability of proteins involved in pre-RC building.

Femtosecond electrochemical transient absorption spectroscopy is employed to explore the fundamental origin of anodic corrosion. It reveals that Ir corrosion originates from ultrafast proton–electron synchronization and that CeO₂ can create femtosecond-scale proton–electron asynchrony for corrosion-resistant low-Ir anodes.

Spatial omics maps molecular features to tissue architecture, but it often misses rare cell populations. Here, the authors present GARDEN, a graph-based framework that detects pathogenic cells and regions across spatial omics, enables 3D tissue reconstruction, and reveals immune and regulatory mechanisms in several diseases.

DNA polymerase ζ (Pol ζ) maintains continuity but impairs accuracy during DNA replication. Here, the authors report a mechanism by which human cells precisely control the essential, yet mutagenic, activity of Pol ζ to ensure both continuation and fidelity during DNA replication challenges.

This study highlights the Wheat Spatial Omics Consortium, which aims to build a spatiotemporal single-cell atlas of wheat in response to different treatments, thereby contributing to the development of sustainable and climate-resilient wheat.

 An snRNA-seq atlas of Tibetan sheep testes across four stages identifies distinct spermatogonial stem cell and Sertoli cell states and key somatic–germ signalling networks, offering clues to reproductive adaptation in high-altitude environments.

The key regulators driving intrinsic immune responses and neuropathic pain remain elusive. Here, the authors elucidate that ZFP612-mediated epigenetic disinhibition of Il1rl1 within the 3D genome in dorsal root ganglion neurons causes neuropathic pain.

The authors found esterified pectin localized at the stiff poles of maize stomata, modulating stomatal opening. These results reveal novel targets for stomatal engineering and breeding crops with higher water use efficiency.

Behçet’s syndrome is a chronic inflammatory disease with oral ulcers being the most common symptom. Here authors present results from a phase 2 randomized double-blind placebo-controlled clinical trial that shows that systemic low dose interleukin-2 could be safely administered to these patients, and the therapy may improve their quality of life.

This work describes FX-Cell and its derivatives to achieve single-cell RNA sequencing from challenging and cryopreserved plant tissues, expanding the scope of single-cell genomics across field-grown samples.

Shrestha et al. reveal that rice PHYTOENE SYNTHASE 2 (OsPSY2) coordinates the carotenoid-derived biosynthesis of abscisic acid and strigolactones, which independently govern iron plaque deposition and aerenchyma development, respectively.

DEAD-box helicase 6 (DDX6), the regulator of P-body assembly, is essential for the survival of acute myeloid leukemia (AML) cells. Here the authors report that DDX6 undergoes phase separation to preserve mRNA subsets in P-bodies, promoting branched-chain amino acid metabolism and chemoresistance in AML.

Gut microbiota influence bone health, but the genetic and metabolic mechanisms are unclear. Here, the authors show that specific bifidobacterial taxa causally reduce bone mineral density, partly via n-3 fatty acid metabolism, highlighting host-microbe interactions with potential therapeutic implications.

Follow-up telephone interviews are crucial but labour intensive in large-scale clinical trials. Here, the authors show that a specialized large language model automates this process, outperforming both existing AI systems and human experts in accuracy and efficiency.

DNA replication in the human genome occurs preferentially at initiation zones (IZs). Here, the authors identify TRESLIN-MTBP as a limiting factor for replication initiation whose loading onto DNA-bound MCM defines IZs. This process establishes IZs and replication timing in human cells.

Immune checkpoint inhibitors have shown promise in tumour immunotherapy but resistance has been seen. Here using pre-treatment hepatocellular carcinoma patient biopsies from patients scheduled for immunotherapy, the authors implicate BCL9 and show that a BCL9-targeting peptide promotes anti-tumour immunity in mouse models through targeting macrophages and promoting anti-tumour T cell responses.

It is challenging to construct lateral homostructures with controllable geometry and repeated alternating configurations. Here the authors develop a generic approach for fabricating twisted lateral homostructures with tunable crystal orientation, epitaxial constrain, and phase stability.

Wei, Bai, Wang, and colleagues present HypnoS, a genetically-encoded fluorescent sensor for the real-time monitoring of intracellular adenosine (iAdo) in a cell type-specific manner. They monitor iAdo dynamics during seizures or sleep-wake cycles with high spatiotemporal resolution in the brain of living animals.

Microcombs are vulnerable to the environmental perturbations. Here, the authors propose a universal mechanism to fully control the microcombs. Based this reconfigurable microsoliton, a wavemeter with a precision of kHz is demonstrated.

Tendons exhibit limited healing capacity and the role of lymphatic vessels in tendon regeneration is largely overlooked. Here they compare control and injured tendon cells from both neonatal and adult mice and identify lymphatic vessels as key regenerative niche elements.

In this study, the authors show that Salmonella enterica serovar Typhimurium co-opts the host mitochondrial citrate carrier (CIC) to regulate the redox state of its vacuole, facilitating intracellular survival.

Terminally differentiated superficial epithelial cells continue dividing in the absence of DNA replication to quickly expand epithelial coverage during rapid growth.

Poly(vinylidene fluoride-co-trifluoroethylene)’s (PVDF-TrFE) piezoelectricity can be enhanced by annealing, however current annealing methods are slow. Here, the authors perform ultra-fast flash annealing of PVDF-TrFE to achieve a high piezoelectricity.

Synthesis of single-crystal complex-oxide films directly on silicon is difficult due to differing interfacial chemistry. Here, the authors demonstrate room-temperature integration of single-crystal lead zirconate titanate on to silicon to act as a gate insulator in a field-effect transistor.

Isoprene emissions are commonly estimated using satellite measurements and model simulations. Here, using eddy covariance, the authors report higher emission rates over the Amazon forest than those estimated with these techniques and a relationship between terrain elevation and isoprene emissions.

In a prospective observational study, symptoms of anxiety and/or depression were associated with worse response to first-line treatment with immunotherapy in patients with advanced non-small-cell lung cancer.