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In maize, ZmDapF1 suppresses the activity of ZmMDH6 in chloroplasts, exacerbating oxidative damage under drought. Knocking out ZmDapF1 or using its favourable allele with lower gene expression enhances drought resilience without yield penalty.

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

This study finds that plastic mulch substantially increases crop yields but also contaminates soils and pollutes the environment. The authors propose biodegradable films, AI-driven farming, and policy reforms to address the productivity–sustainability trade-offs.

Recent studies have shown the potential of higher-order exceptional points originating from the Liouvillian dynamics as opposed to their Hamiltonian counterparts. Here, the authors explore different classes of third-order Liouvillian exceptional points in a two-level system realised in a single trapped ion.

Alzheimer’s disease is characterized by the accumulation of amyloid plaques in the brain. Here, Liu et al. develop a new method, Amyloid-ID, which uses light to label and analyze amyloid deposits in brain tissues, revealing their protein composition and associated molecules.

Highly ionically conductive and flexible solid-state composite battery electrolytes are engineered by alternately stacking inorganic Li_xM_yPS₃ (M = Cd or Mn) nanosheets with lithium-containing organic polymers in a perpendicular orientation to the surface of the electrodes.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Micromitophagy is found to occur in plant male germline cells, mediated by ATG5–HSP90.2 signalling, and is evolutionarily conserved in angiosperms. This mechanism underpins paternal mitochondrial elimination and supports the zygote-to-embryo transition.

Flooding threatens urban economies via direct damages and supply-chain disruptions. Losses grow nonlinearly: wealthier cities incur larger absolute losses, while poorer cities face higher relative impacts, highlighting tailored resilience measures.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Lactate fuels cancer growth by activating ERK signaling through GCN5-mediated lactylation of ERK, which disrupts ERK–MEK interactions. Development of a cell-penetrating peptide blocking lactylation slows KRAS-mutant tumor development.

Structural, genetic, functional and biochemical analyses of the complex flagellar motor of Campylobacter jejuni reveal structural adaptations with an ancient origin also found more widely across bacterial species, including elements exapted from the type IV pilus machinery.

Systems of electron spins in nuclear-spin-rich hosts are gaining attention for quantum memory applications. Using spin ensemble studies, the authors propose transition metal ions in halide double perovskites as promising candidates, featuring long electron spin coherence and deterministic nuclear spin control.

PanoSpace enhances low-resolution spatial transcriptomics data to reconstruct continuous tissue maps at single-cell resolution. In cancer tissues and mouse brain, it refines cell localization, identity, gene expression and microenvironmental interactions.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

The integration of epitaxial complex oxides on semiconductor and flexible substrates is required but challenging. Here, the authors report the highly heterogeneous epitaxy of transferrable BaTiO_3-δ membrane with enhanced flexoelectricity on Ge (011).

Many hydrogen applications require gas delivered under pressure. Here, the authors report that solar water-splitting devices can operate at up to 8 bar and show that the performance gains from elevated pressure depends critically on the choice of materials and device configuration.

A model, trained to generate synthetic, patient-specific angiography images, reduced radiation exposure to patients and clinicians by two-thirds in a multicenter randomized controlled trial involving 1,068 patients.

Ge₂Sb₂Te₅ is widely studied and utilized in phase change memory. Here, the authors report one order of magnitude faster switching speed and as low as one-fifth reset operation power in a Ti-Sb-Te alloy, as compared to Ge₂Sb₂Te₅.

Distributed quantum sensing typically requires shared reference frames to coordinate measurements. Here, authors develop a reversed-encoding protocol that circumvents this requirement, enabling Heisenberg-limited precision in quantum networks without frame alignment.

The MOUNTAINEER phase 2 trial demonstrated the efficacy and safety of tucatinib (HER2-targeted TKI) and trastuzumab (anti-HER2 antibody) in patients with HER2 + , RAS wildtype unresectable or metastatic colorectal cancer that had progressed on chemotherapy, resulting in the approval of the regimen. Here, the authors report the updated analysis of the MOUNTAINEER trial.

Enantioconvergent cross-electrophile coupling of non-redox-active alcohol derivatives is challenging. Now, taking advantage of Ni–C bond homolysis, enantioconvergent coupling of non-redox-active propargylic esters with chlorogermanes enables the synthesis of chiral propargyl germylation products.

The authors realize a two-dimensional hybrid perovskite with robust multiaxial ferroelectricity and nonlinear optical response via molecular fluorination and lone pair expression of Ge²⁺, enabling prominent piezoelectric sensing in composite device

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here the authors report the results of a phase II clinical trial of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in RMC, associating the activation of a myeloid mimicry program in tumor cells to the rapid disease progression and hyper-progression observed in treated patients.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

One-carbon ring expansion reaction of heteroarenes involving typical dearomative cyclopropanation has gained wide attention in the past decade as it allows the facile synthesis of various valuable ring-expanded heterocycles. Herein, the authors report an enantioselective dearomative one-carbon ring expansion of benzofurans via vinyl cations formed by copper-catalyzed cyclization of diynes.

Quantum-dot spin qubits in Si/SiGe quantum wells require a large and uniform valley splitting for robust operation and scalability. Here the authors introduce and characterize a new heterostructure with periodic oscillations of Ge atoms in the quantum well, which could enhance the valley splitting.

USP28 and 53BP1 proteins form a complex to stabilise the tumour suppressor p53, which is required to protect cells from mitotic stress and subsequent genome instability. Here, the authors discover that missense mutations in the C-terminal region of USP28 disrupt 53BP1 interaction and p53 stabilization.

C10, a potent non-nucleoside inhibitor targeting NSP14’s SAM-binding pocket, suppresses viral translation, exhibits immunostimulatory effects, and reverses NSP14-induced transcriptome alterations, offering promise for broader coronavirus treatment.

Persistent phosphors are known from applications such as night-vision goggles where they produce a characteristic green afterglow. The discovery of persistent phosphors that instead operate at near-infrared wavelengths with much longer afterglows may now enable new applications in night-vision surveillance and in bio-imaging.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Hirschsprung disease, characterized by the absence of ganglion cells leading to functional bowel obstruction, can be treated with surgery. Here, the authors report that preoperative nutritional support in children with Hirschsprung disease reduced the risk of postoperative enterocolitis by comparison to standard of care in a randomized controlled trial.

The development of carbon dioxide reduction catalysts at industrial current densities remains challenging. Here, the authors demonstrate that in situ electro-polymerization of cobalt phthalocyanine on a gas diffusion electrode achieves high carbon monoxide selectivity at high current densities.

This study identifies 245 genetic loci associated with head-to-body ratios using 38,202 bone density scan images from the UK Biobank, revealing genetic links to skeletal and brain development, disease susceptibility, and human evolutionary adaptation.

Feng et al. uncover a retrograde trafficking route from the plant vacuole, showing that sorting nexins retrieve the plant-specific SNARE VAMP727 and revealing distinct pathways from the core retromer system.

How cortical interneurons gain regional specification remains elusive. Here authors recruit 685,692 interneurons from the developing telencephalons of humans and macaques to characterize the shared and distinct molecular programs regulating the cortical arealization of primate interneurons.

FeGe is an antiferromagnetic kagome metal with a rich magnetic and electronic phase diagram. Recently it was found that post-growth annealing of FeGe can suppress or induce charge density wave order depending on the annealing temperature. Here, Klemm, Siddique et al show the critical role that annealing induced Ge-vacancies and stacking faults play in the formation of charge density wave order in FeGe.

Kozai, Fernandez-Martinez et al. use high-speed atomic force microscopy to study the permeability barrier of yeast nuclear pore complexes. They show that karyopherins remodel a central plug that shapes barrier dynamics and disorder within the pore.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Schisantherin A (Sin A), a bioactive lignan from Schisandra chinensis, alleviates obesity and liver fat accumulation in mice, but the mechanisms are incompletely understood. Here the authors show that Sin A mitigates obesity and related metabolic disorders by elevating circulating conjugated bile acids, which in turn modulate adipose tissue thermogenesis in mice.

Metabolic dysfunction-associated steatohepatitis (MASH) has an incompletely understood mechanistic basis. Here the authors use gain- and loss-of-function mouse models to show that that E3 ligase TRIM7 in hepatocyte promotes MASH pathogenesis via DUSP10 ubiquitination.

Inspired by the human eye’s dynamic focusing, this work demonstrates an integrated bionic LiDAR that achieves energy-efficient, adaptive 4D imaging, offering a compact and scalable path toward intelligent machine vision.

Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor maturation is gated by developmental timing, revealing a distinct regulatory logic underlying the development of inhibitory neurons.

Silicene is a silicon-based analogue of graphene, but with subtle and potentially useful differences. Wei-Feng Tsai and colleagues show that these differences could be exploited to build electrically-gated silicene devices that generate and control spin-polarized currents with near perfect efficiency.

Kukreja, Jeon et al. leverage spatial transcriptomics to map immune gene expression in the developing mouse brain, identifying key sex-specific changes in the context of maternal gut−immune perturbations.

This study identifies adenosine A_2A receptor (A_2AR) signaling in the choroid plexus as a key driver of cerebrospinal fluid hypersecretion and ventriculomegaly in hydrocephalus. Pharmacological or genetic inhibition of choroid plexus A_2AR mitigates disease pathology, highlighting A_2AR antagonism as a promising therapeutic strategy for hydrocephalus.

Yersinia pseudotuberculosis senses fungal tyrosol signalling through EnvZ–OmpR which triggers T6SS activation and antifungal effector release to reduce fungal competitors in the mouse gut.

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitating the discovery of potential effects of genetic variants, including variants associated with disease, on genome structure and function.