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Solidification upon heating, known as Pomeranchuk effect, is a known phenomenon for 3He. Here, leveraging on the hybridization of organic molecules orbitals with those of inorganic elements in polymers, the authors report the Pomeranchuk effect within an electronic system and the impact of magnetic fields on it.

There is a challenge of overestimation in figures of merit for organic electrochemical transistors due to a kink in the transistor current. Here, the authors investigate the origin of the kink and identify the charge transport phenomena that is impacted.

Native state proteomics of PV interneurons revealed unique molecular features of high translational and metabolic activity, and enrichment of Alzheimer’s risk genes. Early amyloid pathology exerted unique effects on mitochondria, mTOR signaling and neurotransmission in PV neurons.

Floquet engineering is often limited by weak light–matter coupling and heating. Now it is shown that exciton-driven fields in monolayer semiconductors produce stronger, longer-lived Floquet effects and reveal hybridization linked to excitonic phases.

One of three back-to-back papers to show that dosage of BACH2 can modulate T cell differentiation and function and how we might apply this to enhance CAR T cell therapies for cancer.

Microcavity exciton-polaritons in atomically thin semiconductors are a promising platform for valley manipulation. Here, the authors show valley-selective control of polariton energies in monolayer WS2 using the optical Stark effect, thereby extending coherent valley manipulation to a hybrid light-matter regime

Kim, Wang, Clow and colleagues show that long-range chromatin loops bringing distal enhancers or super-enhancers together with promoters are cohesin dependent and cell type specific, whereas most short-range and promoter-centric transcriptional loops are cohesin independent and constitutive.

RNAi therapy has huge potential but effective delivery to target location is a major issue. Here, the authors report on the delivery of RNAi to tumors using self-agglomerating nanohydrogels that can overcome the different delivery barriers and supply multiple RNAi payloads.

The properties of electronic transport through edge states of three-dimensional quantum Hall-like states are not yet resolved. Now, increasing the surface area of the edges is shown to produce increased conductance, suggesting that chiral surface states are present.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

An analysis of 204 countries estimates that diabetes will cost the global economy $10.2 trillion between the years 2020 and 2050.

Although electrometers based on quantum defects have advanced, achieving time-resolved detection of charges with subnanometer resolution remains challenging. Here the authors use a negatively charged tin-vacancy center in diamond to distinguish charge traps at the lattice scale with high temporal precision.

Adding tunable photon-photon nonlinearities to programmable photonic circuits would greatly extend their capabilities. Here, the authors demonstrate this by embedding a photonic-crystal waveguide nanostructure hosting an InAs quantum dot within a programmable linear optical circuit, and using it to realise a proof-of-concept quantum simulation of anharmonic molecular vibrational dynamics.

Microhomology-mediated end joining (MMEJ) and mitotic DNA synthesis (MiDAS) are critical DNA repair pathways in mitosis. Here the authors show that CIP2A–TOPBP1 coordinate mitotic DNA repair through the regulation of factors required for MiDAS and MMEJ.

Scattering resonances are quantum effects occurring in low-temperature molecular collisions. Here the authors observe resonances for the six-atom ND₃-H₂/HD systems in velocity map imaging experiments explained by high-level theoretical predictions.

Liquid charge density wave order is thought to occur in many correlated electron systems but has not been observed experimentally. Now, a liquid-like electronic state is shown to emerge in a transition metal dichalcogenide on photoexcitation.

Friedreich’s ataxia (FRDA) is a neurodegenerative disorder driven by frataxin (FXN) deficiency. Here, the authors show that FXN loss in human microglia causes mitochondrial and lysosomal defects that trigger neuroinflammation and neurodegeneration, rescued by gene editing.

LSFM imaging revealed 3D islet maps: GADA+ cases mirrored controls, while short-duration T1D showed loss of small INS + GCG– islets but preserved larger mixed INS + GCG+ ones, highlighting islet size- and composition-dependent vulnerability

Variable New Antigens Receptors (VNARs) from shark antibodies possess a unique molecular dexterity that allows them to access epitopes inaccessible to conventional antibodies. Here, the authors use crystallography to investigate how two VNARs selectively engage soluble TNF-alpha.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Allogenic mesenchymal stem cells are engineered with three mRNAs to bind to multiple myeloma B cells while activating T cells for cancer therapy.

Carnitine uptake by OCTN2 supports fatty acid metabolism. Here, authors report cryo-EM structures of human OCTN2, revealing the mechanism of sodium ion-dependent carnitine transport and providing insight into disease-associated variants.

Electrochemical hydrogenation drives a reversible conductor–insulator transition in graphene. Authors show that it is 10⁶× faster than other methods and tunable by isotope effects and lattice corrugations, enabling ionic control of 2D electronics.

Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.

A general stereospecific glycosylation is developed that is applicable across a range of monosaccharides. A directing-group-on-leaving-group strategy allows mild donor activation and enables the complete inversion of anomeric configuration with excellent yields. This method can be applied in multistep oligosaccharide syntheses and automated glycan assembly.

Mirusviruses were detected in metagenomic datasets, but little is known about how they infect their hosts. Here, the authors characterize mirusviruses in the marine protist Aurantiochytrium, detecting virions, viral genes and proteins, and establishing this as a valuable model system.

Quantum-dot-based single photon sources represent a promising resource for future quantum networks. Here, the authors realize all-photonic quantum teleportation using photons from two remote near-infrared-emitting quantum dots, using polarization-preserving quantum frequency converters to enable two-photon interference at telecom wavelength.

The spin of an electron bound to a single phosphorus atom in silicon is of interest for spin-based electronics such as quantum computing. Here, Büch et al. show these spin properties are retained even for clusters of a few phosphorus atoms, providing an additional means for quantum bit addressability.

Pan-expansion microscopy of tissue combines staining of proteins and lipids with immunolabeling.

Large-scale sequencing and population genomic analyses reveal frequent transmission, a highly admixed global population structure and evidence of pervasive negative selection in Haemophilus influenzae.

Confidence is key to decision-making, but the dynamics of confidence formation remain elusive. We show that neural populations in parietal cortex reflect the parallel processes of forming a decision and confidence in the decision.

Single photon level of light control is possible by using the effective interaction between single photons and Rydberg atoms. Here the authors utilized such interaction of Stark-tuned Forster resonances to boost the gain of a Rydberg single-photon transistor and perform high precision spectroscopy.

A transverse Peierls transition can occur when transverse acoustic phonons couple with conducting p-orbital electrons. Here, the authors observe an incommensurate transverse Peierls transition and signatures of a chiral charge density wave in EuAl₄.

Urban blue spaces, such as lakes and rivers, play growing roles in cities but are historically vital for providing food. Focusing on four Indian cities, this study finds diverse blue foraging practices most practiced by elderly women, especially among the most disadvantaged groups.

TIRTL-seq is a high-throughput method for paired T cell receptor sequencing at the cohort scale.

Mass-wasting deposits that accumulated against mid-ocean ridge faults have high porosity in which calcium carbonate precipitated, storing seawater carbon dioxide, as revealed by cores of a 61-million-year-old seafloor talus deposit.

Global shark and ray populations have declined sharply, driven by expanding fisheries and inequitable gaps in catch, trade and distribution data. This Review assesses global status, highlights drivers of decline, and outlines the regulatory, market-based and conservation actions needed to reduce mortality and reverse shark and ray biodiversity loss.

Apoptotic cells often release extracellular vesicles that aid in their clearance and provide molecular information to cellular neighbours. Here, the authors show that some adherent apoptotic cells also create vesicles that remain attached at the site of death.

A common mechanism by which cancer cells acquire resistance to chemotherapeutics is through the overexpression of efflux pumps, but platinum anticancer agents that crosslink DNA and interact with proteins are poor efflux pump substrates. Here, the authors design dual warhead drug conjugates by tethering a platinum pharmacophore to the doxorubicin backbone, which exhibit the activity of both parent anticancer compounds and can overcome drug efflux effectively due to covalent binding to intracellular biomolecules.

Cells must coordinate cell division with genome replication. Here, the authors combine rapid protein depletion, clinical CDK4/6 inhibitors, and genome-wide EdU sequencing to reveal that the CDK4/6-RB axis ensures timely loading of DNA replication factors in G1 phase in human cells.

Biased noise qubits, which can selectively suppress certain types of noise, are advantageous for quantum error correction of bosonic codes. Here the authors make an important step in this direction by demonstrating quantum control of a harmonic oscillator with a biased noise qubit.

This study shows that the nodal loop topology in LaSb_xTe_2−x can be controlled by chemical substitution and electron doping. The reversible opening and closing of a gap larger than 400 meV in the nodal loop enables on-demand switching of topology.

A materials platform using tantalum as a base layer and silicon as the substrate to construct superconducting qubits enables device performance improvements such as millisecond lifetimes and coherence times, as well as high time-averaged quality factors.