Search

Hybrid superconductor-semiconductor devices offer a promising platform for topological superconductivity. Here, Ke and Moehle et al. create ballistic Josephson junctions in InSb quantum wells and use magnetic and electric fields to control their free energy landscape.

Authors demonstrate the synthesis and characterization of direct bandgap quantum wells in the hexagonal Si_1−xGe_x system. Photoluminescence experiments show light emission up to room temperature, and the emission wavelength can be tuned by thickness of the wells and the Si composition.

Ferroptosis is an iron-dependent lipid peroxidation-mediated form of cell death that holds promise for targeting treatment-resistant cancer cells. Here, the authors show that AMPK-mediated lipid droplet dynamics modulates the response to ferroptosis inducers in melanoma.

Annunziato, Quan and Donckele et al. identify G3BP2 (Ras–GAP SH3 domain-binding protein 2) as a molecular glue-induced neosubstrate of the CRL4^CRBN E3 ubiquitin ligase. The CRBN–glue neosurface uses a molecular surface mimicry mechanism to recruit and degrade G3BP2 in a compound-dependent manner.

TIRTL-seq is a high-throughput method for paired T cell receptor sequencing at the cohort scale.

Recovering hydrocarbons from oil and gas wells results in highly saline wastewater, also known as flowback and produced water. The introduction of two parameters to estimate the environmental impact of these by-products, relative to energy produced, provides an important tool for assessing the risks associated with the planning and use of wells.

Using a non-human primate model, the authors identified the tissue sites of initial viral rebound after discontinuation of antiretroviral therapy, demonstrating that such rebound preferentially occurs in the gastrointestinal tract-associated lymphoid tissues.

Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship between environmental antigen exposure and subsequent allergy.

Aerial surveys over the Permian Basin found 500+ major methane leaks, many recurring. A few sites leaked continuously and offer quick mitigation wins. These super-emitters may produce ~50% of regional emissions, underscoring the need for frequent monitoring.

A plethora of solid-state nanodevices rely on engineering the quantization of electrons in quantum wells. Here, the authors leverage the thickness of exfoliated 2D crystals to control the quantum well dimensions in few-layer semiconductor InSe and investigate the resonance features in the tunnelling current, photoabsorption and light emission spectra.

Quantum-dot spin qubits in Si/SiGe quantum wells require a large and uniform valley splitting for robust operation and scalability. Here the authors introduce and characterize a new heterostructure with periodic oscillations of Ge atoms in the quantum well, which could enhance the valley splitting.

Charge noise degrades the performance of spin qubits hindering scalability. Here the authors engineer the heterogeneous material stack in ²⁸Si/SiGe gate-defined quantum dots, to improve the scattering properties and to reduce charge noise.

Simon J. James looks back at the richly varied contribution of the science-fiction writer and science popularizer.

Yashinskie, Zhu and colleagues show that p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of autophagy and lysosomal catabolism programmes and increased reliance on lipid headgroup recycling.

In this study, the authors generated iPSC lines from more than 100 sporadic ALS cases, which recapitulated key disease phenotypes and enabled large-scale drug screening, identifying a promising combination therapy of baricitinib, memantine and riluzole.

Certain point defects in crystals can be used as optically addressable quantum bits, much like atoms trapped in vacuum. Ivády et al. show that embedding such artificial atoms in stacking faults can actually improve their optical properties, making them function even more like true atoms.

Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

Groundwater that predates the Holocene is commonly assumed to be unaffected by modern contamination. A global analysis of fossil groundwater suggests that modern contaminants are present in deep wells that tap fossil aquifers.

iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors. They are advantageous for detecting rapid dynamics and large population activity, respectively, as demonstrated in a variety of applications in the mouse brain.

The interactions of CAR-T cells and solid tumors are modeled on a chip.

Neurodegenerative disorders remain poorly treated despite their growing disease burden. Here, authors developed a multiplexed screening platform that identified DNAJB6 as a modulator of condensate maturation and suppressor ALS/FTD-linked toxicity.

An in-depth analysis of tissue biopsies from patients with multiple myeloma and CAR T cell therapy-associated immune-related adverse events (CirAEs) after treatment with commercial BCMA-targeted CAR T cell therapy shows that CD4⁺ CAR T cells mediate off-tumor toxicities and that high CD4:CD8 ratio at apheresis, robust early CAR T cell expansion, ICANS and ciltacabtagene autoleuce treatment are independently associated with the development of CirAEs.

Dendritic cells (DCs) are required to establish thymic central tolerance. Here Srinivasan et al. use single-cell transcriptomics to define thymic conventional dendritic cell (cDC) subsets and find that CD8⁺ single-positive thymocytes modulate the thymus environment to regulate plasmacytoid DC and cDC2 homeostasis and interferon signatures in DCs, while CD4⁺ single-positive thymocytes regulate cDC1 activation via cognate and CD40L–CD40 interactions.

Epstein–Barr virus (EBV) is a widespread herpesvirus linked to cancer and autoimmune disease. The authors in this work design and characterize a stabilized prefusion form of gB, an essential viral fusion protein, advancing EBV vaccine and therapeutic development.

A Gifsy-1 prophage–encoded higher eukaryotes and prokaryotes nucleotide-binding protein, HepS, senses Siphoviridae infection, activates abortive defence by cleaving host transfer RNAs, blocks rival phages and avoids self-targeting via tail-tip variation.

MK-7762 is a new oxazolidinone antitubercular agent that is structurally similar to linezolid, and demonstrated in vivo efficacy, lesion penetration and limited toxicity compared to linezolid, indicating it could be used in broad tuberculosis regimens.

Hybrid 2D layered perovskites are solution-processed quantum wells whose optoelectronic properties are tunable by varying the thickness of the inorganic slab. Here Blancon et al. work out a general behavior for dependence of the excitonic properties in layered 2D perovskites.

Unprecedented groundwater recovery ( ~ 0.7 m/yr) driven by water diversions, strict pumping regulations, and a wet climate occurred in the North China Plain after decades of depletion, showing large-scale recovery is possible under human intervention.

Via an integrative modelling approach that combines population and clinical trial data, the authors find that polygenic risk score-based screening would reduce premature mortality across seven commonly screened conditions.

Chemically induced protein degradation is a powerful alternative to classical inhibition, but some proteins have deeply masked binding pockets that make the development of degrader molecules difficult. Here, the authors discover an alternate site on nuclear receptors that can be targeted by degraders.

Grosjean et al. present a network-aware, self-supervised learning approach for screening neuronal activity dynamics. They demonstrate its applicability across a range of neural interventions.

Existing methods for the modification of exosomes adversely impact structures and functions of exosomal proteins and membranes. Here, the authors develop a chemically engineered platform by leveraging the synergistic interplay between CD38’s catalytic activity and the covalent inhibitor 2'-Cl-araNAD⁺.

Wei et al. perform spatial transcriptomic profiling on synovial tissue biopsy samples from individuals with recent-onset rheumatoid arthritis, finding TGFβ signaling and fibrogenic fibroblast activation drive a treatment-refractory tissue phenotype.

The somitic mesoderm is seen as the main source of brown adipose tissue, although some depots are of partially unknown origin. Here, the authors show that Osr1 labels multipotent dorsal aorta progenitors at E9.5 that contribute to cartilage, muscle, and adipose tissues, revealing a non-somitic contribution to several brown adipose depots.

A single-cell epigenomic atlas of human immune cells highlights cell-type-specific features associated with genetic or environmental exposures.

Deletion of functional sequence is predicted to represent a fundamental mechanism of molecular evolution. Here the authors use CRISPR-based perturbations and epigenetic profiling in chimpanzee cells to identify gene regulatory roles for genomic sequence lost in the human lineage.

Advanced nanoengineering of small-period AG lattices enables the observation of a vanishing density of states that suggests the presence of massless Dirac fermions.

Here the authors present NCATS-SM0225, a small molecule that inhibits ERAD and selectively kills cancer cells by binding VDACs, disrupting calcium homeostasis, and triggering the PERK-STIM1 pathway to degrade ERAD regulators.

CaBLAM is a bioluminescent genetically encoded calcium indicator that delivers high-contrast signals as shown in cell culture, in the in vivo mouse brain and in zebrafish larvae.

Native top-down proteomics reveals epidermal growth factor receptor–estrogen receptor-alpha (EGFR–ER) signaling crosstalk in breast cancer cells and dissociation of nuclear transport factor 2 (NUTF2) dimers to modulate ER signaling and cell growth.

The authors uncover a direct, BAI1-dependent, role for C1q in the control of neural stem cell proliferation and quiescence via MDM2–p53 and p32, a complement cascade-independent mechanism of C1q action that has implications for central nervous system health and disease.

The axis of a spinning electron tends to remain fixed in direction: in contrast, an electron moving in a semiconductor sees a lattice of charged atoms flying past, causing its spin direction to fluctuate. Koralek and colleagues demonstrate that an electric field applied to the semiconductor can balance this spin-destabilizing effect; the collective spin of the entire gas of electrons is conserved, a property well-suited for 'spintronics' applications.

Integrated single-cell and spatial data analysis, combined with bidirectional CRISPR screens, identify the transcription factor GLIS3 as a key driver of chronic inflammation and fibrosis and a potential marker of disease severity in patients with ulcerative colitis.