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Chern ferromagnetism is established in twisted bilayer MoTe₂ devices at large twist angles. Here, the authors observe evidence of antiferromagnetic ground states with zero Hall resistance at an intermediate twist angle around three degrees, demonstrating the sensitivity of the magnetic ground state.

Genome annotation typically requires costly experimental assays across diverse cell types, limiting its scalability. Here, authors introduce BioSeq2Seq, a deep learning framework that leverages DNA sequence and run-on sequencing (RO-seq) data to accurately predict histone modifications, functional elements, gene expression, and transcription factor binding sites.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

Developing efficient battery electrolytes is a slow and complex challenge. Here, authors create a deep active learning framework that rapidly identifies high-performance materials and transfers knowledge to new designs, tripling battery lifespan while requiring significantly fewer experiments.

Biomass-based systems for solar evaporation are a promising sustainable method to address global freshwater scarcity; however, current systems are inefficient. Here, the authors report a dual-function lignin-engineered reconstituted wood framework for a biomass-based solar evaporator.

Influenza viruses adapt to their hosts through diverse mechanisms. Here, authors report that a single mutation in nonstructural protein 1 of influenza B virus enhances innate immune evasion and provides adaptation to its host.

Authors present a bionic robotic trunk with a cable-driven tensegrity skeleton, leveraging synergistic and antagonistic muscle-mimicking mechanisms to achieve rapid and large-range stiffness modulation comparable to that of an elephant trunk.

This study uses two large fundus cohorts to show that retinal foundation models generalize well across populations but exhibit age-related fairness gaps. It highlights how pre-training data composition shapes model generalisability and fairness.

ERAST speeds up homology search and provides a vector database for 1 billion biological sequences.

Climate models overestimate greenhouse gas effects on the temperature difference between Earth’s hemispheres, with this bias strongest in high climate sensitivity models, suggesting future tropical rainfall shifts may be less severe than projected.

Façade-integrated photovoltaics (FIPV) present a promising yet early-stage solution for mitigating building emissions. Combining global building datasets, climate projections and façade-scale simulations, researchers estimate that FIPV could deliver substantial economic and climate benefits.

A soft three-dimensional core–shell cable can form reliable free-standing interconnects between soft, rigid and hybrid electronic components, and can be stretched by up to around 800%.

Covert mortality nodavirus, a pathogen previously known to cause important losses in shrimp aquaculture, is identified as being a potential causative agent of an emerging and severe ocular disease in humans, specifically presenting as persistent ocular hypertensive viral anterior uveitis.

This work effectively addresses the long-standing challenge of competitive kinetics in heterogeneous Fenton-like systems through the synergistic interaction between nitrogen vacancies (Nv) and Fe sites on carbon nitride.

Pseudomonas aeruginosa is a key bacterial pathogen with substantive therapeutic challenges. Here the authors target Tudor Domain Containing 9 using siRNA containing nanoparticles in experimental models of pseudomonas aeruginosa-induced lung injury and suggest modulation of neutrophil cuproptosis.

The chromatin remodeler BRAHMA (BRM) is found as a repressor of plant adaptation to acid stress by inhibiting the STOP1-NRT1.1 signaling module. Under low pH, BRM degradation activates nitrate uptake and alkalinizes the rhizosphere.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Regulating the electronic structure of active sites is key to optimizing supported metal catalysts, yet precise control remains challenging. Here, the authors present a practical and reproducible strategy by tuning surface hydroxyls on TiO₂ via a titanate-derived synthesis and controlled calcination, leading to enhanced water–gas shift activity of Pt/TiO₂ catalysts.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

EGFR-targeted therapy is often used in patients with EGFR-driven cancer but is limited by on-target/off-tumor toxicities. Here, the authors develop a bispecific antibody targeting both EGFR and B7-H3 and demonstrate improved EGFR targeting and tumor selectivity in preclinical models of multiple solid tumors.

Wang, Chu, Chen, Wei and colleagues discover a subset of tumour-associated macrophages expressing SLC2A1 whose spatial proximity to CD8⁺ T cells drives resistance to anti-PD-L1 treatment in non-small-cell lung cancer.

Alternative targets are required for tumor therapy. The authors here show that transmembrane protein 175 (TMEM175) knock out in macrophages improves aPD-1 treatment prognosis with the mechanism of enhanced NLRP3 expression and antigen cross-presentation of macrophages.

The operational stability of perovskite solar cells remains a challenge. Zhang et al. incorporate photoswitchable isomers at grain boundaries to improve their resilience and the stability of the solar cells under light cycling and ultraviolet exposure.

Assessing the hepatotoxicity of a drug is critical in drug development. Here, the authors develop human multi-lineage liver organoids and identify imipramine as an inducer of indirect hepatotoxicity from a drug screen. The study offers insight into indirect hepatotoxicity and an in vitro platform for drug safety testing.

Next-generation autonomous systems call for robust perception capabilities in diverse environments. Dun et al. report an ultraviolet-to-mid-infrared photosynapse array with 65,536 pixels and efficient in situ processing capabilities for dynamic trajectory recognition under challenging conditions.

Alkali metals are widely used as promoters in heterogeneous metal catalysts, yet their precise role remains unclear. Here, the authors elucidate the promotional effects of alkali metals in hydrogenation reactions from a unified perspective and reveal a novel phenomenon termed “strong metal–base interaction”.

Colorectal cancer has high recurrence and metastasis rates making treatment difficult. Here, the authors report on peptide modified cell membrane coated cobalt based metal-organic frameworks which degrades and forms, in situ, photothermal materials with H₂S, allowing for immune-photothermal therapy.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

Constructing catalysts with dual active sites is crucial for optimizing adsorption sites and enhancing catalytic performance. Here, uniformly dispersed CuCo alloy and CoO nanosheet composite catalysts with dual active sites were developed, significantly boosting activity in the water-gas shift reaction.

cf-EpiTracing enables automated profiling of histone modifications in cell-free DNA from human plasma, allowing identification of the cells of origin and disease diagnosis.

This study demonstrates that the reduced serum serine in patients with chemotherapy or women with poor sleep, is linked to the decline of ovarian function. Serine supplementation prevented ovarian damage in mice by inhibiting ferroptosis in ovarian granulosa cells, without affecting chemotherapy efficacy.

Machine learning models using PacBio kinetic signals enable high-sensitivity detection of dZ-DNA and single-nucleotide A/Z base calling to explore the biological roles and biotechnological potential of 2,6-diaminopurine.