Search

Recovering nitrate from surface water can help address interconnected environmental, resource, and energy challenges. A bioinspired photothermal evaporation platform enabling the co-recovery of low-concentration nitrate and freshwater is proposed.

This study applies generalized linear mixed models (GLMM) and advanced transcriptome wide association study (TWAS) methods to improve the discovery of colorectal cancer risk transcription factors and genes, including potential druggable targets.

Fibre integrated circuits created by first preparing circuitry on extremely thin and flexible substrates and then mechanically rolling them up demonstrate microdevice density reaching 100,000 transistors per centimetre and excellent stability under harsh service conditions.

A new self-assembled monolayer at the buried interface of inverted perovskite solar cells improves photostability and favours energy transfer, resulting in devices with a certified power conversion efficiency of 27.19% and 1,500-h stability under the ISOS-L-2 protocol.

TongGeometry both solves and proposes olympiad-level geometry problems. It uses guided tree search to find hard but concise problems, making advanced mathematical reasoning more accessible.

Less is known about the entire microbial pathogen profile of small mammals. Here, the authors analyse 2,408 tissue-resolved metatranscriptomes to map the infectome in small mammals, uncovering high viral, bacterial, fungal and parasitic diversity and showing how geography, hosts, and seasons shape zoonotic risk.

Cerebral palsy lacks reliable biomarkers for early and accurate diagnosis. Here, the authors show serum proteomic signatures of disease and develop a multi-biomarker diagnostic model.

Here the authors report NiGa₂O_4–x(OH)_y for light-driven CO₂ hydrogenation to methanol. The surface Lewis acid–base pairs and -OH groups act as conduits for H^- /H⁺ transport to active sites, enhancing photocatalytic methanol production.

vdW assembly of low-dimensional materials has proven the capability of creating structures with on-demand properties. Here, the authors report on the structural collapse of CNTs in conjunction with a metal-semiconductor junction induced by the VdW encapsulation.

Researchers developed a solar-driven water-electricity cogeneration device using an ion-engine hydrogel, leveraging the synergistic effects of metal coordination and ion-preferential association, generating milliampere level current and 2.0 L m^-2 h^-1 freshwater from seawater.

Veratramine and cyclopamine are valuable molecules in agricultural and medicinal chemistry, but the efficient chemical synthesis approaches are in high demand. Here, the authors report the concise, divergent, and scalable syntheses of veratramine and cyclopamine with 11% and 6.2% overall yield, respectively.

Carbon coating of electrodes is a common way to enhance electrochemical activity, but the interface mechanism is unclear. Here, Wang et al. adopt a molten technique to produce a sample with large flat surface, which enables visualization of the electrode size-dependent interface change during coating.

In situ3D visualization of sodium-ion battery processes is challenging due to the highly active sodium metal and the sluggish kinetics. Here, the authors present a X-ray tomography technique, which enables tracking the sodiation–desodiation process of a Sn anode in battery operation.

Spatiotemporal phase evolution during transformations impacts materials performance in many systems. Here the authors use lithium iron phosphate particles inside a custom-designed battery to characterize in three dimensions the two-phase configuration at various states of charge via X-ray tomography.

Infective endocarditis lacks biomarkers for early diagnosis and personalized care. Here, the authors show proteomic characteristics of plasma and vegetation linked to disease progression, identifying diagnostic and prognostic biomarkers like LRG1 and ADIPOQ, and therapeutic targets like neutrophil traps.

Recent work has enabled the simultaneous analysis of RNA levels and chromatin accessibility for gene regulatory network (GRN) inference, but heterogeneity across omics layers remains a barrier in these approaches. Here, the authors present scTFBridge, a deep-generative model for GRN inference, whereby latent spaces are disentangled into shared and specific components across omics layers.

This study introduces an electrochemical approach for synthesizing 1,3-butadiene via acetylene hydrogenation, offering petroleum-free pathway for C4H6 production. Mechanistic investigations show that optimizing the C2H2/H2O ratio can enhance the kinetics of the rate-limiting step.

Larger LLMs’ self-attention more accurately predicts readers’ regressive saccades and fMRI responses in language regions, whereas instruction tuning adds no benefit.

In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

Insulinomas develop from pancreatic β-cells and secrete insulin, but the underlying genetic defects are largely unknown. In this study, Cao et al. identify recurrent T372R mutations in the transcription factor YY1, and validate this hotspot mutation in 30% of insulinomas.

This Review examines perovskite photodetector technology, exploring the development of standardized perovskite photodetectors and the emergence of customized perovskite photodetectors, including shape-customized detectors, selective photodetectors, multidimensional photodetectors, dynamic-tracking detectors and neuromorphic visual sensors.

The authors develop an approach for photonic terahertz phased array without requiring true time delays or integrated electrodes using optically controlled nonlinear metasurface. Programmable 1D and 2D beamforming are realized across 0.8 ~ 1.4 THz.

Auxin can promote or inhibit hypocotyl elongation. This biphasic effect has puzzled generations of plant biologists. Wang et al. shows that the decreasing apoplastic pH, stimulated by auxin, underlies the change in hypocotyl growth response.

Synthesis of millimetre-sized hexagonal diamond has been demonstrated, facilitated by the formation of intermediate post-graphite phases and temperature gradients.

A strategy for the transfer-free direct growth of ultralong, high-quality graphene nanoribbons, which have desirable electronic properties, between layers of a boron nitride insulator is reported.

Wannier excitons exhibit a relatively large Bohr radius, and this limits the strength of coupling to magnetic ions, in exciton hosting material. Here, Huang et al. overcome this limitation by using self-trapped excitons in Cs₃Cu₂I₅, with a resulting large exciton Zeeman splitting.

Skull-base chordoma (SBC) is a rare, aggressive bone cancer, but its molecular features remain to be characterised. Here, the authors perform proteogenomic analysis of 187 SBC tumours and identify chromosomal instability as a potential prognostic factor and potential therapeutic targets.

Developing simple strategies for the controlled synthesis and stabilization of metastable carbides remains a challenge. Here, the authors show that potassium ions (K⁺) facilitate the formation of metastable ɛ-Fe₂C from an Fe₂N precursor by enhancing the surface carbon chemical potential.

The authors synthesise a Bi-based halide and use it as a photosensitive control gate in a floating-gate transistor, enabling a non-volatile optoelectronic memory with ultra-low energy consumption and large resistive state numbers, for high-accuracy machine learning.

The mechanisms involved in the formation of the premetastatic niche in hepatocellular carcinoma (HCC) are not completely elucidated. Here, the authors show that matrix stiffness in HCC induces cancer-exosome release which increases glucose availability in the lung premetastatic niche favouring metastasis formation and growing.

Efficient light extraction in perovskite X/γ-ray scintillators is hindered by the small Stokes shift of exciton luminescence. Here, Jin et al. exploit the intrinsic strain in 2D perovskite as “self-wavelength shifting” to reduce the self-absorption effect without sacrificing the device response speed.

Hydrogels capable of swift mechanical energy dissipation are desirable for various uses, but traditional energy absorption in hydrogels typically relies on viscoelastic mechanisms and often suffers from slow recovery. Here, the authors report a hydrogel design harnessing molecular friction to achieve efficient energy dissipation and rapid recovery.

Cell fate decisions remain poorly understood at the molecular level. Here Ming et al. show that BMP4 as the signal diverting cell fate away from epiblast/pluripotency to hypoblast/primitive endoderm fate during JGES reprogramming by promoting the dissociation of SALL4 from NuRD.

Radial spokes (RS) are crucial in coordinating ciliary motility. Here, authors use cryo-EM and cryo-ET to gain insight into mammalian RS divergence in ependymal cilia, RS assembly mechanism and the structure-function relationships of ciliary and flagellar axonemes.

Occult node metastasis is a key staging component of non-small cell lung cancer. Here, the authors use deep learning to improve diagnosis of lymph node metastasis from PET and CT radiomics.

Yao and Gong et al. identify WD40 repeat-containing protein 6 (WDR6) to be upregulated in the liver of insulin-resistant mice. WDR6 contributes to promoting hepatic de novo lipogenesis during insulin resistance by upregulation of fatty acid synthase, and the authors identify a small molecule to inhibit this effect of WDR6 and reduce hepatic steatosis.

Stimulating endogenous cardiomyocyte proliferation offers a promising approach for treating cardiac injuries. Here, the authors demonstrate that Foxk1 and Foxk2 promote heart regeneration by enhancing cardiomyocyte proliferation through cell cycle activation and metabolic reprogramming, presenting potential therapeutic targets for ischemic heart disease

Diagnosis of lung cancer from indeterminate pulmonary nodules remains challenging. Here, the authors develop a multi-omics signature to identify oncogenic nodules, and prevent unnecessary procedures.

Here, the authors demonstrate moiré collective vibrations, the mechanical counterparts of moiré excitons, at heterointerfaces of twisted tungsten diselenide/tungsten disulfide heterobilayers.

Electric vehicles offer a route to decarbonization of transport but only under the right electricity source and charging conditions. To shed light on this, Chen et al. model the environmental impacts of different electric vehicles and charging modes in Beijing under a range of wind power scenarios.

The protein tyrosine phosphatase Pez controls intestinal stem cell proliferation in Drosophila by inhibiting the Hippo pathway transcription factor Yorkie. Wang et al. reveal that Pez protein stability is regulated by interactions with the E3 ubiquitin ligase Suppressor of Deltex.

An artificial ligament replacement is made from aligned carbon nanotubes formed into hierarchical helical fibres with nanometre and micrometre channels which are demonstrated for the replacement of anterior cruciate ligaments in both rabbit and ovine models, showing strong integration and functional recovery.