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Here, the authors report the fabrication of broadband flexible photodetectors based on composite graphene-copper phthalocyanine heterojunctions, showing that a moderate external pressure can enhance the performance of the devices. The detectors were also applied for simultaneous contact sensing and non-contact perception as electronic skin sensors.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Extreme environments host diverse microbes, yet their global diversity remains underexplored. Here, the authors analyze both isolate genomes and metagenomes from various extreme habitats to construct a microbial genomic catalog, and use protein language models to identify antimicrobial peptides active against drug-resistant pathogens.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Membrane bioreactors face sustainability issues due to waste. Here, authors propose upcycling end-of-life membranes into curtain-type dynamic membranes, reducing carbon emissions and environmental costs while maintaining filtration performance, offering a sustainable solution for water treatment.

The authors reveal intrinsic long-range-order noncollinear electric dipole order in the van der Waals crystal WO₂Br₂, enabling pressure-driven 90° polarization rotation via multiple transition pathways and distinctive ultrafast phonon dynamics.

In conventional s-wave superconductors, ferromagnetism is strongly suppressed, due to the singlet pairing of the electrons. Here, Xiang, He, Lin, and coauthors find a long-range ferromagnetic order among impurity sites in the spin-orbit coupled Fe(Se,Te) using scanning superconducting quantum interference device microscopy.

Introns, non-coding parts of genes, can hide critical functions. Here, the authors find a 9-nucleotide intronic RNA element that acts as a sensor, reading cell growth signals to control alternative splicing and fly ovarian development via a mechanism also conserved in human cells.

The mid-infrared (MIR) range of the electromagnetic spectrum can be indirectly accessed by frequency upconversion. Here, authors propose a phase-matching-free scheme for broadband and efficient upconversion, covering wavelengths from MIR to ultraviolet with high-order harmonics generated from a NbOI₂ crystal. MIR imaging is demonstrated with a standard silicon camera.

Blue light promotes DNA repair in plants via cryptochrome signalling. Here the authors report that this occurs via suppression of COP1 mediated degradation of the repair factor ADA2b and propose that together photoreceptors and COP1 balance genome stability with growth under fluctuating light.

Photovoltaic modules are susceptible to hot spots and output decline issue under partial shading. To address this challenge, Tang et al. report a silicon solar cell architecture with in-cell reverse conductivity channels, which mitigates thermal damage and stabilizes output without compromising power conversion efficiency

Nicotinamide adenine dinucleotide (NAD) biosynthetic enzymes have been reported to be oncogenic. Here, the authors show that NAPRT, a key enzyme in the deamidated NAD biosynthesis pathway, functions as a suppressor of colon inflammation and tumorigenesis by maintaining DNA repair capability.

Dutta et al. demonstrate that the tumor suppressor complex BRCA1–BARD1 physically interacts with the RNA–DNA helicase Senataxin (SETX) and upregulates the activity of SETX to resolve harmful R-loops crucial for the avoidance of transcription–replication conflicts.

Selective activation of aliphatic C–H bonds in complex polycyclic terpenoids remains a significant challenge. Now a bacterial P450 enzyme has been shown to achieve precise functionalization of inert C–H sites in pentacyclic triterpenoids, unveiling a distinctive relay-oxidation pathway mediated by 1,5-hydogen atom transfer and establishing a versatile chemo-enzymatic platform for accessing previously unexplored chemical space.

Traditional iterative catalysis in RiPP biosynthesis typically modifies linear peptides. Here the authors discover GNAT enzymes that iteratively modify fully folded lasso peptides and engineer them to create lipolasso peptides with expanded chemical diversity.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Proteasomes typically degrades ubiquitin-tagged proteins, but midnolin enables a distinct ubiquitin-independent pathway. Here, the authors present cryo-EM structures of the midnolin-proteasome complex, revealing how midnolin directly captures and feeds untagged nuclear proteins into the proteasome.

Pulmonary fibrosis is a progressive lung disease characterized by scarring and impaired function, with vascular endothelial cells playing a key role in disease progression. Here, the authors show that endothelial mechanosensitive PIEZO1 promotes fibrosis by activating the CAPN2-STAT3-IL-33 signaling axis, identifying a promising therapeutic target for treatment.

14-3-3 proteins play roles in plant growth and stress responses. Here the authors describe a phosphorylation-dependent ubiquitination switch that governs the activity of a rice 14-3-3 protein and immune reprogramming during M. oryzae invasion.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Cutaneous tuberculosis is an infectious disease associated with extracellular matrix remodeling and granuloma-driven fibrosis. Here, the authors present an in vitro model of this disease using skin organoids infected with Mycobacterium tuberculosis, and describe infection-induced alterations in specific pathways and cell populations.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Wide-bandgap perovskite solar cells suffer from instability under rapid thermal cycling. Here, Sun et al. investigate the degradation mechanism, showing that temperature-induced structural strain, phase transition, and increased non-radiative defects drive the degradation processes.

Nav1.7 is a threshold current generator. Here, authors show that Thr1398 underlies the low voltage dependence of hNav1.7, determines its function as a threshold channel. This low-voltage dependence may be exploited to develop Nav1.7 selective inhibitors for pain therapy.

Intracellular pathogens such as Mycobacterium tuberculosis can promote their survival within infected cells by preventing lysosomal acidification. Here, the authors show that M. tuberculosis secretes a protein that promotes phosphorylation of a subunit of the host vacuolar ATPase, thus inhibiting V-ATPase assembly and lysosomal acidification.

A spatiotemporally adaptive targeting strategy ensures sequentially reprogramming metabolism of inflammatory macrophages and senescent stem cells via intracellular NAD⁺ replenishment, accelerating bone and skin tissue regeneration.

A model, trained to generate synthetic, patient-specific angiography images, reduced radiation exposure to patients and clinicians by two-thirds in a multicenter randomized controlled trial involving 1,068 patients.

‘Liquid crystal elastomers are of interest for soft robotics and smart textiles, though existing fabrication methods limit complex actuation. Here the authors report an extrusion method to program a dynamic covalent network for complex actuation.’

This work proposes an oxygen octahedron tilt framework strategy to design high performance lead-free relaxors by introducing a complex BO₆ tilt system and additional local random elastic field, resulting in high energy storage properties.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

Strong paramagnetism is generated in hydrogels rich in carbon–oxygen double bonds simply by coupling with diamagnetic Ca cations. These paramagnetic hydrogels are applied as magnetic resonance imaging contrast agents and magnetic drug carriers.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Here, the authors show that Zika virus (ZIKV) infection induces Th1-like Tfh cells that depend on T-bet for their development and are essential for class switching of ZIKV-specific IgG2c antibodies and maintenance of long-term neutralizing antibody responses.

The authors report the time-reversal symmetry breaking superconductivity in the thin-flake kagome material RbV3Sb5, manifesting primarily as an unconventional form of hysteresis that is not observed in CsV3Sb5. They also observe reentrance of superconductivity during an in-plane field-sweeping process at 400 mK.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

Optimizing mechanical performance for polymer materials is frequently challenging, often require complex methods. Here the authors design an poly(ethylene glycol) material with enhanced mechanical properties by laser printing a micropillar and honeycomb micro-lattice.

IBI318 is a recombinant bispecific IgG1 antibody that targets PD-1 and PD-L1. Here the authors report the results of a phase II trial of IBI318 combined with the receptor tyrosine kinase inhibitor lenvatinib in patients with advanced non-small cell lung cancer with acquired resistance to first-line immune checkpoint inhibitors.

Shang, Zhao, Ying and colleagues report that the mechanosensor PIEZO1 senses blood shear stress in hematopoietic stem cells, driving proliferation and myeloid bias. This axis links mechanical force to inflammation-induced aging, and PIEZO1 emerges as a potential therapeutic target.