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Sluggish post-garnet kinetics persist metastable garnet in subducting slabs, creating a density deficit that stalls slabs at ~1000 km depth transiently, explaining seismic observations without requiring mantle heterogeneity.

Reversible-deactivation radical polymerisations are highly sensitive to oxygen and inhibitors, hindering their industrial application. Here, the authors report a heterogeneous phenanthroline-based conjugated hypercrosslinked polymer photocatalyst for photoinduced copper-catalysed atom transfer radical polymerisations, achieving high oxygen and inhibitor tolerance.

The authors report that Ta-doped PbTiO₃ films with a p-i-n structure can generate a high photovoltaic current, offering the opportunity to advanced optoelectronic and imaging devices.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

The authors report that engineering one-dimensional donor length in covalent heptazine frameworks creates twin molecular junctions, which enable fast charge separation, long-lived charge-separated states, and efficient H₂O₂ photosynthesis.

Extreme environments host diverse microbes, yet their global diversity remains underexplored. Here, the authors analyze both isolate genomes and metagenomes from various extreme habitats to construct a microbial genomic catalog, and use protein language models to identify antimicrobial peptides active against drug-resistant pathogens.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Nicotinamide adenine dinucleotide (NAD) biosynthetic enzymes have been reported to be oncogenic. Here, the authors show that NAPRT, a key enzyme in the deamidated NAD biosynthesis pathway, functions as a suppressor of colon inflammation and tumorigenesis by maintaining DNA repair capability.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

Reti-Pioneer, a retinal imaging artificial intelligence framework, identified diverse systemic diseases and demonstrated feasibility in a primary care silent trial, offering a pathway toward scalable clinical evaluation.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Here, the authors report the fabrication of broadband flexible photodetectors based on composite graphene-copper phthalocyanine heterojunctions, showing that a moderate external pressure can enhance the performance of the devices. The detectors were also applied for simultaneous contact sensing and non-contact perception as electronic skin sensors.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Despite the increasing applications of machine learning in the quantum sciences, applications in the context of topological matter are still limited. Here, the authors demonstrate topological braiding of complex energy bands in a dissipative ultracold atom platform based on a transformer approach, advancing machine-learning-aided search of topological phases.

Traditional iterative catalysis in RiPP biosynthesis typically modifies linear peptides. Here the authors discover GNAT enzymes that iteratively modify fully folded lasso peptides and engineer them to create lipolasso peptides with expanded chemical diversity.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

14-3-3 proteins play roles in plant growth and stress responses. Here the authors describe a phosphorylation-dependent ubiquitination switch that governs the activity of a rice 14-3-3 protein and immune reprogramming during M. oryzae invasion.

Dutta et al. demonstrate that the tumor suppressor complex BRCA1–BARD1 physically interacts with the RNA–DNA helicase Senataxin (SETX) and upregulates the activity of SETX to resolve harmful R-loops crucial for the avoidance of transcription–replication conflicts.

Selective activation of aliphatic C–H bonds in complex polycyclic terpenoids remains a significant challenge. Now a bacterial P450 enzyme has been shown to achieve precise functionalization of inert C–H sites in pentacyclic triterpenoids, unveiling a distinctive relay-oxidation pathway mediated by 1,5-hydogen atom transfer and establishing a versatile chemo-enzymatic platform for accessing previously unexplored chemical space.

Cutaneous tuberculosis is an infectious disease associated with extracellular matrix remodeling and granuloma-driven fibrosis. Here, the authors present an in vitro model of this disease using skin organoids infected with Mycobacterium tuberculosis, and describe infection-induced alterations in specific pathways and cell populations.

Introns, non-coding parts of genes, can hide critical functions. Here, the authors find a 9-nucleotide intronic RNA element that acts as a sensor, reading cell growth signals to control alternative splicing and fly ovarian development via a mechanism also conserved in human cells.

Pulmonary fibrosis is a progressive lung disease characterized by scarring and impaired function, with vascular endothelial cells playing a key role in disease progression. Here, the authors show that endothelial mechanosensitive PIEZO1 promotes fibrosis by activating the CAPN2-STAT3-IL-33 signaling axis, identifying a promising therapeutic target for treatment.

China’s national land-use carbon emissions will peak around 2030–2035, yet nearly half of the provinces exhibit delayed peaks, and hotspots are projected to shift southward, exacerbating pressures in rapidly urbanizing regions, according to scenario-based model simulations.

The authors reveal intrinsic long-range-order noncollinear electric dipole order in the van der Waals crystal WO₂Br₂, enabling pressure-driven 90° polarization rotation via multiple transition pathways and distinctive ultrafast phonon dynamics.

Proteasomes typically degrades ubiquitin-tagged proteins, but midnolin enables a distinct ubiquitin-independent pathway. Here, the authors present cryo-EM structures of the midnolin-proteasome complex, revealing how midnolin directly captures and feeds untagged nuclear proteins into the proteasome.

Blue light promotes DNA repair in plants via cryptochrome signalling. Here the authors report that this occurs via suppression of COP1 mediated degradation of the repair factor ADA2b and propose that together photoreceptors and COP1 balance genome stability with growth under fluctuating light.

A spatiotemporally adaptive targeting strategy ensures sequentially reprogramming metabolism of inflammatory macrophages and senescent stem cells via intracellular NAD⁺ replenishment, accelerating bone and skin tissue regeneration.

Here, the authors show that Zika virus (ZIKV) infection induces Th1-like Tfh cells that depend on T-bet for their development and are essential for class switching of ZIKV-specific IgG2c antibodies and maintenance of long-term neutralizing antibody responses.

Membrane bioreactors face sustainability issues due to waste. Here, authors propose upcycling end-of-life membranes into curtain-type dynamic membranes, reducing carbon emissions and environmental costs while maintaining filtration performance, offering a sustainable solution for water treatment.

In conventional s-wave superconductors, ferromagnetism is strongly suppressed, due to the singlet pairing of the electrons. Here, Xiang, He, Lin, and coauthors find a long-range ferromagnetic order among impurity sites in the spin-orbit coupled Fe(Se,Te) using scanning superconducting quantum interference device microscopy.

Photovoltaic modules are susceptible to hot spots and output decline issue under partial shading. To address this challenge, Tang et al. report a silicon solar cell architecture with in-cell reverse conductivity channels, which mitigates thermal damage and stabilizes output without compromising power conversion efficiency

Wide-bandgap perovskite solar cells suffer from instability under rapid thermal cycling. Here, Sun et al. investigate the degradation mechanism, showing that temperature-induced structural strain, phase transition, and increased non-radiative defects drive the degradation processes.

The mid-infrared (MIR) range of the electromagnetic spectrum can be indirectly accessed by frequency upconversion. Here, authors propose a phase-matching-free scheme for broadband and efficient upconversion, covering wavelengths from MIR to ultraviolet with high-order harmonics generated from a NbOI₂ crystal. MIR imaging is demonstrated with a standard silicon camera.

A model, trained to generate synthetic, patient-specific angiography images, reduced radiation exposure to patients and clinicians by two-thirds in a multicenter randomized controlled trial involving 1,068 patients.

Optimizing mechanical performance for polymer materials is frequently challenging, often require complex methods. Here the authors design an poly(ethylene glycol) material with enhanced mechanical properties by laser printing a micropillar and honeycomb micro-lattice.