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Tumor-associated macrophages play central roles in the cellular immune response in the tumor microenvironment. Here the authors implicate the m6A methyltransferase METTL3 in glioma progression by regulation of the ISG15/FASN modulated lipid metabolism in macrophage.

Qifa Zhang and colleagues report the map-based cloning of the quantitative trait locus GS5, which regulates grain size and yield in rice. GS5 encodes a putative serine carboxypeptidase and increased expression is associated with larger grain.

Here, the authors present genome-wide aDNA from 138 Early Bronze Age individuals from Lower Austria. Their findings point to a patrilocal society with non-strict female exogamic practices and long-distance genetic connections across Central Europe.

Recently there has been interest in using the orbital Hall effect to drive the magnetization of an adjacent ferromagnet. One metal, Tantalum, has been proposed a strong source of orbital current. Here, Liu and Zhu argue that the claimed orbital torques in Tantalum arise instead from self-induced spin-orbit torques in the adjacent ferromagnet.

Wang et al. identify the intragrain impurity nanoclusters of a metastable (FA,Cs)PbI₄ phase, arising from intragrain cation segregation, to be the performance-limiting defect structure in FA–Cs mixed-cation perovskites. An inner salt is introduced to mitigate these intragrain defects, enabling n-i-p perovskite solar cells with efficiency of 26.03%.

A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Pilcher et al. present a single-cell transcriptomics-based immune atlas of participants with newly diagnosed multiple myeloma, reporting on the association of cell types, gene expression and intercellular interactions with disease progression phenotypes.

Replicating the properties of spider silk in synthetic materials is desirable but challenging. Here, the authors report a wet-spinning method using anti-solvent phase separation for polymer hydrogel fibres with favourable structures and properties.

Tools to identify who will develop Crohn’s disease in the future are limited. Here, the authors develop and validate a proteomics-based model that predicts disease onset up to 16 years before clinical diagnosis.

Achieving complete coverage of 2-4 μm pyramids on industrial fully-textured silicon with solution processed perovskite film remains challenging. Here, authors spray-coat alumina particles on silicon for near-conformal deposition of perovskites, achieving efficiency of 32.74% for tandem solar cells.

Irisin attenuates microglial inflammation in PD via ubiquitination-autophagy pathways: PAFAH1B1-RAGE ubiquitination and TFEB-NLRP3 modulation.

Turning CO2 into useful fuels is promising for cleaner energy but remains hard due to low efficiency. This study shows that a spinel-engineered catalyst boosts ethanol formation by promoting C–C coupling while suppressing further carbon-chain growth.

Controllable supply of hydrogen during electroreduction reactions on conventional catalysts is hindered by pH-dependent hydrogen species formation. Here the authors present a lattice-hydrogen cycling mechanism that decouples hydrogen intermediate availability from electrolyte pH.

By integrating a ribo-seq dataset of 195 individuals with RNA-seq and proteomics data from the same cohort, researchers found prevalent post-transcriptional attenuation of eQTL effects and identified omic-specific QTLs associated with schizophrenia.

Polyamide membranes are often fabricated using interfacial polymerization methods, though these methods can compromise membrane structure and performance. Here the authors design a polymerization method using ionic liquid and a doctor blading method to optimize membrane fabrication.

Myocardial ischemia is a pathological condition where cardiomyocytes lack oxygen and energy supply. Here, Cheng et al. develop a photosynthetic system consisting of Chlorella pyrenoidosa (C. pyre) and upconversion nanoparticles encapsulated in a hydrogel, which upon exposure to near-infrared light, enables oxygen production by C. pyre to alleviate the hypoxic myocardial environment.

Lu, Wang et al. profile H3K36me2 throughout oocyte-to-embryo transition, pre-implantation and early post-implantation development and report a role for H3K36me2 in post-implantation embryos to re-establish lineage-specific DNA methylation.

Cobalt-free cathodes are needed for sustainable batteries, but their cycling stability remains a challenge. Here, authors report a dual-phase lithium nickelate, i.e., layered LiNiO₂ and rocksalt LixNi_2-xO₂, stabilized by interlocked domains, synthesized via kinetic control, that delivers high capacity and improved cycle life.

Disulfide bonds are widely found in nature and are prevalent in therapeutic contexts due to their dynamic nature. Here, the authors disclose a click chemistry protocol to convert thiols to disulfides using SO₂F₂, and show its application in aqueous contexts, in flow, and for polymerizations.

The researchers showcase an exciting surface metallic Dirac-vortex cavity design with enhanced power capabilities for electrically pumped Topological Lasers in the THz spectral range.

Here, authors present UNICORN, a multi-task learning framework that integrates foundation model embeddings and multi-omic data to accurately predict cell-type-specific gene expression and uncover biological insights.

Here, the authors demonstrate that VGLL4 maintains cartilage integrity by forming a complex with TEAD4-SMAD3 to regulate extracellular matrix homeostasis. VGLL4 deficiency accelerates osteoarthritis, while its restoration or SMAD3 delivery rescues cartilage damage, suggesting therapeutic potential.

A previously unsampled deep lineage in central Argentina was discovered that had distinctive genetic drift by 8,500 bp and persisted as the main Native American ancestry component in the region up to the present day.

This study demonstrates that the influence range of moiré tuning can be significantly extended beyond the moiré superlattice to a distant conductor through inter-layer drag interaction, presenting a novel strategy for remote moiré engineering.

Acetyl-CoA synthetases have been proposed as targets for development of new antimicrobial drugs. Here, Jezewski et al. identify isoxazole-based compounds with activity against the pathogenic fungus Cryptococcus neoformans, and describe their mechanism of action as inhibitors of fungal acetyl-CoA synthetases.

Here, authors present LABind, a ligand-aware deep learning framework for predicting binding sites of small molecules and ions, with the capacity to generalize to unseen ligands.

It has been previously suggested that STING agonists can improve response to CAR-T therapy. Here the authors report the characterization of the STING agonist IMSA101, showing that STING-induced IL18 secretion enhances CAR-T activity in preclinical cancer models.

Pressure treatment can modify the luminescence properties of materials. Here the authors use pressure to turn nonemissive organic zinc halide perovskites bright with full color tunability, which enables robust optical anti-counterfeiting applications.

By optimizing gate structures and fabrication processes, carbon nanotube metal–oxide–semiconductor field-effect transistors can be fabricated that exhibit a cut-off frequency beyond 1 THz.

Nanoparticle strengthening provides a crucial basis for developing high-performance materials, which often fails to work due to poor thermal stability. Here, the authors achieve thermally stable nanoparticles at 800~1000 °C in chemically complex alloys via controllable sluggish lattice diffusion.

Declining oocyte quality contributes to age-related reduction in fertility; however, the underlying mechanisms are incompletely understood. Here Liu et al. reveal that replenishing mevalonate pathway metabolites and supplementation with a natural compound, 8-isopentenyl flavone, improve aged oocyte quality by restoring cortical F-actin through CDC42 and RAC1 prenylation.

It is crucial, yet challenging, to develop effective polymeric membranes for removing organic micropollutants from water. Here the authors present a data-mechanism-fused machine learning approach to assist the development of such membranes.

Although the number of participants is important for phenotypic prediction accuracy in brain-wide association studies using functional MRI, scanning for at least 30 min offers the greatest cost effectiveness.

Designing two-dimensional membranes to achieve tailored channels while ensuring stability remains challenging. Here, the authors use multifunctional intercalants to create stable, selective subnanochannels in MoS₂ membranes, demonstrating their potential in wastewater treatment.

In vitro transcribed circular RNAs (ivcRNAs) offer a stable and efficient platform for protein replacement therapy. Here, the authors show that localized ivcRNA delivery restores MSI2 and SOX5 expression in chondrocytes, mitigating osteoarthritis progression in mice.

Radical reactivity of diazo compounds, useful organic building blocks, is yet underexplored. Here, the authors report an iodine-catalyzed radical activation of diazo compounds affording a variety of substituted cyclopropanes, pyrroles and epoxides under either thermal- or photo-initiated conditions.

Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour cells.