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The authors introduce the Electromagnetic Frequency Dispersion Coefficient (EFDC), a unified parameter linking material properties to microwave absorption. It enables ultra-thin, broadband absorption with record performance and stable operation across temperatures, simplifying the design of advanced absorbing materials.

Reduced expression of STING in cancer cells due to ER and Golgi dysfunction enables tumor immune escape and limits STING targeted therapies. The authors here develop a cell membrane derived nanodisc system ND-cGAMP-HP that delivers activated STING directly to tumor cells bypassing ER Golgi translocation which activates the IFN-I signaling pathway and induces potent cellular immune responses.

Prokaryotic Argonaute proteins are programmable nucleases. Here, the authors capturing structures of VbAgo at functional stages to show how its C terminus acts as a regulator and demonstrate its ability to cleave RNA in mammalian cells.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

The core downstream mediator of the Norrin/β-catenin pathway remain elusive, hindering the treatment of familial exudative vitreoretinopathy. Here, the authors show that KIF11 acts as a key effector of this axis by preventing phosphorylation-driven PRDX1 phase separation and subsequent ferroptosis.

RNA editing influences gene regulation in cancer. Here, the authors show that EZH2 regulates RNA editing by ADAR1 through remodeling its interactome and nuclear transport, thereby promoting MDM2 expression and prostate cancer progression.

Limited heat dissipation at perovskite interfaces causes local overheating and accelerates degradation in perovskite photovoltaics. Now a solution-processable alkynyl-porphyrin conjugated polymer is inserted between the perovskite and hole-transport layers to enhance interfacial heat dissipation while maintaining efficient charge transport. This thermal and electronic management boosts device efficiency and operational stability.

Two-step thermochemical cycles provide a clean and sustainable route for producing hydrogen and oxygen, yet their practical deployment remains limited by the high temperatures ( > 1500 °C) typically required for most redox-active oxides (RAOs). Here, the authors report Pr3ZrO8 as a new RAO capable of efficient redox cycling within an intermediate temperature window.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

The crystal structure of the CHS-CHIL complex reveals a gating mechanism that enhances CHS activity and specificity. This conserved regulatory paradigm, validated by engineering a CHIL variant, offers strategies to improve flavonoid production in plants.

This study demonstrates that overexpression of irisin, an exercise-induced myokine, ameliorates obesity and insulin resistance in high-fat-diet-fed mice by increasing local IL-33 production and preserving ST2⁺ regulatory T cells in white adipose tissues.

Amid the global PFAS crisis shifting toward (ultra-)short-chain congeners, researchers develop a non-immobilized hydroxyl cycling strategy using water to drive zeolite adsorption regeneration cycles, enabling sustainable water purification upgrades.

This study presents a physics-aware method to compress complex-valued neural networks. By preserving phase structure, it reduces model size by over 99% while improving fidelity in holography and wireless signal processing.

Multiverse and wormholes are experimentally elusive due to dimensional constraints. Here, authors use nonlocal artificial materials and deep learning to emulate photonic parallel spaces, realizing invisible zero-index tunnels and independent optical devices coexisting at the same physical location.

The roles of the piRNA pathway in human oocytes are poorly understood. Here, the authors profile small and long RNAs in single oocytes and show that short piRNAs broadly repress transposable elements, while long piRNAs provide coordinated, endogenous retrovirus-specific repression.

A chromosome-level brachiopod genome reveals deep conservation of BMP-mediated dorsal–ventral patterning and neural inhibition, suggesting the spiralian ancestor retained the ancestral mechanism in bilaterians.

Pancreatic ductal adenocarcinoma has an immune suppressive immune tumour microenvironment, but treatment with clinically available immune checkpoint inhibitors hasn’t improved survival significantly. Here authors show that in mice genomic deletion of VISTA, a checkpoint molecule predominantly expressed in myeloid-derived suppressor cells and leukocytes in the tumour microenvironment, results in enhanced CD8 + T cell response against tumours, providing proof of principle for VISTA-blockade as immunotherapy in pancreatic cancer.

Extreme rainfall reshapes permafrost, cooling shallow soils but warming deeper layers. Impacts depend on climate and ecosystems, potentially accelerating thaw and increasing carbon-release risks.

Bias-voltage-tuneable colloidal quantum dots junctions enable short-wave infrared hyperspectral imagers with megapixel spatial resolution and nanometre-scale spectral resolution for food quality monitoring and materials discrimination.

Fabrication of single liquid-metal fibers is challenged by their limited surface area, thus restricting its functional deployment in soft electronic systems. Here, the authors develop a scalable, solution-deposition strategy for stretchable, multifunctional 1D liquid-metal-based bioelectronic fibers.

An Fe^III/V redox mechanism in Li₄FeSbO₆ on delithiation without Fe^IV or oxygen formation with resistance to aging, high operating potential and low voltage hysteresis is demonstrated, with implications for Fe-based high-voltage applications.

This study uncovers genetic links between plant roots and their microbiome in Brassica napus, identifying microbe-associated loci and a beneficial bacterium, Sphingopyxis, that promotes nitrogen uptake.

Phoretic mites shift between mutualism and parasitism on burying beetles depending on nematode density, with mites suppressing nematodes and reshaping carcass microbiomes, revealing indirect effects driving context-dependent symbiosis.

Interface engineering in magnetic oxides is crucial for advancing spintronic devices, yet challenges remain in manipulating inversion symmetry in non-ideal interfaces. Here, the authors achieve tunable inversion symmetry in (SrRuO₃)₂/(SrTiO₃)₂ superlattices via dynamic control of interfacial disorders, inducing significant changes in Berry curvature and anomalous Hall resistivity.

Cell-to-cell variability limits efficient microbial production. Here, the authors track single cells to reveal enzyme noise as the main source of bioproduction variation, and by coupling growth to pathway performance, they selectively enrich high producers and substantially boost overall titres.

Microbial dormancy-resuscitation dynamics amplify soil carbon responses to warming, especially during non-growing seasons, driven by reduced frozen depth and prolonged thaw, based on a microbial model integrated with multi-year whole-soil warming experiments on the Qinghai-Tibetan Plateau.

A transition-metal-free synthetic strategy for C–H alkylation of electron-poor aromatics is reported, which selectively alkylates the most electrophilic position of electron-deficient aromatics to exhibit ‘anti-Friedel–Crafts’ selectivity. The mechanism is driven via electron donor–acceptor complex photoinitiation with a propagative radical anion mechanism, enabling mild conditions for late-stage drug functionalization.

Existing nickel-catalysed enantioconvergent cross-coupling methods largely rely on Ni(I)/Ni(III) manifolds. Now, a mechanistically distinct platform involving a Ni(II)/Ni(IV) redox cycle enables highly enantioselective difluoromethylation of unactivated alkyl iodides.

Sequential incompatible measurements on a quantum state would need a full multi-time generalisation of quasiprobability in order to be adequately described. Here, the authors propose such a framework, and test it on a trapped-ion system measuring up to three-time correlation functions.

Reactive oxygen species (ROS) serve as endogenous triggers for prodrugs, probes and materials, however ROS-activated bioorthogonal ligation remains as a challenge. Here, the authors report a ROS-activated tetrazine ligation enabled by boronate-caged dihydrotetrazines, and employ it for targeted protein degradation and tumor-selective drug delivery.

The ~200-Myr-old star TOI-2076 hosts a young four-planet system, the orbits and atmospheres of which are still evolving, showing signs of early dynamical reshaping and atmospheric sculpting and offering a rare glimpse of how planetary systems form and transform in their youth.

Cysteinyl leukotriene receptor CysLT2R can be activated by cysteinyl leukotrienes LTC4, LTD4 and LTE4, and is associated with various inflammatory diseases. Here, authors present cryo-EM structures of CysLT2R-Gq bound to LTC4 and LTD4, which are characterized as ago-allosteric modulators of CysLT2R.

GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain imaging genomics.