Nature Search

In retrospect chosen by Philippe Janvier

Philippe Janvier
Books & Arts16 Oct 1997
Nature

Volume: 389, P: 688
Combinatory differentiation of human induced pluripotent stem cells generates functional thymic epithelium driving dendritic cell and CD4/CD8 T cell development

In vitro methods for thymic organoid cultures are useful to examine requirements for T cell development and for generating large numbers of cells for therapeutic purposes. Here the authors use human induced pluripotent stem cells, differentiate these into thymic epithelial organoid cultures and utilise haematopoietic progenitors to show development of T cells in vitro.

Nathan Provin
Manon d’Arco
Matthieu Giraud
ResearchOpen Access23 Jan 2026
Nature Communications

P: 1-24
Spatial patterning of contractility by a self-organized mechanogen activity gradient underlies Drosophila gastrulation

During morphogenesis patterned contractility drives tissue shape changes. Here they show that GPCR signaling and integrin activation give rise to a dynamically translocating gradient of contractility required for a self-organized wave of tissue invagination.

Gayatri Mundhe
Valentin Dunsing-Eichenauer
Thomas Lecuit
ResearchOpen Access23 Jan 2026
Nature Communications

P: 1-21
Environmental enrichment and physical exercise prevent stress-induced social avoidance and blood-brain barrier alterations via Fgf2

Chronic stress disrupts the brain vasculature and contributes to mood disorders, but mechanisms of resilience remain unclear. Here, the authors show that enriched environments increase astrocytic Fgf2 to prevent stress-induced vascular alterations and depressive behavior with relevance to human depression.

Sam E. J. Paton
José L. Solano
Caroline Ménard
ResearchOpen Access16 Jan 2026
Nature Communications

P: 1-23
Canadian net forest CO₂ uptake enhanced by heat drought via reduced respiration

The extreme hot and dry conditions of 2023 reduced soil respiration and enhanced net forest carbon sequestration in Canada, offsetting wildfire emissions, according to satellite-based and in situ observations of CO₂ fluxes.

Guanyu Dong
Fei Jiang
Jing M. Chen
Research05 Jan 2026
Nature Geoscience

P: 1-8
An improved approach to estimate the natural land carbon sink

Michael O’Sullivan
Pierre Friedlingstein
Sönke Zaehle
ResearchOpen Access23 Jan 2026
npj Climate and Atmospheric Science

P: 1-8
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Widespread enhancement of ecosystem carbon fluxes during post moisture pulse

Ecosystems accumulate carbon for several days after moisture pulses, but this benefit fades as soil dries and heat stress intensifies, according to an analysis that uses carbon flux-tower observations, Earth system models, machine learning, and satellite images.

Yu Bai
Fangyue Zhang
Zheng Fu
ResearchOpen Access14 Jan 2026
Communications Earth & Environment

P: 1-11
Socioeconomic and nutritional determinants outweigh gut microbiota influence on neurodevelopment in young children from Antananarivo, Madagascar

Jeanne Tamarelle
Maria V. Doria
Inès Vigan-Womas
ResearchOpen Access17 Jan 2026
Scientific Reports

P: 1-15
Small persistent humid forest clearings drive tropical forest biomass losses

A bookkeeping approach shows that disturbed tropical humid forests experienced net aboveground carbon loss during 1990–2020, primarily driven by small but persistent deforestation clearings owing to persistent land-use conversion without forest regrowth.

Yidi Xu
Philippe Ciais
Wei Li
Research07 Jan 2026
Nature

Volume: 649, P: 375-380
Nation-wide mapping of tree-level aboveground carbon stocks in Rwanda

The authors conduct a national inventory on individual tree carbon stocks in Rwanda using aerial imagery and deep learning. Most mapped trees are located in farmlands; new methods allow partitioning to any landscape categories, effective planning and optimization of carbon sequestration and the economic benefits of trees.

Maurice Mugabowindekwe
Martin Brandt
Rasmus Fensholt
ResearchOpen Access22 Dec 2022
Nature Climate Change

Volume: 13, P: 91-97
The condensed tannins of Okoume (Aucoumea klaineana Pierre): A molecular structure and thermal stability study

Starlin Péguy Engozogho Anris
Arsène Bikoro Bi Athomo
Bertrand Charrier
ResearchOpen Access04 Feb 2020
Scientific Reports

Volume: 10, P: 1-14
Preliminary quantitative assessment of liver and spleen MR imaging and elastography in clinically significant portal hypertension

Constance de Margerie-Mellon
Florian Joly
Bernard E. Van Beers
ResearchOpen Access16 Jan 2026
Scientific Reports

P: 1-13
Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors

In this work, functional antibodies against the cancer-related GPCR NTS1 were generated by immunizing chickens with in silico-designed 3D peptides, offering a strategy for GPCR targeting with potential diagnostic and therapeutic applications.

Marie-Edith Nepveu-Traversy
Malihe Hassanzadeh
Philippe Sarret
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-18
Factors associated with chronic kidney disease among patients with hepatitis c infection attending Kigeme district hospital, Rwanda

Japhet Ndatumuremyi
Isaie Nshimiyimana
Mojeed Akorede Gbadamosi
ResearchOpen Access13 Jan 2026
Scientific Reports

P: 1-12
Cost-effectiveness of maternal vaccine and/or monoclonal antibody strategies against respiratory syncytial virus in Belgian infants

Xiao Li
Lander Willem
Philippe Beutels
ResearchOpen Access19 Jan 2026
npj Vaccines

P: 1-14
Broad versus limited gene panels to guide treatment in patients with advanced solid tumors: a randomized controlled trial

Results from the randomized ProfiLER-02 trial, which compared two gene panels in guiding molecular-based treatment in patients with solid tumors, show that a broader gene panel led to more molecular-based recommended therapies compared to a more limited gene panel.

Olivier Trédan
Damien Pouessel
Jean Yves Blay
ResearchOpen Access07 Apr 2025
Nature Medicine

Volume: 31, P: 1502-1508
Plasma Cyclic Nucleotide Determination in the Investigation of Hypocalcemia

Eric Mallet
Jean-Pierre Basuyau
Claude H De Menibus
Research01 May 1979
Pediatric Research

Volume: 13, P: 647-648
Maintenance olaparib after platinum-based chemotherapy for advanced/metastatic endometrial cancer: GINECO randomized phase IIb UTOLA trial

Single-agent maintenance PARP inhibition may represent an effective strategy for advanced/metastatic endometrial cancer treatment. Here this randomized phase IIb UTOLA trial evaluates the efficacy and safety of orally administered olaparib in female patients (n = 145) without progression following front-line platinum-based chemotherapy for advanced/metastatic endometrial cancer.

Florence Joly
Alexandra Leary
Jérôme Alexandre
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-11
Nanobody therapy rescues behavioural deficits of NMDA receptor hypofunction

A bivalent biparatopic nanobody penetrates the brain, binds to and potentiates the activity of homodimeric metabotropic glutamate receptor 2, correcting cognitive deficits in two preclinical mouse models with endophenotypes resulting from NMDA receptor hypofunction.

Mathieu Oosterlaken
Angelina Rogliardo
Philippe Rondard
ResearchOpen Access23 Jul 2025
Nature

Volume: 645, P: 262-270
The largest reservoir of mitochondrial introns is a relic of an ancestral split gene

Cyril Ferandon
Serge Moukha
Gerard Barroso
ResearchOpen Access23 Apr 2010
Nature Precedings

P: 1
Emerging climate impact on carbon sinks in a consolidated carbon budget

A re-assessment of the global carbon budget shows the natural land sink is substantially smaller than previously estimated, indicating emerging impacts of climate change on the evolution of the carbon sinks.

Pierre Friedlingstein
Corinne Le Quéré
Hanqin Tian
ResearchOpen Access12 Nov 2025
Nature

Volume: 649, P: 98-103
Caffeine Acetylator Phenotyping during Maturation in Infants

Ann Pariente-Khayat
Gerard Pons
Georges Olive
Research01 May 1991
Pediatric Research

Volume: 29, P: 492-495
Electrostriction: it is just a phase

All insulators are electrostrictive: they expand or contract when subjected to an electric field. However, the sign of the electrostrictive coefficient and its relationship with the induced strain is more complex than previously thought.

Jiacheng Yu
Abdelali Zaki
Pierre-Eymeric Janolin
ResearchOpen Access27 Nov 2025
Nature Communications

Volume: 16, P: 1-9
Oxytocin makes us trusting but not gullible

Moïra Mikolajczak
Anthony Lane
Olivier Luminet
ResearchOpen Access21 Sept 2009
Nature Precedings

P: 1
Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies

Variants in the PSMC5 gene impair proteasome function and cellular homeostasis, altering brain development in children. This study reveals underlying molecular mechanisms contributing to this neurodevelopmental phenotype, and suggests therapeutic leads for neurodevelopmental proteasomopathies.

Sébastien Küry
Janelle E. Stanton
Elke Krüger
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-21
Small critical RNAs in the scrapie agent

Steve Simoneau
Marie-Madeleine Ruchoux
Jean-Guy Fournier
ResearchOpen Access16 Jun 2009
Nature Precedings

P: 1
Spatiotemporal coupling of caveolae mechanosensing and RhoA-GEFs regulates cell polarity and directional migration

This study reveals that caveolae and caveolin-1 form a front-rear asymmetry in migrating cells, coupling membrane tension to RhoA-GEF recruitment and activation. This mechanosensing feedback regulates cell polarity and promotes persistent migration.

Vibha Singh
Victor Breton
Christophe Lamaze
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 17, P: 1-20
Benefit and risk associated with interleukin-6 receptor inhibitor administration during severe COVID-19: a retrospective multicentric study

Charlène Lefèvre
Théo Funck-Brentano
Francois Philippart
ResearchOpen Access22 Jan 2026
Scientific Reports

P: 1-12
Continuum of overlapping clones spanning the entire human chromosome 21q

Ilya Chumakov
Philippe Rigault
Daniel Cohen
Research01 Oct 1992
Nature

Volume: 359, P: 380-387
Catastrophic disruption of asteroid 2023 CX1 and implications for planetary defence

2023 CX1 is the only L-chondrite-like asteroid analysed from space to ground. It catastrophically fragmented in the atmosphere, depositing 98% of its energy in one burst—an unusual, high-risk fragmentation mode with implications for planetary defence.

Auriane Egal
Denis Vida
Peter Jenniskens
Research17 Sept 2025
Nature Astronomy

Volume: 9, P: 1624-1637
Land use-induced soil carbon loss in the dry tropics nearly offsets gains in northern lands

Soil carbon loss from human agriculture-related land use in the dry tropics largely offsets gains in northern lands, leading to a small net sink of 0.34 ± 0.30 PgC yr⁻¹ at a global scale.

Huan Wang
Philippe Ciais
Jean-Pierre Wigneron
ResearchOpen Access14 Nov 2025
Nature Communications

Volume: 16, P: 1-12
The oldest amputation on a Neolithic human skeleton in France

Cecile Buquet-Marcon
Charlier Philippe
Samzun Anaick
ResearchOpen Access30 Oct 2007
Nature Precedings

P: 1
Diversity in the haziness and chemistry of temperate sub-Neptunes

The cool sub-Neptune LP 791-18 c, with an equilibrium temperature of 355 K, was found to host a hazy atmosphere, distinct from any other temperate sub-Neptune studied so far. The discovery demonstrates the intrinsic diversity of these worlds.

Pierre-Alexis Roy
Björn Benneke
Jake D. Turner
Research12 Dec 2025
Nature Astronomy

P: 1-14
Control of transmembrane lipid asymmetry in chromaffin granules by an ATP-dependent protein

Alain Zachowski
Jean-Pierre Henry
Philippe F. Devaux
Research06 Jul 1989
Nature

Volume: 340, P: 75-76
Meningococci drive host membrane tubulation to recruit their signaling receptors

The adhesion of meningococci to endothelial cells relies on type IV pili, which induce the formation of long tubular structures on the host cell membrane. Here, the authors show that the tubular structures accumulate and trap host membrane-associated proteins, which facilitates their interaction with bacterial ligands and the activation of adhesion and signaling receptors.

Audrey Laurent-Granger
Kévin Sollier
Mathieu Coureuil
ResearchOpen Access25 Nov 2025
Nature Communications

Volume: 16, P: 1-17
Impact of androgen receptor pathway inhibitors on cognitive function in older adults treated for metastatic prostate cancer

Boué et al. longitudinally assess cognition in patients aged ≥70 years receiving hormone therapy for metastatic prostate cancer. Poorer objective and subjective cognition occurs in patients receiving hormone therapy, particularly when androgen receptor pathway inhibitors (ARPI) are added to androgen deprivation therapy (ADT).

Antoine Boué
Giulia Baciarello
Florence Joly
ResearchOpen Access23 Dec 2025
Communications Medicine

Volume: 6, P: 1-12
Characteristics and prognostic significance of myelodysplasia-related features in VEXAS syndrome

Lin-Pierre Zhao
Olivier Kosmider
Alexandra Zduniak
Research16 Jan 2026
Leukemia

P: 1-5
The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region

Philippe Jay
Claire Rougeulle
Françoise Muscatelli
Research01 Nov 1997
Nature Genetics

Volume: 17, P: 357-361
Continuous helium absorption from both the leading and trailing tails of WASP-107 b

JWST observed helium and water in the atmosphere of the giant planet WASP-107 b, revealing a vast outflow of gas and evidence for recent inward migration. The findings shed light on how giant planets lose mass and evolve over time.

Vigneshwaran Krishnamurthy
Yann Carteret
Jake D. Turner
Research01 Dec 2025
Nature Astronomy

P: 1-13
Stress-induced amorphization as a transformation plasticity mechanism demonstrated in forsterite

Stress-induced amorphization has been observed in some systems as a plasticity mechanism. Here, simulations and microscopy reveal that stress-induced amorphization in forsterite exhibits the features of phase transformation plasticity.

Jean Furstoss
Daniel Pino-Muñoz
Patrick Cordier
ResearchOpen Access22 Jan 2026
Communications Materials

Volume: 7, P: 1-8
Localization of Acetylcholinesterase by Immunofluorescence in Eel Electroplax

PHILIPPE BENDA
SHIGERU TSUJI
JEAN-PIERRE CHANGEUX
Research21 Mar 1970
Nature

Volume: 225, P: 1149-1150
Twists and turns

MARC LE MAIRE
PHILIPPE CHAMPEIL
JESPER V. MØLLER
Research16 Aug 1990
Nature

Volume: 346, P: 617
Hepatic Inactivation of Angiotensin

ANDRÉ L. METHOT
PHILIPPE MEYER
PAUL MILLIEZ
Research01 Aug 1964
Nature

Volume: 203, P: 531-532
Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption

Analysis of snRNA genes in individuals with rare disorders identifies de novo and recurrent variants in RNU5B-1 and RNU5A-1, in addition to previously unreported cases with pathogenic or likely pathogenic variants in RNU4-2.

Caroline Nava
Benjamin Cogne
Christel Depienne
ResearchOpen Access16 May 2025
Nature Genetics

Volume: 57, P: 1374-1388
Maturation of Caffeine N-Demethylation in Infancy: A Study Using the ¹³CO₂ Breath Test

Gérard Pons
Jean-Claude Blais
Georges Olive
Research01 Jun 1988
Pediatric Research

Volume: 23, P: 632-636
Selenoneine and ergothioneine in beluga skin and tissues as key antioxidants in the Inuit diet

Ariane B. Barrette
Philippe Archambault
Pierre Ayotte
ResearchOpen Access14 Oct 2025
Scientific Reports

Volume: 15, P: 1-11
Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Both environmental factors and genetic factors influence human immunity. Albert and colleagues leverage data from the Milieu Intérieur Consortium to comprehensively describe the effects of lifestyle, environment and genetics on human innate and adaptive immunity.

Etienne Patin
Milena Hasan
Matthew L. Albert
Research23 Feb 2018
Nature Immunology

Volume: 19, P: 302-314
Enhanced magnetic field sensitivity of spin-dependent transport in cluster-assembled metallic nanostructures

Santiago Serrano-Guisan
Giulia di Domenicantonio
Christian Félix
Research13 Aug 2006
Nature Materials

Volume: 5, P: 730-734
After the deluge: Mediterranean stagnation and sapropel formation

Martine Rossignol-Strick
Wladimir Nesteroff
Colette Vergnaud-Grazzini
Research14 Jan 1982
Nature

Volume: 295, P: 105-110

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