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The orientation relationship between phases governs crystallographic discontinuity and imposes constraints on the activation of deformation modes. Here, weakening the orientation relationship between L1₂ and B2 phases in a dual-phase high-entropy alloy via plastic deformation and recrystallization significantly improves ductility without sacrificing strength.

Developing strategies for reducing carbon emissions in municipal solid waste management is essential to achieve the net-zero target. Here the authors systematically assess strategy options of different countries for achieving net-zero municipal solid waste management.

A critical challenge of solid-state batteries is Li-filament penetration. Here, by quantifying microstructural properties and employing modeling techniques, the authors provide insight into solid-state battery failure modes and offer design guidelines to enhance safety and performance.

This study presents an approach that directly converts commercial polycrystalline Li into various monocrystalline Li metal anodes with single facets via a recrystallization technique. Using monocrystalline Li(110), the critical current density can be raised by an order of magnitude in solid-state batteries.

Sodium-air batteries are appealing energy storage systems due to high theoretical energy density and high sodium abundance. But they are plagued with low efficiency and large overpotential. Here, authors report long-term reversibility over 1000 cycles with 99% efficiency using a cascade electrocatalysis strategy based on Na[Li_1/3Ru_2/3]O₂ electrodes.

Zhuang, Zi et al. identify cyclin-dependent kinase 3 (CDK3) as a driver of neuron loss in Alzheimer’s disease that is associated with brain atrophy and memory decline in mice. Inhibition of CDK3 (BMX330) is shown to limit neuronal loss and improve cognition.

This work reports a Lewis-acid coordinated strategy to improve stability of a 4.8 V-class PEO-based battery. The batteries using Lewis-acid coordinated electrolytes and Ni-rich cathodes achieve high voltage stability of 4.8 V over 300 cycles.

SARS-CoV-2 continues to evolve, necessitating updated vaccines and therapeutics. Here the authors identify three broadly binding antibodies from vaccinated or infected individuals, characterize their conserved non-overlapping RBD epitopes by structural analysis and demonstrate protective effects in a hamster model.

Prostate cancer diagnosis require MRI analysis, however, scoring can vary between clinicians. Here, the authors develop ProAI to detect prostate cancer from imaging.

Layered oxide cathode materials for sodium-ion batteries often experience irreversible phase transitions and structural instability. Now researchers have developed a P2-type oxide containing earth-abundant elements, featuring an intergrowth phase structure that enables long-cycle, high-energy sodium-ion batteries.

Advanced electrolyte is essential for high-energy-density lithium metal batteries. Here, the authors design a molecular anchoring dilute electrolyte via intermolecular hydrogen bonding with free solvents to improve the battery electrochemical and thermal stabilities.

Thermal power generation faces risks from rising water temperatures and scarcity, worsened by decarbonization efforts that prioritize the retirement of lower-risk units. To reconcile energy security and climate goals, policymakers should factor hydroclimatic risks into power plant retirement and energy transition planning.

Thermal power plants face growing risks from rising water temperatures and water shortages, which can reduce cooling efficiency and threaten energy security. A study maps these risks globally and finds that factoring them into plant closures could improve reliability while supporting climate goals.

This work demonstrates a monolithically integrated VCSEL with an embedded passive cavity, achieving an ultranarrow ~1 MHz linewidth and enabling high-stability chip-scale atomic clocks.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

A soft, stretchable and freely movable fibre sensor called NeuroWorm, inspired by earthworms and that can be magnetically steered through soft tissue, is described as a new platform for dynamic bioelectrical and biomechanical monitoring.

Protonic ceramic electrochemical cells (PCECs) interconvert hydrogen and electricity and therefore have potential as long-duration energy storage systems, but the durability of these devices under industrially relevant conditions is limited. Here the authors report a PCEC that maintains low degradation rates throughout exceptionally long-term durability tests.

Though high entropy oxides have been explored as possible conversion-type negative electrodes for Li-ion batteries, the roles of the different elements remain unclear. Here the authors determine the behavior of each element during electrochemical cycling and connect it to the nanoscale structure.

Here, the authors report tunable luminescence from a single lanthanide ion upon changing excitation conditions through co-doping an energy-modulator ion, thus adjusting the photon transition process of the lanthanide activator ion. Optical encryption has also been demonstrated as an application of this universal strategy.

High entropy oxides provide a new strategy toward materials design by stabilizing single-phase crystal structures composed of multiple cations. Here, the authors apply this concept to the development of conversion-type electrode materials for lithium-ion storage and show the underlying mechanism.

The efficacy of anticancer gene therapy varies by the delivery efficiency of the mRNA cargo as well as their injection method. Here this group reports using LNP-delivered mRNA encoding 3 C protease treated on three different types of solid tumor models showing effective tumor growth inhibition, with three different injection methods, respectively.

Solid-state sodium batteries represent more sustainable options as they combine resource abundance with safety. This work advances their performance, particularly fast cycling lifespan, to an unprecedented level utilizing a hybrid electrolyte.

Lai et al. present a spatially resolved atlas of human atherosclerotic plaques, revealing cellular heterogeneity and identifying lymphoid structures and their potential functions and implications.

The tumor suppressor GATA4 is frequently epigenetically silenced in lung cancer. In this study, Gao et al. demonstrate that GATA4 regulates the expression of TGFBR2 and that TGFRB1 inhibitors can synergise with chemotherapeutics to inhibit the growth of GATA4-deficient tumors in mice.

Solid state battery is regarded as one of the most promising next generation energy storage systems due to high safety and high energy density. Here, authors demonstrate the importance of interfacial local environment in polycrystalline cathodes for electrochemical reactions in solid-state batteries.

Wannier excitons exhibit a relatively large Bohr radius, and this limits the strength of coupling to magnetic ions, in exciton hosting material. Here, Huang et al. overcome this limitation by using self-trapped excitons in Cs₃Cu₂I₅, with a resulting large exciton Zeeman splitting.

The poor structural stability of cathode materials is responsible for the rapid capacity loss of sodium-ion batteries during cycling. This work addresses the instability by introducing vacancies into the transition metal layers and realize long-life pouch cells.

Global lake research is skewed toward economically and socially developed regions, overlooking remote areas. Enhancing resilience and fostering synergistic approaches could help redress these inequities.

Cao et al. report an A-site co-doping strategy by substituting Cs+ cation by alkali metals for perovskite quantum wires embedded in nanoporous alumina template, stabilising the crystal structure and enabling high-colour purity LEDs spanning from blue to green spectral region.

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

Chemo-immunotherapy regimens are now recommended as first-line treatment for patients with advanced esophageal squamous cell carcinoma (ESCC), however survival outcomes remain unsatisfactory. Here the authors report the results of a phase 2 trial of toripalimab (anti-PD1) plus chemotherapy and radiotherapy in patients with treatment-naïve advanced ESCC.

Performance improvement of cathode materials represents one of the most critical technological challenges for lithium-ion batteries. Here the authors show a close correlation between surface chemistry and phase distribution from homogeneity to heterogeneity, and its impact on the cyclic performance.

Herbivore cooperation between insect pests can result in substantially greater damage to crops but also constitutes a good target for improved pest control. Liu et al. reveal how the brown plant-hopper and the rice striped stem-borer obtain mutual benefits when feeding on the same rice plant.

Genomic, transcriptomic and DNA methylation data from tissue samples from 208 Chinese patients with prostate cancer define the landscape of alterations in this population, and comparison with data from Western cohorts suggests that the disease may stratify into different molecular subtypes.

West Pacific ferromanganese crust provides new insights to Late Miocene Cooling associated with the increased continental phosphorus weathering.

Operando monitoring of thermal runaway in Li-ion batteries is critical. Here, authors develop an optical fiber sensor capable of insertion into 18650 batteries to monitor internal temperature and pressure during thermal runaway, facilitating battery safety assessment and early warning capability.