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The authors report that Ta-doped PbTiO₃ films with a p-i-n structure can generate a high photovoltaic current, offering the opportunity to advanced optoelectronic and imaging devices.

Converting syngas into high-value long-chain alcohols is a major industrial challenge due to poor product selectivity. This study achieves 80% selectivity through a modular catalytic design that boosts carbon efficiency while minimizing waste.

This randomized open-label trial shows that hemoadsorption combined with hemodialysis reduces all-cause and cardiovascular mortality, and cardiovascular events in patients with end-stage kidney disease compared to hemodialysis (mainly low-flux hemodialysis plus intermittent hemodiafiltration) alone.

Maintaining genome integrity during different life stages is critical. Here, the authors reveal an RNA editing mechanism in the fungal pathogen Fusarium graminearum that adjusts Mus81 protein function to balance heat-stress survival and sexual reproduction. This stage-specific editing fine-tunes DNA repair for adaptation and reproduction.

The onset of septic cardiomyopathy (SC) is linked to excessive ROS, leading to increased oxidative stress and iron accumulation. Here, the authors report a conducting polymer-stabilized ruthenium nanozyme that shows desirable conductivity and catalytic properties, targets cardiac mitochondria, alleviates lipid peroxidation and oxidative stress, achieving precise therapeutic effects on SC.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

When a femtosecond laser is focused onto a tungsten tip, excited surface plasmon polaritons form a relativistic terahertz soliton at the tip apex in a supersonic argon jet. It exhibits sustained stability over 100-ns durations and 400-μm spatial dimensions and resembles ball lightning.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Zheng et al. show that extending the guide RNA restores the reduced activity of a high-fidelity CRISPR–Cas9 enzyme while preserving accuracy, revealing how strengthened PAM-distal interactions can improve genome-editing performance.

The genetic basis of low-temperature tolerance in maize is unclear. Here, the authors show that the type-A Response Regulator 1 (ZmRR1) and mitogen-activated protein kinase (MPK8) are positive and negative regulators of maize chilling tolerance, and ZmRR1 is phosphorylated by ZmMPK8 during cold treatment.

Chen, Cai et al., present a rigorous human-in-the-loop framework for evaluating the medical performance of AI-generated responses to real clinical questions, using a scale aligned with physician career stages. Although some models perform at levels comparable to early-career physicians, substantial rates of incompetent answers and hallucinations demonstrate that unmonitored clinical deployment remains risky, underscoring the continuing need for expert oversight.

Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

Natural forest conversion reduces soil respiration by 7% through strong declines in autotrophic respiration and raises temperature sensitivity after conversion to agriculture and grassland, with both responses returning to forest levels within 30 years, based on 452 paired observations.

Metabolic reprogramming of immune cells can modulate their response to and ability to respond in infective contexts. Here the authors show phosphoglycerate dehydrogenase mediated serine reprogramming in macrophage is linked to hyper inflammatory responses in murine models of Pseudomonas aeruginosa pneumonia.

High fidelity manipulation of diamond-based spin qubits is difficult at room temperature because of decoherence. Here, the authors show a universal set of logic gates in nitrogen-vacancy centres with average single-qubit and two-qubit gate fidelities of 0.999952 and 0.992, respectively.

A testis-specific E3 ubiquitin ligase complex, ECSASB9, governs spermiogenesis by promoting TUBB4A degradation. Disruption of this pathway impairs male fertility, and pathogenic ASB9 variants are found in infertile men.

Cultivated banana is threatened by Fusarium oxysporum f. sp. cubense tropical race 4 (TR4). In this study, the authors assemble the genome of Musa cheesmanii, a wild banana species that is highly resistant to TR4, and use it in crossbreeding with two cultivars to enhance disease resistance.

Copper nanoclusters are promising photothermal heaters, but their conversion efficiency is limited efficiency. Here, the authors present a rotor-stator ligand architecture that enables enhanced photothermal conversion efficiency of copper nanoclusters.

The synthesis of ionic olefin linked threedimensional covalent organic frameworks (3D COFs) is challenging because of the difficulties in forming stable carbon-carbon double bonds. Here, the authors report a general synthesis of an ionic sp² carbon linked COFs and demonstrate selective capture of ReO₄⁻ ions.

Crystalline polycarbonates can be formed by mixing enantiopure polymers with opposite configurations. Here, the authors produce crystalline intramolecular stereocomplexed polycarbonates using a racemic catalyst, and show that these display similar properties to those formed by mixing the two enantiomers.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Cardiometabolic disease and depression often co-occur, but their multi-organ basis was unclear. Here, the authors analyse UK Biobank imaging and genetics, identifying abdomen-heart-brain networks and 43 shared loci, improving multimorbidity prediction

The fabrication of organic polymers in single-crystal form is challenging. Here a rare single-crystal porous polymer with solution processability is synthesized by combining a one-dimensional chain structure, dynamic covalent bonds and various intermolecular interactions. This polymer is used as a coating on fabric for ammonia capture.

Previous studies on biodistribution of microplastics showed discrepancies. This study provides quantitative data to date on how nanoplastics distribute and eliminate from the body using carbon-14-radiolabelled particles in rats.

Transition metal-catalyzed C−H cyclization for medium-ring synthesis has been limited to reactive C−H bonds, the activation of unreactive C−H bonds still remains a challenge. Here the authors show the direct construction of 7-membered rings via Ni−Al co-catalyzed unreactive C−H cyclization of benzoimidazoles with alkenes, providing a series of tricyclic imidazoles.

Sealing of puncture points after interventional surgeries is a vital requirement, but large diameter sheaths and transapical punctures present a significant challenge for wound closure. Here, the authors present a water-activated tissue adhesive patch designed for quick and strong adhesion to blood vessel and heart tissue surfaces after surgery.

Target identification of natural products plays a critical role in the development of innovative drugs. Here, this group integrates molecular docking and molecular dynamics simulations on Bufalin and reports the potential targets as well as its role in reversing endocrine resistance.

Yang et al. compare neoadjuvant triple therapy versus direct hepatectomy in patients with resectable intermediate or advanced hepatocellular carcinoma. The findings indicate that the neoadjuvant regimen improves overall and event-free survival but is associated with a higher risk of serious adverse events and postoperative complications.

Ming-Rong Wang, Benjamin Berman and colleagues perform whole-exome sequencing and global methylation profiling on different tumor regions of esophageal squamous cell carcinoma. They find evidence for intratumoral heterogeneity and identify late driver mutations targeting oncogenes and early driver mutations occurring in tumor-suppressor genes.

A strategy based on the design of a composite coating that enables slip-enhanced close-contact melting inside sealed phase-change thermal batteries to improve charging rates enables high-performance thermal energy storage over a wide range of temperatures.

Oxidative stress contributes significantly to postmenopausal osteoporosis by impairing osteoblast function, but its precise mechanisms remain unclear. Here, the authors show that estrogen deficiency reduces GPX4 expression, leading to phospholipid peroxidation that impairs osteoblastogenesis, while GPX4 activators including 6- and 8-Gingerols can mitigate these effects.

A multiancestry phenome-wide analysis of copy number variants in the UK Biobank genomes increases power to detect genetic associations with complex traits across human populations.

Fullerene cages that break the isolated pentagon rule are rare and often unstable. Now a range of fullerenes that feature three sequentially fused pentagons of carbon have been stabilized by chlorination.

The development of 3d-metal-catalyzed β-C–H bond activation via 4-membered metallacycles remains an elusive challenge. Here, the authors report a Ni-Al bimetal-catalyzed β-C(sp3)–H bond activation of formamides via 4-membered nickelacycles.

This study identifies four distinct polycystic ovary syndrome (PCOS) subtypes using unsupervised clustering analysis on data from 11,908 women and validated across five diverse cohorts. The subtypes show unique clinical features and suggest that subtype-specific management could enhance treatment precision for PCOS.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Gut microbiota influence bone health, but the genetic and metabolic mechanisms are unclear. Here, the authors show that specific bifidobacterial taxa causally reduce bone mineral density, partly via n-3 fatty acid metabolism, highlighting host-microbe interactions with potential therapeutic implications.