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Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

Low efficiency and immunotoxicity limit rAAVs clinical use. Here, the authors show that encapsulating rapamycin in PF127 micelles modulates cellular biomechanics, enhancing AAV-mediated gene transfer while reducing immunogenicity demonstrating application in osteoimmunological disorders.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

RNase MRP is an essential ribonucleoprotein complex in eukaryotes. Here, authors describe how RNase MRP structurally and functionally diverged from RNase P, through specific RNA-protein adaptations, to evolve a novel ssRNA processing activity in eukaryotes.

The GABA_B receptor is a mandatory heterodimer. Here authors show the existence of GABA_B dimers of dimers in neurons, and their relevance in human health. By solving the structure of this tetramer, they show the structural basis for a negative cooperativity between the dimers within such a complex.

Traditional recycling of polyoxymethylene plastic often leads to significant material loss and toxic emissions. Here, the authors introduce an acidic electrochemical process that efficiently converts plastic waste into valuable chemicals with conversion efficiency approaching 90%.

Neuromorphic computing hardware normally makes an unideal trade-off between energy efficiency, scalability and reliability. Kim et al. report a ferroelectric heterostructure based memristor with near-zero nonlinearity, endurance beyond 10E7 cycles, rectifying ratio exceeding 10E6 and sub-pA off-current.

Neural mechanisms underlying social behavior are not fully understood. Here authors show two lateral septum neuron types in male mice that bidirectionally regulate social memory via distinct hippocampal-hypothalamic circuits.

Climate models overestimate greenhouse gas effects on the temperature difference between Earth’s hemispheres, with this bias strongest in high climate sensitivity models, suggesting future tropical rainfall shifts may be less severe than projected.

Façade-integrated photovoltaics (FIPV) present a promising yet early-stage solution for mitigating building emissions. Combining global building datasets, climate projections and façade-scale simulations, researchers estimate that FIPV could deliver substantial economic and climate benefits.

Ziyi Hu and colleagues report a combined 3D reconstruction and simulation method to reveal the cause of the wiggling effect in advanced Dynamic Random Access Memory. This method provides a tool for etching process optimization to improve reliability

MoS₂ has emerged as a cost-effective catalyst for CO₂ hydrogenation to formate, yet its performance is limited by the difficulty of creating a sufficient density of highly active sulfur-vacancy–confined Mo sites. Here, the authors demonstrate that substituting Mo atoms with confined Co atoms in the MoS₂ lattice markedly enhances the efficiency of CO₂ hydrogenation to formate.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

The operational stability of perovskite solar cells remains a challenge. Zhang et al. incorporate photoswitchable isomers at grain boundaries to improve their resilience and the stability of the solar cells under light cycling and ultraviolet exposure.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

The chromatin remodeler BRAHMA (BRM) is found as a repressor of plant adaptation to acid stress by inhibiting the STOP1-NRT1.1 signaling module. Under low pH, BRM degradation activates nitrate uptake and alkalinizes the rhizosphere.

Achieving rapid and reversible tuning of structures and producing structures with high aspect ratios with polymer self-growth remains challenging. Here, the authors introduce a generalized stretch-induced polymer self-growth method for reversibly constructing structures on a wide range of pre-stretched elastic membranes.

Pulmonary fibrosis is one of the most prevalent parenchymal fibrotic diseases. Here, Zhang et al. show that hydrogel priming enhances chimeric antigen receptor (CAR)-macrophage function, improving therapeutic efficacy in treating pulmonary fibrosis by a mechanical approach.

Scalable fabrication of perovskite films for large-area solar cells remains a critical challenge. Jin et al. identify the solvent-precursor interaction time as a crucial, yet overlooked, kinetic parameter controlling crystallization and propose a protocol for manufacturing high-quality perovskite films.

Researchers report a solid that is amorphous in two dimensions but crystalline in the third, made of stacked disordered atomic layers. This shows that crystalline and amorphous order can coexist within a single material depending on direction.

Tumor-associated macrophages play central roles in the cellular immune response in the tumor microenvironment. Here the authors implicate the m6A methyltransferase METTL3 in glioma progression by regulation of the ISG15/FASN modulated lipid metabolism in macrophage.

Direct air capture (DAC) removes CO₂ from the atmosphere but remains energy-intensive at scale. Here, the authors integrate catalytic solvent regeneration and hybrid solvents with low-temperature membrane vacuum regeneration, significantly improving the energy efficiency and sustainability of liquid-based DAC systems.

Lin et al. identify a mechanism by which swimming exercise attenuates cognitive decline in Alzheimer’s disease mice, via induction of skeletal muscle-derived vesicles containing miR-378a-3p, taken up by microglia to regulate metabolism and enhance plaque clearance.

This study presents an interfacial stress decoupling strategy using dithiol-based self-assembled layers enabling stable palladium hydrogen sensing, demonstrating wafer-scale device fabrication and seamless integration of a portable detection platform.

Accurate single nucleotide variations (SNVs) detection is clinically vital, yet existing techniques can only detect SNVs at specific loci. Here, Mao et al present a new generalized CRISPR/Cas-based strategy, termed PRICE, to identify SNVs in miRNA sequences without sacrificing the sensitivity.

Magnetic kagome metals are an ideal platform for investigating the interplay between spin and charge degrees of freedom. Here, the authors provide evidence of a charge-density wave intrinsically coupled to spin degrees of freedom in GdTi₃Bi₄, consistent with a spin–intertwined charge density wave.

Elevated adipocyte-derived AFABP in obesity disrupts iron homeostasis in intestinal stem cells (ISCs), which impairs PPARα signalling and blocks ISC differentiation after injury.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and autoimmunity.

Agricultural irrigation is energy intensive and a key source of carbon emissions. This study shows that aligning irrigation schedules with renewable energy availability can cut emissions, ease grid load and use surplus clean power. Using China as a case study, it demonstrates a scalable, low-carbon strategy that maintains crop productivity while supporting the energy transition.

In this study, the authors show that chandelier cells in the medial prefrontal cortex integrate circuit inputs, encode stimulus salience across sensory modalities, and thus influence associative learning in male mice.

Previous malaria exposure weakens whole-parasite malaria vaccines by leaving haemozoin, which impairs T cell activation. An mRNA vaccine bypasses this block, restores protective T cells and improves protection when combined with whole-sporozoite vaccination.

A palm-sized fluorescence sensor based on light-emitting diode flashes combined with smart algorithms has the capability to build high-resolution spectra.

Revealing the structural features governing ergodicity breaking is critical to understanding glass formation. Here, the authors synthesise a family of hybrid metal halide glasses, and show that the molecular shape and polarity determine rotational disorder, enabling diverse glass-forming abilities.

Despite pressure to improve the circularity of polysulfone plastic waste, upcycling polysulfones remains technically challenging. This study presents a photocatalytic method that can upcycle various polysulfones into valuable chemicals at ambient conditions.

The presence of EGFR mutations and de novo MET aberrations limited response to EGFR inhibitors in patients with advance non-small cell lung cancer (NSCLC). Here, the authors report a phase 2 randomised clinical trial investigating first-line osimertinib (EGFR inhibitor) plus savolitinib (c-MET inhibitor) in patients with MET-aberrant, EGFR-mutant advanced NSCLC.

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