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Leveraging electron-phonon coupling allows for modulating self-trapped exciton formation for broadband white-light emission. Using transient spectroscopy and DFT calculations, Zhang et al. correlate the structural distortion with self-trapped exciton formation in 2D halide perovskites.

Prostate cancer incidence and mortality rates vary across males from diverse populations. Here, the authors perform a proteome-wide association study across different populations and establish population-specific genetic prediction models.

The oxyhalogenation of methane to mono-halogenated products CH₃X (X = Cl, Br, or I) is among the most promising routes for methane utilization, yet current catalysts still suffer from limited product yields. Here, the authors report a CeO₂ nanorod catalyst with atomically dispersed Pd and Mn surface sites, which achieves highly efficient and selective methane oxychlorination.

Han et al. present a very-large-scale 3D computing reservoir self-assembled from 1D WS₂ nanotubes, with dense mimetic optogenetic synapses matching a fruit fly’s brain. It efficiently handles monomodal and multimodal tasks, featuring optogenetics-inspired, light-tunable computing dynamics.

Areas with increasing ecosystem service supply from 2000 to 2020 spatially overlap with declining resilience in the Loess Plateau, revealing mismatches between service gains and resilience losses, based on a multi-scenario spatial prioritization framework.

Controllable and scalable phase transition of transition metal chalcogenides is challenging. Using in situ microscopic analysis, a non-stoichiometric phase transition from PdTe₂ to PdTe is observed on the atomic scale, providing mechanistic insights into the scalable phase engineering of transition metal chalcogenide films and heterostructures.

Tuning the interfacial structure of silver nanoclusters via steric hindrance modulates their photoluminescence. Locking the ligand shell endows the clusters with room-temperature photoluminescence, thereby enabling atomic-level design of optical devices.

Reduced GC-related content in the influenza A virus genome may be a necessary condition for sustained mammalian transmission and should be included in risk assessment tools for pandemic influenza.

The development of novel two-dimensional antiferromagnets is crucial for enhancing the performance of spintronic devices. Here, authors realize the synthesis of CrOCl monolayer films and nanosheets that exhibit excellent performance.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Sodium metal is of interest for high-energy-density batteries, but the lack of large-area ultrathin sodium metal foils hinders research. Here a metre-length, ultrathin (≤50 μm), mechanically strengthened sodium metal foil is fabricated by a roll-to-roll calendaring process with interfacial lubrication and functional modification.

Conventional doped spiro-OMeTAD hole transport layer often leads to poor device operational stability. Here, the authors employ light to generate protons from bistriflimide dopants in the precursor solution to increase conductivity, achieving efficiency of 20.95% in perovskite solar modules.

The authors assess the sustainability effects of global tobacco use and control in global supply chains, and find that reducing tobacco prevalence may generate benefits to the environment, health, and economy, albeit with a reduction in employment.

High-density dynamic random access memory is crucial for addressing the memory wall issue, yet its three-dimensional integration faces significant challenges. Liao et al. utilize a single-step self-aligned integration scheme, achieving 4 F² density and demonstrating 4-bit operation.

Oxaloacetate is sensed by MDH1, which primes innate immune antiviral defence against influenza virus infection, thus resulting in the activation of ETS2 to promote TBK1-centred type I interferon signalling.

Human Glucose-6- phosphate Transporter (G6PT1) is critical for systemic glucose homeostasis. By integrating multiple cryo-EM structures with functional validation, the study elucidates the molecular mechanism of G6PT1 and its dysregulation in glycogen storage disease.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Using population and ecological genomic approaches, the authors demonstrate the potential for interspecific introgression—the transfer of genetic material following hybridization—to reduce climate change vulnerability. Their findings emphasize the importance of preserving interspecific connectivity.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Using size-specific infrared spectroscopy and quantum-chemical calculations, structural motifs of interference-free neutral water undecamer (H₂O)₁₁ were characterized, revealing three isomer families and insights into hydrogen-bonding networks essential for understanding solvation processes.

Achieiving dynamic light-structure-light feedback loops is challenging, but has potential in the design of optical materials. Here, the authors report the use of a self-adaptive growth strategy for the preparation of materials with ordered photonic crystal structures in perfluorosulfonic acid ionomer films.

Micro-supercapacitors offer the advantage of high power density over lithium batteries and high energy density over electric capacitors, but integration of these advantages is yet to be achieved. Wu et al. develop a graphene-based in-plane micro-supercapacitor with ultrahigh power and energy densities.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Single-cell RNA sequencing, whole-exome sequencing and spatial transcriptome sequencing of gallbladder adenocarcinomas from 75 patients stratifies the disease into groups with distinct clinical outcomes.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

High-entropy alloy (HEA) nanoparticles, self-supporting HEA aerogels and HEA coatings with up to 11 metal elements and uniform elemental distributions have been synthesized at subzero temperatures using a bilayer ice recrystallization method. The process is observed by cryo-transmission electron microscopy and fused multimodal electron tomography.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Monitoring of minimal residual disease is a key method for detecting potential acute myeloid leukaemia relapse. Here, the authors developed a longitudinal mutation burden monitoring strategy using ultra-sensitive mutation sequencing to quantitate VAF below 0.01% for accurate minimal residual disease assessment and relapse prediction.

Rice-infecting arboviruses adopt convergent strategies to overcome host defenses. Here, the authors show that viral proteins from distinct rice viruses boost OsTSN1 nuclease activity to suppress rice antiviral RNA decay immune response through promoting its phase separation and multimerization.

Rice stripe virus deploys its SP protein to dismantle SERRATE condensates in rice cells, blocking microRNA production and enhancing viral spread. This discovery reveals how viruses can hijack host phase separation to modulate gene regulation.

Data heterogeneity presents a challenge in distributed artificial intelligence (AI) for medical imaging across diverse clinical settings. Here, the authors develop HeteroSync Learning, a privacy-preserving distributed learning framework that mitigates data heterogeneity and outperforms classical, state-of-the-art, and foundation models.

Whole-exome sequencing analyses in a cohort of 2,140 participants with female infertility after recurrent in vitro fertilization, coupled with functional analyses, identified genes associated with oocyte and early embryo competence defects.

Conditional knockout of LARP4 in naive CD4⁺ T cells leads to attenuated quiescence exit and clonal expansion.

This protocol isolates lignin from various types of biomass, screens for high-quality lignins, and uses them to directly prepare lignin adhesives without chemical modification, the performance of which is then assessed. It produces lignin adhesives with light colors and superior properties.

The pulsed electrochemical method, combined with a wood-based electrode, enables the simultaneous reduction of oxygen to generate hydrogen peroxide and the regeneration of Fe³⁺ to active Fe²⁺ for radical production. This approach offers a cost-effective and sustainable electro-Fenton process for wastewater treatment.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

In oxide materials, cation doping strongly influences the electronic correlations which promote diverse phenomena such as colossal magnetoresistance and superconductivity. Here, the authors use magnetic microscopy to image the effects of spatially ordered doping on electronic phase separation in oxide superlattices.

Aberrant activation of Wnt/β-catenin signaling contributes to colorectal cancer (CRC) pathogenesis. Here the authors find that the cytoplasmic distribution of TRIM24 E3 ubiquitin ligase triggers ubiquitination and degradation of von Hippel-Lindau, resulting in the accumulation of β-catenin protein in CRC cells.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.