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Cardiovascular surgery and haemodialysis urgently need durable vascular grafts. Here, authors develop a decellularized polymer skeleton-reinforced biotube as a readily-available vascular graft and demonstrate utility in vivo across multiple large animal preclinical models.

Tyrosine kinase inhibitors (TKIs) combined with immunotherapy have improved outcomes in advanced renal cell carcinoma (aRCC), yet resistance persists. This group presents single-cell transcriptomic profiling of aRCC patients treated with TKIs and immune checkpoint inhibitors, uncovering an immunosuppressive microenvironment linked to therapeutic resistance.

Pre-harvest sprouting (PHS) causes severe yield and quality loss in cereal crops worldwide. Here, the authors report a cyclic nucleotide-gated channel/Ca^2 + -permeable channel encoding protein negatively regulate PHS and its involvement in modulating of calcium and hormonal signaling pathways in wheat.

Pulmonary microbiotacomponents in bronchiectasis patients receive repeated antibiotic exposures, whereas previous studies on the effects ofantibiotic treatment focused on typical pathogens rather than commensals. By integrating experimental evolution withsingle-cell resolution, the authors reveal a multifaceted strategy by which Neisseria subflava, a common airwaycommensal associated with bronchiectasis, exploits antibiotic selection to transition towards pathogenicity.

The work presents a method for injection molding that uses controlled shrinkage to create customizable shapes. By manipulating temperature and pressure, it enables the production of complex geometries from a single mold, potentially offering scalable and cost-efficient mass customization.

Extreme environments host diverse microbes, yet their global diversity remains underexplored. Here, the authors analyze both isolate genomes and metagenomes from various extreme habitats to construct a microbial genomic catalog, and use protein language models to identify antimicrobial peptides active against drug-resistant pathogens.

The balance of osteoblasts and osteoclasts is critical for osteogenesis and long-term bone health. Here they identify an osteogenic regulatory axis involving a STAT3-bound enhancer of Etv4, providing insights into the regulation of bone formation.

Researchers boosted the thermoelectric performance of the ionic-bonded compound MnTe by manipulating chemical bonding, achieving improved TE conversion efficiency and zT values via increased electron delocalization and suppressed phonon transport.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Flexible displays face challenges in power use, resolution, and durability. This work presents a flexible micro-LED display driven by HZO-based FeMFETs, achieving low power, high resolution, and strong mechanical reliability.

Here the authors show that marine diatoms produce tryptophanol, a molecule that at extremely low concentrations rapidly activates nitrogen assimilation genes and enzymes. This facilitates acquisition of nitrogen, a vital ocean nutrient.

Flexible batteries often fail under harsh conditions. Here, authors developed a hydrogel electrolyte via synergism of nanophase separation, hydrated eutectic solvation, and hydrogen-bond networks, enabling flexible Zn||I₂ batteries with high specific energy and long lifespan across −40 to 80 °C.

Current single-cell models face data sparsity and interpretability limits. The authors introduce CellVQ to improve generalizability with a cell-state discretisation module, and CellVQ-Graph to integrate genes, interactions, and annotations into a knowledge graph for interpretability.

Researchers demonstrate a minimalist terahertz wireless transceiver in integrated photonics. They break the longstanding constraint between source purity and DSP complexity, realizing 144 Gbps high-speed transmission at subterahertz frequency.

Mutations in the follicle-stimulating hormone receptor (FSHR) cause spontaneous ovarian hyperstimulation syndrome (OHSS). Here, the authors report that estrildid finches naturally carry an analogous pathogenic mutation found in patients but avoid the syndrome by lowering a related receptor’s activity. Blocking this receptor successfully treats OHSS in mice.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Using thermodynamically favourable organic oxidations instead of oxygen evolution enables energy-efficient cathodic reactions, but rates are limited by slow anodic kinetics. Here, the authors report decoupled charge‒discharge electrolysis using a solid redox reservoir to overcome this limitation.

Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,671 high-confidence complexes that uncover new higher-order structures and evolutionary links.

The crystal structure of the CHS-CHIL complex reveals a gating mechanism that enhances CHS activity and specificity. This conserved regulatory paradigm, validated by engineering a CHIL variant, offers strategies to improve flavonoid production in plants.

Sunlight triggers ammonium chloride in aerosols to produce Cl₂ gas, explaining 12-55% of daytime levels. This chlorine source, boosted by black carbon, impacts atmospheric oxidation.

StrucGAP is a structural glycoproteomics analysis platform that distills multi-dimensional information of glycoproteome datasets into structural and functional insights towards mechanistic studies.

The cellular pathology of Japanese encephalitis (JE) remains elusive. Here, the authors use spatial transcriptomics in JE mouse model and show that Ackr1⁺ endothelial cells and Ly6c2⁺ monocytes synergistically drive neuroinflammation, revealing potential therapeutic targets for neurotropic virus infections.

Thrombolytic therapy with tPA risks hemorrhagic transformation (HT). Here, the authors show that tPA upregulates CD177⁺ neutrophils to promote HT, a fibrin-targeted, ROS-responsive polymersome is developed to deliver tPA and inhibit CD177⁺ neutrophils, enabling safe thrombolysis while preventing HT

Mechanical computing is promising for environment-adaptive information processing, however existing methods have limited scalability. Here the authors report a polyaniline composite film enabling scalable logical operations.

A hallmark of the interaction between flat band and dispersive band states in quantum materials is the flat band resonance. Here, the authors report the observation of a flat band resonance in the kagome bilayer material CsCr₆Sb₆ originating from the doublet kagome bands of the bilayer unit.

Wearable bioelectronic skins are essential for health monitoring technologies, but many designs lack the durability and abrasion resistance of human skin. This study presents a bilayered stretchable conductor with a silver particle-impregnated layer that enhances abrasion resistance, conductivity and performs well in harsh environments while maintaining accurate signal capture.

Converting light alkanes into useful olefins is hard because strong bonds and heat drive overoxidation. This study uses a copper-doped titanium dioxide photocatalyst to steer bond breaking, yielding ethylene and hydrogen.

Current antiviral treatment approaches target specific Ebola virus species. Here, the authors develop bispecific antibodies with pan-ebolavirus neutralization capacity, structurally resolve the epitope and neutralization mode and show potent protection in a rodent model.

High-nickel layered positive electrodes suffer from lattice oxygen loss and inherent lattice strain. Here, authors report a self-derived subtractive strategy to form a coherent spinel-phase shell with tunable thickness to confine active oxygen intermediates and suppresses interfacial side reactions.

High entropy spinel oxides host multiple metals in one crystal structure with tunable catalytic properties, but controlling coordination site occupancy of metal cations is difficult. Here, the authors exploit site preference energy differences to direct metal occupancy, boosting conductivity and oxygen evolution activity.

The study introduces polyethyleneimine as an additive in a thermocell, enhancing thermopower from 1.4 to 7.76 mV/K. It achieves long-term stability and scalability by enabling thermosensitive adsorption-desorption, selective reactions, and Manning condensation, converting low-grade heat to electricity efficiently.

While previous studies of Kondo physics have largely focused on electronic properties, the authors here investigate magnon damping in the d-electron van der Waals magnet Fe₃GeTe₂. They observe logarithmic scaling of the damping at low temperatures and a minimum at an intermediate temperature, which they attribute to Kondo coupling between itinerant electrons and local moments.

Given the interest in extracellular vesicles there is a need for simple short scaffold proteins for efficient targeting and cargo loading. Here, the authors identify a candidate scaffold protein and find the truncated version allows for efficient loading which outperforms current scaffold proteins, demonstrating application in sepsis therapy.

Real-time spectrum sensing (RT-SS) is essential for 6G networks to dynamically manage spectral resources and support integrated sensing and communication. Here, the authors develop a thin film lithium niobate photonic system for wideband RT-SS up to 120 GHz with nanosecond-level latency.

This study presents a prefusion-stabilized vaccine candidate against Hantaan virus. The DNA and mRNA-LNP formats induce lasting neutralizing immunity in female mice, highlighting a promising advance in vaccine development.

The authors reveal how two insect-selective animal peptide toxins engage distinct sites on an insect sodium channel to disrupt fast inactivation and leverage these structural insights to AI-design a more potent toxin for biopesticide development.

The authors showcase a lateral Si–Ge avalanche photodiode in the O-band. With low dark current, high gain–bandwidth product of 7564 GHz, it supports 100 Gbps NRZ and 200 Gbps PAM4 signals for high-speed optical communication applications.

Determining the optimal start of the growing season presents a fundamental dilemma for plants. This meta-analysis suggests that plants exhibit high freezing resistance (to -12 °C) and low lethal frost risk (safety margin of 17 °C) during spring emergence, indicating strong long-term evolutionary pressure.

Biomass-derived hard carbon negative electrodes can cut cost, but properties vary by feedstock. Here, authors use data-driven intelligent carbonization to unify performance across diverse biomass, yielding high-capacity, long-life negative electrodes with lower footprints.

This study reveals that BCAA-derived BCKAs impair glucose-induced insulin secretion via activation of LDHA, a disallowed enzyme in pancreatic β-cells. Blocking this signalling axis restores insulin secretion, offering a new target against diabetes.

The human LRP8 protein is a receptor for yellow fever viruses (YFVs). Knockdown of the mosquito orthologue reduces YFV infection in mosquitoes, whereas overexpression of human LRP8 aggravates YFV infection in mice. Purified LRP8 protein blocks YFV infection.

This study identifies GPR146 as a key regulator of fat–liver communication. In mice, reducing GPR146 in fat tissue lowers fat delivery to the liver and protects against obesity and fatty liver disease, highlighting a potential therapeutic target for MASLD.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Recently, superconductivity was achieved in La3Ni2O7 and (La,Pr)3Ni2O7 thin films at ambient pressure due to in-plane compressive strain. Here, the authors report the enhancement of the superconducting onset from about 30 K to over 48 K by applying hydrostatic pressure to the films.

A set of hydroxy promoters physically mixed with cobalt oxides for syngas to light olefins conversion using Fischer–Tropsch synthesis is shown to boost catalyst performance as well as simplifying the process and increasing sustainability.

Electrocatalytic oxidation of fatty alcohols in aqueous media is limited by mass transport due to their low solubility. Here, the authors propose ligand engineering to create hydrophobic microenvironments in Nickel MOFs, enabling efficient oxidation to fatty acids by enriching reactants.

BioMedAgent is a self-evolving LLM multi-agent framework that learns to use various bioinformatics tools and chain them into executable workflows for autonomously carrying out diverse biomedical data tasks initiated by natural-language prompts.

Solid-state molecular motion is an important feature of a number of compounds, but visualization of these dynamics is challenging. Here, the authors report a molecular diffusion method for visualization and regulation of solid state molecular motion, and application in purity testing.