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This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Conversion-type batteries face performance decay under high loading due to shuttle effects and sluggish kinetics. Here, authors introduce an f-d orbital tag-team catalysis mechanism using cerium single-atom catalysts, achieving a competitive iodine loading of 44.7 mg cm⁻² and an areal capacity of 10.2 mAh cm⁻² in zinc–iodine batteries.

Solid-tumor CAR-T therapy is limited by antigen escape, heterogeneity, and on-target/off-tumor toxicity. The author here develops a drug-gated light-activatable, programmable CAR-antigen pairing system that enables flexible multi-antigen targeting with spatial control, achieving effective tumor suppression with minimal off-tumor toxicity.

This work demonstrates that embedding MnCoGe particles within magnesium alloys transforms the irreversible thermal expansion into a self-compensating behavior, yielding zero thermal expansion from 25 to 150 °C while retaining high strength and ultralow density.

Despite being a wonder drug for COVID-19, Paxlovid suffers deficiencies pertinent to ritonavir associated toxicity and rising resistance to nirmatrelvir, which authors in this work show can be overcome by redesigned viral main protease inhibitors as a mono-therapeutic agent.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Hu et al. report a low-temperature polar-solvent strategy for high-yield (162 mg mL⁻¹) perovskite nanocrystal synthesis with suppressed self-absorption. The scintillator films achieve ~7 ns fast decay, 28,800 photons MeV⁻¹ light yield, and dynamic X-ray imaging at 7,680 frame per second.

Researchers boosted the thermoelectric performance of the ionic-bonded compound MnTe by manipulating chemical bonding, achieving improved TE conversion efficiency and zT values via increased electron delocalization and suppressed phonon transport.

Hormone receptor-positive, HER2-negative advanced breast cancer lacks defined treatment options following CDK4/6 inhibitor (CDK4/6i) failure. Here, the authors present a phase Ib clinical trial where the CDK4/6i dalpiciclib is combined with the histone deacetylase inhibitor chidamide in this setting.

Here the authors show that microtubules guide the spatial distribution of cellulose synthase complexes in cotton fibers and produce a gradient of cellulose microfibrils that creates patterned cell wall mechanics that support tip-biased elongation.

Radiotherapy response in colorectal cancer (CRC) is often limited and recurrence is common. Here, the authors show that the kinase NEK8 induces radioresistance by lactate-mediated immunosuppression and that inhibiting NEK8 restores antitumor immunity and improves radiotherapy sensitivity in preclinical CRC.

Neural mechanisms underlying energy metabolism are not fully understood. Here authors show that Phf6-expressing neurons in the medial preoptic area as key regulators of physical activity and energy expenditure, revealing a neural mechanism underlying obesity in Börjeson-Forssman-Lehmann syndrome.

Electrically modulated metasurfaces manipulate light fields but suffer from high operating voltages, low tuning sensitivity, and a reliance on telecommunication bands. This work shows designs of electrically modulated plasmonic metasurfaces that enable continuous and reversible wavelength modulation with a tuning sensitivity up to ~ 1 nm/V at a CMOS-compatible voltage below 5 V in the visible and near-infrared light regime.

Authors propose an oriented diffusion strategy to design interfacial strain controlled magnetoelectric heterostructure, realizing the modulation of interfacial strain polarization coupling for enhancing electromagnetic absorption.

MIR photothermal detection can be limited under weak irradiation due to insufficient thermal sensitivity. Here, the authors show ligand-capped lanthanide nanoparticles enable broadband mid-IR detection through localized heating that modulates visible emission.

Maintaining genome integrity during different life stages is critical. Here, the authors reveal an RNA editing mechanism in the fungal pathogen Fusarium graminearum that adjusts Mus81 protein function to balance heat-stress survival and sexual reproduction. This stage-specific editing fine-tunes DNA repair for adaptation and reproduction.

Flexible displays face challenges in power use, resolution, and durability. This work presents a flexible micro-LED display driven by HZO-based FeMFETs, achieving low power, high resolution, and strong mechanical reliability.

Japonica subspecies has a lower nitrogen use efficiency (NUE) than that of indica rice. Here, the authors show that natural variations in the NIN-like protein 4 (OsNLP4) encoding gene are responsible for the divergence and introgression of the indica OsNLP4 allele into elite japonica cultivar can increase NUE and grain yield.

Extrachromosomal circular DNA (eccDNA) is a regulatory element involved in genomic stability and gene regulation. This study identifies widespread eccDNA in early mammalian embryos. These eccDNAs arise from active genomic regions, increase during a major wave of gene activation, and can regulate key developmental genes.

Despite rapid development of model algorithms, more evidence is needed on the widespread clinical implementation of auto-segmentation tools. In this prospective, multicenter, observational trial, the authors find that AI-assisted delineation performs better than manual delineation while improving time efficiency and reducing performance metrics variability across centers and physicians with varying expertise.

The authors report a metamaterial robot that integrates mechanical intelligence into robotics through embodied versatile computing. The robot performs analog and logic tasks, supports serial and parallel operations, and enables flexible spatiotemporal modulation and self-regulating locomotion.

Prokaryotic Argonaute proteins are programmable nucleases. Here, the authors capturing structures of VbAgo at functional stages to show how its C terminus acts as a regulator and demonstrate its ability to cleave RNA in mammalian cells.

Ribosomal Protein S15 (RPS15) is recurrently mutated in B-cell leukemia but its leukemogenic role remains unclear. Here, the authors establish mutant RPS15 as a cancer driver and reveal mechanisms by which these mutations induce translational defects, DNA damage and genomic instability that together promote leukemogenesis.

In conventional s-wave superconductors, ferromagnetism is strongly suppressed, due to the singlet pairing of the electrons. Here, Xiang, He, Lin, and coauthors find a long-range ferromagnetic order among impurity sites in the spin-orbit coupled Fe(Se,Te) using scanning superconducting quantum interference device microscopy.

Vegetation productivity resilience to fast and slow developing droughts remains poorly understood. This study reports lower resilience, greater sensitivity, and weaker CO₂ fertilization effects under flash drought, indicating limited ecosystem resilience.

Studying RNA in cellular condensates requires precise tools. Here, the authors developed an orthogonal RNA aptamer system for simultaneous RNA visualization and targeted degradation, revealing new roles for specific RNAs in stress granule and NP body dynamics.

Genome annotation typically requires costly experimental assays across diverse cell types, limiting its scalability. Here, authors introduce BioSeq2Seq, a deep learning framework that leverages DNA sequence and run-on sequencing (RO-seq) data to accurately predict histone modifications, functional elements, gene expression, and transcription factor binding sites.

DNA can store vast amounts of data, but current systems rely on many redundant copies and deep sequencing to correct synthetic, storage and readout errors. Here, authors present Gungnir, a DNA storage codec that recovers data from a single, highly error-prone sequence, reducing cost and improving reliability.

Pyridine hydrogenation on supported metal particles is a powerful yet challenging synthetic transformation due to the strong coordinating effect of pyridine that limits hydrogen adsorption and activation. Here the authors adopt dealuminated Beta zeolite to entrap nickel nanoparticles and use the porosity of the support to effectively modulate pyridine and hydrogen activation.

Taurine transporter TauT is a key drug target for multiple diseases. Here, authors reveal structure of human TauT in four states, showing how inhibitors mimic taurine and guiding future TauT-targeted drug design.

RNA editing influences gene regulation in cancer. Here, the authors show that EZH2 regulates RNA editing by ADAR1 through remodeling its interactome and nuclear transport, thereby promoting MDM2 expression and prostate cancer progression.

Protein engineering is often hindered by the gap between modelling and experiment. Here, authors present ORI, a closed-loop computational framework to iteratively optimize proteins, achieving 100-fold higher activity, enhanced thermal stability, and the design of multifunctional enzymes.

A post-functionalised MOF with crown ether motifs achieves rapid, selective capture of radioactive radium from high-activity nuclear waste via a synergistic multi-site binding mechanism, significantly outperforming commercial sorbents.

The scalable fabrication of high-performance p-type 2D transistors remains a major bottleneck towards the development of 2D electronics. Here, the authors report the wafer-scale synthesis of p-type 2H-MoTe₂ films with controllable thickness and the realization of medium scale integrated circuits, such as a 140-transistor full adder.

Using thermodynamically favourable organic oxidations instead of oxygen evolution enables energy-efficient cathodic reactions, but rates are limited by slow anodic kinetics. Here, the authors report decoupled charge‒discharge electrolysis using a solid redox reservoir to overcome this limitation.

Ji, He, Cai, and colleagues report an engineered senescence therapy that exploits lipid metabolic features of senescent cells, repurposing excess lipids as functional resources to improve joint function, and thus alleviating osteoarthritis without eliminating the cells.

RNase MRP is an essential ribonucleoprotein complex in eukaryotes. Here, authors describe how RNase MRP structurally and functionally diverged from RNase P, through specific RNA-protein adaptations, to evolve a novel ssRNA processing activity in eukaryotes.

Ischemic stroke involves complex peripheral and central pathologies. Here, authors develop a spatially tiered strategy using dual stiffness nanoparticles for compartment-specific drug delivery, offering a synergistic treatment paradigm.

Here the authors report that lipidomics analysis of over 13,000 Australians from two cohorts identifies distinct blood lipid signatures linked to habitual dietary exposures. Lipid markers of healthier diets were associated with lower cardiovascular risk and reduced all-cause mortality.

Electrochemical urea oxidation enables sustainable hydrogen production but suffers from some catalyst instability. Here the authors create ligand vacancies to induce metal dimerization, stabilizing the framework while achieving stable industrial-scale operation with low energy consumption.

FLPClusters, which are structurally precise metal clusters incorporating Frustrated Lewis Pairs (FLPs), represent a promising class of catalysts, but their tendency to undergo neutralization limits catalytic efficiency. Herein, the authors report the synthesis of FLPClusters featuring well-defined, tailorable, and accessible FLP active sites.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

This study shows that medial septal parvalbumin neurons causally control hippocampal place cell dynamics during memory encoding, thereby supporting object-place recognition and rescuing sleep deprivation-induced memory deficits.

Pangenome analyses of 28 representative Gossypium hirsutum accessions, including a telomere-to-telomere genome for NDM13, and transcriptomic profiling across 15 tissues highlight structural variations associated with breeding traits.

In C. elegans, a p38 MAPK–ATF-7 pathway upregulates hypodermal CATP-3 during potassium scarcity, integrating neuronal signals to maintain homeostasis, enhance survival, and link potassium regulation to lifespan and immunity. This conserved mechanism is distinct from osmotic stress responses.

Perovskite quantum dot superlattices have emerged as a promising platform for studying collective optical phenomena. Here the authors report collective photoluminescence blinking and photon bunching in a self-assembled CsPbBr₃ quantum dot superlattice, which they attribute to cascade-like biexciton-exciton emission.

Climate warming alters plant lifecycles, but the extent of these shifts is also determined by plants’ inherent traits, not just climate.

Achieving both high strength and toughness in single-covalent-network hydrogels is a challenge. Here, the authors report a transient entanglement strategy which enables energy dissipation and stress redistribution to achieve strong, tough polyacrylamide hydrogels.