Search

G-protein-coupled receptors (GPCRs) function as monomers and in multiple oligomeric forms. Here, authors present a set of 12 assemblies of the apelin receptor (APLNR), providing a detailed view of the monomer-dimer transition.

Conventional neuromorphic vision systems based on pixels-to-one-memristor architecture face efficiency challenge. Here, Sun et al. report an architecture employing one-pixel-to-multiple-memristor structure, mapping weight updates to voltage vectors to enhance both processing speed and energy efficiency.

In vanadium flow batteries, crossovers are critical challenges for membrane design. Here, authors propose a balanced state electrolyte strategy that overcomes crossovers, thereby circumventing existing membrane-related constraints and establishing a new framework for advanced electrolyte design.

Researchers demonstrate a minimalist terahertz wireless transceiver in integrated photonics. They break the longstanding constraint between source purity and DSP complexity, realizing 144 Gbps high-speed transmission at subterahertz frequency.

This randomized open-label trial shows that hemoadsorption combined with hemodialysis reduces all-cause and cardiovascular mortality, and cardiovascular events in patients with end-stage kidney disease compared to hemodialysis (mainly low-flux hemodialysis plus intermittent hemodiafiltration) alone.

Methanotrophic growth on methane and N₂-derived ammonia is inhibited by a toxic intermediate, hydroxylamine, generated via ammonia oxidation. Here the authors ameliorate this toxicity through genetically engineering M. sanxanigenens and feed the biomass to mice to reduce colitis symptoms.

High-performance battery materials often degrade during standard cleaning processes. Here, the authors identify why water washing causes structural collapse in sodium-based oxides and demonstrate that ethylene glycol can safely remove impurities while maintaining the material’s integrity.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

AhR functions as a neuronal brake on axon regeneration, integrating environmental sensing, protein homeostasis and metabolic signalling to control the balance between stress adaptation and axonal repair.

Increased glycolysis in pancreatic cancer promotes immune escape by altering the tumor microenvironment. Here, the authors show that lactate-driven histone lactylation via PCAF increases CXCL1 expression, recruiting neutrophils and enabling immunosuppression, and PCAF inhibition improves anti-PD-1 therapy in pancreatic cancer mouse models.

Functional evolution expands the catalytic repertoire of biosynthetic enzymes. Here, the authors reveal that a tripartite enzyme complex has evolved to catalyze Friedel–Crafts acylation through neofunctionalization of a conserved thiolase architecture.

ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming and local immunosuppression.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

The study identified macrophage-derived lactate as a driver of hypertrophic scar. Lactate influx via MCT1 triggers histone lactylation in fibroblasts to activate profibrotic genes.

Host cell protein degradation machinery including the lysosome is involved in the processing and degradation of protein antigens. Here the authors develop lysosomal targeting vaccine approaches and test these in murine models of influenza infection.

A Dirac-vortex topological photonic crystal fiber is experimentally realized with broadband single polarization single-mode properties.

This work transforms oxygen from an embrittling contaminant into a key asset in titanium alloys, simultaneously overcoming the strength-ductility trade-off and oxygen embrittlement.

Femtosecond electrochemical transient absorption spectroscopy is employed to explore the fundamental origin of anodic corrosion. It reveals that Ir corrosion originates from ultrafast proton–electron synchronization and that CeO₂ can create femtosecond-scale proton–electron asynchrony for corrosion-resistant low-Ir anodes.

Doxycycline has been recommended as post-exposure prophylaxis for prevention of bacterial sexually-transmitted diseases. Here, the authors use mathematical modelling to investigate the potential disease, antimicrobial resistance, and economic implications of this intervention in gay, bisexual, and other men who have sex with men in Australia.

Wang et al. show that promyelocytic leukaemia protein (PML) reduces polyG inclusions via chaperone-mediated disaggregation and proteasome-dependent degradation. This suggests a possible role for PML in various neurodegenerative diseases.

The absence of odd Shapiro steps in microwave-irradiated Josephson junctions (JJs) is considered to be a possible indicator of 4π-periodic supercurrents that are induced by Majorana bound states. Here, by conducting measurements on Al/WTe₂ JJs, the authors suggest that the missing first Shapiro step can instead arise from the intrinsic non-linearity of the current–voltage characteristics in low-to-moderate transparency junctions.

Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

Quantum low-density parity-check error correction codes are anticipated to deliver high performance, but require long-range qubit–qubit interactions. Two of these error correction codes have now been successfully implemented on a superconducting device.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Optical skyrmions can be generated in free space, but topologically protected information transfer requires skyrmions to be stable upon propagation through complex media. Here, authors demonstrate the topological resilience of classical and quantum optical skyrmions transmitted through experimentally simulated atmospheric turbulence.

Ice is not piezoelectric, despite the polarity of water molecules, but bending ice may produce electricity. This has now been experimentally demonstrated, with a flexoelectric coefficient comparable to that of common ceramic materials.

The mechanism of how different anion dopants influence the catalytic performance for sulfur species is currently lacking systematic theoretical studies. Here, an accurate p-p-s electronic coupling descriptor was proposed as a criterion to guide the design of anion-doped Li-S catalysts.

Powering single organic electrochemical transistor (OECT) device is challenging as power reductions can cause unstable device outputs. Wu et al. report a wearable, self-powered biosensor with a dual-OECT amplifier powered by an organic solar cell for monitoring physiological signals under varying light conditions.

Accurate single nucleotide variations (SNVs) detection is clinically vital, yet existing techniques can only detect SNVs at specific loci. Here, Mao et al present a new generalized CRISPR/Cas-based strategy, termed PRICE, to identify SNVs in miRNA sequences without sacrificing the sensitivity.

To overcome various challenges in forensic pathology, the authors present SongCi, a visual-language AI trained on multi-modal autopsy cases of various cohorts. SongCi detects diverse post-mortem diseases and injuries and gives clear image-text explanations for forensic analysis, rivaling senior pathologists.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

Achieving complete coverage of 2-4 μm pyramids on industrial fully-textured silicon with solution processed perovskite film remains challenging. Here, authors spray-coat alumina particles on silicon for near-conformal deposition of perovskites, achieving efficiency of 32.74% for tandem solar cells.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Spatiotemporal coordination of cellular and molecular events is crucial for cell fate commitment. Here, Yang et al. describe how transcription factors, signaling pathways, and epigenomic states regulate left-right patterning and axial mesendoderm lineage commitment during mouse gastrulation.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

The electrochemical semi-hydrogenation of C₂H₂ to C₂H₂ is a promising process, but the competing hydrogen evolution reaction remains a major obstacle. This work presents a novel catalytic strategy to steer active hydrogen species, thereby improving the Faradaic efficiency for ethylene.

The authors propose a universal descriptor for thermal conductivity based solely on the atomic number in the primitive cell and sound velocity, enabling rapid and scalable materials screening.

Zinc-ion capacitors offer high capacity, eco-friendliness, and low cost, and recent designs with improved electrodes, electrolytes, and devices enhance their performance. Here, the authors outline recent progress in multifunctional zinc-ion capacitors, summarize key device types and advances, and highlight current challenges and future development directions.