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Stereoisomers can exhibit distinct chemical behaviors despite identical formulas. Here, the authors reveal how geometric isomers of electrolyte additives tailor solvation and interphasial chemistry, enhancing Zn-ion kinetics and long-term stability in aqueous zinc metal batteries.

On-chip circularly polarized light (CPL) detectors are relevant for various applications, but current approaches have shown a trade-off between wide spectral detection range, high discrimination ratio and high polarization sensitivity. Here, the authors report broadband high-performance CPL detectors based on twisted black phosphorus structures.

Aortic aneurysm and dissection are lethal vascular diseases lacking effective medical therapy. Here the authors show that calcium channel blocker use increases AAD risk, worsens disease progression in models and patients, and may impair post-repair outcomes, warranting caution in at-risk hypertension.

Climate change is altering how plants balance carbon gain and water loss. This study maps global leaf-level water-use efficiency over the past two decades, showing it is highest in regions that are cold or dry, increasing worldwide, and strongly influenced by atmospheric dryness.

The relationship between brain development and smoking behaviour is not well understood. Here, the authors show an association between volume of the left ventromedial prefrontal cortex and smoking initiation in adolescents.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Phase-separated biomolecular condensates are implicated in a myriad of biological processes. Here the authors apply optical tweezers to characterize the viscoelasticity and interfacial tension of a range of condensates, finding that condensates can deviate from simple fluids in opposite directions; and identify shear relaxation as a governing measure of condensate dynamics.

Thymine DNA glycosylase (TDG) was identified as a synthetic-lethal target in p53-deficient cancers through alterations in double-stranded RNA accumulation. A covalent small-molecule inhibitor of TDG exhibited potent efficacy against p53-deficient tumors.

The authors reveal distinct atomic-scale mechanisms underlying phase boundary engineering formation and explain the different electrical properties of two (K, Na)NbO₃ based materials with the similar phase boundary, providing a new mechanistic insight.

SCOPE-DTI introduces a large semi-inductive DTI dataset and optimized deep learning framework for drug-target interaction prediction. It integrates 3D structural modeling and bilinear attention, with experimental validation of drug targets and open access tools for broad research use.

Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.

A strategy based on the design of a composite coating that enables slip-enhanced close-contact melting inside sealed phase-change thermal batteries to improve charging rates enables high-performance thermal energy storage over a wide range of temperatures.

Familial spastic paraplegia (SPG) is a rare heritable neurodegenerative disorders. Here, the authors show SPG80-associated protein UBAP1 deficiency disrupts lysosomal and mTORC1 signal, indicating rapamycin could potentially benefit SPG80 patients.

Authors converted waste ozonation catalysts into carbon-based nano-single-atom-site catalysts through in-situ carbonization of self-doped biological secretions, enabling efficient regeneration and resource reuse.

Potassium tert-butoxide is used in a precious-metal-free alkyl transfer strategy for synthesizing azaarenes and polyazaarenes from alkenes and nitriles via carbon–carbon bond cleavage. This method produces aryl methanes as the sole by-product and allows divergent synthesis of functionalized azaarenes, some of which exhibit visible-light photocatalytic reactivity.

Promoter hypermethylation-mediated silencing of the tumor suppressor RASA4 activates Ras signaling in small cell lung cancer, thereby driving tumor proliferation, metastasis, and chemoresistance, and revealing its role as a prognostic biomarker.

Zhu, Fu, Zhu, Li and colleagues found that the key DNA repair enzyme poly(ADP-ribose) polymerase 1 promotes transcriptional restart after DNA damage through PARylating and stabilizing AFF1 by preventing its ubiquitylation by the E3 ligase Siah1.

This work proposed a fully heterogeneous quantum network that connects diverse user systems and enables multiple quantum tasks. A software-defined quantum network structure is also proposed for coordinating network nodes and optimizing network performance. It paves the way for an open and versatile quantum internet.

The antiangiogenic agent apatinib has been shown to clinically improve responses to immune checkpoint inhibitors in several cancer types. Here the authors report the results of a phase II clinical trial of camrelizumab (anti-PD1) and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma.

The fast skin-permeable polyzwitterion poly[2-(N-oxide-N,N-dimethylamino)ethyl methacrylate] may enable non-invasive transdermal delivery of insulin, and potentially facilitate the use of other protein- and peptide-based therapeutics through transdermal delivery.

Longitudinal analysis of neuroimaging data are useful for analysing heterogeneity in adolescent brain development. Here the authors cluster adolescent participants of the IMAGEN study into groups based on gray matter volume developmental patterns and investigate genome-wide and epigenome-wide associations with these groups.

Radiation-induced malignantly transformed cells undergo multi-scale 3D genome reorganization. TP63 acts as a key mediator, creating accessible chromatin sites that form tumour-specific loops activating the MYC oncogene during malignant transformation.

Inhibitor of differentiation 1 (ID1) has been described as a cancer-promoting factor and also involved in the formation of an immunosuppressive tumor microenvironment. Here the authors report that ID1-expressing tumor associated macrophages favor colorectal cancer progression by promoting cancer cell stemness and CD8⁺ T cell exclusion.

The researchers demonstrate parallel optical matrix–matrix multiplication, which enables fully parallel tensor processing through a single coherent light propagation. The approach provides a scalable, high-efficiency foundation for advancing next-generation optical computing.

Alkyl halides, widely recognized as important building blocks and reagents in organic synthesisbut generating alkyl radicals directly from unactivated alkyl halides under mild conditions remains a challenge. Here the authors report an effective electrooxidation strategy for generating alkyl radicals from unactivated alkyl iodides via an electrochemical halogen-atom transfer process under mild conditions

Wang et al. analyzed data from a large population-based cohort study in China to examine the relationship between blood cell biomarkers and the risk of depression.

Natural products often contain complex N-fused polycyclic structures with multiple substituents and stereocentres. Here, the authors developed a bifunctional organocatalyst that is instrumental in obtaining such structures and applied it to the total synthesis of naucleofficine I and II in 6 steps.