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Unlike animals, plant possess mitochondria and chloroplasts and exhibit a unique defensive adaptation to stress. Here, the authors demonstrate the feasibility of restoring organelle interaction network homeostasis in animal cells by introducing plant-derived photosynthetic systems.

Researchers identify FOXJ3 variants in focal epilepsy and cortical dysplasia and show that FOXJ3 regulates neuronal migration and cortical layer formation by controlling the PTEN–mTOR pathway; disruption of this process leads to abnormal brain development.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

The surface chemical ordering in high entropy alloys is revealed by the surface sensitive imaging tool - scanning tunneling microscopy – which is enabled by the subtle differences in the partial density of states among different elements.

Combining distinct confinement mechanisms can enable the engineering of novel electronic states. Here, the authors integrate a moiré potential with vertical quantum confinement in a heterostructure composed of twisted bilayer MoS₂ on (111)-oriented Bi nanofilms, revealing experimental signatures of a Wigner crystal.

Neuromorphic computing hardware normally makes an unideal trade-off between energy efficiency, scalability and reliability. Kim et al. report a ferroelectric heterostructure based memristor with near-zero nonlinearity, endurance beyond 10E7 cycles, rectifying ratio exceeding 10E6 and sub-pA off-current.

SERS analysis at higher temperatures, such as during photothermal processes, is challenging due to enhancement losses. Here, the authors demonstrate a heat-induced increase in SERS activity mechanistically attributed to assisted hot-hole transfer.

Wearable energy-harvesting devices suffer from low electrical output and poor wear comfort. Here, authors develop a self-powered fabric with good wear comfort that pumps sweat directionally, achieving 6.3 °C skin cooling and a 0.40 mA·cm⁻² DC current output for practical wearable power supply.

Here authors show that isolating interconnected channels in metal-organic frameworks eliminates inefficient molecular shuttling, greatly improving diffusion and separation performance. The strategy enhances isomer separation and material stability.

The authors demonstrate the multifaceted role of LYSET in stabilizing GNPT at the Golgi, by resolving the topology of LYSET and identifying several critical regions for LYSET function and stability.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Inborn errors of cell death (IECD) with autoinflammatory manifestations could be induced by excessive T cell death. Here the authors characterize IECD patients with autoinflammatory manifestations who possess overactive RIPK1 variants which promote T cell death, secretion of TNF and IFN-γ along with activation of monocytes and macrophages which promotes further autoinflammation.

This study reveals that BCAA-derived BCKAs impair glucose-induced insulin secretion via activation of LDHA, a disallowed enzyme in pancreatic β-cells. Blocking this signalling axis restores insulin secretion, offering a new target against diabetes.

Aqueous zinc batteries suffer from poor reversibility due to interfacial instability. Here, the authors propose an electric field-responsive electrolyte design that modulates zinc-ion solvation and interfacial chemistry, leading to uniform deposition and extended cycling stability.

The mid-infrared (MIR) range of the electromagnetic spectrum can be indirectly accessed by frequency upconversion. Here, authors propose a phase-matching-free scheme for broadband and efficient upconversion, covering wavelengths from MIR to ultraviolet with high-order harmonics generated from a NbOI₂ crystal. MIR imaging is demonstrated with a standard silicon camera.

Deep brain stimulation is effective but invasive. Here, the authors develop an injectable conductive hydrogel that forms in situ and enables wireless neuromodulation under volume conduction via capacitive coupling, showing therapeutic potential in a Parkinson’s disease rat model

The late Ming megadrought across north-to-south China, lasting from 1625-1644 CE, was influenced by Pacific sea surface temperature anomalies, weakened solar activity, and volcanic eruptions, according to reconstruction of the Yangtze River's water balance using tree-ring chronology.

Structural colour offers an alternative to pigment-based colouration, but patterning often requires multiple steps. Here, the authors report a one-step, mask-free strategy for the formation of structural colour patterns based on manipulation of a nanoparticle enriched disordered layer.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

A rare variation in the promoter of qRBG1/OsBZR5 is associated with larger rice grains. OsBZR5 is found to negatively regulate grain size in rice, a biological role opposite to other OsBZR members. A regulatory module of OsGSK2–qRBG1–OsBZR1–D2–OFP1 is further revealed.

Thin and conformal tungsten disulfide (WS₂) layers, which are grown at the wafer scale using thermal atomic layer deposition at back-end-of-line compatible temperatures, can function as both barriers and liners for interconnects.

In urethral damage, exogenous implants designed for urethral repair are hindered by the open and harsh urethral microenvironments and the isotropic compression and swelling properties of the material. Here, Yang et al. develop a tri-layer hydrogel with anti-fouling and low-swelling properties for scarless urethral repair.

Crystallizing the perovskite layer on thin tunnel oxide passivated contact silicon cells is challenging due to rapid heat transfer. Zhou et al. address this issue using a 2-mercaptobenzothiazole additive, achieving a tandem cell efficiency of 32.76%.

Stomatin is a component of lipid rafts. Here, Wu et al. show that stomatin modulates the differentiation and functions of adipocytes by regulating adipogenesis signaling and fatty acid influx such that with excessive calorie intake, increased stomatin induces adiposity.

Hanging Coffins were a mortuary tradition practiced in southern China and Southeast Asia. Here, the authors show that different groups of ancient Hanging Coffin practitioners are genetically related, and that they are ancestors of present-day Bo people.

In a prospective multi-centre cohort in China, people living in areas of high soil selenium had a 35% increased risk of incident diabetes over a 3-year study period, with a stronger effect seen for men.

Moiré superlattices are a versatile platform for studying emergent electron and quantum phenomena. Here, the authors demonstrate moiré superlattice formation in complex oxide-WS₂ heterostructures across varying twist angles.

Exhausted CD8⁺ T cells increase proteasome activity due to the accumulation of depolarized mitochondria, which drives the selective degradation of mitochondrial proteins and releases of regulatory haem through haemoprotein breakdown.

Insufficient efficacy is one of the major impediments for further application of sup-tRNA therapies. Here, authors engineer the body sequence of sup-tRNA^Arg and restored retinal function and vision-guided behavior in a mouse model carrying the RPE65-R44X nonsense mutation.