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Hepatitis C virus remains a health burden due to the lack of an effective vaccine, hindered by difficulties in replicating the native E1E2 antigen structure. Here, the authors engineer a stabilized E1E2 heterodimer using cryo-EM-guided modifications, enhancing immunogenicity and paving the way for future HCV vaccine development.

He et al. model electrification of airport ground support equipment across more than 300 U.S. airports, estimating energy consumption, peak power demand, charging infrastructure requirements, and potential cost savings from battery storage and solar integration.

The authors identify Npr1 as a nucleophagy receptor in fission yeast that acts redundantly with Epr1 to degrade nuclear components. Tethering chromatin to the inner nuclear membrane blocks nucleophagy, suggesting a genome protection mechanism.

Zanubrutinib is a second-generation BTK inhibitor, reported to have fewer off-target toxicities while maintaining comparable efficacy to previous BTK inhibitors. Here, the authors report the phase II CHESS trial evaluating frontline Zanubrutinib (second-generation BTK inhibitor) plus rituximab (anti-CD20) induction, followed by chemoimmunotherapy in patients with mantle cell lymphoma.

A link between the oral microbiome and oesophageal squamous cell carcinoma (ESCC) has previously been reported but whether it has a causal role is unclear. Here, the authors identify oral Veillonella-derived valeric acid as having a tumour suppressive function in ESCC via interaction with the elongation translational factor, eEF1A1.

Susceptibility of Nasopharyngeal carcinoma (NPC), associated with Epstein-Barr virus infection, is linked with HLA gene region with mechanisms unclear. The authors here show that the high-risk EBV subtype BALF2 upregulates HLA-DP, leading to CD8⁺ T cell exhaustion, and combined anti-LAG-3 and anti-PD-1 therapy improves anti-cancer efficacy.

Combining distinct confinement mechanisms can enable the engineering of novel electronic states. Here, the authors integrate a moiré potential with vertical quantum confinement in a heterostructure composed of twisted bilayer MoS₂ on (111)-oriented Bi nanofilms, revealing experimental signatures of a Wigner crystal.

The GABA_B receptor is a mandatory heterodimer. Here authors show the existence of GABA_B dimers of dimers in neurons, and their relevance in human health. By solving the structure of this tetramer, they show the structural basis for a negative cooperativity between the dimers within such a complex.

MicroRNAs are promising disease biomarkers, yet accurately measuring them remains challenging. Here, the authors develop SE-SPTM-PCR, a method which improves sensitivity 100-fold and eliminates false signals, showing improved diagnostic performances for cancer and viral reactivation.

This study shows that tropical cyclone heavy rainfall has extended inland along the coasts of the Northern Hemisphere with a rate of 3.8 km per decade since 1980. Nearshore sea-surface warming drives this expansion, with coastal urbanization further amplifying the effect. These findings highlight increasing flood risk for inland populations as cities grow.

Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal cancer with poor prognosis and limited treatment options. This study identifies Prolyl 3- hydroxylase 1 (P3H1) as a critical regulator of PDAC progression through PLK1-β-catenin signaling, driving tumor-associated macrophage recruitment and tumor growth.

Accurate prediction of drug-target affinity (DTA) is central to drug discovery but remains challenging in low-data regimes where deep learning models generalize poorly. This study introduces AdaMBind, a meta-learning-based framework with adaptive task scheduling that substantially improves few-shot DTA prediction, enabling robust identification of high-affinity compounds and experimentally validated inhibitor discovery under stringent data constraints.

BioMedAgent is a self-evolving LLM multi-agent framework that learns to use various bioinformatics tools and chain them into executable workflows for autonomously carrying out diverse biomedical data tasks initiated by natural-language prompts.

Using lattice dynamics, numerical modelling, and ultrafast optoacoustics, this study reveals intrinsic 3D spin angular momentum (SAM) of GHz evanescent acoustic phonons in anisotropic crystals, demonstrates SAM symmetry, and gains insights for SAM-related applications.

Aqueous two-phase systems have potential as biomimetic materials, but often lack stability and are prone to collapse. Here, the authors use interfacial assembly of chitin nanofibres and cellulose nanocrystals to prepare a biobased system with permeability and switchable motility.

This work effectively addresses the long-standing challenge of competitive kinetics in heterogeneous Fenton-like systems through the synergistic interaction between nitrogen vacancies (Nv) and Fe sites on carbon nitride.

In the nonpivotal stage 1 of the randomized phase 3 PRESERVE-003 trial, patients with immunochemotherapy-resistant metastatic squamous non-small cell lung cancer without actionable genomic alterations treated with the next-generation, pH-sensitive anti-CTLA-4 agent gotistobart had encouraging overall survival outcomes compared to docetaxel.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.

In a case series of five patients with treatment-refractory antisynthetase syndrome and five patients with treatment-refractory systemic sclerosis, bispecific T cell engagers blinatumomab and teclistamab improved disease activity and were well tolerated.

Seed size plays an important role in determining soybean yield. Here, the authors report GmSW17, encoding a homolog of Arabidopsis UBP22 that plays a role in deubiquitination, as a positive regulator of soybean seed width and seed weight through inhibition of the G1-to-S transition by interacting with GmSGF11 and GmENY2.

TME is a critical determinant of therapeutic outcomes, yet its dynamic changes during OSCC progression remain poorly understood. The authors here find that redistribution of MDSCs mediated by ANXA1-FPRs contributes to suppression of CD8⁺ T cells. Blocking FPR2 prevents MDSCs infiltration and enhances immune checkpoint therapy.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

Five nuclear spins in silicon and the [[4, 2, 2]] code are used to demonstrate a universal logical gate set and to execute a variational quantum eigensolver computation of the ground-state energy of a water molecule.

TRIP6 phosphorylation triggers a signalling cascade that promotes glycolysis in KRAS-mutant colorectal cancer cells. The resulting lactate accumulation drives extracellular lactylation of CD44 on CD8⁺ T cells, thereby compromising their anti-tumour activity.

Zhou, Ho and colleagues show that, in mice, a schizophrenia-associated mutation impairs belief updating by weakening mediodorsal (MD) thalamus activity. Boosting this activity restored flexible decision-making, suggesting MD thalamus as a potential therapeutic target.

Bistable superlattice switching between two lattice configurations with sharply contrasting periodicities has been observed in monolayer TaIrTe₄, a dual quantum spin Hall insulator.

Bilayer CrTe₂ films grown via molecular beam epitaxy are found to host room-temperature multiferroicity and strong magnetoelectric coupling.

Hypoxia-induced ALDOB lactylation amplifies glycolysis-derived lactate production, creating a self-reinforcing loop that sustained lactylation and mitochondrial fragmentation in pulmonary hypertension.

Tao, Feng, Yang, Liu et al. identify a lncRNA-dependent mechanism that controls ALKBH5-mediated demethylation and expression of ATF4, which confers an adaptive metabolic response under nutrient stress in cancer cells.

N input and warming alter plant traits and mycorrhizal communities, reducing belowground C inputs and stable soil organic C while accelerating decomposition, highlighting root–mycorrhizal interactions as key regulators of soil C under global change.

The chromatin remodeler BRAHMA (BRM) is found as a repressor of plant adaptation to acid stress by inhibiting the STOP1-NRT1.1 signaling module. Under low pH, BRM degradation activates nitrate uptake and alkalinizes the rhizosphere.

Disulfide tethering screening is applied to address the challenge of targeting oncogenic KRAS, historically deemed undruggable due to its high nucleotide affinity and perceived lack of binding sites. Here, the authors developed a disulfide library and a set of 83 cysteine KRAS mutants to perform tethering screens towards the oncogenic KRAS, while describing the discovery of fragment-binding pockets in KRAS G12D, identified by this screening approach.

This study highlights the Wheat Spatial Omics Consortium, which aims to build a spatiotemporal single-cell atlas of wheat in response to different treatments, thereby contributing to the development of sustainable and climate-resilient wheat.

Au/TiO₂@pSiO₂ catalysts achieve simultaneous high CH₄ conversion and H₂O₂ production enabled by water confinement within silica nanopores, which alters proton-coupled electron transfer pathways of water oxidation and oxygen reduction.

Ruan and colleagues show that vascular resident macrophage-derived Sparcl1 has a protective effect during aorta aneurysm progression by interfering with FGF2-induced dysfunctional lymphangiogenesis, TLS formation and immune cell recruitment.

The authors showcase a fast‑response silicon‑carbide optoelectronic microwave source that delivers picosecond carrier‑lifetime control and supports power handling up to 55 MW. It offers continuously tunable P–L‑band pulses with >1 MW peak output over 0.25–1.3 GHz.

Disentangling intertwined orders in quantum materials is challenging. Now, photoemission spectroscopy experiments show that magnetic fields can be used to disentangle such orders in a kagome superconductor.

Accurate single nucleotide variations (SNVs) detection is clinically vital, yet existing techniques can only detect SNVs at specific loci. Here, Mao et al present a new generalized CRISPR/Cas-based strategy, termed PRICE, to identify SNVs in miRNA sequences without sacrificing the sensitivity.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Fang and colleagues report the safety and clinical activity of hypoxia-responsive carcinoembryonic antigen (CEA)-targeted chimeric antigen receptor T cells in CEA-positive solid tumors through intraperitoneal or intravenous infusion in a phase 1 trial.