Search

Conventional tactile sensing schemes operate serially in the time domain with separate sensors and processors. Here, the authors present a massively parallel in-sensor skinomorphic computing scheme based on frequency division multiplexing by using continuous-time data representation, thus reducing wiring complexity.

The specific circuits mediating opioid-induced itch remain not fully understood. Here, authors reveal that morphine suppresses spinal NPY⁺ inhibitory neurons via μ-opioid receptors, which disinhibit GRP-GRPR circuits to trigger itching in mice.

TransBrain translates brain phenotypes between mouse and human via homology mapping, thus making it possible to capitalize on the wealth of knowledge about the mouse brain and gain insights into the human brain.

Tumor-associated macrophages play central roles in the cellular immune response in the tumor microenvironment. Here the authors implicate the m6A methyltransferase METTL3 in glioma progression by regulation of the ISG15/FASN modulated lipid metabolism in macrophage.

The proton-sensing GPCRs detect extracellular low pH and regulate diverse physiological responses. Here, the authors report cryo-EM structures of GPR4, which provide insight into the structural features of proton sensing mechanism.

Zhu, Fu, Zhu, Li and colleagues found that the key DNA repair enzyme poly(ADP-ribose) polymerase 1 promotes transcriptional restart after DNA damage through PARylating and stabilizing AFF1 by preventing its ubiquitylation by the E3 ligase Siah1.

Integrating CO₂ capture and electrochemical conversion avoids the thermal release of CO₂ and thus could potentially lower the energy needed to make useful products from CO₂, but choosing optimal system components is still challenging. Here the authors use piperazine alongside a nickel catalyst for capture and achieve high energy efficiency and stable CO production.

Clonal hematopoiesis is associated with an increased risk of hematologic and a range of inflammation-related diseases. Here, Yang et al. demonstrate a critical role for aberrant thrombopoietin receptor signaling in TET2-mutation driven clonal hematopoiesis.

A persistent gap from theoretical molecules to experimentally viable compounds has hindered the practical adoption of generative algorithms. This study proposes SynGFN as a bridge linking molecular design and synthesis, accelerating exploration and producing diverse, synthesizable, high-performance molecules.

Engineered symbiotic bacteria with blood-induced secretion of multiple effectors effectively inhibit malaria and arbovirus (Dengue and Zika) infections in mosquitoes, providing a promising strategy to combat concurrent transmission of these diseases.

A nucleic acid immunoassay implemented on a lateral flow strip accurately detects SARS-CoV-2 RNA in less than one hour via a fluorescence readout.

Multiplexed spiking data coding schemes could enable artificial visual neurons to emulate the human visual system in a more biologically plausible way. Here, Li et al. present an artificial neuron device capable of encoding visual analog signals into spike trains using multiplexed rate and temporal fusion coding. Reviewer recognition:

Reactive oxygen species (ROS)-based nanocatalytic cancer therapy is hindered by insufficient substrates at the tumor site and potential side effects arising from metabolites. Here the authors report a violet phosphorus-based nanosystem that supplies catalysts and substrates for producing cytotoxic ROS and generates the degradation products that can promote tumor calcification.

High efficiency in perovskite solar cells is achieved by using a molecular hybrid of a self-assembled monolayer with nitrilotribenzoic acid.

The preparation of systems that give blue circularly polarised organic afterglow is desirable but challenging. Here, the authors confine a chiral chromophore within a polymer matrix to limit non-radiative transitions and give blue circularly polarised organic afterglow.

The high trap density associated with tin (II) oxidation impacts the device performance of methylammonium cation-free tin-lead perovskite solar cells. Here, authors employ rubidium acetate for defect passivation and achieve efficient and stable single-junction and all-perovskite tandem solar cells.

An all-analog chip combining electronic and light computing achieves systemic energy efficiency of more than three orders of magnitude and a computing speed of more than one order of magnitude compared with state-of-the-art computing processors.

CRISPR-TO, a system for programmable control of spatial localization of cellular RNAs, is presented and enables functional investigation of endogenous RNA localization in diverse living cells.

Scavenger receptor class A member 3 (SR-A3) is implicated in metabolic diseases, but its relationship with MAFLD remains unclear. Here, the authors show that SR-A3 is an important modulator of hepatic energy metabolism and is a potential therapeutic target against MAFLD.

This Article presents a battery with protons as the charge carrier, as opposed to Li-ion batteries, which rely on the transport of Li-ions. Protons are conducted by means of the Grotthuss mechanism in a hydrated Prussian blue analogue electrode, offering potential for ultrafast rate and long-life batteries.

Transcription elongation is an essential step for gene expression control but remains unclear during spermatogenesis. Here, the authors report that NKAPL, a testis-specific protein distantly related to RNA splicing factors, is a crucial regulator of transcription pause-release.

The powdery mildew resistance gene Pm13 was introgressed into wheat from Aegilops longissima. Here, the authors report the cloning of Pm13 and reveal that it encodes a MLKL_NTD domain-containing kinase.

Shao et al. report that FUS interacts with the transcriptional coactivator TAZ, maintaining liquid-like properties of TAZ biomolecular condensates and enhancing TAZ transcriptional activity.

Earth system models often categorize plants to just a few functional types, and plant characteristics are defined per type, neglecting their diversity. The authors show how the use of plant traits can improve the modeling of global carbon, water, and energy fluxes

SAMHD1 has a dNTPase-independent resection function in genome maintenance. Here the authors show that SAMHD1 is deacetylated at conserved K354 by SIRT1 to facilitate direct binding with ssDNA to promote DNA end resection and homologous recombination.

The efficiency of all-perovskite tandem solar cells is impacted by the nonradiative recombination loss in Sn–Pb mixed narrow bandgap perovskite films. Here, the authors utilize a surface polishing agent with surface passivator to deliver films with a close-to-ideal stoichiometric ratio surface.

Nucleosides and their analogs are pharmacologically important molecules. Here, the authors report an additive-controlled stereodivergent iodocyclization method for the selective synthesis of α- or β-nucleosides.

Using the preserved remains of a short-winged flower beetle in mid-Cretaceous amber, this Article provides some of earliest clues as to the origins of angiosperm pollination.

Remnant tensile strain in the perovskite films induced in the thermal annealing step is a known source of material and device instabilities. Here Xue et al. use a thermal expandable hole transporting layer to compensate the strain and result in most stable wide-bandgap perovskite solar cells so far.

Defects and ion migration in perovskites hinder their potential as active material for flexible photodetectors. Here, the authors provide an electrical field modulation strategy to enhance the operational stability and the signal-to-noise ratio of flexible perovskite photodetectors.

Transient micro-electromechanical system (MEMS) devices that are based on water-soluble material platforms can provide safe implants for biointegrated systems.