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Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Oral leukoplakia is a precancerous lesion that can transform into oral squamous cell carcinoma (OSCC). Here, the authors discover that OSCC migrasome-derived PTGES promotes oral leukoplakia carcinogenesis through macrophages reprogramming.

Molecular devices offer the potential for the scalability and energy efficiency required to develop energy-sustainable AI. Zhang et al. report a single-molecule neuromorphic device that consumes 6.34 aJ per operation and support both short-term to long-term memory, featuring over 10 distinct conductance states.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Epitaxial CuO thin films exhibit crystal-symmetry-dependent orbital Rashba–Edelstein effects, enabling anisotropic orbital torque generation. The work reveals how crystal symmetry governs orbital angular momentum transport in oxide spintronic systems.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

Decoding skin gases can reveal a lot about our health. Here, the authors introduce a monolithic AI-powered wearable ring designed to non-invasively monitor dermal volatile-organic-compounds associated with diet-related metabolism.

Metabolic profiling of extracellular vesicles for diagnostic applications remains challenging. Here authors develop ACTIVITY, a cascade-catalysis strategy to detect metabolically active extracellular vesicles, enabling macrophage phenotyping and differentiation of pneumonia patients from healthy controls.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Euglenophytes evolved via secondary endosymbiosis, exemplifying plastid evolution. Here, the authors solve Euglena gracilis’ photosystem I structure, revealing specific protein organizations and structural features for far-red light absorption. This work informs the engineering of photosystem.

Survival requires prioritizing threats over pain. The authors identify a brain circuit in male mice, where fear signals from the cortex block pain-associated activation in the thalamus, revealing how fear suppresses pain and offering a potential target for therapies.

Nociceptive hypersensitivity and prolonged wound healing due to the interaction of peripheral neuropathy and local immune disorders hinder the regenerative repair of diabetic foot ulcer. Here, the authors report a low-intensity focused ultrasound-activated piezoelectric gel bandage with immune homeostasis modulation and neuropathic pain relief functions for comprehensive repair of diabetic wounds.

The crystal structure of the CHS-CHIL complex reveals a gating mechanism that enhances CHS activity and specificity. This conserved regulatory paradigm, validated by engineering a CHIL variant, offers strategies to improve flavonoid production in plants.

Photoredox catalysis promises transformative advances in proximity labeling and noninvasive therapy, yet photocatalysts rarely combine low-energy light absorption with high excited-state potentials. Here, the authors report Ru-based bio-photocatalysts that integrate greenlight absorption with strong redox power, enabling selective protein and phenol coupling.

Magnetic systems can exhibit flat bands where the magnon bands have little to no energy dispersion. Here, Luo, Chen, and coauthors show the nearly flat bands of the van der Waals antiferromagnet, CrOCl, and demonstrate quasi one-dimensional magnon transport.

Pre-harvest sprouting (PHS) causes severe yield and quality loss in cereal crops worldwide. Here, the authors report a cyclic nucleotide-gated channel/Ca^2 + -permeable channel encoding protein negatively regulate PHS and its involvement in modulating of calcium and hormonal signaling pathways in wheat.

XA-Novo is a mass spectrometry–only de novo antibody sequencing workflow that reconstructs full-length antibodies from single samples or mixtures, enabling rapid sequence recovery and functional re-expression for antibody research and drug discovery.

Multi-trait genetic analysis in East Asians identifies a novel gastric cancer risk locus shared with cardiovascular traits and shows that this variant modulates regulation of nearby genes, including VEZT, with functional effects on gastric cancer cell behaviour.

The development of Tat clusters has advanced the intracellular delivery of functional antibodies at low concentrations, but the variety of proteins that can be successfully delivered remains limited. Here, the authors report that by reversibly modifying the surface of functional proteins with anionic peptides, various protein cargoes (otherwise difficult to deliver) can be delivered into living cells by synergetic electrostatic interactions with the cationic cell-penetrating peptide clusters TAT₃.

How acute stress activates amygdala inhibitory circuits that regulate reproduction remains elusive. Here, the authors uncover a neural tug-of-war between functionally distinct GABA neuronal populations in the posterodorsal medial amygdala that translate stress signals into changes in reproductive hormone rhythms in female mice.

Yu et al. identify HELDR as a lncRNA co-amplified with EGFR in glioblastoma to promote a KAT7-activated malignancy programme, which can be potentially targeted with anti-EGFR therapy for improved therapeutic outcomes.

Chen et al. uncover the mechanism of transferring chirality from chiral perovskite host to a molecular guest mediated by the electronic coupling at the interface. A photoactive charge transfer state is identified, which inherits the chiroptical properties of the host matrix, resulting in selectivity to circularly polarized photons.

Introns, non-coding parts of genes, can hide critical functions. Here, the authors find a 9-nucleotide intronic RNA element that acts as a sensor, reading cell growth signals to control alternative splicing and fly ovarian development via a mechanism also conserved in human cells.

Aqueous zinc batteries suffer from poor reversibility due to interfacial instability. Here, the authors propose an electric field-responsive electrolyte design that modulates zinc-ion solvation and interfacial chemistry, leading to uniform deposition and extended cycling stability.

ProtAIDe-Dx is a deep joint-learning model that uses plasma proteomics to provide simultaneous probabilistic diagnoses across six conditions associated with aging.

Bone marrow ssDNA, specifically EHBP1-ssDNA, drives prostate cancer bone metastasis via integrin α6-FAK signaling, and Defactinib blocks this pathway.

RNA-sequencing’s conversion of molecules to reads confines analysis to relative fold-changes, a metric unreliable across batches. Here, the authors introduce TranScale, a spike-in method with 100 biomimetic standards that converts reads into absolute quantities to resolve systemic biases.

Oncolytic viruses are an approved therapeutic approach for glioblastoma, but, unfortunately, they are efficacious only in some patients. Here, the authors discover that LRRK2 inhibitors enhance viral infection and oncolysis by oncolytic herpes simplex virus (oHSV) in glioblastoma.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Liu, Tao, et al. share a Phase 4 randomized in which nearly 500 women undergoing hysteroscopic surgery received either oliceridine or a standard opioid in combination with propofol sedation, with continuous monitoring of respiratory and recovery parameters. Patients receiving oliceridine experienced fewer episodes of intraoperative hypoxia, required less propofol, and reported higher satisfaction, as did surgeons.

Limited heat dissipation at perovskite interfaces causes local overheating and accelerates degradation in perovskite photovoltaics. Now a solution-processable alkynyl-porphyrin conjugated polymer is inserted between the perovskite and hole-transport layers to enhance interfacial heat dissipation while maintaining efficient charge transport. This thermal and electronic management boosts device efficiency and operational stability.

A set of hydroxy promoters physically mixed with cobalt oxides for syngas to light olefins conversion using Fischer–Tropsch synthesis is shown to boost catalyst performance as well as simplifying the process and increasing sustainability.

You, Hu et al. discover a population of COTL1^high NK cells regulated by GITRL⁺ macrophages and demonstrate their functional importance in mediating anti-tumour immunity in cancer with impaired tumour-specific MHC-I expression.

A dated phylogeny of 16,585 vascular plant species native to China reveals three major centres of endemism, including a potential new global biodiversity hotspot.

Five nuclear spins in silicon and the [[4, 2, 2]] code are used to demonstrate a universal logical gate set and to execute a variational quantum eigensolver computation of the ground-state energy of a water molecule.

In China, about half of the flood events were unobservable by remote sensing, capturing mostly riverine flooding in open areas, while social media fills gaps in densely populated urban settings, according to a social sensing framework that combines satellite precipitation mapping and Sina Weibo posts

Exhausted CD8⁺ T cells increase proteasome activity due to the accumulation of depolarized mitochondria, which drives the selective degradation of mitochondrial proteins and releases of regulatory haem through haemoprotein breakdown.

The conversion of biomass into high-value hydrocarbons offers a clean alternative to fossil fuel-derived chemicals. Now electrocatalytic reductive amination of furfural to ethyl-2-furylmethylamine using waste acetonitrile over an Fe–CuO_x catalyst is reported. Cu²⁺ is used to reverse the reactivity of aldehydes and nitriles, and Fe³⁺ maintains Cu²⁺ dynamic stability.

DNA damage burden and inadequate repair in CUX2⁺ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.

Analysis of FeTe films grown using molecular-beam epitaxy and annealed under a Te flux post-growth shows that stoichiometric FeTe is inherently a superconductor, contradicting the long-held view that it is an antiferromagnetic metal.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Sweat sensors are important in personalized healthcare using natural oxidase to target biomolecules but these reactions are susceptible to external interference. Here, the authors report tryptophan- and histidine-treated copper metal-organic frameworks which show highly selective activity for ascorbate oxidation and can serve as an efficient ascorbate oxidase-mimicking material in sensitive sweat sensors.