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Hemifacial spasms are hard to monitor and counteract. Here, the authors develop an eyewear-based closed-loop system that detects spasms via triboelectric sensors and triggers facial nerve stimulation, reducing spasm severity.

Alternative targets are required for tumor therapy. The authors here show that transmembrane protein 175 (TMEM175) knock out in macrophages improves aPD-1 treatment prognosis with the mechanism of enhanced NLRP3 expression and antigen cross-presentation of macrophages.

Here they show that NONO collaborates with HOXA1 to modulate gene expression during early cardiomyocyte differentiation. This interaction facilitates activation of the Wnt signaling pathway, establishing the NONO-HOXA1-Wnt axis as a key mechanism in cardiac development.

Accurate prediction of molecular properties is crucial for drug discovery, yet existing models often struggle with multi-level feature interaction. Here, the authors introduce the hierarchical interaction message net (HimNet), which enhances representation learning across atomic, motif, and molecular levels, achieving superior performance in property prediction tasks.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Insufficient efficacy is one of the major impediments for further application of sup-tRNA therapies. Here, authors engineer the body sequence of sup-tRNA^Arg and restored retinal function and vision-guided behavior in a mouse model carrying the RPE65-R44X nonsense mutation.

The integration of organic and enzymatic synthesis enhances molecule construction efficiency. Here, the authors present ChemEnzyRetroPlanner, an AI-driven platform for automated hybrid synthesis planning, improving synthesis route efficiency and sustainability.

MMCLKin is a multimodal and multiscale contrastive learning framework for kinase-inhibitor affinity prediction, kinase inhibitor selectivity profiling, virtual screening for known, unknown, and mutated kinases, and interpretable analysis.

High-entropy systems can present a range of striking physical properties, but mainly involve metal alloys. Here, using low-energy proton irradiation, a high-entropy superparaelectric phase is generated in a relaxor ferroelectric composition, increasing polarizability and enabling a capacitive energy density of 45.7 J cm^–3.

A combination of adenovirus-vectored and subunit protein intranasal vaccine enhances immune response against SARS-CoV-2 variants in animal models and humans.

SARS-CoV-2 evolves into new subtypes necessitating further vaccine development. Here the authors generate a trivalent vaccine with Receptor Binding Domains from Delta, BA.5 and XBB.1.5 variants and characterize immunogenicity and protection in mice and safety in a phase I vaccine trial in humans.

This work demonstrates an efficient electrochemical exfoliation approach to achieve high recovery rate for few-layered halogenated MXenes by leveraging gaseous propylene molecules as ‘physical scissors’, to enable advanced tribovoltaic nanogenerators.

p97-UFD1L-NPLOC4 unfolds proteins for proteasomal degradation, but whether it suffices to extract proteins from lipid bilayers is unclear. We show that the UBH-UBX module in FAF2 and its homologs double p97’s ATPase and unfolding activity, and drives membrane protein extraction.

Flexible batteries have been used to power wearable smart electronics and implantable medical devices. Here, the authors report a carbon-rich flexible hydrogen substituted graphdiyne electrode exhibiting superior electrochemical performance in lithium and sodium ion batteries.

The realization of 2D photodetectors with simultaneous high sensitivity to light polarization and intensity is challenging. Here, the authors report the fabrication of broadband black phosphorus meta-polarization detectors combining polarization extinction ratio tending to +/- ∞ and high specific detectivity also under blackbody radiation.

In a first-in-human phase I trial of patients with advanced lung cancer, infusions of autologous T cells edited to delete the PD-1 gene via CRISPR–Cas9 were well tolerated and did not lead to severe treatment-related adverse events.

The gamma-ray burst GRB 060614 was an unusual astrophysical event whose origins are still unclear. This study re-examines the burst’s afterglow data and finds an excess in the spectrum that appears to be consistent with a weak macronova, suggesting that GRB 060614 originated from a compact binary merger.

Deep learning methods can provide useful predictions for drug design, but their hyperparameters need to be carefully tweaked to give good performance on a specific problem or dataset. Li et al. present here a method that finds appropriate architectures and hyperparameters for a wide range of drug design tasks and can achieve good performance without human intervention.

The SARS-CoV-2 Omicron variant has quickly become the predominant circulating variant, due to the high transmissibility and immune escape. Here, the authors develop a trimeric protein vaccine candidate and show a sustained humoral immune response, and protection from challenge (Omicron and Delta) in various animal models.

A recombinant vaccine that targets the receptor-binding domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Conventional bulk infrared detectors usually operate at cryogenic temperatures, leading to high power consumption. Here, the authors report high-performance polarization-sensitive photodetectors based on MoSe₂/PdSe₂ heterostructures, operating from the near- to the long-wave infrared band at room temperature.

Defects and defect migration are detrimental for perovskite solar cell efficiency and long-term stability. Li et al. show that fluoride is able to suppress the formation of halide anion and organic cation vacancy defects by restraining the relative ions via ionic and hydrogen bonds.

Unlike prokaryotic hosts, most genes in eukaryotes are transcribed to monocistronic mRNA for single protein translation. Here, the authors develop a polycistronic system for multiplexed and precalibrated expression of multiple genes, and show its application in constructing yeast cell factories for terpenoids production.

Hydrogen-bonded organic frameworks (HOFs) attract increasing attention as porous materials. Despite the widely studied solid-state properties, little research has been done on the solution state. Here, the authors demonstrate that HOFs fragment into small particles while maintaining their original assemblies upon dispersing in solvents.

Minimum mortality temperature (MMT) changes geographically and over time. Here, by analysing MMTs in 420 global locations during 1984-2018, the authors found that MMT is very close to the local most frequent temperature (MFT) in the same period, and the association between MFT and MMT is not changed when adjusted for lattitude and study year.

The activation of drugs within cellular systems may provide targeted therapies for cancer. Here, the authors make a drug delivery system that is activated within the cell and exploits XIAP expression to cleave a linker region, resulting in the self-assembly of the system and drug release within cancer cells.

Realistic tumour models are critical for the development of clinically relevant treatments. Here, the authors develop a lung cancer assembloid model which recapitulates key components of the primary tumour, and can be used to predict clinical outcome.

Lei et al. show that intranasal immunisation with their vaccine candidate is able to broadly protect mice from SARS-CoV-2 infection, including Omicron variants.

There is an intensive effort in developing multi-shelled metal oxide nanostructures for lithium-ion battery applications. Now, a metal anion-adsorption mechanism, as opposed to the conventional cation adsorption on carbonaceous templates, is demonstrated in the synthesis of vanadium oxide hollow microspheres, which exhibit excellent battery performance.

The authors report a stretchable and integrated energy harvest-storage-application skin-adherent microsystem, by utilizing an all-in-one MXene film simultaneously as micro-supercapacitors, wireless receiver coils and strain sensors.

Small-molecule RNA-targeted degradation can be leveraged to convert strong, yet inactive, binding interactions into potent and specific modulators of RNA function.

Elucidating the hierarchical assembly process is fundamental to the understanding of chirality transfer and chiroptical functions. Here, the authors show that a bisurea molecule self-assembles into chiral double-helices by a supramolecular rosette intermediated hierarchical assembly mechanism.

Enones are privileged structural motifs in bioactive natural products and pharmaceuticals, but the γ-hydroxylation of enones is challenging. Here, the authors report on a mild and efficient method for the direct C(sp3)–H hydroxylation of enones via visible-light-induced hydrogen-atom transfer, without the need for a metal and peroxide.

Several in vitro synthetic enzymatic biosystems (ivSEBs) to produce poly-3-hydroxybutyrate (PHB) via acetyl-coenzyme A (acetyl-CoA) have been reported, but suffer from complicated operation procedures, low yields, and/or dependence on costly ATP. Here, the authors report the design of an ATP-free ivSEB for one-pot, high-yield PHB biosynthesis via acetyl-CoA utilizing starch-derived maltodextrin as the sole substrate.

UGT76G1 is an UDP-glucose dependent glycosyltransferase and a component of the biosynthesis pathway for the natural sugar substitute steviol glycoside. Here, the authors present substrate bound crystal structures of UGT76G1 and provide insights into substrate recognition and catalysis by the enzyme.

Wang et al. propose EasIFA, an efficient enzyme active site annotation algorithm, to advance various fields including drug discovery, disease research, enzyme engineering, and synthetic biology.