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Recovering nitrate from surface water can help address interconnected environmental, resource, and energy challenges. A bioinspired photothermal evaporation platform enabling the co-recovery of low-concentration nitrate and freshwater is proposed.

Spin-crossover complexes are promising candidates for molecular bits owing to their magnetic bistability but engineering high-density bits is challenging due to cooperative switching dynamics. Here the authors modulate the cooperative dynamics of surface-confined spin-crossover complex chains.

Here they show that G9a-mediated H3K9me2 regulates intestinal homeostasis and injury repair through repression of cell cycle arrest genes in both mouse and human.

Off-the-shelf, on-demand allogeneic CAR-T cells could represent a therapeutic alternative to autologous products for cancer therapy. Here the authors report the preclinical characterization of off-the-shelf CRISPR-Cas9– edited IL-13Rα2-specific allogeneic universal CAR-T cells and the results of a first-in-human phase I trial in patients with high-grade glioma.

Progression-free survival with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors remains suboptimal in EGFR L858R-mutated advanced non-small-cell lung cancer (NSCLC), highlighting the need for strategies to delay resistance. Here this group reports a single-arm, phase II study evaluating first-line double-dose firmonertinib in 33 patients with L858R-mutated locally advanced or metastatic NSCLC.

The authors present a wearable MXene-based sensing-processing-visualizing integrated system for tactile-visual recognition, multisensory interaction, trajectory recognition, and real-time feedback.

Multimodal brain recordings are no easy task. Here, the authors introduce a neural implant with integrated carbon nanotube field-effect transistors for multimodal recording of electrical and chemical signals.

A four-qubit quantum error detection circuit with stabilizers can be implemented with spin qubits in a donor-based silicon quantum processor.

Emu3 enables large-scale text, image and video learning based solely on next-token prediction, matching the generation and perception performance of task-specific methods, with implications for the development of scalable and unified multimodal intelligence systems.

Du, Xie, Dai, Jia, et al. assess the role of MEFV variants in Castleman Disease using both in vitro experiments and patient samples. The inflammatory response, scRNA landscape, and high prevalence of MEFV variants propose a critical role for MEFV in Castleman disease.

Fibre integrated circuits created by first preparing circuitry on extremely thin and flexible substrates and then mechanically rolling them up demonstrate microdevice density reaching 100,000 transistors per centimetre and excellent stability under harsh service conditions.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

The xylosyltransferase isoenzymes XT1 and XT2 catalyze the first glycosylation step in the biosynthesis of proteoglycans. Now, bump-and-hole engineering of XT1 and XT2 enables substrate profiling and modification of proteins as designer proteoglycans to modulate cellular behavior.

Lactate fuels cancer growth by activating ERK signaling through GCN5-mediated lactylation of ERK, which disrupts ERK–MEK interactions. Development of a cell-penetrating peptide blocking lactylation slows KRAS-mutant tumor development.

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia in humans, macaques, marmosets and mice.

Monitoring charge carrier dynamics and photocatalytic reaction rates in individual photocatalyst particles is a challenging task that can help us to understand structure–reactivity relationships. Here single-molecule fluorescence imaging is coupled with femtosecond interferometric scattering microscopy to investigate these properties in 2D InSe flakes.

Controlling the hydrothermal reaction kinetics during the fabrication of Sb₂(S,Se)₃ solar cells is challenging. Chen Qian et al. show that sodium sulfide buffers the pH and allows a controlled release of Se, enabling a certified efficiency of 10.7%.

The authors found esterified pectin localized at the stiff poles of maize stomata, modulating stomatal opening. These results reveal novel targets for stomatal engineering and breeding crops with higher water use efficiency.

Here, the authors report the design and synthesis of azidodifluoromethyl imidazolium reagents that enable the in situ generation of carbonimidic difluorides. These intermediates undergo a series of controlled transformations, including chlorination, fluorination, monodefluorination, didefluorination, and subsequent derivatization of N-chlorodifluoromethyl compounds, providing an efficient strategy for the synthesis of structurally diverse N-fluoroalkane and amine derivatives.

The clinical adaptation of CRISPR assays is constrained by complexity and the absence of quality control. Here, authors report a thermally regulated asynchronous CRISPR-enhanced assay enabling direct, highly sensitive one-step detection of monkeypox virus and a human gene in clinical samples.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Molecular-dynamics-simulation-guided evolution of flavoenzymes produces efficient catalysts for non-C₂-symmetric biaryl synthesis with excellent atroposelectivity, offering promise for natural product synthesis and pharmaceutical applications.

CRISPR-based diagnostics are often limited by complex workflows and poor validation. Here the authors develop and validate a one-pot asymmetric CRISPR assay, which permits rapid and sensitive diagnosis of tuberculosis in a format which is suitable for resource-limited settings.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

In an effort to deorphanize G-protein-coupled receptors, a photo-cross-linking platform was established to capture ligands from complex samples. Little-LEN was identified as a ligand for GPR50, which coordinately regulates body metabolism.

Direct enantioselective α-C(sp³)–H functionalization of Lewis-basic N-alkyl anilines has remained a significant challenge in synthetic chemistry. Now it has been shown that a metallaphotoredox-catalysed radical approach, with a sterically hindered aryl ketone photocatalyst, enables site-selective, enantioselective (hetero)arylation with exceptional functional group tolerance.

Deep learning (DL)-based automated treatment planning has the potential to improve radiotherapy planning for patients in cancer but how best to implement them in the clinic is less clear. Here, the authors propose a hybrid strategy to develop a DL-based automated radiotherapy planning solution and demonstrate its real-world effectiveness in producing clinically deliverable plans.

IBI318 is a recombinant bispecific IgG1 antibody that targets PD-1 and PD-L1. Here the authors report the results of a phase II trial of IBI318 combined with the receptor tyrosine kinase inhibitor lenvatinib in patients with advanced non-small cell lung cancer with acquired resistance to first-line immune checkpoint inhibitors.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Finding efficient ways to release hydrogen from liquid carriers is key to advancing clean energy systems. This study introduces a resilient catalyst that drives highly selective hydrogen production from formic acid using low-grade heat.

The role of Leflunomide in αPD1-induced cardiotoxicity remains unclear. Here, the authors show that leflunomide mitigates αPD1-induced cardiac toxicity in melanoma-bearing mice through modulation of the microbiota-indole-3-propionic acid-heart axis.

METTL3 promotes healthy placenta function by regulating m⁶A methylation and histone epigenetics. Deficiency in METTL3 leads to premature senescence, inflammation activation of trophoblasts, contributing to pregnancy complications like preeclampsia.

Researchers repurpose Prussian Blue and Vitamin C to treat dangerously high potassium levels in mice. This approach safely traps potassium without releasing harmful sodium, offering an potential option for heart and kidney patients.

Insects colonized with Metarhizium fungi emit longifolene to lure new hosts for infection to disperse spores. A fungal strain was engineered to emit longifolene to attract and eliminate mosquitoes.

Obtaining phosphorescent polymers at high temperatures is desirable, but molecular motion quenches emission. Here, the authors report a compression-sensitive epoxy resin doped with dyes for high temperature phosphorescence.

Nucleophilic oxidation in electrosynthesis is hindered by slow dehydrogenation and the competing oxygen evolution reaction (OER). Here an oxyanion-stabilized low-coordinated Ni catalyst suppresses OER and Ni over-oxidation, enabling co-production of H₂ and valuable organic compounds.

Tpt1 family proteins are highly conserved and play essential roles in nucleic acid phosphate transfer in an NAD + -dependent manner. Here, the authors present several crystal structures of TkoTpt1 and reaffirm the two-step catalytic mechanism of the Tpt1-catalyzed reactions.