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Zhu, Zhao, Wang et al. describe G-NECNet, a deep learning model for detecting gastric neuroendocrine carcinoma (G-NEC) from H&E-stained biopsy whole-slide images without the need for additional immunohistochemistry. G-NECNet achieves high diagnostic accuracy across multiple datasets.

Here, authors experimentally demonstrate broadband far-field phonon coupling in a valley metamaterial integrated with a Dirac-strip, achieving coupling at a five-wavelength distance.

Yu, Yin, Zhu, Lu and colleagues show that Acr inhibits Cas activity through a scaffold RNA interaction and further develop an RNA truncation optimization strategy to enhance editing performance.

Cobalt ions in different sublayers of the double-layered Ruddlesden–Popper perovskite Sr₃Co₂O₇ are found to develop inequivalent ionic displacements, geometrically generating a polar state while preserving metallic conductivity and exhibiting antiferromagnetism.

A mechano-intelligent transmission mechanism based on the slipknot delivers precise force signals for clinical practice and robotic operations such as minimally invasive surgery and tendon-driven robotics.

Finding efficient ways to release hydrogen from liquid carriers is key to advancing clean energy systems. This study introduces a resilient catalyst that drives highly selective hydrogen production from formic acid using low-grade heat.

Organohalides play roles in marine microbial ecology and biogeochemical cycles. Here, the authors analyse marine metagenomic datasets and construct a database of genes and microorganisms involved in microbial halogenation and dehalogenation of organic compounds in the oceans.

Despite the global spread of the mpox virus, the long-term durability and breadth of infection-induced immunity are not fully understood. Here, the authors analyze MPXV-specific immune responses up to 18 months post-infection, revealing robust cellular immunity and cross-neutralization among orthopoxviruses, which inform reinfection risks and vaccine development strategies.

In this study, the authors perform an interactome study of Zika virus (ZIKV) 5’UTR stem-loop B region and identify two host factors, interleukin enhancer binding factor 3 (ILF3) and DEAH-box helicase 9 (DHX9), that positively regulate antiviral RNAi to inhibit virus replication and ZIKV-induced microcephaly in vivo.

Reversible protonic ceramic cells face electrode interface degradation challenges. This study introduces an atomic trapping strategy to restructure heterointerfaces, improving power output and long-term stability while reducing precious metal usage.

The paper demonstrates a ferroelectric photosensor array that integrates image memorization, low-level processing, and high-level computing. It uses dynamic and switchable photovoltages to perform image tasks, leveraging the bulk photovoltaic effect for enhanced precision and reliability.

The study presents a single-layer photonic computing (SLiM) chip that mitigates error accumulation by decoupling redundancies. It supports deep learning over 200 layers and enables large language models, advancing efficient photonic hardware for AI.

EndoKED is a knowledge extraction and distillation method that connects large language models and large vision models to automate the transformation of raw colonoscopy records into annotated image datasets.

Creating renewable nitriles faces challenges like competitive adsorption and harsh conditions. Here a CoRu dual-atom catalyst enables efficient ammoxidation of aldehydes to nitriles under ambient conditions through synergistic adsorption.

This Review highlights fundamental optical phenomena that have been redefined at the nanoscale by anisotropic polaritons, including anomalous cases of refraction, reflection and focusing.

Atomically dispersed metal atoms on semiconductor surfaces alter the local surface carrier distribution. Here, the authors demonstrate the improvement of the SERS activity of titanate nanotubes by controllable loading with monoatomic W species.

Enhancing rejection of small, neutral organic contaminants by reverse osmosis (RO) membrane is crucial for safe water supply. Here, authors report an amphiphilic nanowire-assisted monomer shuttling strategy that markedly improves the contaminant removal while simultaneously enhanced water permeance.

Sustained epigenetic silencing in monkeys is made more efficient with optimized regulators.

The elastocaloric effect was originally found in natural rubber, but the development of polymer based elastocaloric cooling still remains underdeveloped. Herein, the authors demonstrate that polymer elastomers with uniform molecular chain-lengths exhibit enormous elastocaloric effects through reversible conformational changes.

Lilies are perennial plants with ornamental flowers and large genomes. The authors assemble genomes of two Liliales species, analyze lily phylogeny, flower and stem development (bulbs in lilies, rhizomes in flame lilies), bulb growth transitions, and colchicine biosynthesis.

Utilizing a selenium-dependent enzyme, gut bacteria degrade uric acid via a previously unrecognized anaerobic pathway which gives them a competitive advantage in the gut.

Zhiwei Huang and colleagues report structural and biochemical data showing that the anti-CRISPR protein AcrVA5 functions as an acetyltransferase, modifying MbCas12a at Lys635, a residue required for PAM recognition. Acetylation of Lys635 creates a steric clash that prevents binding of target DNA.

Surface enhancements in glass mobility are complicated in polymers by the interplay of the surface mobile layer thickness with a second length scale (the size of the polymer chains), giving rise to a transient rubbery surface even in polymers with short chains.

By introducing an unconventional spin–orbit torque, the authors demonstrate an all-electrical way to bidirectionally switch the perpendicular chiral antiferromagnetic order in Mn₃Sn, promoting the application of antiferromagnetic spintronics.

During electrocatalytic nitrate reduction, cobalt-based catalysts degrade fast due to the combined effect of nitrate oxidation and electric-field reduction. Here, the authors develop a Co6Ni4 heterostructured catalyst to prevent high valence Co accumulation and achieve efficient ammonia synthesis.

The cryo-EM structure of the GSDMB pore reveals mechanisms by which GSDMB pore-forming activity is regulated by pathogenic bacteria and mRNA splicing.

A unified evolution-driven deep learning framework is presented, which outperforms state-of-the-art methods across various virus mutational driver predictions, and which captures fundamental patterns of virus evolution.

The observed deep-water overflow transport from the Pacific into the South China Sea has increased by 9% since 2009. This finding may have broad implications for the overturning circulations and biogeochemical processes in this region.

SARS-CoV-2 variants of concern such as the Omicron variant pose a challenge for vaccination and antibody immunotherapy. Here, Zhou et al. isolate a broadly neutralizing antibody (bNAb), named ZCB11, that protects Golden Syrian hamsters against Omicron. Applying CryoEM the authors show that ZCB11 heavy chain predominantly interacts with RBD in up confirmation, which interferes with ACE2 receptor binding.

Immunoglobulin A (IgA) is an important part of the mucosal immune response. Here, the authors show that an intestinal commensal protist can enhance mucosal IgA production upon vaccination and that this involves the accumulation of free arachidonic acid in the intestinal lumen.

We present fully forward mode learning, which conducts machine learning operations on site, leading to faster learning and promoting advancement in numerous fields.

The authors show that the presence of strong ocean internal tides in the South China Sea suppresses tropical cyclone intensification, mitigating their impacts on the highly populated surrounding regions.

The development of advanced nanofiltration membranes should be compatible with existing manufacturing process to be practically useful. A process based on nanoemulsion-regulated interfacial polymerization allows the fabrication of low-cost and high-performance membranes.

Acute stress activates autophagy in the lateral habenula, whereas chronic stress suppresses it, with this autophagy having a causal role in maintaining emotional homeostasis against stress, and its restoration through autophagy enhancers offers a novel antidepressant strategy.

EphA2 protects the blood-brain barrier during Streptococcus suis meningitis by promoting autophagy. S. suis disrupts this protection by inducing EphA2 degradation through DCAF15-mediated ubiquitination.

The Set8-Set7 methyltransferase plays a critical role in cell cycle progression and tumorigenesis, and is degraded through modification by the E3 ubiquitin ligase CRL4^Cdt2. Here Wang et al. identify SCF^β-TRCPas an additional E3 ubiquitin ligase that marks Set8 for degradation in response to DNA damage.

IsoNet, an isotopologue similarity networking strategy based on mass spectrometry-resolved stable-isotope tracing metabolomics, enables ab initio elucidation of unknown metabolites and their reactions, which is applied to the glutathione metabolic reaction network.

This study reports an adsorption-independent O₂ activation pathway for superior ¹O₂ electrosynthesis via an O₂ mono-hydrogenation process on compressive-strained rutile TiO₂. The compressive-strained TiO₂ suppresses the formation of reductive unsaturated sites for O₂ adsorption and enhances the reductive ability of atomic hydrogen, thereby enabling direct O₂ hydrogenation into free ^•OOH without the O₂ adsorption.

The conductivity of protonic ceramic electrolytes for fuel cells is unsatisfactory due to poor sintering. Here, the authors report the adverse effects of dynamic Y3+ displacement on high-temperature membrane sintering and propose a new strategy for pre-doping Y into A-site to inhibit its further displacement.