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Magnetic systems can exhibit flat bands where the magnon bands have little to no energy dispersion. Here, Luo, Chen, and coauthors show the nearly flat bands of the van der Waals antiferromagnet, CrOCl, and demonstrate quasi one-dimensional magnon transport.

Meiotic sex chromosome inactivation is essential for spermatogenesis, but how transcription is silenced after initiation remains unclear. Here, authors show that nucleolar components NPM1, SENP3 and rRNA form a phase-separated compartment that excludes RNA polymerase II to enforce XY chromosome silencing.

Chromatographic separation is controlled by thermodynamic and kinetics, but engineering both factors remains challenging. Here the authors demonstrate engineering of covalent organic framework from both thermodynamics and kinetics perspectives for chromatographic separation of halogenated isomers.

Determining the optimal start of the growing season presents a fundamental dilemma for plants. This meta-analysis suggests that plants exhibit high freezing resistance (to -12 °C) and low lethal frost risk (safety margin of 17 °C) during spring emergence, indicating strong long-term evolutionary pressure.

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

Pulmonary fibrosis is a progressive lung disease characterized by scarring and impaired function, with vascular endothelial cells playing a key role in disease progression. Here, the authors show that endothelial mechanosensitive PIEZO1 promotes fibrosis by activating the CAPN2-STAT3-IL-33 signaling axis, identifying a promising therapeutic target for treatment.

Dong and colleagues report that blockade of T cell-expressed cytotoxic and regulatory T cell molecule results in selective mitigation of immune-related toxicities without affecting antitumor efficacy of immune checkpoint inhibitors.

Machine learning was used to screen a library of diverse lipids on the basis of their spatial conformation and identify an LNP formulation that enabled organ-targeted mRNA delivery and tumour suppression. The work highlights the critical role of ionizable lipid conformation in LNP engineering.

Here, the authors show that residues N490 and M492 of Hepatitis E Virus capsid protein are pivotal, albeit not exclusive, host tropism determinants of hepatitis E virus (HEV) for swine infection, which enhance the understanding of HEV’s zoonotic transmission and host specificity.

Zhuang, Zi et al. identify cyclin-dependent kinase 3 (CDK3) as a driver of neuron loss in Alzheimer’s disease that is associated with brain atrophy and memory decline in mice. Inhibition of CDK3 (BMX330) is shown to limit neuronal loss and improve cognition.

SLC6A6 localizes to the inner mitochondrial membrane and mediates mitochondrial taurine import, which sustains mitochondrial tRNA modifications and cell growth.

Chen et al. apply unsupervised clustering to structural brain images of women with postpartum depression and integrate molecular data to characterize neurobiological variation. The study identifies two distinct subtypes with different structural, connectivity, and molecular profiles that may guide personalized care.

Here, the authors present structural and mechanistic insights into the inhibition of fungal β-1,3-glucan synthase, a key enzyme in fungal cell wall synthesis, by triterpenoid drugs.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Complex systems often interact through groups rather than simple pairwise connections, which can reshape how dynamics unfold on networks. Here, the authors develop a framework based on system disorder to quantify how dynamics transform across higher-order structures, uncover structural and dynamical governing factors, and demonstrate its applicability across contagion and opinion processes.

The performance of 2D photodetectors in the near-infrared range is usually constrained by fundamental limits. Here, the authors report hybrid photodetectors based on 2D MoS₂/WSe₂ heterostructures integrated with plasmonic metasurfaces, exploiting anapole states to enhance the responsivity and improve their chiral discrimination ratio in the telecommunication range.

Atomic catalytic pairs enable multistep transformations, yet the roles of spatial arrangement and coordination symmetry in homonuclear pairs remain unclear. Here, the authors construct atomically dispersed homonuclear Pt₁–Pt₁ pairs with asymmetric Pt₁C₃–Pt₁O₁C₃ coordination on reduced graphene oxide, enabling efficient transfer hydrogenation of azobenzene.

It remains unclear whether and how endometrial dysfunction leads to infertility in polycystic ovary syndrome (PCOS), independent of the ovary. Here, the authors show that elevated ERα and histone lactylation impair endometrial receptivity in PCOS and serve as potential therapeutic targets.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

Periodic marine oxygen oscillations occurred throughout the middle Ediacaran Gaskiers Glaciation, probably stemming from increased organic carbon burial destabilizing ocean redox systems, according to geochemical constraints and modelling.

A percolating interaction between antipolar regions and engineered defect pairs facilitates antipolar rotations, enabling superior energy storage performance in AgNbO₃-based ceramics.

While iron catalysis holds immense promise in organic synthesis due to the comparatively wide availability and low toxicity of the metal, modulation of the catalyst’s oxidation state still typically relies on conventional and wasteful approaches. Here, the authors integrate mechanochemistry into iron-catalyzed regiodivergent hydroarylation of alkenes with indoles, leading to an efficient generation of alkylated indoles.

Lattice strain impacts battery cathode performance and cycle life. Here, authors visualize and quantify strain in layered oxides through electron backscatter diffraction imaging, revealing heterogeneous, cycle-dependent distortions that slow Li transport and limit capacity, with irreversible layer bending driving capacity fade.

Quasi-BICs are known for their high sensitivity to structural disorder, which strongly affects their quality factor. Here, authors introduce quasi-bound flat bands in the continuum — optical states originating from disorder-induced band folding. Their theoretical and experimental results provide a paradigm for designing devices of high-quality factor and broad angular response.

Metal-cation-free CO₂ electroreduction in strong acid minimizes reactant loss and salt precipitation yet struggles with CO₂ activation and hydrogen evolution competition. Here, the authors report bioinspired sharp gold triangles with a proton-blocking layer that polarize CO₂ and suppress hydrogen evolution.

Metastatic cancer cells rely on metabolic flexibility to survive. Here, the authors show that metastatic breast cancer cells use lactate for mitochondrial oxidation via the CD147/MCT1/LDHB complex to sustain stemness and promote metastasis.

Surface reconstruction during reactions often generates unique active sites that boost catalytic performance. Here, the authors show that supported Ni₃InC₀.₅ nanoparticles undergo CO₂-induced surface oxidation, forming defective In₂O₃₋ₓ layers and inverse In₂O₃₋ₓ/Ni interfaces during CO₂ hydrogenation.

The authors investigate how in vitro fertilization-derived mouse embryos differ from those obtained via natural mating and observe changes in the epigenetic and transcriptomic landscapes. They further show that CPI-455, inhibitor of the histone demethylase KDM5, may facilitate both human and mouse embryo development in vitro.

Near-edge plasma treatment of Hf0.5Zr0.5O2 capacitors results in dielectric permittivity of 921, stored charge density of 349 μC/cm2, and energy density of 584 J/cm3 when the material’s ferroelectricity abruptly disappears after polarization fatigue.

Growth factor signalling has been shown to alleviate tissue fibrosis and promote repair. Here, the authors use fibroblast growth factor 7 (FGF7) knockout mice and an FGF7-loaded hydrogel to show that this factor can promote functional regeneration of tendon.

Here, the authors create a high-quality-factor chiral metasurface that enables record-high room-temperature valley-selective emission in MoSe₂ monolayers, independent of excitation polarization.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

OTX2 binds to and activates genes involved in embryonic genome activation, including TPRX1 and TPRX2. OTX2 knockdown impairs embryonic genome activation and early development, which can be partially rescued by overexpression of TPRX1 and TPRX2.

The oxidative intermolecular amination of C-H bonds represents a straightforward method to construct aliphatic allylic amines. However, the utilization of widely available internal alkenes remains a synthetic challenge. Here, the authors present a regioselective Cu-catalyzed oxidative allylic C-H amination of internal olefins with azodiformates.