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SCOPE-DTI introduces a large semi-inductive DTI dataset and optimized deep learning framework for drug-target interaction prediction. It integrates 3D structural modeling and bilinear attention, with experimental validation of drug targets and open access tools for broad research use.

Limited genomic resources constrain our understanding of fern evolution and conservation. Here, the authors present the genome of Brainea insignis, a monotypic endangered fern, and identify evolutionary signatures to guide conservation strategies from comparative and population genomic analyses.

Controlling the hydrothermal reaction kinetics during the fabrication of Sb₂(S,Se)₃ solar cells is challenging. Chen Qian et al. show that sodium sulfide buffers the pH and allows a controlled release of Se, enabling a certified efficiency of 10.7%.

While iron catalysis holds immense promise in organic synthesis due to the comparatively wide availability and low toxicity of the metal, modulation of the catalyst’s oxidation state still typically relies on conventional and wasteful approaches. Here, the authors integrate mechanochemistry into iron-catalyzed regiodivergent hydroarylation of alkenes with indoles, leading to an efficient generation of alkylated indoles.

Growing demand for robust plasma and serum proteomics highlights the need for better standardization. Here, the authors introduce an open 211-peptide internal standard that enables consistent quantification, cross-platform alignment and clinical utility across serum and plasma studies.

Using a large dataset of neural recordings and modern video-analysis methods, Wang, Kurgyis et al. describe a rich, structured encoding of movement across and within brain areas in mice performing both instructed and uninstructed movements in a task.

Initially anode-free sodium batteries promise high energy density but suffer from poor rate and low-temperature capability. Here, authors introduce a fluorinated sodiophilic interphase (BiF3@Al) which enables fast Na plating/stripping, demonstrating extended lifetime under harsh conditions.

Charge recombination of perovskite nanocrystals is crucial for their optoelectronic performance. Here the authors develop a continuous-wave-photoexcitation platform to study their time-resolved photoluminescence under operational conditions.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Communication between room-temperature and cryogenic environments is a bottleneck to the scaling of cryogenic devices. Here, the authors introduce a technique for in situ writing and erasing of circuits at low temperatures, enabling reversible construction of patterns without a photoresist.

SUANPAN: A programmable and reconfigurable photonic linear vector machine with extreme scalability formed by a series of emitter-detector pairs as the independent basic computing units and implemented through time-space encoding.

Brainstem gliomas are an aggressive form of paediatric cancer. Here, the authors use metabolomics to assess differences in metabolites during radiotherapy.

Hemodynamic management is essential in critical care, but optimal targets for heart rate and blood pressure remain unclear. Here, the authors show that a time-dependent Cox model can derive personalized, real-time targets associated with reduced mortality.

Limited current output hinders triboelectric nanogenerators for maritime applications. Authors design a rolling-mode TENG with multi-tunnel grating electrodes, achieving 185.4 W/(m³·Hz) power density. They demonstrate a self-powered ocean sensing system for water quality monitoring and wireless communication.

Patients undergoing treatment with PD-1 blockade can experience inflammatory arthritis as an adverse event. Here, the authors use single-cell RNA sequencing to identify IL1B^hi macrophages in PD-1-inhibitor-induced arthritis, but not rheumatoid arthritis.

The Li dendrites and adverse Li-electrolyte reactions hinder the practical use of Li metal batteries. Here, authors propose an organic/inorganic artificial solid electrolyte interphase, where an outer metal layer ensures uniform Li nucleation and a F-rich inner layer acts as an electronic insulator.

Diagnosis of lung cancer from indeterminate pulmonary nodules remains challenging. Here, the authors develop a multi-omics signature to identify oncogenic nodules, and prevent unnecessary procedures.

So far infinite-layer nickelates have only been observed to superconduct in single-thin-film form. Here, the authors demonstrate superconductivity in [(Nd_0.8Sr_0.2NiO₂)₈/(SrTiO₃)₂]₁₀ superlattices.

The limited functionality and complex fabrication of polymer material with externally controlled reversible deformation hinder their further development. Here, the authors produce fluorescent and robust photoactuators with single layered janus structure for different applications.

Human GWAS paradoxically linked FTO SNPs to both lean mass and sarcopenia/obesity. Here, Guang et al used CRISPR-edited stem cells to reveal that an obesogenic FTO SNP accelerates both muscle development and aging, by increasing RNA m6A demethylation.

The cortex is very active during sleep. Wang et al. used macroscopic Ca²⁺ imaging to record the global cortical activity from the entire dorsal cortex of mice during sleep and uncover an unexpected role of the cortex in controlling REM sleep.

Achieving bright and efficient blue emission in metal halide perovskite light-emitting diodes has proven to be challenging. Here, the authors demonstrate high EQE and spectrally stable blue light-emitting diodes based on mixed halide perovskites, with emission from 490 to 451 nm by using a vapour-assisted crystallization technique.

Gonadotropes in the pituitary secrete follicle-stimulating hormone and luteinizing hormone to control gonadal function and fertility, but whether they exert actions on extra-gonadal organs is not fully understood. Here the authors report that gonadotropes regulate liver steatosis independent of the ovaries in mice.

The authors describe the cocrystal structure of the highly efficient polyethylene terephthalate-degrading hydrolase PHL7 with its product terephthalic acid and elucidate the role of residues in subsites I and II for its thermal stability and of residue L210 for its high activity.

Temporal causation models perform poorly in causal inference for variables with limited temporal variations. This paper establishes a causal inference model, which can reveal the nonlinear complex casual associations based on cross-sectional Earth System data.

Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Here, the authors present a multinational study on the application of deep learning algorithms for COVID-19 diagnosis against multiple lung conditions as controls.

Rapid and early detection of SARS-CoV-2 will aid intervention to stop disease spread. Here the authors present a one-pot CRISPR-based rapid detection system with visual readout.

Experimental studies about the trainability and generalization capacities of quantum neural networks are highly in need. Here, the authors implement a previously proposed parametrization and training scheme using a 6-qubit superconducting quantum processor.

A technique for the large-scale mass-spectrometric quantification of glycopeptides in plasma samples allows for the profiling of more than a thousand glycopeptide features in plasma samples, as shown for patients with COVID-19.

Wireless implantable medical devices (IMDs) are hamstrung by both size and efficiency required for wireless power transfer. Here, Zaeimbashi et al. present a magnetoelectric nano-electromechanical systems that can harvest energy and sense weak magnetic fields like those arising from neural activity.