Search

This study reports that the gene SMPED1, located in a previously identified dichogamy-determining region in Alpinia species, controls the timing of sex-organ synchrony, improving our understanding of the evolutionary mechanisms of plant sexual diversity.

Nitrogen promotes wheat’s recovery after drought stress through the TaSnRK2.10-TaNLP7 module. This breakthrough connects drought-stress signalling with nitrate response pathways, providing a genetic framework for developing climate-resilient crops.

The potential of leveraging diverse geometric configurations of the catalysts to achieve divergent synthesis remains largely untapped. Here, the authors report a stereodivergent three-component borylfunctionalization of alkynes, enabled by ligand-modulated geometric variations in nickel catalysts.

Anti-TSLP biologics have shown promise for the clinical treatment of type 2 respiratory disease. Here the authors present a clinical trial of CM326, a monoclonal antibody against TSLP, and show the clinical effects in patients with eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP), who present with type 2-dominant inflammation.

Here, the authors find that high-pressure treatment in a diamond anvil cell turns initially non-emissive organic small molecules emissive after decompression, where their color can be tuned through the maximum applied pressure.

This work introduces GLORI 2.0 and 3.0, enabling sensitive m⁶A quantification from RNA inputs as low as a few hundred cells.

CRISPR-based diagnostics are often limited by complex workflows and poor validation. Here the authors develop and validate a one-pot asymmetric CRISPR assay, which permits rapid and sensitive diagnosis of tuberculosis in a format which is suitable for resource-limited settings.

A pharmacophore-oriented 3D molecular generation method, which efficiently generates diverse, drug-like molecules is proposed. It successfully identifies new inhibitors in real-world drug discovery.

The authors introduce and demonstrate a programmable optically-driven organic micro-actuator for precise manipulation of on-chip structures. This paves the way for adaptive, multifunctional photonic systems.

An asymmetric self-assembled monolayer improves the efficiency of perovskite/silicon tandem solar cells compared with symmetric self-assembled monolayers, resulting in a certified power conversion efficiency of up to 34.58%.

The accrual of soil carbon from absorptive fine roots exceeds that of leaf litter in forests despite lower productivity, according to an analysis of field observations from Northern Hemisphere forest sites.

Seawater desalination and wastewater treatment face challenges like low flux and membrane fouling. Here, authors develop an omniphobic ZIF8 composite membrane that captures volatile organic compounds and enhances water evaporation, achieving high flux and stability for sustainable purification.

Gong et al. report an all-perovskite photovoltaic-powered battery using ethyl viologen diiodide and its derivative to modify the perovskite solar cell and the battery cathode, enabling an overall energy conversion efficiency of 18.54%. The flexible version powers a wearable glucose monitor for 24 h.

Producing light olefins from polyethylene (PE) is challenging. This study reveals a PE self-confined cracking mechanism over zeolites, achieving exceptional olefin yields (>70%) independent of zeolite properties, enabling efficient plastic recycling.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

This study identifies a regulatory module in which UBC32 and SC35 regulate bZIP49 splicing to maintain potassium balance, revealing how poplar adapts to salt stress and providing new insights into plant responses to soil salinity.

Early and accurate clinical assessment of disease severity in COVID-19 patients is essential for planning the allocation of scarce hospital resources. An explainable machine learning tool trained on blood sample data from 485 patients from Wuhan selected three biomarkers for predicting mortality of individual patients with high accuracy.

Cholecystectomy is associated with an increased risk of colorectal cancer, and the underlying mechanism remains elusive. Here, the authors show that cholecystectomy-related microbiome and bile acid alterations disrupts the FXR/β-catenin interaction, and ultimately exacerbates colorectal tumorigenesis.

Broadband achromatic metalenses hold promise for enabling high-performance optical imaging in a compact form factor. Here, the authors report the realization of high-efficiency Si3N4 achromatic metalenses in the visible range and demonstrate their integration onto a commercial imaging chip.

The advance in improving the operational lifetime of organic solar cells is currently limited. Here, the authors report a radical scavenger capped zinc oxide nanoparticles as the electron transport layer, achieving operationally stable devices with efficiency of 19.47%.

The primary entry route of vanilloid ligands to the vanilloid-binding site in transient receptor potential vanilloid 1 (TRPV1) is found to be a distinct and targetable hydrophobic pathway at the TRPV1–cell membrane interface rather than through direct membrane penetration.

Abiotic methylation triggered by plastic debris can occur independently of light conditions and therefore drive methylmercury formation in dark waters, according to an experimental study combined with density functional theory calculations.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

A new p-type small molecule enhances defect passivation and improves interfacial charge transport in perovskite solar cells, enabling devices with a certified power conversion efficiency of 26.72%, 97% of which is maintained after 2,500 h of continuous operation.

To emulate nature biological processing, highly-integrated ultra-sensitive artificial neuromorphic system is highly desirable. Here, the authors report flexible sensor array of 1024 pixels using combination of carbon nanotubes and perovskite QDs as active matetials, achieving highly responsive device for reinforcement learning.

Experimental systems in which non-trivial topology is driven by spontaneous symmetry breaking are rare. Now, topological gaps resulting from two excitonic condensates have been demonstrated in a three-dimensional material.

Low-dimensional perovskites afford high efficiencies in solar cells but at the expense of stability. Rao et al. develop a template growth approach to form low-dimensional perovskites from low-reactivity and hence more stable organic cations.

The authors report a molecular ferroelectric (TMCM)[FeCl₄], which shows strong magnetostrictive and magnetoelectric effects at room temperature. The spin-lattice coupling of FeCl₄ and flexible structure of organic cations are responsible for these effects.

Diarrhoea is a major cause of morbidity and mortality in China. Here, the authors present results from a large sentinel surveillance scheme from 217 hospitals in all 31 provinces in mainland China, including ~150,000 patients with acute diarrhoea and covering years 2009-2018.

China operates a national surveillance program for acute respiratory infections and sampled over 200,000 patients between 2009–2019. Here, the authors present results from this program and describe patterns by age, pathogen type, presence of pneumonia, and season.

Protocol for fabricating synthetic viscoelastic antigen-presenting cells and their application in T cell engineering. These synthetic cells support robust T cell activation and expansion and improve chimeric antigen receptor transduction efficiency.

A suite of bridged rhodamine dyes (BriDyes) offers excellent brightness, solubility, photostability, and tunable cell permeability along with resistance to photoblueing, making them exceptional all-purpose dyes for fluorescence biomaging.

Diatomic catalysts show promise for the oxygen reduction reaction, but their complex kinetics hinder rational design. Here, the authors synthesize strongly bonded Fe-Co diatomic catalysts where Co acts as the main active site and Fe aids *OH adsorption, revealing a synergistic effect.

R9AP is a key receptor for entry of Epstein–Barr virus into human epithelial and B cells, and interacts directly with the viral glycoprotein gH/gL complex to mediate virus–host membrane fusion.

Photonic memristor arrays fabricated from hexagonal boron nitride/silicon heterostructures provide a scalable, silicon-compatible solution for artificial vision systems, featuring broad spectral reconfigurability and promising performance characteristics.

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

Clinical trials of CD47 blocking antibody in human cancer patients have not yielded ideal results. Here the authors show that USP2 stabilizes CD47 through deubiquitination, whereas USP2 inhibition enhances macrophage phagocytosis, reprograms tumor microenvironment and synergizes with anti-PD-1 treatment.

Pressure treatment can modify the luminescence properties of materials. Here the authors use pressure to turn nonemissive organic zinc halide perovskites bright with full color tunability, which enables robust optical anti-counterfeiting applications.

This study elucidates that d-galacturonic acid and d-glucuronic acid regulate apple fruit softening by repressing MdHb1 expression through the MdMYB2/MdNAC14/MdNTL9-MdHb1 regulatory module, offering new insights into postharvest fruit quality control.