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A few anisotropic van der Waals materials have been shown to host hyperbolic polaritons in the visible and infrared ranges. Here, the authors characterize the complex dielectric function of hexagonal boron nitride in the deep-ultraviolet regime, supporting a natural hyperbolic dispersion and predicting hyperbolic exciton polaritons.

Most patients with B-cell leukemia respond to chimeric antigen receptor T cell (CAR T) therapy, yet many relapse due to loss of CAR T function. Here, the authors show that the metabolism of CAR T from short- and long-term responders is different, which may explain why CAR T lose functionality.

Intestinal homeostatic imbalance represents a hallmark of various diseases. Here, the authors report a montmorillonite-based oral fermentation system that enables in-situ biosynthesis of diverse bioproducts for restoring gut homeostasis.

Moiré superlattices are a versatile platform for studying emergent electron and quantum phenomena. Here, the authors demonstrate moiré superlattice formation in complex oxide-WS₂ heterostructures across varying twist angles.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Supersolid phases are quantum-entangled states of matter exhibiting the dual characteristics of superfluidity and solidity. Here, the authors map the phase diagram of K₂Co(SeO₃)₂. and identify signatures of two supersolid phases separated by a 1/3 magnetization plateau.

This work reports a catalyst with atomically dispersed Fe and Pd dual sites for photothermal catalytic CH₄ oxidation, and demonstrates that the in-situ formation of charge-polarized regions can induce the polarization and cleavage of C-H bonds.

Perovskite solar cells rival silicon in efficiency but suffer from poor long-term stability, partly due to laser scribing defects. The authors regulate crystallization using (E)-But-2- ene-1,4-diamine dihydrochloride, achieving high module efficiency and enhanced durability.

Here the authors identify via an East Asian mQTL study (n = 7,619) nearly 29,000 novel mCpG. It shows that mQTLs are strongly enriched for disease heritability, especially when ancestry is matched, underscoring their utility in interpreting GWAS results.

Aqueous batteries often rely on acidic or alkaline electrolytes that cause side reactions and environmental concerns. Here, the authors develop a covalent organic polymer negative electrode that enables long-life Mg²⁺/Ca²⁺ storage in neutral, environmentally benign electrolytes.

Current radiative coating strategies only consider reducing CO₂ emissions in service stage. Here, the authors present a life‑cycle–based design using a carbon‑negative filler and durable resin, achieving CO₂ reductions across the entire lifespan compared to the commercial reflective cooling baseline.

Developing non-precious-metal oxygen evolution reaction catalysts to replace precious metal components is a promising strategy to reduce the cost, yet it remains a challenge. Herein, the authors report a catalyst system with high-spin Co3 + , achieving efficient acidic water oxidation.

A structureless holographic approach is proposed to generate and control complex plasmonic fields on flat metal films. This method facilitates dynamic manipulation of energy flow and enables the guided transport of particles like a surface slide.

The work presents a model that predicts battery degradation using field-accessible data without historical cycling information. It combines a mixture of expert’s network with features from partial charging curves and relaxation voltage to classify degradation modes and predict long-term trajectories under uncertain future conditions.

Interfacial charge transfer limits fast-charging sodium-ion batteries. Here, authors demonstrate a P2-type positive electrode that utilizes potential-dependent anion-specific adsorption to accelerate charge transfer, enabling high-rate capability and stable cycling in Ah-scale pouch cells.

Powdery mildew and stem rust are two major wheat pathogens. Here, the authors report the cloning of powdery mildew resistance gene Pm37, reveal that it’s a susceptible allele of stem rust resistance gene Sr22, and speculate the allelic variation causing functional divergence.

Plant diversity plays a key role in regulating ecosystem processes, yet its influence on global soil carbon release remains unclear. This study suggests that higher plant species richness is associated with greater soil respiration in low- to mid-productivity forests but has little effect in highly productive systems.

Nearly all organisms exhibit codon usage bias (CUB), traditionally thought to reflect a unidirectional selection maximally matching CUB and the cellular tRNA supply. Here, the authors propose alternatively that a slight mismatch optimizes the balance between translational cost and functional payoff.

Seawater electrolysis for green hydrogen faces the critical challenge of preventing chloride oxidation. Here, the authors report that reconstructed sulfate layers on NiFeS anodes establish a hydrogen-bond network that selectively weakens chloride binding while allowing hydroxide access for electrolysis.

This work proposes an oxygen octahedron tilt framework strategy to design high performance lead-free relaxors by introducing a complex BO₆ tilt system and additional local random elastic field, resulting in high energy storage properties.

Obesity and related metabolic disorders have become a global epidemic. Here, authors reveal that arginase 1 drives hepatic lipid production via a non-enzymatic interaction with ERK2, offering a promising therapeutic target for metabolic diseases.

RORγt⁺ antigen-presenting cells (APC) are playing a role in the generation of oral tolerance via their interaction with regulatory T cells recognising dietary and commensal bacterial antigens. Here authors show that a cis transcriptional regulatory element is responsible for RORγt specifically in APCs through interaction with RUNX3 and formation of chromatin loops, which determines a transcriptional program that distinguishes these oral tolerance mediating APCs from RORγt⁺ T cells.

The underlying regulatory mechanisms of of human cortical diversity remains poorly understood. Here, authors profiled human brain cells to study how they use different gene programs across cortical regions, revealing molecular rules and specific transcription factors that drive functional specialization of neurons in the brain

Sterically hindered aryl C-glycosides are biologically important, yet their efficient, stereoselective synthesis remains challenging because severe anomeric congestion limits existing glycosyl cross-coupling methods with bulky aryl partners. Here, the authors report a ligand-enabled stereospecific Pd-catalyzed coupling delivering hindered aryl C-glycosides.

Compact Un1Cas12f1 enzyme suits AAV delivery but is limited by narrow PAMs and modest activity. Here, authors engineer evoCas12f to recognize broader NTNR/NYTR PAMs and boost editing efficiency up to 91%, enabling efficient multiplex editing, base editing, and gene activation in cells and mice.

The authors propose here a computing-in-memory architecture based on tunable Gaussian like memory cells for processing Kolmogorov-Arnold networks, to achieve parallel computation with higher energy efficiency compared to general-purpose CMOS architectures.

Metabolic reprogramming of immune cells can modulate their response to and ability to respond in infective contexts. Here the authors show phosphoglycerate dehydrogenase mediated serine reprogramming in macrophage is linked to hyper inflammatory responses in murine models of Pseudomonas aeruginosa pneumonia.

Spatial CRISPR screens probe the functional impact of mutations within intact tissues. Here, authors present Spatial Perturb-Seq, a technology that localizes CRISPR perturbations and cell identities in situ, uncovers communication between cells, and shows how genes act beyond their cellular borders.

Assessing the hepatotoxicity of a drug is critical in drug development. Here, the authors develop human multi-lineage liver organoids and identify imipramine as an inducer of indirect hepatotoxicity from a drug screen. The study offers insight into indirect hepatotoxicity and an in vitro platform for drug safety testing.

Cross-linking mass spectrometry is widely used to study protein structures and interactions but remains challenging to analyze comprehensively. Here, the authors develop a deep learning–based platform that enables deeper, systematic analysis of cross-linked peptides across DDA and DIA.

The performance of 2D photodetectors in the near-infrared range is usually constrained by fundamental limits. Here, the authors report hybrid photodetectors based on 2D MoS₂/WSe₂ heterostructures integrated with plasmonic metasurfaces, exploiting anapole states to enhance the responsivity and improve their chiral discrimination ratio in the telecommunication range.

Alternative targets are required for tumor therapy. The authors here show that transmembrane protein 175 (TMEM175) knock out in macrophages improves aPD-1 treatment prognosis with the mechanism of enhanced NLRP3 expression and antigen cross-presentation of macrophages.

The limited tunability of threshold voltage is a major obstacle for applying two-dimensional transistors in post-silicon electronics. Here, the authors show that bimetallic thiophosphates, such as LiInP₂S₆, enable programmable threshold voltages in both n-type and p-type 2D transistors, leading to low-power, high-speed complementary logic inverters.

The light-driven enzyme catalytic systems composed of NAD(P)H regeneration and NAD(P)H-dependent enzymatic process emerge as biomanufacturing platforms for the synthesis of value-added chemicals. Here, the authors present a photo-enzyme-membrane catalytic system coupled with multi-enzyme cascade for ethylene glycol synthesis.

Antifungal aureobasidin A (AbA) targets inositol phosphorylceramide (IPC) synthase. The authors trap its ceramide-bound and drugbound states, revealing the catalytic and drug-inhibition mechanisms, providing basis for antifungal drug development.

Emergent constraints correct model bias in hydrological impacts of land use and land cover change. Constrained estimates project weaker reductions in water availability globally and over the tropics and subtropics induced by future afforestation.

The details of how the DNMT3A regulatory domains cooperate with its methyltransferase domain and with histone marks remained unclear. Here, the authors use structural biology and molecular dynamics to better understand this interaction.

Oestrogen receptor activation generates DNA breaks at regulatory elements that control gene expression. This study shows that APOBEC3B is required for these breaks, by deaminating cytosines within R-loops at oestrogen receptor-regulated enhancers.

PAN2-PAN3 complexes trim poly(A) tails of mRNAs. Here, the authors show that PAN2 associates with translation initiation factors and that germline-specific deletion of Pan2 in mice causes male infertility and compromises stability of key components of the translational machinery.

Prostate cancer heterogeneity limits the efficacy of current therapeutic approaches. Here, the authors develop two methods, snFLARE-seq and mxFRIZNGRND, using formalin-fixed paraffin embedded samples for analysing the transcriptomic and metabolomic landscape of different anatomical origins.

In this work, authors show that Legionella YopJ-family acetyltransferase effector subverts host immunity through a dual mechanism against the JAK-STAT pathway; inactivating JAK1 activity by lysine acetylation and blocking its corresponding receptor binding via direct interaction.

We demonstrate a mid-infrared Mach-Zehnder modulator operating from 3.95 to 4.5 μ m, achieving >20 GHz bandwidth, 17 dB extinction ratio, V_πL = 22 V ⋅ cm implemented on lithium niobate on sapphire platform. The device is used to demonstrate 10 Gbit s⁻¹ data transmission, and a 70 GHz broad frequency comb.

The absence of a generic feature reference for single-cell scATAC-seq data limits analyses and hinders the development of comprehensive cell atlases. Here, the authors built cPeaks, a reference of 1.4 million consensus chromatin accessibility peaks to improve scATAC-seq analysis resolution.

The development of covalent organic framework (COF) photocatalysts for high-concentration H₂O₂ production remains challenging. Here, the authors report a large language model–driven design strategy to construct robust and active COF photocatalysts capable of producing high concentrations of H₂O₂.

Barium isotope variations in the Izu arc lavas reveal the combined role of slab-derived fluids and mélange diapir melting in arc magma formation.

A conserved hexameric ring functions as an effector carrier in bacterial type VI secretion systems. Here, the authors shed light on the ring’s assembly mechanisms and how it recognizes structurally diverse protein cargos in Bacteroides fragilis.

Intestinal motility defects caused by lower acetylcholine levels in the gut are compensated by bacteria that generate ammonia from urea which facilitates the release of acetylcholine via upregulation of voltage-gated channels on enteric neurons.

Satellite data and experiments show heatwaves and extreme rain more than gradual warming drive lake algal blooms by accumulating phosphorus and forming dense particles to sink to cooler water, and pre-heatwave rainfall intensifies their outbreaks.