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Feng, Luo and colleagues show that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrogenase (SORD).

Candida auris is a fungal pathogen notorious for persistent skin colonization and transmission in healthcare settings. Here, Zhao et al. explore the mechanisms driving pathogen’s adherence to skin, involving a conserved adhesin, as well as the potential of collagen coatings as a strategy to reduce C. auris adherence to abiotic surfaces.

Lipid particles loaded with RNA coding for tumour-unspecific antigens can enhance early responses of type-I interferons, mediating the success of immune checkpoint inhibitors as well as epitope spreading.

By integrating single-cell transcriptomics and T cell receptor repertoire analyses of regulatory T (T_reg) cells in a cohort of patients with acute coronary syndrome from the LILACS trial, Case et al. show that low-dose interleukin-2 clonally expands T_reg cells and maintains their suppressive program by bypassing BACH2 downregulation.

The histone methyltransferase ASH1L has been linked to tumorigenesis, mainly in leukemia. Here, authors report that ASH1L cooperates with HIF-1α to induce a pro-metastatic transcriptome in prostate cancer cells, and promotes conversion of monocytes to lipid-associated tumor-associated macrophages in the bone metastatic niche.

An integrated observation-driven and model-driven approach demonstrates that, from 2005 to 2021, periods of high atmospheric methane growth were linked to trends and variations in OH levels driven by fluctuations in air pollutants, especially during extreme events.

Achieving phosphorus circularity is a key challenge to realizing sustainable phosphorus use, and recycling is a major route to accomplish this goal. This Review explores global barriers to phosphorus recycling and discusses approaches to overcome the technical, economic and societal challenges in attaining sustainable phosphorus management.

The understanding of the reemergence of pressure induced superconductivity in alkali-metal intercalated FeSe is hampered by sample complexities. Here, Sun et al. report the electronic properties of (Li_1–xFe _x )OHFe_1–ySe single crystal not only in the reemerged superconducting state but also in the normal state.

The study of isotopes away from the beta stability valley is crucial for the understanding of nuclear structure, especially for neutron-deficient heavy nuclei. Here, the authors report the observation of the alpha-decay isotope 210-protactinium (Pa), extending the alpha-decay systematics of underexplored regions of the nuclides chart.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Tropical cyclones can occur concurrently in the same basins in clusters, potentially resulting in greater damage. Here the authors show that global warming causes a shift in hotspots of such clusters towards the North Atlantic.

Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

Network glass fracture is a sudden, complex process lacking clear precursors. Here, the authors develop the local intelligent stress threshold indicator (LISTI), a neural network-based tool that predicts nanoscale crack nucleation by correlating local stress thresholds with structural topology, offering a method to identify fracture-prone zones in network glasses.

Chiral antiferromagnets, such as Mn3Pt, host a variety of transport phenomena arising due to the chiral arrangement of the spins. Herein, the authors find two contributions to the anomalous hall effect in Mn3Pt, and through comparison with other chiral antiferromagnets develop a universal scaling law for the anomalous hall effect in chiral antiferromagnets.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

This Review discusses multiomic approaches for the characterization and biological understanding of cellular senescence, including detailed case studies on skeletal muscle and adipose tissue that highlight current outstanding issues in the field.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

Global land cover conversions increased carbon uptake during 1982 to 2019, with newly established forests in the Northern Hemisphere driving gains that counterbalanced emissions from tropical deforestation.

Structure relaxation is an iterative process particularly demanding in large-scale material discovery campaigns. Here, the authors realize a deep generative model able to relax material structures in a single step while estimating its accuracy.

An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as air pollution and passive smoking.

Alfajaro et al identify that a bat MERS-like coronavirus HKU5 uses ACE2 as a receptor from its natural bat reservoir Pipistrellus abramus and American mink. Structural analyses demonstrate a unique interaction between the HKU5 receptor binding domain and bat ACE2. This highlights the receptor flexibility of merbecoviruses and identifies mink as potential intermediate hosts, informing viral surveillance and countermeasure development.

Diverse plant species synthesize salicylic acid from phenylalanine through a pathway that includes a conserved triple-enzyme module that converts benzoyl-CoA to salicylic acid.

Graphene is known to display unique functional properties due to its two-dimensional structure. Here, the authors measure the thermal conductivity of suspended graphene as a function of sample length, finding that thermal conductivity is higher in longer samples as a result of two-dimensional phonons.

Classical theory predicts that glass dynamics exhibit a singularity at some finite temperature. Zhao et al. test this theory in fossil amber by determining upper bounds of the equilibrium relaxation times, and find no such behaviour even far below the glass transition challenging conventional assumptions.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

A global map of human subcellular architecture yields protein complex structures, reveals protein functions, identifies assemblies with multiple localizations or cell-type specificity and decodes paediatric cancer genomes.

A hybrid extracellular matrix–hydrogel with tunable mechanical stiffness and biochemical composition of young or aged cardiac tissue is used to identify the specific contributions of extracellular matrix ligands and mechanics for fibroblast aging.

Su, Zhao, Jiang and colleagues identify IGFBP6 as an intrinsic downregulator of the inflammatory response lost in disturbed flow-induced atherosclerotic plaque development, suggesting that its restoration may represent a viable therapeutic strategy.

Geopolymers formed in the mineral-catalyzed reaction of organic molecules act as electron shuttles to accelerate microbial dissimilatory iron reduction, which severely threatens the stability of the iron-carbon association in anoxic environments.

The observation of the transition from hcp H₂ to a post-hcp structure with a six-fold larger supercell at pressures above 212 GPa is reported, indicating the trend of H₂ polymerization through molecular association.

A soft mesh microelectrode array can seamlessly integrate in developing brains, enabling long-term, stable mapping of how single-neuron activity and population dynamics emerge and evolve during brain development.

Molecular simulations reveal how diamond and graphite crystallize from molten carbon. Following Ostwald’s step rule, the liquid’s low density drives metastable graphite formation even within the diamond thermodynamic stability zone, explaining discrepancies in high-pressure carbon phase experiments.

Non-intrusive integration of metasurfaces with vertical cavity surface-emitting lasers enables fully arbitrary wavefront control for directional laser emission.

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

Precipitation is a key driver of plant growth. Here the authors integrate ground-based observations, remote sensing and process-based models to disentangle the relative contribution of preceding-year and current-year precipitation on plant productivity and identify its predictors across biomes.

Meta-analyses in up to 1.3 million individuals identify 87 rare-variant associations with blood pressure traits. On average, rare variants exhibit effects ~8 times larger than the mean effects of common variants and implicate candidate causal genes at associated regions.

A clinical study of women with abnormal breast mammograms establishes a workflow to evaluate the capability of breast photoacoustic computed tomography in the classification, monitoring and segmentation of lesions.

A large-scale meta-analysis across eight biobank datasets identifies common genetic variants associated with mosaic loss of the X chromosome in female participants.

According to a neutron-scattering study of the structural and magnetic properties of the pnictide CeFeAsO_1−xF_x, the phase diagram of this material shows considerable similarities with the high-T_c cuprate superconductors. These results are an important addition to the effort to find out where superconductivity in these iron–arsenic alloys arises.

Insulator-to-metal transitions induced by spontaneous magnetization above room temperature have rarely been observed. Here, the authors show that this transition, along with concurrent high-temperature ferrimagnetic order, is realized in the novel 3d/5d hybridized quadruple perovskite oxide CaCu₃Ni₂Os₂O₁₂.

The phase transitions of rare earth nickelates have attracted intensive study as they arise from the complex interplay of charge, spin and lattice degrees of freedom. Here Guo et al. present evidence that LaNiO₃ has an unanticipated magnetically ordered metallic phase.

Methods for studying the adsorption behaviour of molecules onto surfaces under reactive and non-reactive conditions are needed to improve photocatalysts for water treatment. Here the authors develop an imaging technique, adCOMPEITS, to quantify the adsorption of micropollutants on Au/TiO₂ and identify a long-range enhancement effect.

Probing endogenous protein localization and function in vivo remains challenging due to laborious gene targeting and monofunctional alleles. Here, using a toolkit consisting of genetically-encoded epitope probes, their cognate tags, and an array of adapter proteins, the authors describe a methodology that enables visualization and manipulation of endogenous proteins in vertebrate systems.

Powdery mildew disease seriously threatens wheat production by reducing grain yield and quality. Here, the authors clone the Znf-BED-bearing NLR protein encoding powdery mildew resistance gene Pm6Sl derived from wild wheat species Aegilops longissima and show its application in breeding resistance cultivars.

Material implementation of machine learning algorithms for advanced computing at cryogenic temperature remains rare. Here, the authors report a cryogenic in-memory computing platform using chiral edge states of magnetic topological insulators.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.