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Showing 1–50 of 1433 results
Advanced filters: Author: Michael Stark Clear advanced filters
  • Adoptive regulatory T cell (Treg) therapy holds promise for the treatment of a range of immunopathological conditions. Here the authors explore the HLA engineering of allogenic Treg products that avoid T cell and NK cell attack and maintain immunomodulatory function in a human skin-xenograft model.

    • Oliver McCallion
    • Weijie Du
    • Fadi Issa
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Controlling the reactivity of the propagating chain end in polymerization reactions is crucial for achieving well-defined polymers. Here, the authors present a strategy for processive catalytic polymerization by encapsulating catalysts for ring-opening metathesis polymerization into the sub-surface cages of a metal-organic framework.

    • Zefeng Zhou
    • Yang Wang
    • Jia Niu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Turbulence onset in shear flows is often modeled as a memoryless directed percolation (DP) transition. The authors show that in channel flow, turbulent stripes age near the critical point, questioning the DP analogy and revealing geometry-dependent transition dynamics.

    • Vasudevan Mukund
    • Chaitanya S. Paranjape
    • Björn Hof
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Reliable measuring the voltage dynamics of individual neurons in the intact brain is significantly challenging. Here authors developed an all-optical method combining two-photon voltage imaging and optogenetics to measure and induce synaptic plasticity in vivo, revealing LTP of inhibition in cerebellar circuits and providing a blueprint to link synaptic changes to learning.

    • Jacques Carolan
    • Michelle A. Land
    • Michael Häusser
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Two types of on-chip silicon device utilizing silicon T centres are developed: an O-band light-emitting diode and an electrically triggered single-photon source. Further, a new method of spin initialization with electrical excitation is demonstrated.

    • Michael Dobinson
    • Camille Bowness
    • Daniel B. Higginbottom
    Research
    Nature Photonics
    Volume: 19, P: 1132-1137
  • Cells must coordinate cell division with genome replication. Here, the authors combine rapid protein depletion, clinical CDK4/6 inhibitors, and genome-wide EdU sequencing to reveal that the CDK4/6-RB axis ensures timely loading of DNA replication factors in G1 phase in human cells.

    • Anastasia Sosenko Piscitello
    • Ann-Sofie Nilsson
    • Bennie Lemmens
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Observed 730 Myr after the Big Bang, a little red dot is found to anchor an overdensity of eight galaxies and seems to be embedded in a massive host dark matter halo.

    • Jan-Torge Schindler
    • Joseph F. Hennawi
    • Riccardo Nanni
    ResearchOpen Access
    Nature Astronomy
    P: 1-13
  • Mepolizumab (anti-IL-5 therapy) has been shown to reduce type 2 inflammation in asthma. Here the authors use bulk transcriptomics from nasal samples before and after mepolizumab treatment to assess the changes and associations with treatment outcomes.

    • Courtney L. Gaberino
    • R. Max Segnitz
    • Matthew C. Altman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Malaria control and elimination require environmentally safe strategies. Here, the authors propose L-DOPA, a naturally occurring tyrosine derivative, as a mosquito dietary intervention that can shorten lifespan and reduce malaria parasite burden of female Anopheles gambiae mosquitoes.

    • Emma Camacho
    • Yuemei Dong
    • Arturo Casadevall
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • Rare earth mineralisation at Maoniuping formed when its carrying carbonatite brine-melt reacted with surrounding siliceous rocks, forming an antiskarn. The melt lost its fluxing alkali elements, which led to deposition of coarse grained bastnäsite.

    • Yan Liu
    • Michael Anenburg
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Selective chemical upcycling of polyolefin mixtures remains challenging due to the structural similarity of their backbones. Now it has been shown that a single-site nickel catalyst can preferentially and efficiently cleave branched C–C bonds, enabling the hydrogenolytic separation of isotactic polypropylene from mixtures containing both isotactic polypropylene and polyethylene.

    • Qingheng Lai
    • Xinrui Zhang
    • Tobin J. Marks
    Research
    Nature Chemistry
    Volume: 17, P: 1488-1496
  • Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

    • B. Kool
    • K. Verhaegh
    • V. Zamkovska
    ResearchOpen Access
    Nature Energy
    Volume: 10, P: 1116-1131
  • Beck et al. develop a model where striosomes create a flexible “decision-space” that adapts to environmental context and internal state. It explains how we make choices and why decision-making varies between people, and in neuropsychiatric disorders.

    • Dirk W. Beck
    • Cory N. Heaton
    • Alexander Friedman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-30
  • Here, the authors show the emergence of valley-polarized Floquet-Bloch states in 2H-WSe2 upon below-band-gap driving using circularly polarized light.

    • Sotirios Fragkos
    • Baptiste Fabre
    • Samuel Beaulieu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Implementing the Kunming-Montreal Global Biodiversity Framework requires robust commitments from actors across society. However, the Convention on Biological Diversity’s pledge system is still nascent and has structural deficiencies. Integrated guidance on society-wide biodiversity commitments that complement governmental efforts is urgently needed to effectively accelerate progress towards global biodiversity targets.

    • Yun Cao
    • Dandan Yu
    • Haigen Xu
    Comments & Opinion
    Nature Reviews Biodiversity
    Volume: 1, P: 616-617
  • The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

    • Lauri A. Aaltonen
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 82-93
  • Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

    • Claudia Calabrese
    • Natalie R. Davidson
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 129-136
  • Using subnational Demographic and Health Survey data from 75 low and middle-income countries, the authors show that many households lack access to decent living standards as basic prerequisites for human well-being. Major inequalities exist within and across countries and by socio-economic backgrounds.

    • Roman Hoffmann
    • Omkar Patange
    • Kian Mintz-Woo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Analysis of soundscape data from 139 globally distributed sites reveals that sounds of biological origin exhibit predictable rhythms depending on location and season, whereas sounds of anthropogenic origin are less predictable. Comparisons between paired urban–rural sites show that urban green spaces are noisier and dominated by sounds of technological origin.

    • Panu Somervuo
    • Tomas Roslin
    • Otso Ovaskainen
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 9, P: 1585-1598
  • Khan et al. report a non-catalytic function of the methyltransferase SETD2 in regulating nuclear morphology and genome integrity. The SETD2 amino terminus functions as a scaffold helping CDK1 associate with lamins during nuclear-envelope disassembly

    • Abid Khan
    • Cheng Zhang
    • Brian D. Strahl
    Research
    Nature Cell Biology
    Volume: 27, P: 1327-1341
  • Resting T cells are difficult to manipulate, and are a reservoir for latent HIV. Here, the authors develop a lipid nanoparticle formulation with the ability to transfect resting primary human T cells, enabling delivery of mRNAs that result in reactivation of latent HIV. This could help development of HIV cure strategies.

    • Paula M. Cevaal
    • Stanislav Kan
    • Michael Roche
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • The authors use time-resolved scanning near-field optical microscopy to probe the ultrafast excitonic processes and their impact on waveguide operation in transition metal dichalcogenide crystals. They observe significant modulation of the complex index by monitoring waveguide modes on the fs time scale, and identify both coherent and incoherent manipulations of WSe2 excitonic resonances.

    • Aaron J. Sternbach
    • Simone Latini
    • D. N. Basov
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-6
  • Efficient sunlight-to-fuel conversion requires materials that produce long-lived charges, but increasing carrier lifetimes in visible-light-active photocatalysts has proven difficult. Now it has been shown that rapid charge deactivation via metal-centred states prevents long lifetimes and limits photocatalytic performance. These insights bridge solid-state and molecular photochemistry, informing strategies for improved photocatalyst design.

    • Michael Sachs
    • Liam Harnett-Caulfield
    • James R. Durrant
    ResearchOpen Access
    Nature Chemistry
    Volume: 17, P: 1348-1355
  • With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

    • Matthew H. Bailey
    • William U. Meyerson
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-27
  • Electric control of magnetic interactions in a molecular spin-frustrated triangle is demonstrated through experiments and supported by ab initio calculations. This result opens new pathways for scalability by local control of qubit–qubit coupling.

    • Alberto Cini
    • Michael Böhme
    • Maria Fittipaldi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • Understanding how copper nanoparticles evolve under electrochemical conditions is crucial for the development of selective CO2 reduction electrocatalysts. Here the authors prepare well-defined nanocrystals and use advanced operando imaging and spectroscopic techniques to reveal the Cu–CO species-driven dynamic evolution of Cu electrodes.

    • Yao Yang
    • Julian Feijóo
    • Peidong Yang
    Research
    Nature Catalysis
    Volume: 8, P: 579-594
  • Path-integral Monte Carlo (PIMC) techniques are used to simulate thermodynamic properties of warm dense matter but currently suffer from uncontrolled approximations and exponentially scaling computational costs. Here, the authors provide a way to overcome these issues, developing PIMC simulations of warm dense beryllium in agreement with x-ray Thomson scattering.

    • Tobias Dornheim
    • Tilo Döppner
    • Jan Vorberger
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • The ratio between the levels of two synaptic proteins in cerebrospinal fluid predicts future cognitive resilience versus decline among presymptomatic individuals and individuals with early Alzheimer’s disease harboring amyloid and tau pathology.

    • Hamilton Se-Hwee Oh
    • Deniz Yagmur Urey
    • Tony Wyss-Coray
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 1592-1603
  • The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

    • Ludmil B. Alexandrov
    • Jaegil Kim
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 94-101
  • In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

    • Yiqun Zhang
    • Fengju Chen
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • How mitochondria positioning dynamically adapts to changes in cell shape is poorly understood. Here, Bradbury et al. show that cell-size-dependent trafficking of TRAK2 mRNA underpins the cell-size-scaling of mitochondria distribution and activity.

    • Joshua J. Bradbury
    • Georgia E. Hulmes
    • Shane P. Herbert
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • The DNA-dependent protease SPRTN cleaves toxic DNA-protein crosslinks (DPCs). Here, the authors show that SPRTN is activated by DPC-ubiquitylation through an allosteric ubiquitin binding interface. This regulatory mechanism enables precise control of SPRTN activity during DNA repair.

    • Sophie Dürauer
    • Hyun-Seo Kang
    • Julian Stingele
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

    • Maria Koromina
    • Ashvin Ravi
    • Niamh Mullins
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 1393-1403
  • HistoPlexer, a deep learning model, generates multiplexed protein expression maps from H&E images, capturing tumour–immune cell interactions. It outperforms baselines, enhances immune subtyping and survival prediction and offers a cost-effective tool for precision oncology.

    • Sonali Andani
    • Boqi Chen
    • Gunnar Rätsch
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 7, P: 1292-1307
  • The energy potentials created by laser light can trap atoms. An analogous effect that traps electrons in solid-state systems is now proposed. The electron traps are created in quantum wells and wires in the presence of quasiparticles composed of two electrons and a hole. The idea could lead to advances in ultrafast optical and new optoelectronic devices.

    • Martin J. A. Schuetz
    • Michael G. Moore
    • Carlo Piermarocchi
    Research
    Nature Physics
    Volume: 6, P: 919-923
  • The feasibility of Floquet engineering in graphene has been called into question due to its fast decoherence processes. Measurements of graphene’s photoemission spectrum now support the generation of Floquet states in this material.

    • Marco Merboldt
    • Michael Schüler
    • Stefan Mathias
    ResearchOpen Access
    Nature Physics
    Volume: 21, P: 1093-1099
  • Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

    • Matthew A. Reyna
    • David Haan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17