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Efficient adenine base editors (ABEs) often induce bystander and off-target effects. Here, Shang et al. developed a YA (Y = T or C) motif preferred ABE(ABE8e-YA) that minimizes these effects, enabling precise and effective pathogenic mutation correction, disease modeling, and in vivo gene therapy.

K11/K48 branched ubiquitin chains regulate protein degradation and cell cycle progression. Here, the authors report the structural basis of how such a branched ubiquitin chain is recognized by the human 26S proteasome, revealing a multivalent binding mode that underlies selective recognition.

Charge transport and extraction in polycrystalline perovskite films are often hindered by inefficient carrier transfer across grain domain boundaries (GDBs). Here, authors employ supramolecular assisted Rb+ delivery for in-situ GDB bridging, achieving efficiency of 26.02% for perovskite solar cells.

Controlling the reactivity of the propagating chain end in polymerization reactions is crucial for achieving well-defined polymers. Here, the authors present a strategy for processive catalytic polymerization by encapsulating catalysts for ring-opening metathesis polymerization into the sub-surface cages of a metal-organic framework.

Confocal microscopy enables high-resolution, high-plex 3D cyclic immunofluorescence of 30- to 50-µm-thick tissue sections. The approach allows for rich phenotypic assessments of intact cells and intercellular interactions with subcellular resolution.

Integrated scanning probe techniques in combination with first-principles theory unveil the crystallization of electron polarons into quasi-one-dimensional polaron superlattices in individual polypentacene molecules.

The electrochemical stability window and Li⁺ transport limit the energy-dense and fast-charging capability of lithium metal batteries. Here, authors report a trifluoride ether-based electrolyte to stabilize energy-dense lithium metal batteries under high current rates.

Fan, Shang, Song, Chen et al. identify the Integrator–PP2A complex (INTAC) as a key regulator of cancer cell sensitivity to BET inhibitors through directly interacting with the RACK7–KDM5 complex to orchestrate epigenetic silencing in a catalytic-independent manner.

Turing-structured topology electrocatalysts are reported to control the reorientation of interfacial water through the tuning of surface oxophilicity. The optimal Turing catalyst achieves a formate Faradaic efficiency of 92.0% at 1,000 mA cm⁻².

Solid oxide cells for interconversion of hydrogen and electricity typically have planar designs with low performance per unit mass and volume. Zhou et al. fabricate solid oxide cells with 3D architectures, improving space utilization and mass-normalized performance.

Wang and colleagues describe the design and characterization of lipidated nanophotosensitizers, promoting photodynamic suppression of primary tumor growth and inhibition of metastasis by disabling tumor extracellular vesicles.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Commercial solutions to assess air quality and safety in underground mines often suffer from low accuracy, high installation and maintenance costs, without providing data on noxious gases. Here, the authors present a wireless, battery-free sensing platform for environmental monitoring of underground mines.

Polyploidy and subsequent post-polyploid diploidization (PPD) contribute to evolutionary success of plant species. Here, using 11 genomes from all nine subfamilies of Malvaceae as an example, the authors provide evidence to support the “polyploidy for survival and PPD for success” hypothesis.

N fertilization increases N₂O emissions over time by raising soil N availability, lowering pH, and stimulating N₂O-producing microbes, making global fertilizer induced N₂O emissions from cropland ~110% higher than IPCC estimates.

Peer review information

Nature Communications thanks the anonymous reviewer(s) for their contribution to the peer review of this work. A peer review file is available.

Si et al. demonstrated that wheat TaNHLP1 interacts with ABA regulators and RACK1A to increase tiller number, and that promoter variants that elevate TaNHLP1 expression enhance yield. This regulatory module is conserved across plants.

Rechargeable sodium-chlorine (Na-Cl₂) batteries hold promise for grid energy storage but face challenges of corrosive thionyl chloride (SOCl₂) electrolytes. Here, authors introduce a non-corrosive ester as an alternative, enabling Na-Cl₂ batteries with a wide temperature range from −40 to 80 °C.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Developing strong, thermally resistant adhesives for load-bearing applications remains challenging. Here, the authors report a class of solution-sheared supramolecular oligomers that exhibit exceptional adhesive strength and toughness across a broad temperature range.

A dual-site electrocatalyst is developed to greatly enhance methanol production from CO₂ reduction via a cascade process, taking advantage of molecular-scale CO spillover.

Despite the lower device efficiency, tin perovskite based solar cells are preferred choices compared to lead-based counterparts due to much lower toxicity. Here Jiang et al. use a fullerene derivative to greatly suppress carrier interface recombination and obtain record high cell efficiency of 12%.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Doping of Nb₂O₅ materials without phase changes has been proven difficult, with successful doping depending on different factors such as ionic radius similarity. In this work, the authors introduce a high-entropy-doping approach to Nb₂O₅ without phase change with rapid-charging capabilities as a negative electrode for lithium-ion batteries.

Water electrolysis can produce clean hydrogen, but it is limited by the slow anodic oxygen evolution reaction. Now, a local electronic manipulation strategy for stabilizing high-valence Ru single site catalysts has been developed. The catalyst demonstrates efficient bifunctional activity for water electrolysis.

Ocean stratification — density-related layering of seawater — influences oceanographic and climatic processes. This Review outlines observed and projected changes in stratification, noting a 0.8% dec⁻¹ increase in 0–2,000 m stratification from 1960–2024, and a further 1.4% dec⁻¹ increase by 2100 under SSP2-4.5.

Visible-light integrated photonics enables compact optical systems for biosensing, quantum information, and atomic clocks. Here, authors demonstrate a vector spectrum analyzer with over an octave of bandwidth and MHz accuracy for broadband characterization of visible-light integrated devices.

Through a synthetic-bioinformatic natural product approach combined with peptide optimization, a nature inspired antibiotic, paenimicin, was identified from Paenibacillaceae family. Paenimicin features a dual-target mechanism of action and shows broad-spectrum activities against multi-drug-resistant pathogens both in vitro and in vivo.

Overcoming the suppressive tumor microenvironment (TME) is crucial to improving the efficacy of cancer therapy. Here the authors show that, in mouse cancer models, administration of exogenous IL-16 establishes a Th1-dominant TME via regulation of glutamine catabolism and triggers a Th1 cell-macrophage crosstalk, enhancing anti-tumor immune responses and the efficacy of immunotherapy.