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Heart failure affects millions worldwide with limited treatment options. Here, the authors develop a biodegradable, self-powered vagus nerve stimulator that attenuates cardiac damage at different disease stages without requiring battery replacement or surgical removal.

Optical heterostructures have potential in integrated photonics and optoelectronics but are challenging to prepare in single-component systems. Here, the authors report an intrinsic optical heterostructure in an organic nanosheet, with enhanced fluorescence in an inner zone.

Reconciling broad substrate generality with high enantioselectivity remains a core limitation of enantioselective catalysis. In this study, the authors design a new-to-nature photoenzyme that unlocks enzymatic deracemization of structurally diverse allenes, an entropically disfavored process inaccessible to natural biocatalysts.

Electrochemical urea oxidation can coproduce nitrite and H₂, but it typically lacks selectivity. Here, the authors address this issue by designing doped Lewis acid sites to trigger a hydroxyl spillover mechanism, resulting in highly selective nitrite production and efficient energy conversion.

The authors report superconducting topological surface states (TSS) on MBE-grown Fe(Te,Se) films by high-resolution laser-ARPES. Near the FeTe limit, the surface state disappears due to an electron-correlation-driven topological transition associated with decoherence of the d_xy-orbital-derived bands.

Untargeted metabolomics faces challenges in metabolite origin inference and metabolite annotation. Here, the authors present TidyMass2, a user-friendly computational framework with metabolite origin inference and feature-based functional module analysis to enhance biological interpretation.

A four-qubit quantum error detection circuit with stabilizers can be implemented with spin qubits in a donor-based silicon quantum processor.

Engineered bacteria sense gut bleeding and secrete repair materials.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

A self-powered symbiotic transcatheter pacemaker that regenerates energy via electromagnetic induction from the cardiac motion demonstrates a month-long operation in a porcine model of arrhythmia and surpasses the critical energy condition for lifelong service.

Zhu, Zhao, Wang et al. describe G-NECNet, a deep learning model for detecting gastric neuroendocrine carcinoma (G-NEC) from H&E-stained biopsy whole-slide images without the need for additional immunohistochemistry. G-NECNet achieves high diagnostic accuracy across multiple datasets.

A chromosome-level Bactrian camel genome and multi-omics comparisons reveal adaptive evolution and convergent selection in desert ungulates, highlighting lipid/sterol metabolism—especially INSIG1—as a key driver of metabolic flexibility for desert survival.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Monocytes/macrophages exert pro-atherogenic functions depending on their metabolic programming. Here, the authors show the pivotal role of methionine metabolism in the proinflammatory and migratory functions of monocytes/macrophages and identify MAT2A as a potential target for the management of atherosclerosis.

Modelling suggests the carbon cost for nitrogen assimilation by plants will rise substantially under future climate change with further increase at higher latitudes, due partly to enhanced contributions of soil inorganic nitrogen.

Inspired by nature, this study reports a dual-gradient aerogel via freeze-casting. It blends flexibility with rigidity, offers high sensitivity and wide range, withstands extreme heat and cold, with promise for integration in spacesuits.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

DNA data storage is an alternative to silicon-based data storage, but it demands advanced encryption and readout techniques. Here, the authors present an enhanced DNA origami cryptography protocol for data storage, using DNA-PAINT super-resolution imaging and unsupervised clustering to retrieve information in DNA cryptography.

IBI318 is a recombinant bispecific IgG1 antibody that targets PD-1 and PD-L1. Here the authors report the results of a phase II trial of IBI318 combined with the receptor tyrosine kinase inhibitor lenvatinib in patients with advanced non-small cell lung cancer with acquired resistance to first-line immune checkpoint inhibitors.

Oximes are used in many scientific and industrial domains, ranging from organic synthesis through biotechnology to materials science. Here the authors introduce an approach that enables the synthesis of oximes from hydrocarbons via the oxidative oximation of methylene C-H bonds — the most prevalent molecular unit in the world of molecules.

This study defines a two-receptor entry mechanism for coxsackievirus A6: heparan sulfate for initial attachment and KRM1 for uncoating. Protective antibodies that block KRM1 binding were identified, offering a path for therapeutic development.

CABLE harnesses cytoarchitectural information such as cell or nuclear shape to infer fiber tracts in the brain of, for example, marmosets, macaques or humans.

An avian influenza H7N9 virus causes severe human disease, including acute and often lethal respiratory failure. Here, the authors report that plasma levels of angiotensin II, a regulatory peptide of the renin–angiotensin system, are associated with disease severity and fatal outcome in infected patients.

Heatwaves pose a growing threat to cities, and vegetation is often touted as a mitigation option. This study finds that while lawns provide a burst of intense cooling, trees access deeper water and provide moderate but more prolonged relief.

Unnatural α- and γ-amino acids display a diverse range of biological activities and serve as crucial intermediates in pharmaceutical production. Here, the authors report a four-component reaction to facilitate the switchable synthesis of α- and γ-amino acids from a shared extended p-quinone methide through a tailored amination strategy.

The ALPK1 agonist UDSP-Hep stimulates tumour-cell antigen presentation, macrophage–DC cross-priming and differentiation of protective memory T cells.

Here, the authors show that a human gut fungus, Clavispora lusitaniae P4013B, alleviates colitis in mice through the activation of the aryl hydrocarbon receptor, in turn mediated by its metabolite indole-3ethanol, indicating its potential as a probiotic for inflammatory bowel disease.

HOM formation from a same VOC can vary by over a factor of three depending on chemical conditions. A RO₂ oxidation fraction concept explains this variability and cautions against directly applying lab yields to the atmosphere.

Here, the authors structurally and biochemically characterise the YcfA-YcfC enzyme system, crucial for biosynthesis of the anticancer and antimicrobial agent 6-thioguanine.

We experimentally demonstrate the deterministic entanglement-assisted quantum communication based on the continuous-variable entangled state over 20 km fiber channel.

Creating different pore environments within a covalent organic framework (COF) leads to useful multicompartment structure and multiple functions. Here, the authors propose a strategy to construct amphiphilic COFs with separated hydrophilic and hydrophobic nanochannels by precisely controlling the distribution of hydrophilic and hydrophobic segments in two different kinds of pores.

Stereodivergent construction of non-adjacent stereocentres remains challenging in asymmetric synthesis, with prior examples limited to one cyclic or allenic stereocentre. Now it has been shown that Ni-catalysed migratory hydroalkylation of trisubstituted alkenes enables enantio- and diastereodivergent access to all four stereoisomers of acyclic molecules bearing remote 1,3- or 1,4-stereocentres.

By resonant excitation of an InAs quantum dot embedded in a microcavity, a deterministic single-photon source is demonstrated. Single-photon purity of 0.9795(6), photon indistinguishability of 0.9856(13), and an overall end-to-end efficiency of 0.712(18) are simultaneously obtained.

To overcome the transverse wrinkles and voids between MXene nanosheets, the authors fabricated MXene fibers via a combination of static filling and dynamic thermal drawing, achieving optimized mechanical and electrical performance.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Water in the mantle transition zone beneath Northeast Asia is sourced from the Earth’s surface and introduced by the subducted Pacific slab, according to a study of potassium isotopes from Cenozoic volcanics.