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High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease in which macrophage-driven inflammation plays a central role. Here the authors show that macrophage Gsα promotes AAA by stabilizing NLRP3 inflammasome activity, while Gsα silencing via lipid nanoparticles suppresses inflammation and disease progression.

Thermogenic adipocytes are a potential therapy to combat obesity, although the process underlying their activation remains unclear. Here, the authors use epigenetic profiling to demonstrate RUNX1 and RUNX2 inhibit thermogenesis by distinct mechanisms.

Decoding skin gases can reveal a lot about our health. Here, the authors introduce a monolithic AI-powered wearable ring designed to non-invasively monitor dermal volatile-organic-compounds associated with diet-related metabolism.

The cellular origin and developmental trajectory of DICER1 syndrome-associated tumors are currently unknown. Here, the authors employ a lineage-traceable genetically modified mouse model for DICER1 syndrome to identify universal fibroblasts as the likely cellular origin of mouse Dicer1 sarcoma and map their developmental trajectory, findings that are validated in human DICER1 mesenchymal tumors.

Single-atom catalysts excel in selective hydrogenation but are limited by insufficient binding sites for larger multidentate substrates. Here, the authors report a heteronuclear Rh–Co dual-atom catalyst anchored on defective graphene, overcoming the activity–selectivity trade-off in nitrile hydrogenation.

Removing trace acetylene from ethylene is vital for plastic production, yet catalysts often overreact and waste the product. This work reveals that palladium dual-atom catalyst on carbon greatly speeds the reaction while keeping ethylene intact.

This randomized open-label trial shows that hemoadsorption combined with hemodialysis reduces all-cause and cardiovascular mortality, and cardiovascular events in patients with end-stage kidney disease compared to hemodialysis (mainly low-flux hemodialysis plus intermittent hemodiafiltration) alone.

Self-aggregation in self-assembled monolayers adversely affects on hole transport performance in inverted perovskite solar cells. To address this issue, Shen et al. propose an indole/carbazole co-adsorption strategy to construct phase-homogeneous monolayers featuring alternating molecular arrangements.

Cancer stem cells contribute to cancer evasion and relapse by suppressing the immune response. Here, the authors identify sterol O-acyltransferase 1 (SOAT1) as a cancer stem cell immune checkpoint and propose that SOAT1 inhibition results in oxysterol-mediated reprogramming of intratumoral regulatory T cells via a trans-cellular 20SOHC-GPR132, ultimately enhancing anti-tumor immunity in various preclinical mouse models.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

Strong optical anisotropy is commonly achieved by complex engineered materials. Here, authors synthesize elemental crystals of type-II red phosphorus made of wavy tubular structures, exhibiting strong birefringence in the visible and near-infrared spectral region. They demonstrate anisotropic photoluminescence, Raman scattering and second-harmonic generation.

Photocatalytic CO₂ reduction is fundamentally limited by inefficient utilization of solar energy, particularly low-energy photons. Here, the authors report a nanoscale greenhouse structure (Bi@Fe₂O₃) that enables cascaded full-spectrum solar utilization and enhances solar-driven CO₂ reduction with water to CH₄.

Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,671 high-confidence complexes that uncover new higher-order structures and evolutionary links.

Efficient electrical control of domain walls underpins fast, low-energy magnetic memories. Wu et al report field-free domain wall velocities of 1 km s⁻¹ at 20 MA cm⁻² in ferrimagnetic NiCo₂O₄, arising from giant nonadiabatic spin-transfer torque.

The GABA_B receptor is a mandatory heterodimer. Here authors show the existence of GABA_B dimers of dimers in neurons, and their relevance in human health. By solving the structure of this tetramer, they show the structural basis for a negative cooperativity between the dimers within such a complex.

Using an evolutionary optimization approach, the authors report a culture medium that matures stem cell-derived heart cells, improving their structure, metabolism and electrical activity to advance highly functional models for in vitro testing.

Designing complex carbon frameworks for specific applications often relies on trial-and-error. Here, authors integrate machine learning and interfacial mechanisms to evolve graphene quantum dot carbon frameworks, enabling selective detection and clearance of metabolically reprogrammed senescent cells.

This study reveals that coagulation pretreatment can unexpectedly worsen reverse osmosis membrane fouling by altering solution chemistry and microbial behaviour, challenging its role in long-term membrane performance in zero-liquid discharge systems.

Given the interest in extracellular vesicles there is a need for simple short scaffold proteins for efficient targeting and cargo loading. Here, the authors identify a candidate scaffold protein and find the truncated version allows for efficient loading which outperforms current scaffold proteins, demonstrating application in sepsis therapy.

Major depressive disorder involves disrupted molecular polarity homeostasis, with conventional antidepressants hindered by delayed onset and drug resistance. Here, the authors engineered near-infrared-responsive IC@His-ICG nanomotors for photochemical polarity switching, achieving targeted hippocampal neuromodulation in rodents to restore monoamine balance and relieve depression/anxiety.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

The growth of the smallest aerosol particles is critical to their impacts on climate and air quality. Here, the concentration gradient of nanoparticles is shown to be an important microphysical mechanism for their rapid initial growth.

The impact of the environment on the health of individuals has been of interest in recent years with some protective effects shown against conditions such as depression and anxiety. In here the authors show that exposure to green space and the natural environment is associated with a decreased risk of depression among cancer survivors.

Conventional methods for constructing 2,5-dihydropyrroles often rely on elaborate multi-step procedures or complex starting materials. Herein, the authors describe a palladium-catalyzed chemodivergent protocol for synthesizing functionalized 2,5-dihydropyrrole scaffolds from readily accessible 1,3-enynes and anilines.

An oxidative activation strategy using pyridyl phosphonium salts and potassium persulfate is reported. This approach, which governs the reaction pathway, enables the synthesis of C4-fluorinated and C4-trifluoromethylaminated pyridines with a broad functional group tolerance and is used for the late-stage synthesis and modification of bioactive molecules.

Antifungal aureobasidin A (AbA) targets inositol phosphorylceramide (IPC) synthase. The authors trap its ceramide-bound and drugbound states, revealing the catalytic and drug-inhibition mechanisms, providing basis for antifungal drug development.

Development of the pangenome-informed genome assembly (PIGA) workflow enabled the generation of 1,116 diploid genome assemblies (55 de novo and 1,061 pangenome-informed), representing an extensive resource of medically relevant genic variations.

Pulmonary fibrosis is a progressive lung disease characterized by scarring and impaired function, with vascular endothelial cells playing a key role in disease progression. Here, the authors show that endothelial mechanosensitive PIEZO1 promotes fibrosis by activating the CAPN2-STAT3-IL-33 signaling axis, identifying a promising therapeutic target for treatment.

This study reported widespread declines in resilience after multi-year droughts and showed that biodiversity and climate strongly shape forest resilience after multi-year droughts, but human footprint makes biodiversity’s contribution consistently and strongly negative.

Mass spectrometry (MS)-based proteomics is increasingly central to systems biology. Here, the authors present a high-throughput, multi-organ workflow that profiles 11,472 proteins in 507 mouse samples, enabling rapid, system-level evaluation of drug efficacy and toxicity.

The mechanism of respiratory viral infection impacting distant immune responses in the uterus remains to be explored. The authors here identify pulmonary infection induces IL1R2⁺ myeloid cells migration to decidua, disrupting gestational immunity. Dipeptidyl peptidase 4 (DPP4) inhibitor treatment curbs this cell accumulation and alleviates immune dysregulation.

Variant mapping of sorghum promoters identifies CRISPR-accessible mutations that upregulate gene expression.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

An integrative neuroimaging and modelling framework dissociates critical-period language experience from sensory deprivation in congenital deafness, identifying gradient signatures of experiential brain plasticity.

Abrupt transitions from drought to extreme precipitation occur more often under higher atmospheric greenhouse gas levels, and are favored through the influence of soil moisture deficits on convective precipitation, revealed by a global assessment based on reanalysis data and climate model projections.

Zheng et al. show that extending the guide RNA restores the reduced activity of a high-fidelity CRISPR–Cas9 enzyme while preserving accuracy, revealing how strengthened PAM-distal interactions can improve genome-editing performance.

Moiré superlattices are a versatile platform for studying emergent electron and quantum phenomena. Here, the authors demonstrate moiré superlattice formation in complex oxide-WS₂ heterostructures across varying twist angles.

Chen et al. introduce SequenTx, a virtual-cell-inspired framework for the rational design of sequential therapy. It offers a computational strategy to navigate therapy-induced tumour evolution by modelling dynamic cellular state transitions.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

The longevity of leaves determines the overall duration of photosynthesis for plants. This study suggests that climate change drives leaf longevity convergence toward intermediate ranges, which, by altering leaf traits and enhancing photosynthetic capacity, strengthens ecosystem stability and is closely linked to vegetation diversity.

By analysing genome-wide cfDNA fragmentation, a prospective case-control study develops a machine learning model that sensitively detects early breast cancer, classifies tumour subtypes, and assesses lymph node involvement from a single blood draw

CellVoyager is an artificial intelligence agent capable of exploring new biological hypotheses by autonomously analyzing single-cell RNA sequencing datasets and accounting for background information and prior analyses.