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DISC1 has pleiotropic functions and is strongly associated to mental disorders. Here, authors reveal a tetrameric core of DISC1 that impinges on well conserved, bacteria derived dimerisation domains. Importantly, such arrangement confers multivalency in DISC1 binding to its many partners.

Self-aggregation in self-assembled monolayers adversely affects on hole transport performance in inverted perovskite solar cells. To address this issue, Shen et al. propose an indole/carbazole co-adsorption strategy to construct phase-homogeneous monolayers featuring alternating molecular arrangements.

Meiotic sex chromosome inactivation is essential for spermatogenesis, but how transcription is silenced after initiation remains unclear. Here, authors show that nucleolar components NPM1, SENP3 and rRNA form a phase-separated compartment that excludes RNA polymerase II to enforce XY chromosome silencing.

A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.

Commercial live attenuated influenza vaccines (LAIVs), usually contain a high proportion of defective interfering particles (DIPs), are not sufficiently protective. With mice models, the authors here reveal that LAIV with low DIPs replicates better, enhances immune response and facilitates cross-neutralization protection against lethal challenge of influenza strains.

Ubiquitin tagging controls protein fate, but how the COP1-DET1 E3 ligase works was unclear. Here, the authors present cryo-EM structures of an inactive stacked assembly that switches to an active dimer on substrate binding, with DET1 guiding enzymes to start and co-workers to extend ubiquitin chains.

The limited scalability of 1D semiconductors has restricted their large-area optoelectronic applications so far. Here, the authors report the low-temperature synthesis of wafer-scale van der Waals nanomeshes composed of self-welding Te nanowires on various substrates, showing improved transport and photoelectric properties.

Dang et al. integrate GWAS with functional genomics to analyze 15 common autoimmune diseases, mapping interconnections and differences in target genes, association signals, and the immune cell types in which signals act. They show cell-type-specific signals within loci, prioritize associated genes, and identify shared and distinct functional modules, clarifying regulatory mechanisms.

This study introduces a meta-lens-based hyperspectral radiation thermometry that accurately measures temperatures up to 2973 K with error lower than 0.32%. The method is six times more precise than current methods and holds protentional for developing miniaturized, two-dimensional temperature sensors.

ANKLE1 senses DNA tension and negative supercoiling, enhancing cleavage of stretched, supercoiled DNA to resolve chromatin bridges, highlighting its unique mechanosensitive role in maintaining genome stability during cell division.

Flooding threatens urban economies via direct damages and supply-chain disruptions. Losses grow nonlinearly: wealthier cities incur larger absolute losses, while poorer cities face higher relative impacts, highlighting tailored resilience measures.

The role of protein UFMylation in cancer remains to be understood. Here, the authors show that UFM1-specific ligase 1 and AKT positively regulate each other through UFMylation and phosphorylation, facilitating lipid synthesis and breast tumor growth.

The development of sustainable water oxidation catalysts is crucial for hydrogen production, yet cobalt-based materials often suffer from instability. Here, the authors report that co-doping LiCoO₂ with nickel, iron, and palladium yields a durable electrode with stability of over 2,000 hours.

The genomic characterisation of nasopharyngeal carcinoma (NPC) remains crucial. Here, the authors perform whole-genome sequencing for 70 NPCs with EBV gene expression, report the somatic alterations and EBV-mediated effects converging on NF-κB activation and immune escape and identify targetable homozygous MTAP deletions.

Heterostructures combine the unique properties of each constituent, improving the efficiency and stability of perovskite-based optoelectronic devices, yet the films suffer from poor compositional and structural uniformity. Here, the authors demonstrate a ligand-assisted welding process to fabricate a series of epitaxial 2D and 3D perovskite heterostructures.

Achieving wireless and high charge density neural stimulation remains challenging. To address this issue, the authors develop a sonocapacitor from piezoelectric-dielectric composite nanospheres and two-dimensional cellulose.

It is highly desired to explore cheap, non-toxic transition metals catalysts for semihydrogenation of acetylene. Here, isolated Cu atoms anchored onto a defective nanodiamond-graphene support exhibit robust catalytic performance in acetylene semihydrogenation in comparison with supported Cu clusters.

Previous clinical studies suggested that Insulin-like growth factor binding-protein 7 (IGFBP7) is elevated in early stages of diabetes. Here authors showed tubule and glomerular-specific IGFBP7 promotes diabetic kidney disease.

Current aqueous zinc-metal batteries present poor cryogenic performance caused by kinetic sluggishness and interfacial instability. Here, authors propose an aqueous electrolyte with a medium‑permittivity window by mixing a high ‑ε and a low‑ε component (ethyl acetate), enabling battery cycling up to −50 °C.

Non-Hermiticity is usually considered detrimental to quasiparticle physics. Here, the authors show that such an assumption of Hermiticity can be lifted in the context of a lattice model containing two non-Hermitian Dirac cones, with one hosting amplifying Dirac quasiparticles and the other hosting decaying ones.

The presentation of systemic lupus erythematosus has been known to differ by ancestry, but the underlying genetic factors remain unclear. Here, the authors report ancestry-specific susceptibility loci and better risk prediction when using data from matched ancestral groups.

The combination of plasmon-mediated electron enrichment and a continuous-flow reactor overcomes key challenges in selective methane oxidation, achieving a methanol production rate of over 6.5 mmol·g-1·h-1 with the selectivity of 100% and sustained stability over 100 h under ambient pressure.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

A membrane system operating without electricity and inspired by natural fractal transport patterns achieves exceptional nanofiltration performance, offering a simple and reliable source of potable water for decentralized communities.

Smart windows offer more efficient sunlight modulation and heat management. Here, the authors propose a co-assembly strategy to produce smart windows that combine electrochromic and thermochromic functions with tunable components and ordered structures for dynamic solar radiation regulation.

Fe-cyclopentadienone complexes have been widely utilized in various hydrogenation and dehydrogenation catalytic processes, yet their applications have largely been restricted to non-asymmetric versions. Herein, the authors report the synthesis of a chiral Fe- cyclopentadienone complex and its application in the catalytic asymmetric hydrogenation of acylsilanes.

Maintaining lower temperature is critical for the quality of grain storage. Here, authors explore the applicability of radiative cooling material applied to granary in ten climates, and demonstrate its broad potential for promoting sustainable storage, especially in resource-constrained regions.

Generalizable Pathology Foundation Model (GPFM) consolidates expertise from a variety of existing models for use in a broad spectrum of computational pathology tasks.

Short stature is a hallmark of Werner Syndrome, but the underlying mechanisms are not well studied. Here they report that WRN regulates bone development and growth by opening SHOX-G-quadruplexes via its helicase activity both in vitro and in vivo.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Signalosomes amplify cellular responses, but how they avoid uncontrolled activation is unclear. The authors use quantitative super-resolution imaging and mathematical modeling to reveal optimal RIP3:RIP1 ratios that ensure precise cell death signaling.

Teng and Zeng et al. use cryo-electron microscopy to show that the crescent scaffold of KICSTOR anchors GATOR1 to lysosomes and disruption of the interaction causes mTORC1 hyperactivation and TFE3 mislocalization. KICSTOR enables nutrient-dependent mTORC1 regulation by binding anionic lipids for lysosomal targeting.

Iodide promotes HONO production during nitrate photolysis by influencing the surface enrichment of nitrate, accelerating reactive nitrogen cycling in the marine atmosphere.

Catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a challenge, due to the limited catalytic systems and substrate scope. Herein, the authors report the enantioselective azidation/click cascade reaction of N-propargyl-β-ketoamides via copper catalysis, affording a variety of chiral 1,2,3-triazoles.

The authors cloned anti-NMDAR (N-methyl-d-aspartate receptor) monoclonal antibodies from the immune B cells of persons with autoimmune encephalitis and revealed their precise binding epitopes on NMDARs and the pathological mechanism underlying the downregulation of synaptic function.

RNA editing provides epigenetic diversity and is thought to be decreased in cancer. However, this report describes a phenomenon of increased RNA editing associated with malignancy in human liver tumors. The increased editing of AZIN1 is facilitated by the correlative increase in the editing enzyme ADAR1 and induces an amino acid change that leads to subcellular relocalization, increased stability and affinity for antizyme. This effect impairs antizyme's function and increases the stability of its target oncoproteins, providing protumorigenic functions. The hyperediting of AZIN1 is a protumorigenic event in liver cancer pathogenesis.

The high cost of Pt severely limits fuel cell deployment, but alternative Pt-free catalysts suffer from a low activity and, especially, durability. Now, a low-Pt-content catalyst consisting of Pt and Fe single atoms, dispersed on a nitrogen-doped carbon matrix, and Pt–Fe nanoparticles is shown to exhibit excellent activity and durability in fuel cells.

It remains a great challenge to achieve large-scale fabrication of single atom-anchored heterostructured catalysts with high stability, low cost, and convenience. Here, the authors report single iron atom-dispersed Mo-based nanosheets synthesized from a scalable two-dimensional mineral hydrogel approach for hydrogen evolution reaction in alkaline condition.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.