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Emerging evidence underscores biophysical characteristics of cancer cells as key modulators of cancer metastasis. Here, the authors reported a single-cell mechanophenotyping chip that screens deformable CTCs to reveal the hematogenous metastatic potential of bacteria-infected breast cancer.

Extracellular contractile injection systems (eCISs) are bacteriophage tail-derived toxin delivery complexes that are present in many prokaryotes. Here, the authors present an analysis of eCIS tail fiber genes in bacterial and archaeal genomes, providing insights into their diversity, target cells, functional adaptations, and evolutionary dynamics.

The authors report the time-reversal symmetry breaking superconductivity in the thin-flake kagome material RbV3Sb5, manifesting primarily as an unconventional form of hysteresis that is not observed in CsV3Sb5. They also observe reentrance of superconductivity during an in-plane field-sweeping process at 400 mK.

Leveraging electron-phonon coupling allows for modulating self-trapped exciton formation for broadband white-light emission. Using transient spectroscopy and DFT calculations, Zhang et al. correlate the structural distortion with self-trapped exciton formation in 2D halide perovskites.

Precise surface engineering of nanoparticles is essential for advancing bioimaging technologies, yet achieving atomically controlled ligand functionalization remains a challenge. Here, the authors develop an interphase-assisted ligand exchange method, which leverages mass transfer resistance between immiscible phases to precisely control the concentration of foreign ligands interacting with gold nanoclusters.

Banerjee and colleagues find that activity within the orofacial motor cortex in a highly vocal rodent reflects different features of the produced song, forming a hierarchical control network with downstream structures to guide vocal production.

How site-specific tumor microenvironment (TME) drives the metastasis of high-grade serous ovarian cancer (HGSOC) remains unclear. Here, the authors employ an integrated single cell multi-omics approach to map the spatiotemporal heterogeneity of HGSOC metastasis TME and identify an interaction network within the TME driven by SELENOP⁺ macrophages and pre-exhausted CD8⁺ T cells.

Hepatectomy is an important part of hepatocellular carcinoma (HCC) treatment but postoperative recurrence limits long-term survival. Here, the authors report a phase II clinical trial investigating perioperative tislelizumab (anti-PD-1) and lenvatinib (multi tyrosine kinase inhibitor) in patients with resectable HCC with a high-risk of recurrence.

Subtle variation can reshape protein structure but are hard to identify. Here, authors present MELO, which measures and locates structural changes, outperforms existing tools, and uncovers over 10,000 previously missed protein structure change pairs.

Benchmarking greenhouse gas emissions from wastewater treatment plants is an essential step in developing mitigation strategies. This is now achieved for the USA by modelling over 15,000 facilities using Monte Carlo simulations to obtain a national baseline.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Strong paramagnetism is generated in hydrogels rich in carbon–oxygen double bonds simply by coupling with diamagnetic Ca cations. These paramagnetic hydrogels are applied as magnetic resonance imaging contrast agents and magnetic drug carriers.

CDK4/6 inhibitors are promising treatments for ER+ breast cancer, however resistance remains a challenge. Here, the authors analyse the NeoPalANA cohort and indicate that a 33 gene signature was predictive of response to neoadjuvant anastrozole and palbociclib.

A flexible digital artificial intelligence chip with a compute-in-memory architecture is fabricated using a commercial low-temperature polycrystalline silicon thin-film transistor process and shows high accuracy in human daily activity monitoring using multimodal physiological signals.

Here, in a large-scale clinical trial, the authors associate gut microbiota composition and metabolic status with effectiveness of dietary fiber intervention in prediabetes, and provide a clinically applicable model to guide microbiome-targeted personalized medicine.

A four-qubit quantum error detection circuit with stabilizers can be implemented with spin qubits in a donor-based silicon quantum processor.

The authors found esterified pectin localized at the stiff poles of maize stomata, modulating stomatal opening. These results reveal novel targets for stomatal engineering and breeding crops with higher water use efficiency.

Wearable silent speech systems hold potential for restoring communication in patients suffering from speech impairments. Tang et al. report an AI-driven silent speech system for dysarthria patients, which enables zero-time-delay expression and context-aware emotion decoding-based sentence expansion.

Flooding threatens urban economies via direct damages and supply-chain disruptions. Losses grow nonlinearly: wealthier cities incur larger absolute losses, while poorer cities face higher relative impacts, highlighting tailored resilience measures.

Although methods to enantioselectively assemble consecutive carbon stereocenters are abundant, establishing enriched continuous heteroatomic stereocenters remains a challenge. Here the authors report a protocol to synthesize continuous heteroatomic stereocenters from cyclic amine boranes and diazo compounds via asymmetric B-H insertion reaction.

Controllable and scalable phase transition of transition metal chalcogenides is challenging. Using in situ microscopic analysis, a non-stoichiometric phase transition from PdTe₂ to PdTe is observed on the atomic scale, providing mechanistic insights into the scalable phase engineering of transition metal chalcogenide films and heterostructures.

Parasitoid wasps are reared and released as biocontrol agents to manage aphids and protect crops. Here, the authors use genomes from 542 wasps to show that, in spite of wide scale release of low-diversity captive individuals, diversity in wild populations is maintained.

A wearable paper-based microfluidic device tracks cortisol in sweat via gold nanoflower colorimetric assays and captures circadian rhythms, stress responses and jet lag disruptions.

The efficiency of selenium photovoltaics is hindered by the poor crystallization of the Se film. Wen, Li, Lu and colleagues use light to initiate Se crystallization, suppressing dewetting and enabling the formation of a continuous film, which achieves a certified efficiency of 10.3%.

PAK4 promotes Mdm2-mediated NLRP1 ubiquitination and degradation by phosphorylating Mdm2 at Ser186, thereby suppressing GEM-induced pyroptosis via the NLRP1/caspase-9/caspase-3/GSDME axis in pancreatic cancer cells

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

The bridging hydride species (Zn–H–Zn), commonly formed through H₂ dissociation on ZnO surfaces, are essential for hydrogenating unsaturated hydrocarbons. Here, the authors show that surface hydroxyls on ZnO nanorods can migrate to nearby oxygen vacancies and similarly generate reactive Zn–H–Zn species, which they identify by solid-state NMR spectroscopy as active in CO₂ hydrogenation to methanol.

Monitoring charge carrier dynamics and photocatalytic reaction rates in individual photocatalyst particles is a challenging task that can help us to understand structure–reactivity relationships. Here single-molecule fluorescence imaging is coupled with femtosecond interferometric scattering microscopy to investigate these properties in 2D InSe flakes.

SpatialZ generates virtual single-cell spatial transcriptomics slices between experimentally measured sections, enabling accurate and efficient building of 3D cell atlases of different tissues.

Birds uniquely exhibit high expression of constitutively active GCGR in white adipose tissue (WAT) enhancing lipid metabolism, WAT browning, and weight loss in mice. A naturally occurring human GCGRH339R mutation mimics this avian-like metabolism, suggesting therapeutic potential for obesity

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Infants listened to lullabies and other songs recorded in cultures and languages that were unfamiliar to them. They relaxed more in response to the lullabies. This suggests that infants may be predisposed to respond to common features of lullabies.

Diverse plant species synthesize salicylic acid from phenylalanine through a pathway that includes a conserved triple-enzyme module that converts benzoyl-CoA to salicylic acid.

A mechano-intelligent transmission mechanism based on the slipknot delivers precise force signals for clinical practice and robotic operations such as minimally invasive surgery and tendon-driven robotics.

Proteolysis-targeting chimeras (PROTACs) hold therapeutic promise but face challenges of high molecular weight, polarity, and poor drug-like properties. Here, authors develop PLA-based SM-PROTACs that achieve efficient target degradation and superior low-dose, long-term tumor inhibition in vivo

The SpatialEx(+) framework uses histology to generate and integrate complementary spatial multi-omics data across samples.

Multielectron molecular CO₂ reduction in acid is challenged by weak CO binding and competing hydrogen evolution. Here a methanol Faradaic efficiency of 62% is achieved in acid by tuning the microenvironment with cationic, hydrophobic and aerophilic layers.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.