Search

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Extracellular vesicles from lung epithelial cells deliver ACE2 and TMPRSS2 to recipient cells, enabling SARS-CoV-2 infection beyond receptor-expressing cells and expanding viral tropism.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

AlphaFold’s success in protein structure predictions has led to similar attempts to predict interactomes. Here, the authors demonstrate that AI-based screens are very limited in discovering truly novel interactions compared to experimental screens, exposing open challenges in interaction prediction.

The genomewide meta-analysis of lumbar spinal stenosis LSS identifies 73 previously unreported loci in addition to 15 known loci and highlights spinal degeneration as a key pathogenic mechanism. Overall, the findings expand knowledge of the genetic background of LSS.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Genome annotation typically requires costly experimental assays across diverse cell types, limiting its scalability. Here, authors introduce BioSeq2Seq, a deep learning framework that leverages DNA sequence and run-on sequencing (RO-seq) data to accurately predict histone modifications, functional elements, gene expression, and transcription factor binding sites.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

Orbital hybridization and quantum confinement are used to realize Ising-like superconductivity in trilayers of gallium, which alone is probably not strongly enough spin–orbit coupled to host such superconductivity under high in-plane magnetic fields.

Three-body low-energy s-wave states play an important role in few-body physics and associated universal phenomena, yet their experimental observation in nuclear system has been elusive. Here, the authors identify the three-body s-wave properties in neutron-rich ¹⁰He nuclei with improved statistics and sensitivities.

Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic derivatives.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Here, authors demonstrate an ultrafast time-gating protocol using a sub-micron-thick layer of epsilon-near-zero indium-tin oxide, yielding a strong four-wave mixing signal while reducing scattering and scintillation.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

A deep learning framework integrates protein language models, protein interactions and domains, medical knowledge graphs and electronic health records to map variants to phenotypes.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Cerebellar Purkinje cells feature intrinsic activity early in postnatal development. Here, the authors show that disrupting this early activity impairs gene expression, morphological development, and motor function, linking deficits to cerebellar disorders.

Divergent white matter metabolic patterns reveal a mechanistic basis for cognitive resilience and enhance prediction of future cognitive decline beyond established aging and dementia biomarkers.

The authors deplete the cohesin activator NIPBL during the mitosis-to-G1-phase transition. They observe that structural loop formation is impaired proportionally to loop length, while gene activation and enhancer–promoter interactions are only mildly impaired.

Argon-42 is a background in experiments that search for dark matter or neutrinoless double-beta decay. Now, the isotope’s abundance is measured by combining a laser-based atom trapping technique with isotope pre-enrichment.

A deep-tissue light source made from mechanoluminescent transducers stimulated by focused ultrasound enables wide imaging of live animal vasculature, and modulation of neuronal activity and behaviour.

Elevated temperature is shown to rapidly increase the abundance and solubility of key auxin regulators, ARF7 and ARF19. Natural variation in this thermoregulated accumulation correlates with plant growth responses, suggesting a tunable mechanism for temperature adaptation.

Global cropland subsoil hides a “biogeochemical engine” where crop roots, soil texture, nitrifier communities, and hydrological conditions interact to fuel nitrification, silently driving soil acidification and groundwater nitrate pollution.

Thin and conformal tungsten disulfide (WS₂) layers, which are grown at the wafer scale using thermal atomic layer deposition at back-end-of-line compatible temperatures, can function as both barriers and liners for interconnects.

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

In the nonpivotal stage 1 of the randomized phase 3 PRESERVE-003 trial, patients with immunochemotherapy-resistant metastatic squamous non-small cell lung cancer without actionable genomic alterations treated with the next-generation, pH-sensitive anti-CTLA-4 agent gotistobart had encouraging overall survival outcomes compared to docetaxel.

Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.

Two-dimensional (2D) metal halide perovskites exhibit efficient photoinduced emission at room temperature, but control over charge carrier transport remains limited. Here formamidinium-based layered 2D perovskites are developed with high predicted symmetry. The absence of octahedral distortion results in an exciton diffusion length of 2.5 µm.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

The DNA origami vaccine platform DoriVac is shown to support multiplexed nanoparticles carrying diverse antigens against emerging infectious diseases and variants.

Verhaege et al. identify a conserved fibroblast barrier population at the base of the choroid plexus that compartmentalizes brain–CSF interfaces and is disrupted by inflammation, revealing a new site of central nervous system immune entry and barrier regulation.

A tunable tendon-like mechano-culture system shows that matrix tension drives myofibroblast activation in systemic sclerosis, while immune cells override tension-mediated control of fibrotic gene expression.

Lin et al. investigate the immune response in severely ill H7N9 patients and its link to early-life influenza imprinting. They find that individuals first exposed to H2N2 develop faster, higher-avidity cross-reactive antibodies and tend to experience less severe illness.

Cytomegalovirus (CMV) seropositivity exacerbates immune complications in people living with HIV (PLHIV). Here, the authors utilize multi-omics and immune phenotyping data and show that CMV seropositivity induces pro-inflammatory cytokines and further identify FCRL6 as a potential biomarker for immune activation.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Hybrid back-contact silicon solar cells using a multifunctional front layer for both light trapping and passivation enable the use of a thicker absorber, outperforming the 125-μm-thick silicon heterojunction devices, with a certified efficiency of 27.62%.

Photoinduced ligand-to-metal charge transfer is used to enable abiotic cross-couplings in metalloenzymes. Engineering a 2-histidine metal site and substituting iron with nickel activates PsEFE for nickel-catalysed C(sp²)–S coupling reactions between thiols and aryl bromides. Directed evolution yielded metalloenzyme variants that can produce a range of thioethers with high efficiency.

Here, using anatomy, transcriptomics, and functional assays, the authors reveal how Japanese wisteria climb using an unusual vascular architecture. Ectopic cambia arise from cortical cells and repurpose conserved cambium regulators, including KNOX genes.

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

Conjugated polymers are promising for compact energy storage and actuation devices though it is challenging to balance these properties. Here the authors report a polymer system suppressing ion hydration for a multifunctional microdevice.

Achieving lateral doping gradients in organic semiconductors (OSCs) via solution processing is crucial but remains a challenge. A gold-activated persulfate doping strategy can locally oxidize OSCs and create a lateral doping gradient, enabling low contact resistance and high carrier mobility in solution-processed organic field-effect transistors.

The authors demonstrate a magnetic compute-in-memory platform that performs convolution using domain wall motion, enabling highly energy- and area-efficient processing for future AI hardware.

Analysis of the asexually reproducing Amazon molly Poecilia formosa and its sexually reproducing progenitors Poecilia mexicana and Poecilia latipinna reveals that it maintains a divergent mutational landscape and has evaded functional mutational decay via gene conversion.

The fetal globin gene repressors BCL11A and ZBTB7A directly bind γ-globin gene promoter regions. Repressor binding is disrupted by naturally occurring point mutations located upstream of the transcriptional start site that are associated with hereditary persistence of fetal hemoglobin.

Conventional slurry electrodes limit high-energy lithium batteries. This work shows that dry-processed electrodes with molecularly coupled carbon–binder networks enable high mass and active material loading, supporting stable high-voltage operation and enhancing battery energy density.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Idiopathic pulmonary fibrosis is a fatal human disease driven by the accumulation of apoptosis-resistant fibroblasts that impede homeostatic lung repair. Here, the authors show that elevated BCL-2 expression in fibroblasts drives their survival and senescence prolonging fibrosis in mice, while BCL-2 inhibition reverses persistent fibrosis.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

From 2014–2017, marine heatwaves caused global mass coral bleaching, where the corals lose their symbiotic algae. The authors find, this event exceeded the severity of all prior global bleaching events in recorded history, with approximately half the world’s reefs bleaching and 15% experiencing substantial mortality.

The physics of resonant electro-optic microcomb generation is underexplored, limiting their potential applications. Now several technological advances are realized by studying the state space of a thin-film lithium niobate photonic frequency comb.