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This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

This study reveals how collective spin excitations called magnons lose their spin in antiferromagnetic insulators, enabling long-distance spin transport and offering new design principles for future low-power spintronic technologies.

Developing noble-metal-free electrocatalysts for acidic water electrolysis is vital for hydrogen production. The authors design a Cr and Nd co-doped Co3O4 anode catalyst with enhanced activity and durability and introduce an in-situ acid circulation strategy to mitigate membrane poisoning.

Cell-type-specific 3D genome maps are hard to generate experimentally. Here, the authors develop Hi-Compass, a deep-learning framework that predicts chromatin interactions from accessibility data across variable sequencing depths, recovering chromatin loops and linking disease variants to target genes.

Molecular devices offer the potential for the scalability and energy efficiency required to develop energy-sustainable AI. Zhang et al. report a single-molecule neuromorphic device that consumes 6.34 aJ per operation and support both short-term to long-term memory, featuring over 10 distinct conductance states.

Electronic skins are capable to monitor stimuli such as temperature and pressure, though they are susceptible to crosstalk diminishing sensitivity. Here the authors report a mechanically and electronically hybrid network using vanadium oxide and liquid metal particles to optimize selectivity and sensitivity.

This study uses genome-wide screening and mouse genetics to uncover how cells control proinsulin, identifying the Golgi as a central hub and revealing PDIA6 as a key regulator of proinsulin production in pancreatic β-cells.

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

Bacterial therapies for cancer face safety and complexity challenges. Here, the authors develop an engineered Serratia marcescens platform that leverages natural pigment biosynthesis to trigger antitumor immunity and enable rapid bacterial clearance, controlled by near-infrared light.

Cryo-EM structures of ZYG11B-EloB-EloC-substrate complex reveal architecture of CRL2^ZYG11B E3 ligase. ZYG11B forms both monomeric and dimeric assemblies, and functional assays show that dimerization enhances substrate ubiquitination and degradation.

CellLoop maps 3D chromatin loops in single cells, revealing how distinct DNA folding patterns shape gene activity, define cell identity, and organize spatial genome domains, providing new insights into cellular diversity and genome function.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Pre-harvest sprouting (PHS) causes severe yield and quality loss in cereal crops worldwide. Here, the authors report a cyclic nucleotide-gated channel/Ca^2 + -permeable channel encoding protein negatively regulate PHS and its involvement in modulating of calcium and hormonal signaling pathways in wheat.

Photovoltaic-thermoelectric (PV-TE) hybrid systems offer a platform for enhancing the energy conversion efficiency of photovoltaic devices. Here, the authors present solution-processed PV-TE hybrid systems optimized for heat utilization and current matching, experimentally demonstrating a maximum efficiency of 50.28%.

Meiotic sex chromosome inactivation is essential for spermatogenesis, but how transcription is silenced after initiation remains unclear. Here, authors show that nucleolar components NPM1, SENP3 and rRNA form a phase-separated compartment that excludes RNA polymerase II to enforce XY chromosome silencing.

Ionic thermoelectric cells suffer from compromised performance upon miniaturization due to reduced thermal gradients. Here, the authors propose an ultrathin asymmetric architecture that couples ionic modulation with pseudocapacitive storage, enabling high power density for self-powered wearables.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

Researchers report a metal-organic framework with “gate-channel-cavity” for the energy-efficient separation of propylene. By combining sieving gates with a large diffusion channel, the material achieves record-fast diffusion and high capacity for industrial use.

The study presents NMR-Solver, an automated framework that determines small-molecule structures from NMR spectra by combining large-scale spectral matching with physics-guided optimization, enabling accurate and interpretable structure elucidation.

In this study, the authors identify an Aurka–Bhlhe41 axis, which prevents microglia from aging-like dysfunction by limiting CD22 upregulation, preserving myelin debris clearance and remyelination, and highlighting a potential therapy target for neurodegeneration.

Ocean fronts have long been regarded as fishery hotspots. Here, global analyses reveal more pronounced responses to barrier effects than to hotspot effects, with fisheries clustering on either the warm or cold side of fronts while avoiding the other.

2D semiconductors are considered a promising platform to complement silicon in next-generation electronics. Here, the authors report the fabrication of generic logic blocks based on bias-gated 2D MoS₂ transistors, showing the design of logic circuits with transistor count saving of over 60% compared to conventional Si electronics.

The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

Observations and models show decadal ocean temperature regime shifts have increased strongly over the past 150 years due to human warming, linked to abrupt ecological and fishery changes and likely to further intensify without major emission cuts.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

The mechanisms underlying impaired myelination during aging remain incompletely understood. Here, Gao et al. report that ACSS2-mediated acetate utilization is essential for maintaining the oligodendrocyte progenitor cell pool and facilitating myelination throughout life.

A retrospective analysis of a publicly funded NIPT programme in Hebei province, China, covering more than 1.18 million pregnancies, shows that first-tier NIPT achieved high coverage, reduced invasive testing by 97% and was more cost-effective than maternal serum screening, and the NIPT positive results were linked to higher risks of adverse pregnancy outcomes, suggesting potential early warning value.

Hyperbolic topological states have attracted broad interest but are thus far limited to static and spatial topological states in type-I hyperbolic lattices. Here, the authors report a comprehensive study of spatial and spatiotemporal topological states in newly discovered type-II hyperbolic lattices.

Current antiviral treatment approaches target specific Ebola virus species. Here, the authors develop bispecific antibodies with pan-ebolavirus neutralization capacity, structurally resolve the epitope and neutralization mode and show potent protection in a rodent model.

Lithium||sulfur batteries are limited by sluggish solid-state sulfur conversion. Here, authors investigate spin-state transitions as a key kinetic barrier and design a spin-regulated catalyst that accelerates sulfur conversion, suppresses polysulfide shuttling, and enables high-capacity pouch cells.

Methanotrophic growth on methane and N₂-derived ammonia is inhibited by a toxic intermediate, hydroxylamine, generated via ammonia oxidation. Here the authors ameliorate this toxicity through genetically engineering M. sanxanigenens and feed the biomass to mice to reduce colitis symptoms.

This study reveals that coagulation pretreatment can unexpectedly worsen reverse osmosis membrane fouling by altering solution chemistry and microbial behaviour, challenging its role in long-term membrane performance in zero-liquid discharge systems.

Stacking XA48-mediated effector-triggered immunity with XA21-mediated pattern-triggered immunity in Oryza sativa japonica reconstitutes the broad-spectrum resistance from wild rice.

Cold tolerance at the booting stage is critical for the expansion of rice cultivation area. Here, the authors report that a CAMTA family transcription factor encoding gene CTB3 positively regulates japonica rice booting stage cold tolerance and its upstream and downstream interactors to fulfill the functionality.

SDM based on multi-core fiber is a promising approach for capacity scaling in submarine cables. Yingyu Chen, Jinkai Zhou, and colleagues report the field validation of a deployed 7-core fiber submarine link, achieving 410.5 Tbit/s over 140 km with C + L band cladding-pumped MC-EDFAs.

In vivo adenine base editing corrects a common Pex1 pathogenic allele in mouse models of Zellweger spectrum disorder, rescuing liver pathology, fatty acid levels, body weight and peroxisome function.

The template-free synthesis of colloidal assemblies with molecule-like architectures from colloidal quantum dots holds promise for optical applications but remains challenging. Here we report a one-pot synthesis of geometries resembling sp-, sp²-, and sp³-hybridized orbitals.

Oocyte development requires tight regulation of transcription and RNA metabolism. Here, the authors identify DDX5 as a master regulator that integrates transcriptional and post-transcriptional programs to maintain RNA homeostasis, thereby ensuring oocyte competence and fertility.

Hydrogen movement on catalyst surfaces shapes how effectively reactions form useful products. This study shows that subtle surface tuning greatly boosts hydrogen flow and enables highly efficient solar-driven conversion of carbon dioxide to methane.

Numerous feathered dinosaurs and early birds have been discovered from the Jurassic and Cretaceous, but the early evolution of feather-feeding insects is not clear. Here, Gao et al. describe a new family of ectoparasitic insects from 10 specimens found associated with feathers in mid-Cretaceous amber.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

A unified optoelectronics platform comprising dual-comb generation, modulation and metasurface-enabled beam steering serves as a transmitter for any standards between 2G and 6G. This architecture reduces power usage and costs, enabling a direct link between edge data-centre devices and the wireless network.

An AND logic nanoparticle designed to respond to both acidic pH and hypoxia signals for immune activation in tumour microenvironment allows safe systemic therapy of metastatic cancers.

BioMedAgent is a self-evolving LLM multi-agent framework that learns to use various bioinformatics tools and chain them into executable workflows for autonomously carrying out diverse biomedical data tasks initiated by natural-language prompts.

Microreactors are valued for efficient mixing and precise control in nanoparticle synthesis; however, when encapsulating sensitive proteins and enzymes, conventional fluidic shear causes serious damage and activity loss. Here, the authors show that gas-liquid slug-flow microchannels provide efficient mixing, narrow residence time distribution, and suitable shear compared to single-phase flow microchannels, microstructured continuous stirred-tank reactors, and batch reactors, reporting a low PDI and productivity equivalent to 100 lab-scale batch reactors for the preparation of catalase nanocapsules.

Deep brain stimulation is effective but invasive. Here, the authors develop an injectable conductive hydrogel that forms in situ and enables wireless neuromodulation under volume conduction via capacitive coupling, showing therapeutic potential in a Parkinson’s disease rat model