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Cardiovascular surgery and haemodialysis urgently need durable vascular grafts. Here, authors develop a decellularized polymer skeleton-reinforced biotube as a readily-available vascular graft and demonstrate utility in vivo across multiple large animal preclinical models.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Pulmonary microbiotacomponents in bronchiectasis patients receive repeated antibiotic exposures, whereas previous studies on the effects ofantibiotic treatment focused on typical pathogens rather than commensals. By integrating experimental evolution withsingle-cell resolution, the authors reveal a multifaceted strategy by which Neisseria subflava, a common airwaycommensal associated with bronchiectasis, exploits antibiotic selection to transition towards pathogenicity.

Authors present a framework that harmonizes electronic health record data across hospitals by integrating medical knowledge, large language models, and graph learning. It enables cross-institutional analysis without sharing patient-level data.

Whether habits emerge gradually or suddenly remains an open question. Here the authors show that mice abruptly switch from goal-directed to habitual control, marked by a rapid dorsal striatal shift from outcome- to stimulus-driven processing.

Chern ferromagnetism is established in twisted bilayer MoTe₂ devices at large twist angles. Here, the authors observe evidence of antiferromagnetic ground states with zero Hall resistance at an intermediate twist angle around three degrees, demonstrating the sensitivity of the magnetic ground state.

RNA editing influences gene regulation in cancer. Here, the authors show that EZH2 regulates RNA editing by ADAR1 through remodeling its interactome and nuclear transport, thereby promoting MDM2 expression and prostate cancer progression.

The authors present a multi-core neuromorphic architecture that enables energy‑efficient training of deep spiking neural networks via backpropagation. The design features a multi-engine core, multi-level parallelism, sparsity optimization, and FPGA validation.

Landform assemblages co-develop with ecosystems to distinguish fundamental permafrost properties across a continental-scale ecoclimate gradient, combining into finer-scale permafrost landsystems that vary with geological and climatic legacies to define predictable consequences of thaw.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

Three-body low-energy s-wave states play an important role in few-body physics and associated universal phenomena, yet their experimental observation in nuclear system has been elusive. Here, the authors identify the three-body s-wave properties in neutron-rich ¹⁰He nuclei with improved statistics and sensitivities.

This long-term, large-scale intervention and follow-up MRI study suggests that sustained visceral fat loss, rather than weight loss, is linked to better cognition and attenuation of brain atrophy years later, mainly via improved glycaemic control.

The role of long non-coding RNAs (lncRNAs) in regulating cancer progression remains to be explored. Here, the authors identify an antisense lncRNA in the IGF1R locus (IGF1RAS1) which strongly interacts with super enhancers and modulates MYC expression in metastatic prostate cancer.

Using an evolutionary optimization approach, the authors report a culture medium that matures stem cell-derived heart cells, improving their structure, metabolism and electrical activity to advance highly functional models for in vitro testing.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Room-temperature multiferroic materials are highly demanded for designing next-generation of spintronic devices. Here, the authors demonstrate an emergent room-temperature ferrimagnetism and polar phase in highly strained La₂CoRuO₆ epitaxial films through engineered 3d−4d cation ordering.

Understanding and controlling phase-separated biomolecular condensate mechanochemistry is critical for their function and material properties. In this study, the authors developed assays that enable the study of mechanical transitions and fusion dynamics in condensate droplets, revealing that UV-induced thymine dimerization alters condensate nucleation and coalescence.

Ji, He, Cai, and colleagues report an engineered senescence therapy that exploits lipid metabolic features of senescent cells, repurposing excess lipids as functional resources to improve joint function, and thus alleviating osteoarthritis without eliminating the cells.

He et al. identify a central regulator of condensate size and dynamics in the Chlamydomonas CO₂-fixing condensate, the pyrenoid. KEY1 phosphorylates EPYC1, a linker protein for Rubisco, to maintain pyrenoid size and number through the cell cycle.

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Here, the authors show that two genes encoding KATANIN p60 in maize promote growth and fertility via proper cell expansion and division. Aberrant microtubule organization in mutants alters cell shape, delays G1, and disrupts preprophase band formation and nuclear positioning.

It is challenging to achieve both reversible shape reconfiguration and autonomous motion with a synthetic soft material. Here, the authors report the development of an elastomer-hydrogel composite that shows both behaviors as a result of asymmetric solvent uptake.

AhR functions as a neuronal brake on axon regeneration, integrating environmental sensing, protein homeostasis and metabolic signalling to control the balance between stress adaptation and axonal repair.

Au nanowires with an unconventional hexagonal close-packed (4H) phase stabilize the 4H-phase high-entropy alloys grown epitaxially on their surface through a facile chemical synthesis. The resulting core–shell nanostructures demonstrate promising overall water electrolysis performance.

The authors report a non-equilibrium spatially distributed electric field strategy for 2 nitrogen fixation in ambient air plasma.

Global travel hubs could be key in future pandemic surveillance efforts. Here, using a global metapopulation model calibrated to epidemiology, phylogeography and air travel, the authors show that traveler-focused genomic surveillance at key hubs can speed up detection of SARS-CoV-2 variants under resource constraints.

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

Accurate characterization of emerging quantum sensors requires an imaging technique that does not depend on defect-specific optical readout. Here, using a NV center in diamond, the authors detect and map boron vacancy defects in hBN via spin cross-relaxation, enabling quantitative nanoscale imaging and spectroscopy without detecting hBN emission.

Predicting antimicrobial resistance from bacterial genomic data is challenging. Here, the authors introduce AMR-GNN, a graph neural network that integrates multiple genomic representations to improve prediction, reduce clonal bias, and identify biomarkers.

The efficiency of contrastive dimension reduction depends on selecting a valid background for a target dataset. Here, the authors introduce BasCoD, a statistical testing framework that evaluates background validity and improves contrastive dimension reduction in single-cell genomics applications.

This study uses brain recordings, self-reports, and facial analysis to decode acute pain in epilepsy patients. Machine learning reveals stable neural markers in mesolimbic, striatal, and cortical regions, plus facial cues, enabling reliable pain detection in naturalistic settings.

This study shows that the intestine uses a specific pathway to generate the energy (ATP) needed to move dietary fat out of intestinal cells. A protein called ANKRD9 helps regulate this energy supply; without it, fat builds up in the intestine, and the body remains lean.

A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.

The impact of the environment on the health of individuals has been of interest in recent years with some protective effects shown against conditions such as depression and anxiety. In here the authors show that exposure to green space and the natural environment is associated with a decreased risk of depression among cancer survivors.

The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2⁺ upper-layer 2/3 cortical neurons, enabling their survival during development.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Controlling mitochondrial ROS has potential to regulate inflammatory responses, however targeting it in macrophages can be difficult. Here, the authors create hybrid membrane extracellular vesicles capable of targeted delivery to macrophages to modulate mitochondrial ROS, promoting diabetic wound healing.

DNA hybridisation thermodynamics parameters underlie rational design of oligonucleotides for diagnostics and nanotechnology. Here, the authors present an accurate method to measure the free energy of a given DNA structure at specific temperature and buffer conditions.

Extreme thermal transport in 2D materials challenges classical models. Here the authors combine microheater-based thermal control and Raman thermometry to reveal high in-plane thermal conductivity and non-diffusive phonon transport in suspended monoisotopic hBN.

Multicolour soliton microcombs generation currently lacks spectral tunability and uses degenerate optical parametric oscillators (OPOs). Here, authors demonstrate the class of hyperparametric solitons in a silicon-nitride microresonator nondegenerate OPO, which is pumped in the C-band and producing a tuneable signal in the O-band.

A BiCu dilute alloy catalyst is designed to overcome the CO₂-poor environment in CO₂ post-capture liquid electrolysis. This catalyst enhances CO* coverage and enables asymmetric CO–CHO coupling, a lower-energy pathway than conventional symmetric C–C coupling, doubling the energy efficiency for electrified ethylene synthesis from a CO₂ post-capture liquid.

The Shastry-Sutherland model consists of orthogonal dimers in a two dimensional plane, and has proved a rich basis for both theoretical and experimental investigation of quantum magnetism. Here, Brassington et al show that Yb2Be2SiO7 hosts an anisotropic variant of the Shastry Sutherland model.

It remains unclear why some BRCA-deficient high-grade serous carcinomas (HGSC) do not respond to platinum-based therapy. Here, multi-omic analysis of BRCA1- and BRCA2-deficient HGSC attributes co-occurring mutations, DNA repair deficiency and tumor microenvironment features to short survival in these patients.

Chen et al. engineer TRANSFER (trogocytosis-inspired receptor transfer and functional effector release), a method to deliver functional cargos from donor to recipient cells in a specific manner via direct cell–cell contact.

Single-variant and ultrarare variant burden analyses leveraging exome sequencing data from 22 cohorts identify new risk genes for amyotrophic lateral sclerosis and show cumulative effects of several rare variants on disease risk.

Bistable superlattice switching between two lattice configurations with sharply contrasting periodicities has been observed in monolayer TaIrTe₄, a dual quantum spin Hall insulator.

Genetic analyses in more than 15,000 individuals from across the Americas, including individuals with autism and family members, define the genetic landscape of autism in Latin American populations and identify significant overlap with other ancestries.