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The substrate surface engineering approach prevents the formation of twin structures, while the elimination of twins greatly enhances carrier mobility and suppresses bipolar conduction, leading to optimized power factor in twin-free Bi₂Te₃ films.

Uncovering the genetic mechanisms that determine seed weight is vital for improving soybean cultivars. Here, the authors identify a bZIP transcription factor, a GSK3-like gene family member, and a MFT ortholog, along with their potential interactions, as key regulators of soybean seed weight.

The authors report associations of social isolations and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioral phenotypes among UK Biobank participants.

Independent single-chain one-dimensional vdW crystals with a well-defined chemical structure are prepared, featuring a width of approximately 0.8 nm, a length reaching the micrometre scale and a single-chain ratio of up to 90%. Atomically smooth vdW interfaces, good crystallinity and air stability are demonstrated, and the chains show typical single-electron tunnelling behaviour.

According to a data model analysis, dark brown carbon emitted by wildfires exerts radiative effects that can rival or exceed those of black carbon, extending into mid- and high-latitude regions, including the Arctic.

Metainterfaces that have repetitive surface unit structures, and are inspired by the mortise–tenon and finger-joint structures used in traditional woodworking, can be used to create functional interfaces with enhanced electronic and thermal transport.

Germano-silicate used as a building material for integrated photonics circuits substantially reduces optical losses, approaching levels comparable to those in optical fibres.

Ibrutinib treatment increased the proportion of Teff-like cells and the expression of TCF1 and BCL11B in CD8 + T cells. Upregulation of TCF1 and BCL11B in Teff-like cells was associated with favorable responses to ibrutinib.

Mg₃(Sb, Bi)₂ is a potential next-generation thermoelectric with cost-effectiveness compared with Bi₂Te₃; however, it suffers from poor moisture corrosion resistance. Here, an anodic protection strategy is presented that substantially reduces corrosion, enabling the 28-day performance of a module in high-temperature and high-humidity environment.

Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,671 high-confidence complexes that uncover new higher-order structures and evolutionary links.

Selenization is a key step in kesterite solar cell fabrication, but controlling ion migration during this process is challenging. Cui et al. address this issue by introducing a Li₂SnS₃ interphase, achieving a certified power conversion efficiency of 15.0%.

An enzyme that specifically recognizes dephospho-CoA (dpCoA)-capped RNAs is used to quantify dpCoA-RNAs in cells.

Microbially derived 10-oxostearic acid (10-oxoSA) interacts with PPARα in the colon to alleviate gut inflammation in acute and chronic mice models.

Zhao et al. develop a microwell cell-chip-based culture platform that enables high-throughput generation of micro-tumourspheres and enrichment of functional cancer stem cells from biopsies obtained from patients with breast cancer, facilitating personalized drug testing.

Bias-voltage-tuneable colloidal quantum dots junctions enable short-wave infrared hyperspectral imagers with megapixel spatial resolution and nanometre-scale spectral resolution for food quality monitoring and materials discrimination.

The authors realize a two-dimensional hybrid perovskite with robust multiaxial ferroelectricity and nonlinear optical response via molecular fluorination and lone pair expression of Ge²⁺, enabling prominent piezoelectric sensing in composite device

Determining the optimal start of the growing season presents a fundamental dilemma for plants. This meta-analysis suggests that plants exhibit high freezing resistance (to -12 °C) and low lethal frost risk (safety margin of 17 °C) during spring emergence, indicating strong long-term evolutionary pressure.

In a transistor configuration, a new germanium/silicon nanowire has characteristics such as conductance, on-current and switching time delay that are better than those of state-of-the-art silicon metal-oxide-semiconductor field-effect transitors.

Robotic grippers struggle to handle fragile and varied objects across environments. Here, the authors introduce a liquid metal gripper that adapts its shape and stiffness for gentle, multiscale grasping and active release.

Here, the authors show that residues N490 and M492 of Hepatitis E Virus capsid protein are pivotal, albeit not exclusive, host tropism determinants of hepatitis E virus (HEV) for swine infection, which enhance the understanding of HEV’s zoonotic transmission and host specificity.

Microplastics and nanoplastics were found at a higher level in brain tumour samples from living patients than in healthy human brain samples from cadavers, with a correlation between microplastic surface area and tumour proliferation.

Supported subnanometric clusters are a much sought-after class of catalyst, but governing the anchoring onto the support and the resulting properties of the clusters remains a challenge. Now the authors show how UTL-type germanosilicate can stabilize ultra-fine Pt clusters, resulting in a superior catalyst for propane dehydrogenation.

A new method for performing genome-wide fine-mapping with functional annotations outperforms current methods across several metrics, including error control, mapping power, resolution, precision, replication rate and cross-ancestry phenotype prediction.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

This study shows that greening peri-urban areas boosts rainfall within cities, revealing their hidden role in shaping intra-urban precipitation and supporting climate-resilience planning.

Thymine DNA glycosylase (TDG) was identified as a synthetic-lethal target in p53-deficient cancers through alterations in double-stranded RNA accumulation. A covalent small-molecule inhibitor of TDG exhibited potent efficacy against p53-deficient tumors.

Molecular mimicry between a gut commensal and a tumour antigen forms part of an important mechanistic framework that can boost the efficacy of immune checkpoint blockade therapy and restrain tumour growth.

Soil-based compound dry-hot extremes represent a critical yet underappreciated driver of ecosystem stress. This study shows that their frequency and coverage area have increased markedly in China due to anthropogenic soil warming, which may pose growing adverse impacts on vegetation productivity.

FeGe is an antiferromagnetic kagome metal with a rich magnetic and electronic phase diagram. Recently it was found that post-growth annealing of FeGe can suppress or induce charge density wave order depending on the annealing temperature. Here, Klemm, Siddique et al show the critical role that annealing induced Ge-vacancies and stacking faults play in the formation of charge density wave order in FeGe.

Sphingolipids mediate inflammation, although the role of lipid aldehyde 2-HD is poorly understood. Here, the authors show ALDH3B1 detoxifies 2-HD to protect retinal vasculature, with 2HD accumulation causing vascular abnormalities.

Newly emerging SARS-CoV-2 variants underscore the need for broad-spectrum antiviral solutions. This study shows a macrocyclic peptide inhibitor that locks the SARS-CoV-2 spike trimer into a “closed” conformation by engaging a conserved region, and demonstrates that intranasal administration of the peptide inhibitor protects against Omicron variants.

Indium antimonide quantum dots offer strong potential for short-wave infrared light detection, but earlier methods produced broad size distributions and limited spectral reach. The authors created size-uniform nanocrystals and used them to build high-efficiency, environmentally friendly broadband infrared detectors.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

RORγt⁺ antigen-presenting cells (APC) are playing a role in the generation of oral tolerance via their interaction with regulatory T cells recognising dietary and commensal bacterial antigens. Here authors show that a cis transcriptional regulatory element is responsible for RORγt specifically in APCs through interaction with RUNX3 and formation of chromatin loops, which determines a transcriptional program that distinguishes these oral tolerance mediating APCs from RORγt⁺ T cells.

Little is known about the long-term effectiveness of risk-based target-to-treat cholesterol-lowering interventions on cardiovascular risk. Here, the authors show that treat-to-target cholesterol-lowering interventions could exert an equivalent protective effect of statin therapeutic trials using data from a 29-year cohort study.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

We report assembly of an organic scaffold within perovskite structures, resulting in the suppression of the lone pair expression of Ge and templating the symmetric octahedra.

The 26S proteasome degrades hundreds of proteins in eukaryotic cells. Here, the authors use biochemical, single-molecule, and structural studies to reveal how subunits in the proteasomal ATPase motor contribute to substrate capture and mechanical degradation.

In this study, long-read RNA sequencing achieves accurate single-nucleotide polymorphism calling, haplotype phasing and allele-specific expression analysis.

Combining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome profiles, enabling sophisticated analysis of the regulatory landscape across cell types and tissues.

Weak interlayer van der Waals (vdW) bonding has significant impact on the structure and properties of vdW layered materials. Here authors use in-situ aberration-corrected ADF-STEM for an atomistic insight into the cation diffusion in the vdW gaps and the etching of vdW surfaces at high temperatures.

For proper mitochondrial inheritance, paternal sperm mitochondria must be eliminated. Here, authors identify ALKB-1 mediated tRNA demethylation as essential for this clearance in Caenorhabditis elegans, revealing an epitranscriptomic quality checkpoint tied to male fertility.

This study identifies 245 genetic loci associated with head-to-body ratios using 38,202 bone density scan images from the UK Biobank, revealing genetic links to skeletal and brain development, disease susceptibility, and human evolutionary adaptation.