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CRISPR–Cas tools enable genome regulation but are often too large for efficient AAV delivery. Here, authors engineer a compact enhanced TnpB–ωRNA system (enTnpB) as a versatile genome regulation platform and develop a single-AAV regimen, ImmunAct, to activate endogenous cytokines and enhance cancer immunotherapy.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

A single-breath-hold 3D abdominal MRI technique (SSE-CEST) enables label-free mapping of glucose, glycogen and mobile protein in human liver, offering motion-robust, high-resolution imaging for cancer detection and metabolic monitoring.

Using artificial intelligence, authors model how air pollution may increase susceptibility to SARS-CoV-2. NPC1 is identified via genetic and laboratory analyses as a key pathway that enhances viral entry after exposure to fine particulate matter.

Yu et al. report a self-assembled heterogeneous microstructure consisting of chiral-deficit grains and chiral-rich grain boundaries in chiral perovskite with the former as in-plane spin valves for spin selection. Retinomorphic sensor arrays based on the chiral perovskite film enable binocular artificial visual systems.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

Zanubrutinib is a second-generation BTK inhibitor, reported to have fewer off-target toxicities while maintaining comparable efficacy to previous BTK inhibitors. Here, the authors report the phase II CHESS trial evaluating frontline Zanubrutinib (second-generation BTK inhibitor) plus rituximab (anti-CD20) induction, followed by chemoimmunotherapy in patients with mantle cell lymphoma.

The GABA_B receptor is a mandatory heterodimer. Here authors show the existence of GABA_B dimers of dimers in neurons, and their relevance in human health. By solving the structure of this tetramer, they show the structural basis for a negative cooperativity between the dimers within such a complex.

He et al. report that the host-derived macrophages/monocytes enhanced malaria transmission by reducing the abundance of transmission-blocking microbiota in mosquito midgut via SRA-mediated phagocytosis. In addition, the depletion of macrophages/monocytes or the use anti-SR-A neutralizing antibodies significantly enhances the transmission-blocking efficacy of anti-Pfs25 monoclonal antibodies.

Autophagy has been reported to have an important role in glioblastoma temozolomide resistance but the underlying mechanisms are unclear. Here, the authors identify RFC4-STK38-BECN1 complex as a driver of autophagy activation and subsequent temozolomide resistance in preclinical models of glioblastoma.

Sunlight triggers ammonium chloride in aerosols to produce Cl₂ gas, explaining 12-55% of daytime levels. This chlorine source, boosted by black carbon, impacts atmospheric oxidation.

The MoSi₂N₄ family is an emerging class of van der Waals materials with interesting properties. Here, the authors report a systematic characterization of point defects in monolayer WSi₂N₄ and MoSi₂N₄, showing their influence on the electronic properties of the materials.

Electrochemical nitrate reduction rivals Haber-Bosch ammonia synthesis rates but suffers from poor energy efficiency. Here, the authors show that underpotential deposited hydrogen can be unlocked to accelerate nitrate conversion, offering an pathway to energy-efficient ammonia production.

A MoSe₂ piezocatalyst with lattice strain upcycles wastewater pollutants into value-added chemicals, offering an environmental and energy solution by accelerating carbon reduction and lowering reaction energy barriers.

The authors reveal intrinsic long-range-order noncollinear electric dipole order in the van der Waals crystal WO₂Br₂, enabling pressure-driven 90° polarization rotation via multiple transition pathways and distinctive ultrafast phonon dynamics.

Piezotronics are promising for mechano-sensation but limited in direct-current electronics. The authors propose the capacitive piezotronics, giving a new approach for mechanically controlled devices in high-frequency alternating-current systems.

Neural mechanisms underlying energy metabolism are not fully understood. Here authors show that Phf6-expressing neurons in the medial preoptic area as key regulators of physical activity and energy expenditure, revealing a neural mechanism underlying obesity in Börjeson-Forssman-Lehmann syndrome.

Genome annotation typically requires costly experimental assays across diverse cell types, limiting its scalability. Here, authors introduce BioSeq2Seq, a deep learning framework that leverages DNA sequence and run-on sequencing (RO-seq) data to accurately predict histone modifications, functional elements, gene expression, and transcription factor binding sites.

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of premature infants with unclear mechanisms. Here, the authors show that CD177⁺ neutrophil–platelet aggregates promote neutrophil extracellular trap (NET)-linked thromboinflammation in NEC and that blocking CD177/NET formation or low-molecular-weight heparin alleviates disease in mouse models.

Magnetic tunnel junctions face challenges in emulating neuromorphic devices within a single film stack platform. Chen et al. fabricate spintronics-based artificial synapses and spiking neurons and implement a convolutional spiking neural network, showing 96% accuracy in a gesture recognition task.

Maintaining nanocatalysts under extreme heat is a major challenge due to structural disintegration. Pre-filling support vacancies creates a confinement field that anchors rhodium nanoparticles, preserving their integrity and activity during methane oxidation.

This study identifies an autocrine role for hepatic FGF1, wherein its circadian rhythmicity synchronizes triglyceride secretion with activity. Disruption of this clock-regulated pathway impairs lipid homeostasis.

The biological basis of afternoon nap remains unclear. Here, authors show that NPAS2 in mPFC TH-positive neurons activates POU2F2 to suppress TH level and dopamine production, thereby reducing wake-promoting neural activity and driving nap behavior.

Most kiwifruit species are vulnerable to high levels of heat stress. Here, the authors report natural variation at the GATA transcription factor binding site of EGY3 gene mediates chloroplastic ROS homeostasis to confer kiwifruit thermotolerance.

By engineering single residue of protein with a light-switchable molecule, this study reveals that local hydrophobicity propagates through hydrogen bond network to reshape protein structure and function, shifting the paradigm to structure–hydration– function.

The function of metal-organic frameworks is governed by their synthesis precision. Here, the authors report a light-driven strategy enabling ambient-temperature synthesis for cobalt-porphyrin frameworks, overcoming traditional thermal constraints.

In this study, the authors identify a microcircuit containing three subgroups of neurons associated with sensory-induced escape in the mouse temporal association cortex (TeA): sensory, sensory-motor decision and motor command neurons.

Ji, He, Cai, and colleagues report an engineered senescence therapy that exploits lipid metabolic features of senescent cells, repurposing excess lipids as functional resources to improve joint function, and thus alleviating osteoarthritis without eliminating the cells.

In this study, the authors present two distinct neuronal subpopulations, sharing a speed encoding model, in the mouse dorsal periaqueductal grey, controlling running and backing away behaviors, respectively.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

Traditional recycling of polyoxymethylene plastic often leads to significant material loss and toxic emissions. Here, the authors introduce an acidic electrochemical process that efficiently converts plastic waste into valuable chemicals with conversion efficiency approaching 90%.

Mixed-matrix membranes incorporating soluble macrocycle compounds represent a promising class of materials for gas separation but achieving high selectivity for helium extraction from natural gas remains challenging. Here the authors incorporate a cyclic Cyclen with specific intra-ring dimensions as a pore-structure modifier to enhance He/CH₄ selectivity.

Near-infrared-II carbon dots offer exceptional deep-tissue penetration for biomedical imaging, but challenges remain in their synthesis and photoluminescence mechanisms. In this work, the authors designed and synthesized a series of carbon dots (CDs-1 to CDs-3) through extension of aniline-based frameworks, achieving tunable emission extending into the NIR-II region, and applied these CDs in deeptissue NIR-II imaging of the hepatobiliary system.

Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal cancer with poor prognosis and limited treatment options. This study identifies Prolyl 3- hydroxylase 1 (P3H1) as a critical regulator of PDAC progression through PLK1-β-catenin signaling, driving tumor-associated macrophage recruitment and tumor growth.

In the nonpivotal stage 1 of the randomized phase 3 PRESERVE-003 trial, patients with immunochemotherapy-resistant metastatic squamous non-small cell lung cancer without actionable genomic alterations treated with the next-generation, pH-sensitive anti-CTLA-4 agent gotistobart had encouraging overall survival outcomes compared to docetaxel.

This study presents a prefusion-stabilized vaccine candidate against Hantaan virus. The DNA and mRNA-LNP formats induce lasting neutralizing immunity in female mice, highlighting a promising advance in vaccine development.

Catalysts combining different active sites can enhance chemical reactions by activating multiple steps simultaneously. Herein, aluminum dual-atom sites paired with nickel nanoclusters enable efficient, selective acetylene hydrogenation under mild conditions.

Determining the optimal start of the growing season presents a fundamental dilemma for plants. This meta-analysis suggests that plants exhibit high freezing resistance (to -12 °C) and low lethal frost risk (safety margin of 17 °C) during spring emergence, indicating strong long-term evolutionary pressure.

This study shows that tropical cyclone heavy rainfall has extended inland along the coasts of the Northern Hemisphere with a rate of 3.8 km per decade since 1980. Nearshore sea-surface warming drives this expansion, with coastal urbanization further amplifying the effect. These findings highlight increasing flood risk for inland populations as cities grow.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

Ming et. al. reports a memristor with an intrinsic ionic gradient that enables stable second-order dynamics and physically modulated learning rates. The device supports stable, energy-efficient continual reinforcement learning and adaptive decision-making.

Single-atom catalysts promise efficient reactions, but readily aggregate at high temperatures, limiting durability. Confining single metal atoms in liquid metal stabilizes them, enabling long-lasting ethane dehydrogenation at high temperature.

The mycotoxin deoxynivalenol (DON) threatens global human and animal health. Here, the authors identify two key functional enzymes in a bacterium that initiate the complete degradation of DON to CO2, elucidating their core catalytic mechanisms and biotechnological application potential.

Femtosecond laser pulse-induced coherent helicity switching of magnetic vortices in permalloy disks on picosecond timescales is reported.

The authors uncover a noncanonical role for Arabidopsis POT1b in maintaining genome stability through ROS regulation, establishing an unexpected connection between telomere biology and cellular oxidative stress.

Influenza viruses adapt to their hosts through diverse mechanisms. Here, authors report that a single mutation in nonstructural protein 1 of influenza B virus enhances innate immune evasion and provides adaptation to its host.

Authors present a bionic robotic trunk with a cable-driven tensegrity skeleton, leveraging synergistic and antagonistic muscle-mimicking mechanisms to achieve rapid and large-range stiffness modulation comparable to that of an elephant trunk.

Accurate characterization of emerging quantum sensors requires an imaging technique that does not depend on defect-specific optical readout. Here, using a NV center in diamond, the authors detect and map boron vacancy defects in hBN via spin cross-relaxation, enabling quantitative nanoscale imaging and spectroscopy without detecting hBN emission.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.