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Researchers report a metal-organic framework with “gate-channel-cavity” for the energy-efficient separation of propylene. By combining sieving gates with a large diffusion channel, the material achieves record-fast diffusion and high capacity for industrial use.

The authors demonstrate a neuromorphic imaging system that combines optical and electronic, spatial and temporal processing near the sensor, enabling parallel sensing and computation in typical indoor and outdoor environments without any light source requirements.

This work presents a quantum-cutting heterostructure that emits tunable near-infrared light (900-2200 nm) under ultralow-power excitation. It enables AI-assisted multiplexed gas detection, offering a scalable strategy for broadband NIR light sources

Coral reefs are declining globally, but regional degradation drivers are poorly quantified. This study reveals that coral loss in the northern South China Sea is predominantly linked to human coastal activities, suggesting that tailored local management may effectively reduce reef collapse.

Selective activation of aliphatic C–H bonds in complex polycyclic terpenoids remains a significant challenge. Now a bacterial P450 enzyme has been shown to achieve precise functionalization of inert C–H sites in pentacyclic triterpenoids, unveiling a distinctive relay-oxidation pathway mediated by 1,5-hydogen atom transfer and establishing a versatile chemo-enzymatic platform for accessing previously unexplored chemical space.

This study demonstrates a sustainable strategy to co-upcycle spent lithium-ion batteries and plastic waste into carbon nanotube composites with microwave absorption, enabling efficient metal recovery while reducing environmental and carbon impacts.

Gas transport through an ångström-sized Janus aperture in graphene, which is created by ozone etching, is investigated by using high-resolution transport measurements and high-throughput atomistic simulations. Rectified gas flow for various gases is demonstrated with rectification ratios of up to two orders of magnitude for oxygen.

Analyses of heterogeneous assemblies of native NMDA receptors from whole-brain tissue of mice reveal new characteristics of conformational diversity and channel opening.

Here, in a study of over 6,000 women across China, the authors show that Mycoplasma hominis infection strongly influences vaginal microbiota and is linked to higher risk of cervical lesions, highlighting its importance in women’s reproductive health.

VRK Serine/Threonine Kinase 2 (VRK2) has shown to play a significant role in apoptosis, cell growth, and immune response. Here the authors report that VRK2 is a key regulator of hepatocellular carcinoma (HCC) which can enhance myelocytomatosis oncogene (MYC) protein stability and transcriptional activity resulting in HCC progression when expressed increased levels

Surface-selective In³⁺ substitution in BiVO₄ suppresses hole polarons by weakening electron-phonon coupling. This strategy releases trapped carriers, significantly enhancing solar water splitting efficiency for sustainable fuel production.

Protein kinases contribute to hepatocellular carcinoma progression and immune evasion. This study identifies SPAK as a key driver of oncogenesis and immune exhaustion, showing that SPAK inhibition synergizes with anti-PD-1 therapy to enhance antitumor efficacy.

Newly emerging SARS-CoV-2 variants underscore the need for broad-spectrum antiviral solutions. This study shows a macrocyclic peptide inhibitor that locks the SARS-CoV-2 spike trimer into a “closed” conformation by engaging a conserved region, and demonstrates that intranasal administration of the peptide inhibitor protects against Omicron variants.

Perovskites are widely used as templates for designing noncentrosymmetric materials, whereas their anion-centred counterparts have not been extensively explored. Here, authors develop a strategy to design heterocationic anti-perovskite materials with a noncentrosymmetric structure, yielding outstanding nonlinear optical properties.

Multi-axis atropisomers are common, but techniques for structural elucidation are limited. Here, the authors report a correlation between molecular dynamics and electronic through-space conjugation (TSC), along with absolute separation of the syn and anti conformers.

A biohybrid chiral hydrogel combining cell-membrane-coated nanoparticles with a D-chiral matrix reduces tumour stemness via biochemical and biophysical regulation, boosting radioimmunotherapy and preventing postoperative glioblastoma recurrence.

Single-chain polymer dots used as ultrasmall fluorescent probes enable nanometre-resolution imaging and are capable of tracking kinesin-1 stepwise motion in living cells using a standard spinning-disk confocal microscope.

Achieving efficiency by approaching the theoretical limit in silicon heterojunction solar cells remains challenging. Here, the authors fabricate devices using rear-side polishing and progressive RF/VHF PECVD film deposition schemes for doping layers, realizing a certified cell efficiency of 27.0%.

Printable mesoscopic perovskite solar cells are a promising device design, yet their efficiency is limited by charge collection. Ma et al. use hexamethylene diisocyanate to eliminate unreacted organic cations at grain boundaries, enhancing hole collection.

Tertiary lymphoid structures (TLS) within the tumour microenvironment are important for prognostic and immunotherapeutic indications in cancer. Here the authors use a spatial and single cell transcriptomics analysis of gastric cancer (GC) samples and show transcriptomic differences grouped by types of TLS and generate a prognostic transcriptomic signature to help predict outcome in GC patients.

Binding of particles to molecular or macroscopic objects generates a universal entropic pulling force. Simulations and experiments on vibrating bead-chains and DNA with multivalent ions confirm this entropic pulling effect, with implications for cellular disassembly processes and molecular machine design.

Enzyme-bound ketyl radicals derived from thiamine diphosphate are selectively generated through single-electron oxidation by a photoexcited organic dye and shown to lead to enantioselective radical acylation reactions.

Pancreatic ductal adenocarcinoma (PDAC) is highly lethal, with treatment effectiveness, including immunotherapy, limited by immunosuppressive tumor microenvironment. This study identifies TNK2/ACK1 as a driver of immune evasion in pancreatic cancer via STAT5A-HVEM signaling that disables CD8⁺ T cells while TNK2 inhibition restores antitumor immunity and synergizes with anti-PD-1 and chemotherapy in PDAC models.

Growth factor signalling has been shown to alleviate tissue fibrosis and promote repair. Here, the authors use fibroblast growth factor 7 (FGF7) knockout mice and an FGF7-loaded hydrogel to show that this factor can promote functional regeneration of tendon.

CXCR4 is a less-studied co-receptor for HIV entry that also serves as the receptor for the chemokine CXCL12. In this study, the authors reveal how HIV-2 engages CXCR4 and how CXCL12 inhibits this interaction, uncovering structural features that underlie viral specificity and inhibition

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Catalyst design is typically tailored to individual reactions because universal descriptors connecting molecular structure to ideal active-site configurations are lacking. Here, the authors reveal a reactant-dependent volcano trend in Pt-catalyzed cycloalkane dehydrogenation, dictated by the Pt–Pt coordination number.

This work presents an ultracompact silicon modulator with a 110-GHz bandwidth within 10 µm² footprint, enabling 130 Gbps data transmission. This breakthrough overcomes the bandwidth-footprint limitation for next-generation optical interconnects.

Type 2 diabetes is an established risk factor for dementia. Here, the authors use data from 33,136 older Chinese adults to show that polygenic risk for type 2 diabetes was associated with vascular dementia but not Alzheimer’s disease.

High-pressure diamond anvil cell experiments reveal that compression strengthening of nanocrystalline nickel increases as its grain sizes decrease to 3 nanometres, owing to dislocation hardening and suppression of grain boundary plasticity.

Critical-sized bone defects still present clinical challenges. Here the authors show that transplantation of neurotrophic supplement-incorporated hydrogel grafts promote full-thickness regeneration of the calvarium and perform scRNA-seq to reveal contributing stem/progenitor cells, notably a resident Msx1+ skeletal stem cell population.

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

The contribution of the extracellular matrix and its degradation to the aging process is not well understood. Here, the authors show that degraded elastin fragments, which increase in the circulation with age, promote aging, while counteracting elastin fragment signals alleviates inflammation, promotes healthy aging and extends lifespan.

Current CO₂ utilization relies on high-purity CO₂, requiring energy-intensive capture and purification. This study developed a solar-powered heterojunction catalytic system that directly converts atmospheric CO₂ with ammonia into urea.

This study identifies BAG3 as a conserved immune regulator in plants and demonstrates that its cleavage by metacaspase 4 triggers cell death and antiviral defense, offering a potential strategy for engineering virus-resistant crops.

Thinopyrum intermedium and Roegneria kamoji are wheat relatives commonly used in distant hybridization breeding program. Here, the authors report the genome assemblies of the two species and reveal their phylogenetic relationship and genome compositions.

The gut microbiota bacterium Ruminococcus gnavus is implicated in the development of cirrhotic liver encephalopathy through the production of neurotoxins.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.