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Researchers demonstrate chaos transfer between two optical fields in an optomechanical system.

Through shaping of colloidal particles, optical traps with prescribed force–displacement profiles are generated and are used to design a microscopic constant-force spring capable of delivering a constant piconewton-scale restoring force for displacements of several micrometres. Potential future applications include the imaging of sensitive biological membranes.

When senescent cells accumulate during adulthood they negatively influence lifespan and promote age-dependent changes in several organs; clearance of these cells delayed tumorigenesis in mice and attenuated age-related deterioration of several organs without overt side effects, suggesting that the therapeutic removal of senescent cells may be able to extend healthy lifespan.

This study reveals high-spin state formation and quintet-mediated emission in diphenylhexatriene oligomers. Quintet states dominate delayed fluorescence up to room temperature, establishing a spin-selective platform for quantum technologies.

A neuromorphic sensing system combining a flexible piezoelectric sensor array, event-triggered circuitry and a memristive chip enables energy-efficient, low-latency edge processing of event-based data through analogue in-memory computing.

This study demonstrates how to combine molecular dynamics computer simulations with experimental biophysical data to determine accurate atomic-resolution ensembles of intrinsically disordered proteins.

Biexciton complexes in atomically thin transition metal dichalcogenides have unusually large binding energies. Here, the authors explore biexciton formation dynamics in monolayer MoSe₂ in the presence of magnetic fields up to 25 T.

Environmental justice and drinking water in the US: Higher proportions of Hispanic/Latino, American Indian/Alaskan Native, and non-Hispanic Black residents were associated with higher public water arsenic and uranium at the county-level, findings differed by region.

A groundbreaking study reveals how physical confinement triggers ferroptosis. It finds the nucleus acts as a mechanosensor, orchestrating Drp1 and cPLA2 that leads to mitochondrial dysfunction and ultimately, cell death.

Materials with a Kitaev spin liquid ground state are sought after as models of quantum phases but candidates so far form either zig-zag or incommensurate magnetic order. Ruiz et al. find a crossover between these states in β-Li₂IrO₃ under weak magnetic fields, indicating strongly frustrated spin interactions.

Challenges in mapping modern molecular and anatomical datasets into a common atlas are not fully addressed. Here authors present approaches to aligning multimodal neuroimaging data and quantifying geometric variability. Authors also make sure open-source code, dataset standards, and a web interface are available, enabling large scale integration of datasets essential to modern neuroscience.

This study shows how commercial fishing and increasing temperatures impact predator-to-prey body mass ratios (PPMR) in the Northeast Atlantic. Authors identify an increase in PPMR that may weaken ecosystem stability, giving insight for sustainable fisheries management under future climate warming.

In an interferometer using the ballistic propagation of electrons in a quantum Hall conductor, the phase of a single-electron wavefunction can act as a sensor for the detection of fast electric fields of small amplitude.

The systemic discovery of metal–small-molecule complexes from biological samples is a difficult challenge. Now, a method based on liquid chromatography and native electrospray ionization mass spectrometry has been developed. The approach uses post-column pH adjustment and metal infusion combined with ion identity molecular networking, and a rule-based informatics workflow, to interrogate small-molecule–metal binding.

Systematic screening of transcription factors reveals conserved mechanisms governing cortical radial glia lineage progression across primates and provides a framework for functional dissection of gene regulatory networks in human cortical neurogenesis.

Fluorescence microscopy during CryoFIB milling produces an interferogram that can be used to direct lamella production to labeled structures with accuracy beyond the axial diffraction limit. The approach relies only on real-time feedback from the structure, requiring no image registration.

The authors report an experimental study of the Hall effect measuring electrical quantities in ultracold fermionic quantum simulators. This provides a way forward in measuring transport properties in these platforms and verifying long-standing theoretical predictions.

Effective haptic interfaces are advantageous for technology that involves human-computer interaction. Here Liu et al. fabricate thin liquid crystal polymer network coatings which can be modulated by applying an alternating electric field; such switchable topography could be applied to haptic interfaces.

Frustrated quantum magnets have been studied intensely, owing to their potential of hosting exotic quantum magnetism, however, experimental realisation of model systems, such as the spin-1/2 Heisenberg antiferromagnet on an anisotropic triangular lattice is challenging. Here Gen et al demonstrate that the rhenium oxyhalides, A3ReO5X2, though chemical substitution can span a diverse effective spin Hamiltonians.

Peripartum cardiomyopathy (PPCM) is a potentially fatal heart condition with poorly understood molecular causes. Here, the authors show that loss of the protein PTRH2 in female mice leads to postpartum heart failure, identifying it as a potential therapeutic target.

Equivariant neural networks are state-of-the-art for machine learning-driven molecular dynamics (MD) simulations but have high computational cost. Here, the authors develop a Euclidean transformer that balances accuracy, stability, and speed, enabling stable long-timescale simulations of complex molecules

This study uses single-nucleus RNA sequencing to analyze lung tissue from 141 individuals with chronic obstructive pulmonary disease. Distinct patterns of spatially resolved changes in cell composition and cell states that correlate with clinical features are highlighted.

In this work, researchers show how laser annealing is used to create complex 2D gradients in magnetic properties, which can steer spin waves and domain walls. This fast, maskless method enables the development of next-generation computing devices.

The discovery of a vast reservoir of primordial neutral hydrogen gas surrounding a young galaxy cluster just one billion years after the Big Bang offers new insight into how the first large cosmic structures assembled.

Coordinated X-ray and radio observations reveal that disk winds and jets occur mutually exclusively in 4U 1630–472, providing new observational constraints on the interplay between different modes of outflow in X-ray binaries.

iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors. They are advantageous for detecting rapid dynamics and large population activity, respectively, as demonstrated in a variety of applications in the mouse brain.

Germano-silicate used as a building material for integrated photonics circuits substantially reduces optical losses, approaching levels comparable to those in optical fibres.

Optically active spin defects in diamond and hBN are promising solid-state quantum sensors but often fall short for chemical sensing. Here the authors show that BN nanotubes hosting such defects create a nanoporous, omnidirectional quantum “mesh” sensor at room temperature, enhancing chemical detection through high surface area and improved sample accessibility.

A completely solid-state, single-chip, microwave-frequency surface acoustic wave phonon laser can generate coherent phonons from thermal noise or resonantly amplify injected phonons using only a direct current bias field.

The xylosyltransferase isoenzymes XT1 and XT2 catalyze the first glycosylation step in the biosynthesis of proteoglycans. Now, bump-and-hole engineering of XT1 and XT2 enables substrate profiling and modification of proteins as designer proteoglycans to modulate cellular behavior.

Pender et al. evaluated depression and anxiety symptom trajectories in autistic adults receiving routine therapy in UK primary care.

Each valley of the mini-Brillouin zone ("mini valley") of twisted bilayer graphene (TBG) contains two Dirac cones that hybridize to form flat bands. Theory predicts that these two Dirac cones have the same chirality, leading to topological obstruction. Here, the authors confirm this prediction experimentally.

Using a virtual reality apparatus in rats that dissociates external landmarks from self-motion cues, the authors describe how the two modes of theta phase coding in the hippocampus during navigation are controlled via distinct computations.

deQuilettes et al. show that hexylammonium bromide forms an iodide-rich 2D structure and bromide gradient at the surface of 3D perovskite, both of which limit interfacial charge and energy losses in perovskite solar cells.

The early postnatal roles of dendrite-targeting interneurons in primary visual cortex (V1) remain elusive. Here, the authors find that somatostatin interneurons in mouse V1 exhibit a uniquely delayed developmental trajectory for innervation and sensory responses, highlighting a window for the emergence of a key mechanism for normalization in cortical circuits.

Understanding the dynamic behavior of metal clusters at high temperatures is challenging due to a lack of theoretical knowledge. Here, the authors use a machine-learned potential for thiolate-protected gold clusters to reveal atom-scale mechanisms of cluster disordering and cluster-cluster reactions.

State-of-the-art approaches for modelling electrified solid–electrolyte interfaces are critically discussed, highlighting key challenges in incorporating thermodynamic open-boundary conditions, large electrostatic potentials and their dynamic fluctuations into realistic ab initio simulations.

Reduced order modeling is of paramount importance for accelerating engineering design and characterization. Here, authors propose a SHallow REcurrent Decoder-based Reduced Order Model (SHRED-ROM) to reconstruct high-dimensional, parametric and complex dynamics from limited sensor measurements.

One of three back-to-back papers to show that dosage of BACH2 can modulate T cell differentiation and function and how we might apply this to enhance CAR T cell therapies for cancer.

The order in which driver mutations of colorectal cancer occur in intestinal epithelium can determine whether clones are positively or negatively selected and can shape subsequent tumour development.

The relation between magnetooptical activity and chirality has previously been confused. Chiral polymer films are presented with state-of-the-art Verdet constants, revealing the role of chirality, and a strategy to enhance the magnetooptical B term.

The authors demonstrate a zero-field supercurrent diode effect in NbSe₂/NiI₂/NbSe₂ vertical Josephson junctions, where NiI₂ is a two-dimensional multiferroic material. The diode efficiency is even as a function of field, making the device “resilient" to stray fields from nearby circuit components.

Here, the authors demonstrate the electrical tunability of the nonlinear interactions, ultrafast formation and decay dynamics of layer-hybridized excitons in a field-effect device based on natural homobilayer MoS₂.

Uncertainty-aware machine learning models are used to automate the training of reactive force fields. The method is used here to simulate hydrogen turnover on a platinum surface with unprecedented accuracy.

Stanage et al. identify a role for transfer RNA nuclease SLFN11 in replication-stress-induced cell death in cisplatin-treated cells lacking PrimPol. SLFN11 is activated upon single-stranded DNA accumulation at stalled forks followed by replication protein A exhaustion and cell death.

Central charge, a key quantity in conformal field theories, is crucial in the study of critical phenomena, yet its measurement has remained elusive. Here, the authors extract the central charge of several quantum critical models by accurately preparing their ground states on a superconducting quantum processor.