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Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

The biological basis of afternoon nap remains unclear. Here, authors show that NPAS2 in mPFC TH-positive neurons activates POU2F2 to suppress TH level and dopamine production, thereby reducing wake-promoting neural activity and driving nap behavior.

The development of Tat clusters has advanced the intracellular delivery of functional antibodies at low concentrations, but the variety of proteins that can be successfully delivered remains limited. Here, the authors report that by reversibly modifying the surface of functional proteins with anionic peptides, various protein cargoes (otherwise difficult to deliver) can be delivered into living cells by synergetic electrostatic interactions with the cationic cell-penetrating peptide clusters TAT₃.

Supported noble metal catalysts are vital for industrial, environmental, and energy applications, but precisely tuning active-site geometry remains challenging beyond conventional particle size control. Here, the authors present a perovskite-based surface defect engineering strategy that enables atomic-level regulation of noble metal active sites for improved hydrocarbon oxidation.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Self-aggregation in self-assembled monolayers adversely affects on hole transport performance in inverted perovskite solar cells. To address this issue, Shen et al. propose an indole/carbazole co-adsorption strategy to construct phase-homogeneous monolayers featuring alternating molecular arrangements.

Authors present a specialized diagnostic tool called ClinDiag-GPT trained on real-world cases. It outperformed baseline models of existing large language models and could serve as a clinical assistant to physicians.

Lithium metal offers high specific capacity but suffers from dendrite growth and poor cycling stability. Here, authors develop a 3D Li-Zn-Li3N/CNT composite combining ductile Li-Zn alloy and a mechanically robust Li3N-CNTs network, enabling thin, durable electrodes with uniform lithium deposition, demonstrating a pouch-cell with a specific energy of 553 Wh kg-1.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

He et al. report that the host-derived macrophages/monocytes enhanced malaria transmission by reducing the abundance of transmission-blocking microbiota in mosquito midgut via SRA-mediated phagocytosis. In addition, the depletion of macrophages/monocytes or the use anti-SR-A neutralizing antibodies significantly enhances the transmission-blocking efficacy of anti-Pfs25 monoclonal antibodies.

The interlayer π-π stacking primarily results in irreversible dispersibility of GO, providing supramolecular view for the regulation of graphene-based materials.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Li et al. identify small spherical vesicles budding from plant multivesicular bodies as likely retrograde carriers and demonstrate that SNX proteins drive their formation, revealing a distinct mechanism for protein recycling during plant development.

Guo et al. report a surface-energy homogenization strategy to fabricate InP-based quantum dots with strong electron confinement, enabling green LEDs with efficiency of 23.50% and retaining a peak efficiency over 20% even at a resolution up to 8,460 PPI for active-matrix displays.

The incorporation of alkali metals in kesterite solar cells enables high efficiency but is challenging to control. Xu et al. show that combining Na and Li ions yields optimal phase formation, enabling efficient solar cells and modules.

The role of long non-coding RNAs (lncRNAs) in regulating cancer progression remains to be explored. Here, the authors identify an antisense lncRNA in the IGF1R locus (IGF1RAS1) which strongly interacts with super enhancers and modulates MYC expression in metastatic prostate cancer.

By constructing tailored donor-acceptor structures in 3D COFs via artificial defects and electronic tuning, researchers overcame inherent limitations in conjugation and light absorption, achieving stable and efficient photocatalytic H₂O₂ production.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Researchers demonstrate a minimalist terahertz wireless transceiver in integrated photonics. They break the longstanding constraint between source purity and DSP complexity, realizing 144 Gbps high-speed transmission at subterahertz frequency.

This study explores the role of protein hyperacetylation in heart failure with preserved ejection fraction (HFpEF). It identifies Dlat as a key regulator of mitochondrial fatty acid oxidation, offering insights for clinical HFpEF interventions.

Despite rapid development of model algorithms, more evidence is needed on the widespread clinical implementation of auto-segmentation tools. In this prospective, multicenter, observational trial, the authors find that AI-assisted delineation performs better than manual delineation while improving time efficiency and reducing performance metrics variability across centers and physicians with varying expertise.

In vanadium flow batteries, crossovers are critical challenges for membrane design. Here, authors propose a balanced state electrolyte strategy that overcomes crossovers, thereby circumventing existing membrane-related constraints and establishing a new framework for advanced electrolyte design.

Tumor-infiltrating T cells (TIL) are key mediators of the anti-tumor immune responses. However, chronic exposure to tumor antigens leads to the acquisition of an exhausted phenotype. Here, the authors present a bispecific T-cell engager that combines an anti-TIM-3 antibody with an IFN-α fusion protein (BiDT) and facilitates T cell-dendritic cells (DC) interactions. In preclinical mouse models, the enhanced T cell-DC crosstalk, dependent on CD28 co-stimulation and IL-2 signaling, boosts anti-tumor immunity and the generation of memory T cell responses.

An electrothermal fluorination methodology has been developed to transform granular activated carbon-sorbed aqueous film-forming foam waste into graphene and a fluorinating reagent, subsequently enabling lithium recovery from brine sources.

By engineering single residue of protein with a light-switchable molecule, this study reveals that local hydrophobicity propagates through hydrogen bond network to reshape protein structure and function, shifting the paradigm to structure–hydration– function.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

Here, the authors show that the PLA2G6 protein is a component of the IP3R1–GRP75–VDAC1 complex at the mitochondria-associated endoplasmic reticulum (ER) membrane, maintaining the integrity and function of ER–mitochondria contacts.

Grain chalkiness is an undesirable trait that severely compromises rice quality. Here, the authors report the cloning of an E3 ubiquitin ligase encoding gene Chalk9 and reveal its crucial role in regulating grain chalkiness through mediating the ubiquitination-dependent degradation of OsEBP89.

FLPClusters, which are structurally precise metal clusters incorporating Frustrated Lewis Pairs (FLPs), represent a promising class of catalysts, but their tendency to undergo neutralization limits catalytic efficiency. Herein, the authors report the synthesis of FLPClusters featuring well-defined, tailorable, and accessible FLP active sites.

RNA polymerase II (RNAPII) is typically considered as an essential enzyme. Here the authors show that natural degradation of RNAPII drives chromatin reorganization in growing oocytes, preparing the chromatin for genome activation after fertilization.

Susceptibility of Nasopharyngeal carcinoma (NPC), associated with Epstein-Barr virus infection, is linked with HLA gene region with mechanisms unclear. The authors here show that the high-risk EBV subtype BALF2 upregulates HLA-DP, leading to CD8⁺ T cell exhaustion, and combined anti-LAG-3 and anti-PD-1 therapy improves anti-cancer efficacy.

High entropy spinel oxides host multiple metals in one crystal structure with tunable catalytic properties, but controlling coordination site occupancy of metal cations is difficult. Here, the authors exploit site preference energy differences to direct metal occupancy, boosting conductivity and oxygen evolution activity.

It remains unclear how opponent serotonin and dopamine signals regulate striatal activity to exert opposing effects on behavior. This study reveals how the complement of serotonin and dopamine receptors expressed by cells in the striatum enable the two neuromodulators to exert opposing functions during reward learning.

Blue light promotes DNA repair in plants via cryptochrome signalling. Here the authors report that this occurs via suppression of COP1 mediated degradation of the repair factor ADA2b and propose that together photoreceptors and COP1 balance genome stability with growth under fluctuating light.

Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal cancer with poor prognosis and limited treatment options. This study identifies Prolyl 3- hydroxylase 1 (P3H1) as a critical regulator of PDAC progression through PLK1-β-catenin signaling, driving tumor-associated macrophage recruitment and tumor growth.

A hallmark of the interaction between flat band and dispersive band states in quantum materials is the flat band resonance. Here, the authors report the observation of a flat band resonance in the kagome bilayer material CsCr₆Sb₆ originating from the doublet kagome bands of the bilayer unit.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Accurately mapping diverse cell types in complex tissues remains a challenge for spatial transcriptomics. Here, the authors present UCASpatial, an entropy-weighted algorithm that enables ultra-precision deconvolution to resolve fine-grained immune landscapes and explore intercellular mechanisms.

The authors demonstrate a generative model-based inverse design strategy that synergistically optimizes the composition and polarization configurations in Bi_0.5Na_0.5TiO₃-based ceramics, achieving enhanced energy-storage performance under low fields.

Androgenetic alopecia is the most common type of hair loss, but its drivers remain poorly elucidated. Here, the authors show that hyperactive contraction of the follicle connective tissue sheath impairs hair growth by activating mechanosensitive signaling, suggesting a tractable therapeutic target.

Cold tolerance at the booting stage is critical for the expansion of rice cultivation area. Here, the authors report that a CAMTA family transcription factor encoding gene CTB3 positively regulates japonica rice booting stage cold tolerance and its upstream and downstream interactors to fulfill the functionality.

Here, the authors demonstrate that Inhibiting PTBP1 corrects E2A splicing imbalance, reprograms muscle cell development, and rescues defective muscle regeneration in a Duchenne muscular dystrophy mouse model.

Grain number per panicle (GNP) is a yield-determining trait of rice. Here, the authors identify a GSK3-like kinase-encoding gene GNP2 and a bZIP transcription factor-encoding gene GNP5, demonstrating their synergistic regulation of GNP and showing that specific allele combinations of these genes enhance rice yield in field conditions.

The MoSi₂N₄ family is an emerging class of van der Waals materials with interesting properties. Here, the authors report a systematic characterization of point defects in monolayer WSi₂N₄ and MoSi₂N₄, showing their influence on the electronic properties of the materials.

An agent-driven simulation framework paired with a multisensor mapping system enables robust simultaneous localization and mapping for quadruped robots, advancing perception in complex simulated and real-world environments through stable, drift-free three-dimensional mapping.

Traditional recycling of polyoxymethylene plastic often leads to significant material loss and toxic emissions. Here, the authors introduce an acidic electrochemical process that efficiently converts plastic waste into valuable chemicals with conversion efficiency approaching 90%.

Copper nanoclusters are promising photothermal heaters, but their conversion efficiency is limited efficiency. Here, the authors present a rotor-stator ligand architecture that enables enhanced photothermal conversion efficiency of copper nanoclusters.

Environmental persistence of organofluorines, stemming from the high bond energy of C–F bonds and resultant chemical inertness, poses substantial environmental safety concerns. Here, the authors reclaim valuable hydrocarbons from fluorinated compounds, including aryl fluorides, alkyl fluorides, and perfluoroalkyl substances, by developing a mechanochemical hydrodefluorination strategy.