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Tumor-reactive T cell receptors are rapidly identified from lymphocyte scRNA-seq data.

Hierarchical immobilization of multicomponent biomacromolecules is promising for constructing advanced biopharmaceuticals, but remains challenging. Here, the authors report a multicomponent synergistic approach integrating in-situ and dynamic exchange methods to construct hierarchical biopharmaceutical formulations.

Uncontrollable hemorrhage is a leading cause of preventable death. Here, Huang et al. develop a rapid, self-expanding, coagulation-promoting hemostatic powder for non-compressible hemorrhage management.

The complexity of the evolved metabolic networks of flavonoids complicates pathway elucidation and design. Here, the authors identify enzymes that modify isoflavan scaffolds from the genome and transcriptome data of Glycyrrhiza glabra, and reconstruct de novo glabridin biosynthesis in yeast.

This study shows that circulating proteins mediate the health effects of air pollution on multiple diseases and proposes a protein-based risk score for prediction of pollution-related disease susceptibility.

The interaction between immune cells and the peripheral nervous system during the progression of vascular diseases is poorly understood. Here, the authors use a mouse model of neointimal hyperplasia (NIH) and show that Tenascin (Tnc)-positive myofibroblasts originate from adventitial fibroblasts and promote activation of sensory nerves and CCL-2-dependent accumulation of macrophages to drive inflammation and vascular remodeling.

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

A recent randomised controlled trial demonstrated effectiveness of a smart pillbox for oral HIV pre-exposure prophylaxis adherence in men who have sex with men in China. Here, the authors show that the intervention is cost effective, with greater benefits for more socially vulnerable groups.

The lack of high-energy positive materials hinders the development of magnesium metal batteries. Here, authors design an anion receptor-mediated electrolyte that enables the electrochemical cooperation between fluoride and magnesium, and develop a high-performance Mg | |FeO0.7F1.3 battery prototype.

Electrochemical urea oxidation can coproduce nitrite and H₂, but it typically lacks selectivity. Here, the authors address this issue by designing doped Lewis acid sites to trigger a hydroxyl spillover mechanism, resulting in highly selective nitrite production and efficient energy conversion.

Modifying the light-absorbing or catalytic properties of a photocatalyst typically requires tedious preparation, resulting in a lengthy development process. Here, the authors address this limitation by achieving manganese-based low-energy photoredox catalysis through the in-situ assembly of simple Mn salts with inexpensive coordinating chemicals.

Ionic bonds have potential in enhancing organic phosphorescence, but often precise molecular design is required. Here, the authors report the use of ionic alkyl chain hosts for the preparation of ionic phosphorescent materials, with the chromophores having quaternary ammonium groups added.

The mechanisms underlying increased cardiometabolic risk from cancer treatment in childhood cancer survivors remain to be explored. Here, epigenome-wide analysis in childhood cancer survivors identified DNA methylation sites that mediate treatment-related cardiometabolic risks and are associated with inflammatory and metabolic pathways.

Xiao et al. report the synthesis of a fullerene derivative bearing four piperazidine groups to engineer the tin halide perovskite/C60 interface, enabling the photovoltaic devices with a power conversion efficiency of 22.49% and an output power density of 64.1 μW cm-2 under 1,000 lux white light illuminance.

Electrochemical hydrogenation of quinoxaline is a promising alternative to traditional methods but is limited by low current density and Faradaic efficiency. Here, the authors report a Ru single atoms doped Co₃O₄ nanosheet catalyst that regulates interfacial water to achieve excellent performance.

Intermittent fasting (IF) has been recognized as a potential cancer therapeutic approach but its effect on tumor growth is limited. This study demonstrates that response to IF varies between glioblastoma subtypes, with IF specifically inhibiting Tp53-driven glioblastoma due to a reshaping of the gut microbiota and subsequent altered methionine metabolism suppressing TGF- β signaling.

The histone methyltransferase ASH1L has been linked to tumorigenesis, mainly in leukemia. Here, authors report that ASH1L cooperates with HIF-1α to induce a pro-metastatic transcriptome in prostate cancer cells, and promotes conversion of monocytes to lipid-associated tumor-associated macrophages in the bone metastatic niche.

Personalized nanovaccines derived from autologous tumour cells and engineered to display dendritic cell-like features enhance immune activation and prevent postoperative metastatic cancer in preclinical models.

Ma et al. report an organic cation engineering strategy to improve the luminescent properties and charge transport in organic-inorganic antimony halide films, enabling red LEDs with efficiency up to 19.4% and half-lifetime of 10,190 min. Large-area (12.15 cm²) LEDs show efficiency of 14.2%.

CRISPR-Cas12a diagnostics are limited by strict PAM requirements. Here, authors show that higher temperatures activate numerous noncanonical PAMs, enabling a versatile one-pot platform that improves sensitivity, specificity, and rapid on-site pathogen detection.

Multifunctional underwater sensors with integrated self-powered signal transmission, effective thermal-moisture regulation, and multi-signal decoupling are desirable of underwater tasks. Here, the authors report a three-dimensional thermoelectric device composed of porous polyurethane foam coated with a waterproof conductive layer for human-machine interaction in aquatic settings.

Emerging evidence underscores biophysical characteristics of cancer cells as key modulators of cancer metastasis. Here, the authors reported a single-cell mechanophenotyping chip that screens deformable CTCs to reveal the hematogenous metastatic potential of bacteria-infected breast cancer.

Shifts in phenology can significantly impact organism fitness, ecosystem function, and the provision of ecosystem goods and services. Through a global meta-analysis, this study shows how shifts in the timing of leaf-out and first flowering due to warming and precipitation changes depend on plant functional group and climate region.

O-GlcNAc chromatin modifications dynamically reshape the transcriptional program of oncogene-induced senescence, forming complexes that activate SASP genes and repress cell-cycle genes; JUN and GATAD2A are identified as key regulators.

How the vascular endothelial cells support the functional adaptation of pancreatic islets under obesity-associated metabolic stress is poorly understood. Here, the authors show that the ER stress sensor IRE1α employs its RNase activity to play an important regulatory role in this process.

Cardiometabolic disease and depression often co-occur, but their multi-organ basis was unclear. Here, the authors analyse UK Biobank imaging and genetics, identifying abdomen-heart-brain networks and 43 shared loci, improving multimorbidity prediction

The differential cholinergic modulation of two different premotor inputs to projection neurons in the vocal motor pallial nucleus RA provides a mechanism for adult songbirds to stabilize their songs.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Epigenetic traits can persist across generations through small RNAs and chromatin marks. Here, the authors show that SET-24, a non-enzymatic SET protein, partners with HCF-1 to maintain RNAi silencing and sustain chromatin states and small RNA populations in C. elegans.

This study reports that genomic signatures composed of the loss of pluripotency inhibitors, expansion of pluripotency activators and maintenance of an epigenetically permissive state contribute to the plantlet formation in Kalanchoe.

Cystine levels in pancreatic ductal adenocarcinoma (PDAC) tumour microenvironment are deficient, despite its crucial role for cancer cell maintenance. Here, the authors show that adaptation to cystine limitation stress promotes PDAC growth through induces metabolic reprogramming to promote PDAC tumor growth, while conferring a vulnerability in lipid metabolism targetable by lomitapide.

Altermagnets combine spin-split electronic bands with zero net magnetization, making them ideal for integration into spin-based information processing devices. Here Guo, Chen, Zeng, and coauthors demonstrate a magnetic memory making use of the altermagnetic spin splitting torque in a three terminal MRAM device.

The understanding of the “enhanced permeability retention” (EPR) effect which enables cancer nanocarriers to penetrate solid tumors remains controversial. Here this group evaluates a range of intravenously injectable lipid-coated mesoporous silica nanoparticles exploring the role of proteins attached to the surface of nanoparticles in transcytosis-dominant cancer drug delivery.

Intermittent hypobaric pressure extends the lifespan and rescues the osteoporosis phenotype in aged mice by activating the ion channel transmembrane protein 59 (TMEM59) and eliminating senescent cells via lysosome-dependent cell death.

Thymine DNA glycosylase (TDG) was identified as a synthetic-lethal target in p53-deficient cancers through alterations in double-stranded RNA accumulation. A covalent small-molecule inhibitor of TDG exhibited potent efficacy against p53-deficient tumors.

Three new euharamiyidan species from the Jurassic period of China are described, cementing the alliance with multituberculates and showing that the initial divergence between groups of extant mammals—monotremes on the one side, marsupials and placentals on the other—goes back to the Triassic period.

The role of protein UFMylation in cancer remains to be understood. Here, the authors show that UFM1-specific ligase 1 and AKT positively regulate each other through UFMylation and phosphorylation, facilitating lipid synthesis and breast tumor growth.

This study shows that optimally sized nanocarriers reach Duchenne muscular dystrophy muscle primarily through transcytosis, where they can deliver tamoxifen to improve muscle health and strength in mice.

Infrared information encryption is a promising technique for data transmission, though current strategies fail to transmit data in real-time. Here the authors report a multilayer relaxor ferroelectric polymer stack which exhibits rectangular temperature wave for real-time and programmable encryption.

Atomically thin nitrogen crystals, termed nitrogene, have been theoretically predicted, but their synthesis has remained elusive so far. Here, the authors report experimental evidence of the formation of nitrogen-based crystalline structures compatible with nitrogene on Ag(100) surfaces via ion-beam-assisted epitaxy.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.