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Autophagy has been reported to have an important role in glioblastoma temozolomide resistance but the underlying mechanisms are unclear. Here, the authors identify RFC4-STK38-BECN1 complex as a driver of autophagy activation and subsequent temozolomide resistance in preclinical models of glioblastoma.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

The interlayer π-π stacking primarily results in irreversible dispersibility of GO, providing supramolecular view for the regulation of graphene-based materials.

The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

The authors propose an asynchronous sublattice distortion mechanism to elucidate the complex phase transitions in HfO₂-based materials. The phase transitions among the orthorhombic, tetragonal, and monoclinic phases are governed by the orientation of the orthorhombic phase.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Wang, Guo, Zhang and colleagues obtain four cryo-electron microscopy snapshots that show how IscB is kept off by two RNA lids, with a car-pedal-like guide shift activating cleavage after ~11-nt pairing. They also engineer hinge regions that boost flexibility and improve genome editing in cells.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

SnRK1β1A in rice promotes susceptibility to multiple fungal diseases, and disrupting this infection-inducible gene confers broad-spectrum resistance without compromising growth or yield under normal field conditions.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

Cancer cells could sense the availability of glucose to coordinate macromolecular synthetic processes. Here the authors find that glucose-activated adenylosuccinate lyase (ADSL) possesses a moonlighting function of promoting protein succination, thereby upregulating lipogenesis in hepatocellular carcinoma cells.

Exhausted CD8⁺ T cells increase proteasome activity due to the accumulation of depolarized mitochondria, which drives the selective degradation of mitochondrial proteins and releases of regulatory haem through haemoprotein breakdown.

By constructing tailored donor-acceptor structures in 3D COFs via artificial defects and electronic tuning, researchers overcame inherent limitations in conjugation and light absorption, achieving stable and efficient photocatalytic H₂O₂ production.

Inborn errors of cell death (IECD) with autoinflammatory manifestations could be induced by excessive T cell death. Here the authors characterize IECD patients with autoinflammatory manifestations who possess overactive RIPK1 variants which promote T cell death, secretion of TNF and IFN-γ along with activation of monocytes and macrophages which promotes further autoinflammation.

This study reveals that Amphotericin B activates glucocerebrosidase to remodel late endosomal lipid and protein composition, promoting respiratory viral entry. This highlights a risk of secondary viral infections during antifungal therapy.

In this work the authors employed deep learning-based methods to design mini-protein that block membrane insertion of complement C9. These well performed inhibitors provide an alternative approach for preventing diseases associated with abnormal complement activation.

Preparation of phosphorescent materials from bio-based materials is desirable, but achieving the desired properties can be challenging. Here, the authors report the development of 3D printable woody materials by grafting carboxyl functional groups onto lignocellulose matrices.

A synthetic genetic circuit made up of recombinase-based cell-fate branching devices enables precise control over the ratios of cell types in an offspring population derived from one founder strain, and could be used to build user-defined multicellular aggregates.

Selective activation of aliphatic C–H bonds in complex polycyclic terpenoids remains a significant challenge. Now a bacterial P450 enzyme has been shown to achieve precise functionalization of inert C–H sites in pentacyclic triterpenoids, unveiling a distinctive relay-oxidation pathway mediated by 1,5-hydogen atom transfer and establishing a versatile chemo-enzymatic platform for accessing previously unexplored chemical space.

Tuning the emission of metal nanoclusters is a challenge. Here, the authors report on solvation-induced isomerization and modulation of electron transfer dynamics to achieve controllable emission across the entire visible range.

3Snet-CLID integrates signal-preserving deep learning denoising with direct Richardson–Lucy deconvolution to achieve over 5-fold resolution improvement on standard microscopes, enabling artifact-free nanoscale imaging of live-cell organelles and structures.

Blue light promotes DNA repair in plants via cryptochrome signalling. Here the authors report that this occurs via suppression of COP1 mediated degradation of the repair factor ADA2b and propose that together photoreceptors and COP1 balance genome stability with growth under fluctuating light.

Researchers identified a previously unrecognized progeroid neuropathy caused by mutations in IVNS1ABP. Patient-derived fibroblasts, induced pluripotent stem cells, and neural progenitor cells exhibited disrupted dynamics, resulting in defective cytokinesis, DNA damage, and cellular senescence, which in turn led to premature neurogenesis in cerebral organoids.

Clarifying how different acid sites function in zeolite catalysts is essential yet difficult due to their overlapping roles. This study uncovers distinct reaction pathways and a key trade-off that governs ethylene formation from ethanol.

This study presents azo-Q2a, a quinidine-derived photo-switchable molecule that enables optical control of Na_V1.5. It exhibits selectivity, and its binding mode is revealed by cryo-EM, offering a potential strategy for managing heart arrhythmia.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

C-14 hydroxyl group is critical for the function of ent-kaurane diterpenoids (ent-KTs). Here, the authors report discovery and engineering of bacterial P450s for C-14 hydroxylation in ent-KTs.

DGAT1 controls sex-specific CD8⁺ T cell responses in tumours, reducing mitochondrial function and tumour control in female mice, but protecting against oxidative stress and tumour growth in male mice through androgen receptor signalling.

Ordered antihedgehog polar lattices are engineered in antiferroelectric PbZrO₃ thin films via interfacial dislocation networks. The authors reveal that these ordered topological structures originate from mismatch.

Both endogenous and exogenous signaling pathways are involved in the maintenance of self-renewal and pluripotency of human embryonic stem cells (hESCs). Here, the authors uncover that endogenous VEGF signaling safeguards pluripotency and prevents extra-embryonic differentiation in primed hESCs via activation of transcription factor NANOG and suppression of BMP signaling activity.

Avalanche field-effect transistors (AFETs) based on 2D materials have shown promising results, but they are normally limited by high breakdown fields and low ionization indexes. Here, the authors report AFETs based on anisotropic 2D ReSe₂ showing a breakdown electric field down to 2.55 kV/cm and an ionization index up to 38.79.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Excessive inflammation contributes to mortality in sepsis. Here, the authors propose a protective function for DPEP2 in monocytes, with sepsis-induced repression of DPEP2 causing a metabolic shift toward inflammatory cytokine production, while LNP-mediated Dpep2 expression restoration shows therapeutic potential.

‘Desalination of hypersaline waters is challenging for conventional methods. Here, authors enhance MOF-801 membranes by regulating missing linkers, improving water transport and achieving high salt rejection, offering an efficient solution for water purification.’

Li, Li, Yang and Huang et al. show that ultraviolet-induced ribotoxic stress activates ZAK signaling to phosphorylate the Integrator subunit INTS12, thus promoting Integrator recruitment to CSB-bound, stalled RNA polymerase II (Pol II) and facilitating Pol II removal during efficient transcription-coupled nucleotide excision repair.

FRIL is an antiviral legume lectin that recognizes complex type N-glycans. Here, authors discover a process to activate the inert recombinant lectins, and engineer a shift of FRIL’s glycan recognition to high mannose N-glycans.

Solid-state lithium-sulfur batteries face practical challenges such as low utilization and cycle life. Here, authors introduce design strategies that enable practical operation, leading to the demonstration of a high loading Li₂S-anode free pouch cell that operates under “low stack pressure” of 10 MPa.

This study maps how insect wings form by charting cell fate changes in the silkworm wing disc over time. The authors identify a central fate-transition cell population and show how the hormone 20E rapidly accelerates wing development through coordinated gene regulation.

Using sunlight to turn carbon dioxide into fuels is appealing, but reactions are often inefficient. This study shows a photothermal catalyst that lets hydrogen move between sites, enabling selective conversion of carbon dioxide to methane.

A global study of 1602 soil samples identifies dominant bacterial plant pathogens and reveals microbial traits, soil carbon and climate that promote natural suppression, while climate change may increase disease risks in many regional hotspots.

A metal-ion-assisted RNA folding technique is used to modulate the mechanical interactions between RNA nanoparticles and cell membranes for improved protein expression and mRNA therapy.

Stretchable liquid-metal electronics is limited by high surface tension, fluidity, and poor wettability. Here, Lee et. al. presents a universal cryogenic transfer method for liquid metal particles, enabling high-throughput fabrication of wafer-scale stretchable integrated electronics with robust electrical performance.

A battery-free smart mask enables multiday exhaled breath condensate monitoring by integrating a regenerable hydrogel, an electrochemical lactate sensor and a perovskite solar cell, allowing autonomous tracking of metabolic lactate in humans.

An evaluation across 193 countries for the 2026 Global Action Plan update showed that countries with strong multisectoral governance and early surveillance adoption achieved long-term improvements in reducing antimicrobial resistance.

Electrochemical nitrate reduction can simultaneously remove pollutants and produce ammonia but is often limited by hydrogen side reactions. This study shows that nanoconfined CuCo catalysts enable a proton-coupled electron transfer pathway that delivers highly selective, efficient and stable ammonia synthesis.

Electroreduction of CO on copper is notable for enabling C–C coupling, but a fundamental understanding of what drives product selectivity is lacking. Here a series of well-defined copper nanocrystals with tunable shape and size are used to control product selectivity, with strain identified as a major factor in n-propanol formation.

Here they show that NONO collaborates with HOXA1 to modulate gene expression during early cardiomyocyte differentiation. This interaction facilitates activation of the Wnt signaling pathway, establishing the NONO-HOXA1-Wnt axis as a key mechanism in cardiac development.

Femtosecond laser pulse-induced coherent helicity switching of magnetic vortices in permalloy disks on picosecond timescales is reported.