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This study shows that primary cilia in the hypothalamic arcuate nucleus, by inhibiting AgRP neuronal activity, are essential for butyrate’s effects of suppressing appetite and enhancing glucose metabolism.

Chern ferromagnetism is established in twisted bilayer MoTe₂ devices at large twist angles. Here, the authors observe evidence of antiferromagnetic ground states with zero Hall resistance at an intermediate twist angle around three degrees, demonstrating the sensitivity of the magnetic ground state.

Investigating how aging predisposes individuals to a higher metastatic risk, the authors identify that extracellular vesicles secreted by senescent hepatocytes carry miRNAs that enhance metastatic potential in tumor-bearing aged mice, with relevance for older adults with cancer.

Bottom-up assembly of protocell building blocks into self-supporting, macroscopic, and robust prototissues that are stable in water and exhibit biomimetic behaviors remains challenging. The authors present a gas-liquid microfluidics-assisted diffusion-inhibited complexation strategy that enables low-cost, high-throughput fabrication of protocells and large-scale (>10 cm) 3D construction of prototissues.

Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease in which macrophage-driven inflammation plays a central role. Here the authors show that macrophage Gsα promotes AAA by stabilizing NLRP3 inflammasome activity, while Gsα silencing via lipid nanoparticles suppresses inflammation and disease progression.

Pulmonary arterial hypertension (PAH) is a fatal disease involving disrupted metabolic and mitochondrial regulation. Here the authors show that REV-ERBα protects against PAH by repressing BNIP3-driven mitophagy in pulmonary vascular smooth muscle cells, revealing a potential circadian-based therapeutic target.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

This study identifies an FDA-approved leukemia drug, Homoharringtonine, that can eliminate aged fat cells, improve metabolic health, reduce inflammation and extend lifespan in mice, revealing a potential approach to treat age- and obesity-related metabolic disease.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

By constructing tailored donor-acceptor structures in 3D COFs via artificial defects and electronic tuning, researchers overcame inherent limitations in conjugation and light absorption, achieving stable and efficient photocatalytic H₂O₂ production.

Neuromorphic computing hardware normally makes an unideal trade-off between energy efficiency, scalability and reliability. Kim et al. report a ferroelectric heterostructure based memristor with near-zero nonlinearity, endurance beyond 10E7 cycles, rectifying ratio exceeding 10E6 and sub-pA off-current.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

Grain chalkiness is an undesirable trait that severely compromises rice quality. Here, the authors report the cloning of an E3 ubiquitin ligase encoding gene Chalk9 and reveal its crucial role in regulating grain chalkiness through mediating the ubiquitination-dependent degradation of OsEBP89.

The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

Cancer cells could sense the availability of glucose to coordinate macromolecular synthetic processes. Here the authors find that glucose-activated adenylosuccinate lyase (ADSL) possesses a moonlighting function of promoting protein succination, thereby upregulating lipogenesis in hepatocellular carcinoma cells.

Gel-based soft materials are attractive for flexible electronics, though are constrained by unfavorable mechanical properties. Here the authors design a geometry programmed self-wrinkling strategy for organo-hydrogels, enhancing mechanical and electronic properties.

Li, Li, Yang and Huang et al. show that ultraviolet-induced ribotoxic stress activates ZAK signaling to phosphorylate the Integrator subunit INTS12, thus promoting Integrator recruitment to CSB-bound, stalled RNA polymerase II (Pol II) and facilitating Pol II removal during efficient transcription-coupled nucleotide excision repair.

Blue light promotes DNA repair in plants via cryptochrome signalling. Here the authors report that this occurs via suppression of COP1 mediated degradation of the repair factor ADA2b and propose that together photoreceptors and COP1 balance genome stability with growth under fluctuating light.

Tuning the emission of metal nanoclusters is a challenge. Here, the authors report on solvation-induced isomerization and modulation of electron transfer dynamics to achieve controllable emission across the entire visible range.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

Inborn errors of cell death (IECD) with autoinflammatory manifestations could be induced by excessive T cell death. Here the authors characterize IECD patients with autoinflammatory manifestations who possess overactive RIPK1 variants which promote T cell death, secretion of TNF and IFN-γ along with activation of monocytes and macrophages which promotes further autoinflammation.

SnRK1β1A in rice promotes susceptibility to multiple fungal diseases, and disrupting this infection-inducible gene confers broad-spectrum resistance without compromising growth or yield under normal field conditions.

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.

3Snet-CLID integrates signal-preserving deep learning denoising with direct Richardson–Lucy deconvolution to achieve over 5-fold resolution improvement on standard microscopes, enabling artifact-free nanoscale imaging of live-cell organelles and structures.

Seed size plays an important role in determining soybean yield. Here, the authors report GmSW17, encoding a homolog of Arabidopsis UBP22 that plays a role in deubiquitination, as a positive regulator of soybean seed width and seed weight through inhibition of the G1-to-S transition by interacting with GmSGF11 and GmENY2.

Preparation of phosphorescent materials from bio-based materials is desirable, but achieving the desired properties can be challenging. Here, the authors report the development of 3D printable woody materials by grafting carboxyl functional groups onto lignocellulose matrices.

Grain protein content determines rice nutrition quality. Here, the authors show that a single nucleotide polymorphism in the promoter region of OsGluA2, encoding a glutelin type-A2 precursor, is responsible for glutelin content difference between the indica and japonica rice subspecies.

This study presents azo-Q2a, a quinidine-derived photo-switchable molecule that enables optical control of Na_V1.5. It exhibits selectivity, and its binding mode is revealed by cryo-EM, offering a potential strategy for managing heart arrhythmia.

The DNA origami vaccine platform DoriVac is shown to support multiplexed nanoparticles carrying diverse antigens against emerging infectious diseases and variants.

Wang, Guo, Zhang and colleagues obtain four cryo-electron microscopy snapshots that show how IscB is kept off by two RNA lids, with a car-pedal-like guide shift activating cleavage after ~11-nt pairing. They also engineer hinge regions that boost flexibility and improve genome editing in cells.

As the properties of polymer gels are influenced by solvent as well as the network, choice of solvent is important for determination of properties. Here, the authors report the use of polyethylene glycol as a solvent for the formation of a dissipative gel, with coupling of elasticity and viscosity.

An evaluation across 193 countries for the 2026 Global Action Plan update showed that countries with strong multisectoral governance and early surveillance adoption achieved long-term improvements in reducing antimicrobial resistance.

This work studies van der Waals InSe crystals grown on China space station. Microgravity growth condition annihilates interlayer stacking-faults in InSe, activates its intrinsic sliding ferroelectricity and enhances the super linear emission property.

A metal-ion-assisted RNA folding technique is used to modulate the mechanical interactions between RNA nanoparticles and cell membranes for improved protein expression and mRNA therapy.

Insufficient efficacy is one of the major impediments for further application of sup-tRNA therapies. Here, authors engineer the body sequence of sup-tRNA^Arg and restored retinal function and vision-guided behavior in a mouse model carrying the RPE65-R44X nonsense mutation.

Exhausted CD8⁺ T cells increase proteasome activity due to the accumulation of depolarized mitochondria, which drives the selective degradation of mitochondrial proteins and releases of regulatory haem through haemoprotein breakdown.

Solid-state lithium-sulfur batteries face practical challenges such as low utilization and cycle life. Here, authors introduce design strategies that enable practical operation, leading to the demonstration of a high loading Li₂S-anode free pouch cell that operates under “low stack pressure” of 10 MPa.

Shoot branching is critical in determining soybean yield. Here, the authors report natural variation of Dt2 in controlling soybean branching number and the interaction of Dt2 with GmAgl22 and GmSoc1a to activate transcription of GmAp1a and GmAp1d.

Here the authors use CRISPR activation screens to identify metabolite-sensing receptors that affect lymphocyte targeting and infiltration of tumors and engineer CAR T and CAR NK cells with these receptors to enhance solid tumor killing in mice.

DGAT1 controls sex-specific CD8⁺ T cell responses in tumours, reducing mitochondrial function and tumour control in female mice, but protecting against oxidative stress and tumour growth in male mice through androgen receptor signalling.

Antifungal aureobasidin A (AbA) targets inositol phosphorylceramide (IPC) synthase. The authors trap its ceramide-bound and drugbound states, revealing the catalytic and drug-inhibition mechanisms, providing basis for antifungal drug development.

Stretchable liquid-metal electronics is limited by high surface tension, fluidity, and poor wettability. Here, Lee et. al. presents a universal cryogenic transfer method for liquid metal particles, enabling high-throughput fabrication of wafer-scale stretchable integrated electronics with robust electrical performance.

Previous observations of the valley Hall effect have been limited to the linear regime. Now a nonlinear version is demonstrated with a larger magnitude than in the linear case.

Newly emerging SARS-CoV-2 variants underscore the need for broad-spectrum antiviral solutions. This study shows a macrocyclic peptide inhibitor that locks the SARS-CoV-2 spike trimer into a “closed” conformation by engaging a conserved region, and demonstrates that intranasal administration of the peptide inhibitor protects against Omicron variants.

Here researchers reveal a microexon in the Ank3 gene encoding Ankyrin G allows cortical interneurons to fine-tune calcium signaling and firing, revealing the contribution of alternative splicing to the functional diversity among different types of neurons.

A dated phylogeny of 16,585 vascular plant species native to China reveals three major centres of endemism, including a potential new global biodiversity hotspot.

In neuromorphic computing, time-series prediction is a significant challenge to recurrent neural network architecture. Here, the authors present ambipolar transistors implementing a physical echo-state network for efficient time-series and image tasks, achieving high accuracy via static and dynamic computing modes.