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Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

Here they establish an NTR-based genetic ablation tool in axolotls to investigate the function of specific cells. They use this system to demonstrate the capacity of ependymoglial cells for central nervous system regeneration.

Acne is a common skin disease caused by the anaerobic Cutibacterium acnes. Here, the authors report a microneedles patch loaded with near infrared-driven self-oxygenating ZnO₂@PDA-MnO₂ nanomotors for photothermal therapy of acne.

The catalytic enantioconvergent N-alkylation of hydrazine derivatives with alkyl halides offers an attractive route to chiral hydrazines, but remains challenging due to the lack of efficient asymmetric catalytic systems and the difficulty in achieving regioselectivity. Herein, the authors report the copper-catalyzed enantioconvergent N-alkylation of hydrazine derivatives with racemic α-haloamides.

This study reports graphene–amorphous carbon with interwoven networks, achieving a flexural strength of 203 MPa. Microscopy shows that crack deflection at graphene/amorphous interfaces underlies its superior performance.

Wafer-scale monolayer MoO₃ enables the integration of dielectrics with ultralow capacitance equivalent thickness on atomically thin semiconductors, achieving high yield and effective operation of n-type and p-type top-gated transistors.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Using a wafer-scale monolayer 2D MoS₂ process instead of conventional silicon-based devices to manufacture components of spaceborne communication systems demonstrates radiation tolerance, low bit error rate and long-term stability, even under much harsher radiation environments.

Sodium metal is of interest for high-energy-density batteries, but the lack of large-area ultrathin sodium metal foils hinders research. Here a metre-length, ultrathin (≤50 μm), mechanically strengthened sodium metal foil is fabricated by a roll-to-roll calendaring process with interfacial lubrication and functional modification.

A membrane system operating without electricity and inspired by natural fractal transport patterns achieves exceptional nanofiltration performance, offering a simple and reliable source of potable water for decentralized communities.

A thin-film engineering method is employed to preserve high pressure solids in diamond capsules at ambient conditions, enabling tunable preserved pressures, controllable particle size, atomic-scale characterization, and potential large-scale uses.

Bicyclo[2.1.1]hexanes (BCHs), three-dimensional benzene bioisosteres characterized by high sp3-carbon content, hold great promise for diverse applications in medicinal chemistry. Here, authors report a secondary amine–catalyzed asymmetric [2π + 2σ] cycloaddition of bicyclo[1.1.0]butanes (BCBs) with α,β-unsaturated aldehydes.

Memristor arrays based on molecular crystal with van der Waals-linked cages are fabricated, enabling ultralow energy switching, high endurance and seamless integration into neuromorphic computing hardware.

A scalable integration process for ultrafast two-dimensional flash memory can be used to integrate 1,024 devices with a yield of over 98%. The channel length of the devices could also be scaled down to sub-10 nm.

The authors employ a 3D printing technique to induce a triple-twinned martensitic microstructure in a commercial titanium alloy, achieving both high strength and enhanced strain hardening.

Defective perovskite surfaces limit solar cell efficiency. Liu et al. introduce a small amount of a polar aprotic solvent into the defect passivation solution, enabling surface reconstruction of the perovskite layer and enhancing its overall quality.

Direct growth of graphene on h-BN is desired to improve device performance. Here, the authors demonstrate the direct growth of large-area and continuous graphene/h-BN vertical heterostructures via a co-segregation approach.

Zhao et al. demonstrate that ZmCRY1s, blue-light receptors in maize, interact with GL2 in blue light to promote C32 aldehyde accumulation thereby modulating epidermal wax composition and enhancing UV-B tolerance, revealing a light-regulated wax biosynthetic mechanism critical for maize stress adaptation.

Efforts to develop P2X7 drugs are hampered by species differences. Here, authors reveal the structural basis for these disparities and show that transgenic mice provide a powerful model for testing selective inhibitors with greater clinical relevance.

Self-organized growth often suffers from a lack of long-range order in preparing large-area nanostructures. Here, the authors develop a direct electrochemical growth technique for preparing ordered magnetic networks without the use of templates.

The combination of plasmon-mediated electron enrichment and a continuous-flow reactor overcomes key challenges in selective methane oxidation, achieving a methanol production rate of over 6.5 mmol·g-1·h-1 with the selectivity of 100% and sustained stability over 100 h under ambient pressure.

In this work, authors present a nanoinducer (bacNID), which enables targeted bacterial protein degradation via ClpXP, leading to the effective treatment of bacterial infection (Staphylococcus aureus and Salmonella typhimurium) without inducing resistance.

A full-featured 2D NOR flash memory chip realized by an atomic device to chip technology combines a superior 2D electronic device as a memory core and a powerful CMOS platform to support complex instruction control.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

MRGPRX1 is a key GPCR expressed in the DRG for itch perception, generating scratch or avoidance behaviors. Here, authors provide structural and pharmacological insights into itch sensation, activation and G-protein signaling downstream of MRGPRX1.

Graphene has the high carrier mobility and short photoresponse time required for efficient photodetection, but broad and weak optical absorption are severe drawbacks. Here, the authors show that twisted bilayer graphene with van Hove singularities exhibits a strong light-matter interaction and selectively enhanced photocurrent generation.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

The HKU25 clade MERS-related coronaviruses with broad distribution are shown to use ACE2 as a functional receptor, revealing unexpected receptor plasticity and offering new insights into coronavirus evolution, host range and potential zoonotic risk.

The positive electrode/electrolyte interface is crucial for the performance of all-solid-state lithium batteries. Here, authors use a sintering technique to form a conformal interface between high-entropy disordered rock salt electrodes and garnet-type electrolytes to reduce interfacial resistance.

High-resolution electron microscopy requires robust and noise-free substrates to support the specimens. Here, the authors present a polymer- and transfer-free direct-etching method for fabrication of graphene grids with ultraclean surfaces and demonstrate cryo-EM at record high resolution.

Confining high-entropy nanoparticles in molecular sieves enhances catalytic performance but lacks scalable synthesis methods. This study presents a versatile quenching strategy, producing uniform HE-NPs@MSs with high propane dehydrogenation activity.

Bilayer graphene (BLG) is promising for optoelectronic applications due to its tunable bandgap, but its large-area growth on Cu substrates is still challenging. Here, the authors demonstrate the fast synthesis of high-coverage meter-scale BLG on commercial Cu foils by introducing CO₂ during the growth.

Electrified reactive capture converts CO₂ from carbonate solutions but suffers from low Faradaic efficiency. Here, the authors report a templated synthesis with defined pores and Ni single atoms to accumulate CO₂, achieving 46% energy efficiency to syngas at 300 mA/cm²

Gate-all-around (GAA) nanosheet field-effect transistors (FETs) based on 2D semiconductors hold promise to complement silicon in future integrated circuits. Here, the authors report the wafer-scale growth of high-κ dielectric/semiconductor β-Bi₂SeO₅/Bi₂O₂Se/α-Bi₂SeO₅ heterostructures and their application for high performance 2D GAA FETs.

Viruses exploit host cell machinery for replication, but their spatial cues remain elusive. Using nanochip-enabled membrane shaping, the authors discover saddle curvature association of viral proteins, revealing a new spatial regulation mechanism.

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here the authors report the results of a phase II clinical trial of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in RMC, associating the activation of a myeloid mimicry program in tumor cells to the rapid disease progression and hyper-progression observed in treated patients.

The Dark sectioning algorithm removes the background and provides single-frame optical sectioning in fluorescence microscopy. It offers improved quantitative analysis and deep-tissue segmentation accuracy and is compatible to diverse modalities.

Here, the authors reveal progressive conformational changes of α-synuclein fibrils upon binding with polysaccharide heparin, suggesting that biopolymers have a crucial role in remodeling the structures and pathological activities of amyloid fibrils.

A size-sieved complex precipitation in Sc-added Al–Mg alloys achieves a high-density dispersion of both fine Al₃Sc nanoprecipitates and in situ formed core-shell Al₃(Mg, Sc)₂/Al₃Sc nanophases with high hydrogen-trapping ability.

Stem cells are highly resistant to viral infection, irrespective of any interferon response. Here the authors discover that VAMP5 as a potent cell-autonomous defense factor protects ESCs from various viruses’ infection, including SARS-CoV-2 by interacting with RNA replication complexes to defend against viral infection.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Combination of p- and n-doped graphene is important in optoelectronic applications, but spatially selective doping of graphene is challenging. This work reports large-scale growth of graphene monolayers with spatially modulation doping and built-in single-crystalline p–n junctions.

Dirac semimetals possess an electronic dispersion relation which is linear in three dimensions, making them three-dimensional analogues of graphene. Here, the authors report large negative magnetoresistance in single-crystal Cd₃As₂nanowires, evidencing a sought-after chiral anomaly effect.

A reference-quality genome assembly of hexaploid oat variety ‘Sanfensan’ and genome assemblies of its diploid and tetraploid Avena ancestors provide insights into the evolutionary history of allohexaploid oat.

WS₂ is a promising material for application in next-generation electronics, yet current methods of fabrication can only yield micrometre-sized domains. Here, via ambient-pressure CVD, the authors report the growth of high-quality, uniform monolayer WS₂single crystals of the order of millimetres.

Silicon-integrated graphene photodetectors exhibit promising bandwidths at telecom wavelengths, but their responsivity is usually limited. Here, the authors report the wafer-scale fabrication of waveguide-integrated detectors based on twisted bilayer graphene, showing responsivities up to 0.65 A/W and 3-dB bandwidths >65 GHz.